O67907 (KCY_AQUAE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Cytidylate kinase
Short name=CK
EC=2.7.4.25

Alternative name(s):
Cytidine monophosphate kinase
Short name=CMP kinase

Gene names

Name:	cmk
Ordered Locus Names:	aq_2153

Organism

Aquifex aeolicus (strain VF5)

Taxonomic identifier

224324 [NCBI]

Taxonomic lineage

Bacteria › Aquificae › Aquificales › Aquificaceae › Aquifex

Protein attributes

Sequence length	222 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + (d)CMP = ADP + (d)CDP. HAMAP MF_00238
Subcellular location	Cytoplasm By similarity HAMAP MF_00238.
Sequence similarities	Belongs to the cytidylate kinase family. Type 1 subfamily.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW cytidylate kinase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 222	222	Cytidylate kinase HAMAP MF_00238		PRO_0000131871
Regions
	Nucleotide binding	7 – 15	9	ATP By similarity

Sequences

	Sequence		Length	Mass (Da)
	O67907 [UniParc]. Last modified August 1, 1998. Version 1. Checksum: 523BDCDFB48128C8	FASTA	222	25,400
	10 20 30 40 50 60 MKIAIDGPSA SGKSTVAKII SQKLNIPYLE TGLVYRTYAY VSLKFKVPIQ DIDKLFSLPV 70 80 90 100 110 120 KVVPKIGKTE VYIEGKPVNE EDLRSEEVGK RASELGSIPE FRERINKLFK EIINNKQMVV 130 140 150 160 170 180 EGRDAGTHII PEAPVKVFIT ASPEERAKRR YEQLKELGYE VSFEEILQKI LERDKRDMER 190 200 210 220 PKYPFKPAED AVIIDTTRKS VEEVVEEVLK IIHERSQSAE LI

References

[1]	"The complete genome of the hyperthermophilic bacterium Aquifex aeolicus." Deckert G., Warren P.V., Gaasterland T., Young W.G., Lenox A.L., Graham D.E., Overbeek R., Snead M.A., Keller M., Aujay M., Huber R., Feldman R.A., Short J.M., Olsen G.J., Swanson R.V. Nature 392:353-358(1998) [PubMed: 9537320] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: VF5.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE000657 Genomic DNA. Translation: AAC07867.1.
PIR	G70484.
RefSeq	NP_214476.1. NC_000918.1.
3D structure databases
ProteinModelPortal	O67907.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1193896.
GenomeReviews	Gene locus aq_2153 in contig AE000657_GR.
KEGG	aae:aq_2153.
NMPDR	fig|224324.1.peg.1491.
PATRIC	20961146. VBIAquAeo85532_1664.
Phylogenomic databases
HOGENOM	HBG354377.
OMA	DIGTVIC.
PhylomeDB	O67907.
ProtClustDB	CLSK2748566.
Enzyme and pathway databases
BioCyc	AAEO224324:AQ_2153-MONOMER.
Family and domain databases
HAMAP	MF_00238. Cytidyl_kinase_type1. [Tree]
InterPro	IPR003136. Cytidylate_kin. IPR011994. Cytidylate_kinase_dom. [Graphical view]
KO	K00945.
PANTHER	PTHR21299:SF2. Cytidylate_kin. 1 hit.
Pfam	PF02224. Cytidylate_kin. 1 hit. [Graphical view]
TIGRFAMs	TIGR00017. Cmk. 1 hit.
ProtoNet	Search...

Entry information

Entry name

KCY_AQUAE

Accession

Primary (citable) accession number: O67907

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 15, 1998
Last sequence update:	August 1, 1998
Last modified:	January 25, 2012
This is version 66 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program