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Protein

Sulfide-quinone reductase

Gene

sqr

Organism
Aquifex aeolicus (strain VF5)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Catalyzes the oxidation of hydrogen sulfide, with the help of a quinone. Consecutive reaction cycles lead to the accumulation of a polysulfide product on the active site Cys residues; these products are released when they exceed a critical length, typically as cyclooctasulfur.2 Publications

Catalytic activityi

n sulfide + n quinone = polysulfide + n quinol.2 Publications

Cofactori

FAD1 PublicationNote: Binds 1 FAD per subunit.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei105FAD; via carbonyl oxygen1 Publication1
Active sitei156Cysteine persulfide intermediate1 PublicationBy similarity1
Binding sitei294FAD; via amide nitrogen1 Publication1
Binding sitei314FAD; via amide nitrogen1 Publication1
Binding sitei346Quinone; via carbonyl oxygen1 Publication1
Active sitei347Cysteine persulfide intermediate1 PublicationBy similarity1
Binding sitei382FAD1 Publication1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi9 – 13FAD1 Publication5
Nucleotide bindingi34 – 36FAD1 Publication3
Nucleotide bindingi42 – 43FAD1 Publication2

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

FAD, Flavoprotein, Nucleotide-binding

Enzyme and pathway databases

BRENDAi1.8.5.4. 396.

Names & Taxonomyi

Protein namesi
Recommended name:
Sulfide-quinone reductase (EC:1.8.5.42 Publications)
Short name:
SQR
Alternative name(s):
Sulfide:quinone oxidoreductase2 Publications
Gene namesi
Name:sqrImported
Ordered Locus Names:aq_2186Imported
OrganismiAquifex aeolicus (strain VF5)Imported
Taxonomic identifieri224324 [NCBI]
Taxonomic lineageiBacteriaAquificaeAquificalesAquificaceaeAquifex
Proteomesi
  • UP000000798 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004308241 – 430Sulfide-quinone reductaseAdd BLAST430

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi280 ↔ 4221 Publication
Disulfide bondi419 ↔ 4301 Publication

Keywords - PTMi

Disulfide bond, Quinone

Interactioni

Subunit structurei

Homotrimer.1 Publication

Protein-protein interaction databases

DIPiDIP-48896N.
STRINGi224324.aq_2186.

Structurei

Secondary structure

1430
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi4 – 8Combined sources5
Helixi12 – 24Combined sources13
Beta strandi29 – 33Combined sources5
Beta strandi35 – 40Combined sources6
Helixi42 – 44Combined sources3
Helixi45 – 49Combined sources5
Helixi55 – 57Combined sources3
Beta strandi58 – 62Combined sources5
Turni63 – 65Combined sources3
Helixi66 – 69Combined sources4
Beta strandi71 – 74Combined sources4
Beta strandi78 – 82Combined sources5
Turni83 – 86Combined sources4
Beta strandi87 – 90Combined sources4
Beta strandi95 – 97Combined sources3
Beta strandi99 – 103Combined sources5
Beta strandi108 – 110Combined sources3
Helixi116 – 119Combined sources4
Helixi126 – 141Combined sources16
Beta strandi146 – 150Combined sources5
Helixi158 – 173Combined sources16
Helixi177 – 179Combined sources3
Beta strandi182 – 185Combined sources4
Beta strandi187 – 190Combined sources4
Turni194 – 197Combined sources4
Helixi202 – 212Combined sources11
Beta strandi216 – 218Combined sources3
Beta strandi222 – 226Combined sources5
Beta strandi228 – 234Combined sources7
Beta strandi240 – 244Combined sources5
Beta strandi246 – 251Combined sources6
Beta strandi253 – 255Combined sources3
Helixi258 – 261Combined sources4
Turni265 – 267Combined sources3
Turni270 – 272Combined sources3
Beta strandi284 – 286Combined sources3
Beta strandi289 – 291Combined sources3
Helixi314 – 332Combined sources19
Beta strandi339 – 341Combined sources3
Beta strandi345 – 350Combined sources6
Beta strandi352 – 366Combined sources15
Beta strandi368 – 375Combined sources8
Helixi377 – 395Combined sources19
Helixi401 – 411Combined sources11
Beta strandi415 – 418Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3HYVX-ray2.30A/B/C/D/E/F1-430[»]
3HYWX-ray2.00A/B/C/D/E/F1-430[»]
3HYXX-ray2.90A/B/C/D/E/F1-430[»]
ProteinModelPortaliO67931.
SMRiO67931.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO67931.

