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Protein
Submitted name:

Cytochrome c oxidase subunit I

Gene

coxA2

Organism
Aquifex aeolicus (strain VF5)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotation

Keywords - Biological processi

Electron transport, Respiratory chainUniRule annotation, Transport

Keywords - Ligandi

HemeUniRule annotation, Iron, Metal-binding

Enzyme and pathway databases

BioCyciAAEO224324:GJBH-1572-MONOMER.

Names & Taxonomyi

Protein namesi
Submitted name:
Cytochrome c oxidase subunit IImported
Gene namesi
Name:coxA2Imported
Ordered Locus Names:aq_2192Imported
OrganismiAquifex aeolicus (strain VF5)Imported
Taxonomic identifieri224324 [NCBI]
Taxonomic lineageiBacteriaAquificaeAquificalesAquificaceaeAquifex
Proteomesi
  • UP000000798 Componenti: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei12 – 3827HelicalSequence analysisAdd
BLAST
Transmembranei58 – 8326HelicalSequence analysisAdd
BLAST
Transmembranei95 – 11319HelicalSequence analysisAdd
BLAST
Transmembranei133 – 15018HelicalSequence analysisAdd
BLAST
Transmembranei170 – 19526HelicalSequence analysisAdd
BLAST
Transmembranei215 – 23723HelicalSequence analysisAdd
BLAST
Transmembranei258 – 27619HelicalSequence analysisAdd
BLAST
Transmembranei288 – 30821HelicalSequence analysisAdd
BLAST
Transmembranei345 – 36420HelicalSequence analysisAdd
BLAST
Transmembranei384 – 40421HelicalSequence analysisAdd
BLAST
Transmembranei416 – 43722HelicalSequence analysisAdd
BLAST
Transmembranei470 – 49829HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Interactioni

Protein-protein interaction databases

STRINGi224324.aq_2192.

Structurei

3D structure databases

ProteinModelPortaliO67937.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 520520COX1InterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the heme-copper respiratory oxidase family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiENOG4107RQ2. Bacteria.
COG0843. LUCA.
HOGENOMiHOG000249472.
InParanoidiO67937.
KOiK02274.
OMAiLVVHNTS.
OrthoDBiEOG64FKC6.

Family and domain databases

Gene3Di1.20.210.10. 1 hit.
InterProiIPR000883. COX1.
IPR023615. Cyt_c_Oxase_su1_BS.
IPR023616. Cyt_c_Oxase_su1_dom.
[Graphical view]
PANTHERiPTHR10422. PTHR10422. 2 hits.
PfamiPF00115. COX1. 1 hit.
[Graphical view]
PRINTSiPR01165. CYCOXIDASEI.
SUPFAMiSSF81442. SSF81442. 1 hit.
PROSITEiPS50855. COX1. 1 hit.
PS00077. COX1_CUB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O67937-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MWVMQVSNAI KFIILTEIIF PTLLLVFGIY HGVMQVFYRS GIIKAESFLG
60 70 80 90 100
IDYYQGLTLH GVINVIVYTT IFIVGFSNAI VAYSLKKPLR EKVQWIALGM
110 120 130 140 150
MVIGTLMAAW AMFTGRATVL YTFYPPLIAH WTFYLGAVLL VLGSLVPFFF
160 170 180 190 200
DWIPSAIQWK RENPDQKLPL AVFGTFVNFI LWTIMIVPVA IEILFQLLPL
210 220 230 240 250
SLGLVDEINP LLARTLFWFF GHPVVYFWLL PAYVALYTIL PKIVSEKGKL
260 270 280 290 300
YSDPAARLAF ILFLIFSLPV GLHHQFTDPG ITNTWKLIHA LFTFGVALPS
310 320 330 340 350
MITAFTVATS LEYSVKAEHP ELKNSKFYWW TFLPFMRLEG NKWMFSYFFA
360 370 380 390 400
GLVLFFIGGI TGIVNASYNV NLVVHNTAYV PGHFHTTVGG LVLLVFFALS
410 420 430 440 450
LYMVSKLRGS EVKLKGLAVL APYFWMQGMF MFSYAMMVGG VVVGFPRRTN
460 470 480 490 500
AGLTYLNPDS PLYRPEWTGY AQLAAVGGVL LAIGFAFYFA SLIATALAPK
510 520 530 540 550
VRESTLEFPI ADAYHDAPAP LLNNLKTWTV AAIILAVLSY IPPLYDASVR
560 570 580 590
GVFFKSPAYN EKFPMPLKQL QGAEKKEEKK ELSKAEGGIT QK
Length:592
Mass (Da):66,484
Last modified:August 1, 1998 - v1
Checksum:i67891C0B0FD544B5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000657 Genomic DNA. Translation: AAC07900.1.
PIRiE70488.
RefSeqiNP_214506.1. NC_000918.1.
WP_010881442.1. NC_000918.1.

Genome annotation databases

EnsemblBacteriaiAAC07900; AAC07900; aq_2192.
GeneIDi1193987.
KEGGiaae:aq_2192.
PATRICi20961214. VBIAquAeo85532_1697.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000657 Genomic DNA. Translation: AAC07900.1.
PIRiE70488.
RefSeqiNP_214506.1. NC_000918.1.
WP_010881442.1. NC_000918.1.

3D structure databases

ProteinModelPortaliO67937.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi224324.aq_2192.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC07900; AAC07900; aq_2192.
GeneIDi1193987.
KEGGiaae:aq_2192.
PATRICi20961214. VBIAquAeo85532_1697.

Phylogenomic databases

eggNOGiENOG4107RQ2. Bacteria.
COG0843. LUCA.
HOGENOMiHOG000249472.
InParanoidiO67937.
KOiK02274.
OMAiLVVHNTS.
OrthoDBiEOG64FKC6.

Enzyme and pathway databases

BioCyciAAEO224324:GJBH-1572-MONOMER.

Family and domain databases

Gene3Di1.20.210.10. 1 hit.
InterProiIPR000883. COX1.
IPR023615. Cyt_c_Oxase_su1_BS.
IPR023616. Cyt_c_Oxase_su1_dom.
[Graphical view]
PANTHERiPTHR10422. PTHR10422. 2 hits.
PfamiPF00115. COX1. 1 hit.
[Graphical view]
PRINTSiPR01165. CYCOXIDASEI.
SUPFAMiSSF81442. SSF81442. 1 hit.
PROSITEiPS50855. COX1. 1 hit.
PS00077. COX1_CUB. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: VF5Imported.

Entry informationi

Entry nameiO67937_AQUAE
AccessioniPrimary (citable) accession number: O67937
Entry historyi
Integrated into UniProtKB/TrEMBL: August 1, 1998
Last sequence update: August 1, 1998
Last modified: March 16, 2016
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.