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Protein
Submitted name:

Cytochrome c oxidase subunit I

Gene

coxA2

Organism
Aquifex aeolicus (strain VF5)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotation

Keywords - Biological processi

Electron transport, Respiratory chainUniRule annotation, Transport

Keywords - Ligandi

HemeUniRule annotation, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Submitted name:
Cytochrome c oxidase subunit IImported
Gene namesi
Name:coxA2Imported
Ordered Locus Names:aq_2192Imported
OrganismiAquifex aeolicus (strain VF5)Imported
Taxonomic identifieri224324 [NCBI]
Taxonomic lineageiBacteriaAquificaeAquificalesAquificaceaeAquifex
Proteomesi
  • UP000000798 Componenti: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei12 – 38HelicalSequence analysisAdd BLAST27
Transmembranei58 – 83HelicalSequence analysisAdd BLAST26
Transmembranei95 – 113HelicalSequence analysisAdd BLAST19
Transmembranei133 – 150HelicalSequence analysisAdd BLAST18
Transmembranei170 – 195HelicalSequence analysisAdd BLAST26
Transmembranei215 – 237HelicalSequence analysisAdd BLAST23
Transmembranei258 – 276HelicalSequence analysisAdd BLAST19
Transmembranei288 – 308HelicalSequence analysisAdd BLAST21
Transmembranei345 – 364HelicalSequence analysisAdd BLAST20
Transmembranei384 – 404HelicalSequence analysisAdd BLAST21
Transmembranei416 – 437HelicalSequence analysisAdd BLAST22
Transmembranei470 – 498HelicalSequence analysisAdd BLAST29

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Interactioni

Protein-protein interaction databases

STRINGi224324.aq_2192.

Structurei

3D structure databases

ProteinModelPortaliO67937.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 520COX1InterPro annotationAdd BLAST520

Sequence similaritiesi

Belongs to the heme-copper respiratory oxidase family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiENOG4107RQ2. Bacteria.
COG0843. LUCA.
HOGENOMiHOG000249472.
InParanoidiO67937.
KOiK02274.
OMAiLVVHNTS.
OrthoDBiPOG091H0PA9.

Family and domain databases

CDDicd01660. ba3-like_Oxidase_I. 1 hit.
Gene3Di1.20.210.10. 1 hit.
InterProiIPR033943. ba3-like_Oxidase_I.
IPR000883. COX1.
IPR023616. Cyt_c_oxase-like_su1_dom.
IPR023615. Cyt_c_Oxase_su1_BS.
[Graphical view]
PANTHERiPTHR10422. PTHR10422. 2 hits.
PfamiPF00115. COX1. 1 hit.
[Graphical view]
PRINTSiPR01165. CYCOXIDASEI.
SUPFAMiSSF81442. SSF81442. 1 hit.
PROSITEiPS50855. COX1. 1 hit.
PS00077. COX1_CUB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O67937-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MWVMQVSNAI KFIILTEIIF PTLLLVFGIY HGVMQVFYRS GIIKAESFLG
60 70 80 90 100
IDYYQGLTLH GVINVIVYTT IFIVGFSNAI VAYSLKKPLR EKVQWIALGM
110 120 130 140 150
MVIGTLMAAW AMFTGRATVL YTFYPPLIAH WTFYLGAVLL VLGSLVPFFF
160 170 180 190 200
DWIPSAIQWK RENPDQKLPL AVFGTFVNFI LWTIMIVPVA IEILFQLLPL
210 220 230 240 250
SLGLVDEINP LLARTLFWFF GHPVVYFWLL PAYVALYTIL PKIVSEKGKL
260 270 280 290 300
YSDPAARLAF ILFLIFSLPV GLHHQFTDPG ITNTWKLIHA LFTFGVALPS
310 320 330 340 350
MITAFTVATS LEYSVKAEHP ELKNSKFYWW TFLPFMRLEG NKWMFSYFFA
360 370 380 390 400
GLVLFFIGGI TGIVNASYNV NLVVHNTAYV PGHFHTTVGG LVLLVFFALS
410 420 430 440 450
LYMVSKLRGS EVKLKGLAVL APYFWMQGMF MFSYAMMVGG VVVGFPRRTN
460 470 480 490 500
AGLTYLNPDS PLYRPEWTGY AQLAAVGGVL LAIGFAFYFA SLIATALAPK
510 520 530 540 550
VRESTLEFPI ADAYHDAPAP LLNNLKTWTV AAIILAVLSY IPPLYDASVR
560 570 580 590
GVFFKSPAYN EKFPMPLKQL QGAEKKEEKK ELSKAEGGIT QK
Length:592
Mass (Da):66,484
Last modified:August 1, 1998 - v1
Checksum:i67891C0B0FD544B5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000657 Genomic DNA. Translation: AAC07900.1.
PIRiE70488.
RefSeqiNP_214506.1. NC_000918.1.
WP_010881442.1. NC_000918.1.

Genome annotation databases

EnsemblBacteriaiAAC07900; AAC07900; aq_2192.
GeneIDi1193987.
KEGGiaae:aq_2192.
PATRICi20961214. VBIAquAeo85532_1697.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000657 Genomic DNA. Translation: AAC07900.1.
PIRiE70488.
RefSeqiNP_214506.1. NC_000918.1.
WP_010881442.1. NC_000918.1.

3D structure databases

ProteinModelPortaliO67937.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi224324.aq_2192.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC07900; AAC07900; aq_2192.
GeneIDi1193987.
KEGGiaae:aq_2192.
PATRICi20961214. VBIAquAeo85532_1697.

Phylogenomic databases

eggNOGiENOG4107RQ2. Bacteria.
COG0843. LUCA.
HOGENOMiHOG000249472.
InParanoidiO67937.
KOiK02274.
OMAiLVVHNTS.
OrthoDBiPOG091H0PA9.

Family and domain databases

CDDicd01660. ba3-like_Oxidase_I. 1 hit.
Gene3Di1.20.210.10. 1 hit.
InterProiIPR033943. ba3-like_Oxidase_I.
IPR000883. COX1.
IPR023616. Cyt_c_oxase-like_su1_dom.
IPR023615. Cyt_c_Oxase_su1_BS.
[Graphical view]
PANTHERiPTHR10422. PTHR10422. 2 hits.
PfamiPF00115. COX1. 1 hit.
[Graphical view]
PRINTSiPR01165. CYCOXIDASEI.
SUPFAMiSSF81442. SSF81442. 1 hit.
PROSITEiPS50855. COX1. 1 hit.
PS00077. COX1_CUB. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiO67937_AQUAE
AccessioniPrimary (citable) accession number: O67937
Entry historyi
Integrated into UniProtKB/TrEMBL: August 1, 1998
Last sequence update: August 1, 1998
Last modified: November 30, 2016
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.