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Protein

Sulfide-quinone reductase

Gene

sqr

Organism
Aquifex aeolicus (strain VF5)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Catalyzes the oxidation of hydrogen sulfide, with the help of a quinone. Consecutive reaction cycles lead to the accumulation of a polysulfide product on the active site Cys residues; these products are released when they exceed a critical length, typically as cyclooctasulfur.2 Publications

Catalytic activityi

n sulfide + n quinone = polysulfide + n quinol.2 Publications

Cofactori

FAD1 PublicationNote: Binds 1 FAD per subunit.1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei105 – 1051FAD; via carbonyl oxygen1 Publication
Active sitei156 – 1561Cysteine persulfide intermediate1 PublicationBy similarity
Binding sitei294 – 2941FAD; via amide nitrogen1 Publication
Binding sitei314 – 3141FAD; via amide nitrogen1 Publication
Binding sitei346 – 3461Quinone; via carbonyl oxygen1 Publication
Active sitei347 – 3471Cysteine persulfide intermediate1 PublicationBy similarity
Binding sitei382 – 3821FAD1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi9 – 135FAD1 Publication
Nucleotide bindingi34 – 363FAD1 Publication
Nucleotide bindingi42 – 432FAD1 Publication

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

FAD, Flavoprotein, Nucleotide-binding

Enzyme and pathway databases

BioCyciAAEO224324:GJBH-1566-MONOMER.
BRENDAi1.8.5.4. 396.

Names & Taxonomyi

Protein namesi
Recommended name:
Sulfide-quinone reductase (EC:1.8.5.42 Publications)
Short name:
SQR
Alternative name(s):
Sulfide:quinone oxidoreductase2 Publications
Gene namesi
Name:sqrImported
Ordered Locus Names:aq_2186Imported
OrganismiAquifex aeolicus (strain VF5)Imported
Taxonomic identifieri224324 [NCBI]
Taxonomic lineageiBacteriaAquificaeAquificalesAquificaceaeAquifex
Proteomesi
  • UP000000798 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 430430Sulfide-quinone reductasePRO_0000430824Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi280 ↔ 4221 Publication
Disulfide bondi419 ↔ 4301 Publication

Keywords - PTMi

Disulfide bond, Quinone

Interactioni

Subunit structurei

Homotrimer.1 Publication

Protein-protein interaction databases

DIPiDIP-48896N.
STRINGi224324.aq_2186.

Structurei

Secondary structure

1
430
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi4 – 85Combined sources
Helixi12 – 2413Combined sources
Beta strandi29 – 335Combined sources
Beta strandi35 – 406Combined sources
Helixi42 – 443Combined sources
Helixi45 – 495Combined sources
Helixi55 – 573Combined sources
Beta strandi58 – 625Combined sources
Turni63 – 653Combined sources
Helixi66 – 694Combined sources
Beta strandi71 – 744Combined sources
Beta strandi78 – 825Combined sources
Turni83 – 864Combined sources
Beta strandi87 – 904Combined sources
Beta strandi95 – 973Combined sources
Beta strandi99 – 1035Combined sources
Beta strandi108 – 1103Combined sources
Helixi116 – 1194Combined sources
Helixi126 – 14116Combined sources
Beta strandi146 – 1505Combined sources
Helixi158 – 17316Combined sources
Helixi177 – 1793Combined sources
Beta strandi182 – 1854Combined sources
Beta strandi187 – 1904Combined sources
Turni194 – 1974Combined sources
Helixi202 – 21211Combined sources
Beta strandi216 – 2183Combined sources
Beta strandi222 – 2265Combined sources
Beta strandi228 – 2347Combined sources
Beta strandi240 – 2445Combined sources
Beta strandi246 – 2516Combined sources
Beta strandi253 – 2553Combined sources
Helixi258 – 2614Combined sources
Turni265 – 2673Combined sources
Turni270 – 2723Combined sources
Beta strandi284 – 2863Combined sources
Beta strandi289 – 2913Combined sources
Helixi314 – 33219Combined sources
Beta strandi339 – 3413Combined sources
Beta strandi345 – 3506Combined sources
Beta strandi352 – 36615Combined sources
Beta strandi368 – 3758Combined sources
Helixi377 – 39519Combined sources
Helixi401 – 41111Combined sources
Beta strandi415 – 4184Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3HYVX-ray2.30A/B/C/D/E/F1-430[»]
3HYWX-ray2.00A/B/C/D/E/F1-430[»]
3HYXX-ray2.90A/B/C/D/E/F1-430[»]
ProteinModelPortaliO67931.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO67931.

