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Protein

Cytochrome c oxidase subunit 2

Gene

coxB

Organism
Aquifex aeolicus (strain VF5)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B).UniRule annotation

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.UniRule annotation

Cofactori

Cu cationUniRule annotationNote: Binds a copper A center.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductaseUniRule annotation
Biological processElectron transport, Respiratory chainUniRule annotation, Transport
LigandCopperUniRule annotation, Metal-bindingUniRule annotation

Enzyme and pathway databases

BioCyciAAEO224324:G1G15-1565-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 2UniRule annotation (EC:1.9.3.1UniRule annotation)
Gene namesi
Name:coxBImported
Ordered Locus Names:aq_2190Imported
OrganismiAquifex aeolicus (strain VF5)Imported
Taxonomic identifieri224324 [NCBI]
Taxonomic lineageiBacteriaAquificaeAquificalesAquificaceaeAquifex
Proteomesi
  • UP000000798 Componenti: Chromosome

Subcellular locationi

  • Cell membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei16 – 39HelicalSequence analysisAdd BLAST24
Transmembranei60 – 81HelicalSequence analysisAdd BLAST22

GO - Cellular componenti

Keywords - Cellular componenti

Membrane

Interactioni

Protein-protein interaction databases

STRINGi224324.aq_2190

Structurei

3D structure databases

ProteinModelPortaliO67934
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini92 – 221COX2_CUAInterPro annotationAdd BLAST130

Sequence similaritiesi

Belongs to the cytochrome c oxidase subunit 2 family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiENOG4105CV4 Bacteria
COG1622 LUCA
HOGENOMiHOG000115086
InParanoidiO67934
KOiK02275
OMAiWSYEYTD
OrthoDBiPOG091H05L4

Family and domain databases

Gene3Di1.10.287.90, 1 hit
InterProiView protein in InterPro
IPR002429 CcO_II-like_C
IPR001505 Copper_CuA
IPR008972 Cupredoxin
IPR014222 Cyt_c_oxidase_su2
IPR011759 Cyt_c_oxidase_su2_TM_dom
IPR036257 Cyt_c_oxidase_su2_TM_sf
PfamiView protein in Pfam
PF00116 COX2, 1 hit
PF02790 COX2_TM, 1 hit
SUPFAMiSSF49503 SSF49503, 1 hit
SSF81464 SSF81464, 1 hit
TIGRFAMsiTIGR02866 CoxB, 1 hit
PROSITEiView protein in PROSITE
PS00078 COX2, 1 hit
PS50857 COX2_CUA, 1 hit

Sequencei

Sequence statusi: Complete.

O67934-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEQVIALPYK WWAEAVTVWL IVAVVIYLIV AIPGIYFIYK YRYKPGEREI
60 70 80 90 100
GDHDFEGHMG LEALLTIIPL LTVIFLATYS FTIFKKQRTV PDGAMTIKVT
110 120 130 140 150
AFMWGWQFDY LDENGKVIKT VVTGYHANDY NLQEFEKPVI PAGKPIRALL
160 170 180 190 200
TSMDVIHSFF VLPARITEDM VPGRTTYLWF QINKPGEYWV FCREYCGTGH
210 220 230
SHMFTKLKVV PPEQFTAWLY GKNEVAIKSN NKEVAR
Length:236
Mass (Da):27,303
Last modified:August 1, 1998 - v1
Checksum:i9C4718A102200D32
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000657 Genomic DNA Translation: AAC07901.1
PIRiB70488
RefSeqiNP_214503.1, NC_000918.1
WP_010881439.1, NC_000918.1

Genome annotation databases

EnsemblBacteriaiAAC07901; AAC07901; aq_2190
GeneIDi1193984
KEGGiaae:aq_2190

Similar proteinsi

Entry informationi

Entry nameiO67934_AQUAE
AccessioniPrimary (citable) accession number: O67934
Entry historyiIntegrated into UniProtKB/TrEMBL: August 1, 1998
Last sequence update: August 1, 1998
Last modified: March 28, 2018
This is version 130 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
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Main funding by: National Institutes of Health