Family & Domainsi

Sequence similaritiesi

Belongs to the SQRD family.Curated

Phylogenomic databases

eggNOGiENOG4107SA8. Bacteria.
COG0446. LUCA.
HOGENOMiHOG000008171.
InParanoidiO67931.
KOiK17218.
OMAiAYEFAFI.
OrthoDBiPOG091H09D4.

Family and domain databases

Gene3Di3.50.50.60. 3 hits.
InterProiIPR023753. FAD/NAD-binding_dom.
[Graphical view]
PfamiPF07992. Pyr_redox_2. 1 hit.
[Graphical view]
SUPFAMiSSF51905. SSF51905. 3 hits.

Sequencei

Sequence statusi: Complete.

O67931-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKHVVVIGG GVGGIATAYN LRNLMPDLKI TLISDRPYFG FTPAFPHLAM
60 70 80 90 100
GWRKFEDISV PLAPLLPKFN IEFINEKAES IDPDANTVTT QSGKKIEYDY
110 120 130 140 150
LVIATGPKLV FGAEGQEENS TSICTAEHAL ETQKKLQELY ANPGPVVIGA
160 170 180 190 200
IPGVSCFGPA YEFALMLHYE LKKRGIRYKV PMTFITSEPY LGHFGVGGIG
210 220 230 240 250
ASKRLVEDLF AERNIDWIAN VAVKAIEPDK VIYEDLNGNT HEVPAKFTMF
260 270 280 290 300
MPSFQGPEVV ASAGDKVANP ANKMVIVNRC FQNPTYKNIF GVGVVTAIPP
310 320 330 340 350
IEKTPIPTGV PKTGMMIEQM AMAVAHNIVN DIRNNPDKYA PRLSAICIAD
360 370 380 390 400
FGEDAGFFFA DPVIPPRERV ITKMGKWAHY FKTAFEKYFL WKVRNGNIAP
410 420 430
SFEEKVLEIF LKVHPIELCK DCEGAPGSRC
Length:430
Mass (Da):47,449
Last modified:August 1, 1998 - v1
Checksum:i7489B07FADEAA9A8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000657 Genomic DNA. Translation: AAC07903.1.
PIRiG70487.
RefSeqiNP_214500.1. NC_000918.1.
WP_010881436.1. NC_000918.1.

Genome annotation databases

EnsemblBacteriaiAAC07903; AAC07903; aq_2186.
GeneIDi1193920.
KEGGiaae:aq_2186.
PATRICi20961200. VBIAquAeo85532_1690.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000657 Genomic DNA. Translation: AAC07903.1.
PIRiG70487.
RefSeqiNP_214500.1. NC_000918.1.
WP_010881436.1. NC_000918.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3HYVX-ray2.30A/B/C/D/E/F1-430[»]
3HYWX-ray2.00A/B/C/D/E/F1-430[»]
3HYXX-ray2.90A/B/C/D/E/F1-430[»]
ProteinModelPortaliO67931.
SMRiO67931.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-48896N.
STRINGi224324.aq_2186.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC07903; AAC07903; aq_2186.
GeneIDi1193920.
KEGGiaae:aq_2186.
PATRICi20961200. VBIAquAeo85532_1690.

Phylogenomic databases

eggNOGiENOG4107SA8. Bacteria.
COG0446. LUCA.
HOGENOMiHOG000008171.
InParanoidiO67931.
KOiK17218.
OMAiAYEFAFI.
OrthoDBiPOG091H09D4.

Enzyme and pathway databases

BRENDAi1.8.5.4. 396.

Miscellaneous databases

EvolutionaryTraceiO67931.

Family and domain databases

Gene3Di3.50.50.60. 3 hits.
InterProiIPR023753. FAD/NAD-binding_dom.
[Graphical view]
PfamiPF07992. Pyr_redox_2. 1 hit.
[Graphical view]
SUPFAMiSSF51905. SSF51905. 3 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiSQRD_AQUAE
AccessioniPrimary (citable) accession number: O67931
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 29, 2014
Last sequence update: August 1, 1998
Last modified: November 30, 2016
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.