Family & Domainsi

Sequence similaritiesi

Belongs to the SQRD family.Curated

Phylogenomic databases

eggNOGiENOG4107SA8. Bacteria.
COG0446. LUCA.
HOGENOMiHOG000008171.
InParanoidiO67931.
KOiK17218.
OMAiAYEFAFI.
OrthoDBiPOG091H09D4.

Family and domain databases

Gene3Di3.50.50.60. 2 hits.
InterProiIPR023753. FAD/NAD-binding_dom.
[Graphical view]
PfamiPF07992. Pyr_redox_2. 1 hit.
[Graphical view]
SUPFAMiSSF51905. SSF51905. 3 hits.

Sequencei

Sequence statusi: Complete.

O67931-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKHVVVIGG GVGGIATAYN LRNLMPDLKI TLISDRPYFG FTPAFPHLAM
60 70 80 90 100
GWRKFEDISV PLAPLLPKFN IEFINEKAES IDPDANTVTT QSGKKIEYDY
110 120 130 140 150
LVIATGPKLV FGAEGQEENS TSICTAEHAL ETQKKLQELY ANPGPVVIGA
160 170 180 190 200
IPGVSCFGPA YEFALMLHYE LKKRGIRYKV PMTFITSEPY LGHFGVGGIG
210 220 230 240 250
ASKRLVEDLF AERNIDWIAN VAVKAIEPDK VIYEDLNGNT HEVPAKFTMF
260 270 280 290 300
MPSFQGPEVV ASAGDKVANP ANKMVIVNRC FQNPTYKNIF GVGVVTAIPP
310 320 330 340 350
IEKTPIPTGV PKTGMMIEQM AMAVAHNIVN DIRNNPDKYA PRLSAICIAD
360 370 380 390 400
FGEDAGFFFA DPVIPPRERV ITKMGKWAHY FKTAFEKYFL WKVRNGNIAP
410 420 430
SFEEKVLEIF LKVHPIELCK DCEGAPGSRC
Length:430
Mass (Da):47,449
Last modified:August 1, 1998 - v1
Checksum:i7489B07FADEAA9A8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000657 Genomic DNA. Translation: AAC07903.1.
PIRiG70487.
RefSeqiNP_214500.1. NC_000918.1.
WP_010881436.1. NC_000918.1.

Genome annotation databases

EnsemblBacteriaiAAC07903; AAC07903; aq_2186.
GeneIDi1193920.
KEGGiaae:aq_2186.
PATRICi20961200. VBIAquAeo85532_1690.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000657 Genomic DNA. Translation: AAC07903.1.
PIRiG70487.
RefSeqiNP_214500.1. NC_000918.1.
WP_010881436.1. NC_000918.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3HYVX-ray2.30A/B/C/D/E/F1-430[»]
3HYWX-ray2.00A/B/C/D/E/F1-430[»]
3HYXX-ray2.90A/B/C/D/E/F1-430[»]
ProteinModelPortaliO67931.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-48896N.
STRINGi224324.aq_2186.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC07903; AAC07903; aq_2186.
GeneIDi1193920.
KEGGiaae:aq_2186.
PATRICi20961200. VBIAquAeo85532_1690.

Phylogenomic databases

eggNOGiENOG4107SA8. Bacteria.
COG0446. LUCA.
HOGENOMiHOG000008171.
InParanoidiO67931.
KOiK17218.
OMAiAYEFAFI.
OrthoDBiPOG091H09D4.

Enzyme and pathway databases

BioCyciAAEO224324:GJBH-1566-MONOMER.
BRENDAi1.8.5.4. 396.

Miscellaneous databases

EvolutionaryTraceiO67931.

Family and domain databases

Gene3Di3.50.50.60. 2 hits.
InterProiIPR023753. FAD/NAD-binding_dom.
[Graphical view]
PfamiPF07992. Pyr_redox_2. 1 hit.
[Graphical view]
SUPFAMiSSF51905. SSF51905. 3 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiSQRD_AQUAE
AccessioniPrimary (citable) accession number: O67931
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 29, 2014
Last sequence update: August 1, 1998
Last modified: September 7, 2016
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.