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Protein

Cytochrome c oxidase subunit 2

Gene

coxB

Organism
Aquifex aeolicus (strain VF5)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B).UniRule annotation

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.UniRule annotation

Cofactori

Cu cationUniRule annotationNote: Binds a copper A center.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotation

Keywords - Biological processi

Electron transport, Respiratory chainUniRule annotation, Transport

Keywords - Ligandi

CopperUniRule annotation, Metal-bindingUniRule annotation

Enzyme and pathway databases

BioCyciAAEO224324:GJBH-1569-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 2UniRule annotation (EC:1.9.3.1UniRule annotation)
Gene namesi
Name:coxBImported
Ordered Locus Names:aq_2190Imported
OrganismiAquifex aeolicus (strain VF5)Imported
Taxonomic identifieri224324 [NCBI]
Taxonomic lineageiBacteriaAquificaeAquificalesAquificaceaeAquifex
Proteomesi
  • UP000000798 Componenti: Chromosome

Subcellular locationi

  • Cell membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei16 – 3924HelicalSequence analysisAdd
BLAST
Transmembranei60 – 8122HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Interactioni

Protein-protein interaction databases

STRINGi224324.aq_2190.

Structurei

3D structure databases

ProteinModelPortaliO67934.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini92 – 221130COX2_CUAInterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the cytochrome c oxidase subunit 2 family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiENOG4105CV4. Bacteria.
COG1622. LUCA.
HOGENOMiHOG000115086.
InParanoidiO67934.
KOiK02275.
OMAiVVLPMEM.
OrthoDBiPOG091H05L4.

Family and domain databases

Gene3Di1.10.287.90. 1 hit.
2.60.40.420. 1 hit.
InterProiIPR001505. Copper_CuA.
IPR008972. Cupredoxin.
IPR014222. Cyt_c_oxidase_su2.
IPR002429. Cyt_c_oxidase_su2_C.
IPR011759. Cyt_c_oxidase_su2_TM_dom.
[Graphical view]
PfamiPF00116. COX2. 1 hit.
PF02790. COX2_TM. 1 hit.
[Graphical view]
SUPFAMiSSF49503. SSF49503. 1 hit.
SSF81464. SSF81464. 1 hit.
TIGRFAMsiTIGR02866. CoxB. 1 hit.
PROSITEiPS00078. COX2. 1 hit.
PS50857. COX2_CUA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O67934-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEQVIALPYK WWAEAVTVWL IVAVVIYLIV AIPGIYFIYK YRYKPGEREI
60 70 80 90 100
GDHDFEGHMG LEALLTIIPL LTVIFLATYS FTIFKKQRTV PDGAMTIKVT
110 120 130 140 150
AFMWGWQFDY LDENGKVIKT VVTGYHANDY NLQEFEKPVI PAGKPIRALL
160 170 180 190 200
TSMDVIHSFF VLPARITEDM VPGRTTYLWF QINKPGEYWV FCREYCGTGH
210 220 230
SHMFTKLKVV PPEQFTAWLY GKNEVAIKSN NKEVAR
Length:236
Mass (Da):27,303
Last modified:August 1, 1998 - v1
Checksum:i9C4718A102200D32
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000657 Genomic DNA. Translation: AAC07901.1.
PIRiB70488.
RefSeqiNP_214503.1. NC_000918.1.
WP_010881439.1. NC_000918.1.

Genome annotation databases

EnsemblBacteriaiAAC07901; AAC07901; aq_2190.
GeneIDi1193984.
KEGGiaae:aq_2190.
PATRICi20961206. VBIAquAeo85532_1693.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000657 Genomic DNA. Translation: AAC07901.1.
PIRiB70488.
RefSeqiNP_214503.1. NC_000918.1.
WP_010881439.1. NC_000918.1.

3D structure databases

ProteinModelPortaliO67934.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi224324.aq_2190.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC07901; AAC07901; aq_2190.
GeneIDi1193984.
KEGGiaae:aq_2190.
PATRICi20961206. VBIAquAeo85532_1693.

Phylogenomic databases

eggNOGiENOG4105CV4. Bacteria.
COG1622. LUCA.
HOGENOMiHOG000115086.
InParanoidiO67934.
KOiK02275.
OMAiVVLPMEM.
OrthoDBiPOG091H05L4.

Enzyme and pathway databases

BioCyciAAEO224324:GJBH-1569-MONOMER.

Family and domain databases

Gene3Di1.10.287.90. 1 hit.
2.60.40.420. 1 hit.
InterProiIPR001505. Copper_CuA.
IPR008972. Cupredoxin.
IPR014222. Cyt_c_oxidase_su2.
IPR002429. Cyt_c_oxidase_su2_C.
IPR011759. Cyt_c_oxidase_su2_TM_dom.
[Graphical view]
PfamiPF00116. COX2. 1 hit.
PF02790. COX2_TM. 1 hit.
[Graphical view]
SUPFAMiSSF49503. SSF49503. 1 hit.
SSF81464. SSF81464. 1 hit.
TIGRFAMsiTIGR02866. CoxB. 1 hit.
PROSITEiPS00078. COX2. 1 hit.
PS50857. COX2_CUA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiO67934_AQUAE
AccessioniPrimary (citable) accession number: O67934
Entry historyi
Integrated into UniProtKB/TrEMBL: August 1, 1998
Last sequence update: August 1, 1998
Last modified: September 7, 2016
This is version 122 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.