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O67876

- HEM2_AQUAE

UniProt

O67876 - HEM2_AQUAE

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Protein
Delta-aminolevulinic acid dehydratase
Gene
hemB, aq_2109
Organism
Aquifex aeolicus (strain VF5)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen By similarity.

Catalytic activityi

2 5-aminolevulinate = porphobilinogen + 2 H2O.

Cofactori

Binds 1 zinc ion per monomer By similarity.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi123 – 1231Zinc; catalytic By similarity
Metal bindingi125 – 1251Zinc; catalytic By similarity
Metal bindingi133 – 1331Zinc; catalytic By similarity
Active sitei198 – 1981Schiff-base intermediate with substrate By similarity
Binding sitei208 – 2081Substrate 1 By similarity
Binding sitei220 – 2201Substrate 1 By similarity
Metal bindingi236 – 2361Magnesium By similarity
Active sitei251 – 2511Schiff-base intermediate with substrate By similarity
Binding sitei277 – 2771Substrate 2 By similarity
Binding sitei316 – 3161Substrate 2 By similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. porphobilinogen synthase activity Source: UniProtKB-EC
Complete GO annotation...

GO - Biological processi

  1. protoporphyrinogen IX biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Heme biosynthesis, Porphyrin biosynthesis

Keywords - Ligandi

Magnesium, Metal-binding, Zinc

Enzyme and pathway databases

BioCyciAAEO224324:GJBH-1508-MONOMER.
UniPathwayiUPA00251; UER00318.

Names & Taxonomyi

Protein namesi
Recommended name:
Delta-aminolevulinic acid dehydratase (EC:4.2.1.24)
Short name:
ALAD
Short name:
ALADH
Alternative name(s):
Porphobilinogen synthase
Gene namesi
Name:hemB
Ordered Locus Names:aq_2109
OrganismiAquifex aeolicus (strain VF5)
Taxonomic identifieri224324 [NCBI]
Taxonomic lineageiBacteriaAquificaeAquificalesAquificaceaeAquifex
ProteomesiUP000000798: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 330330Delta-aminolevulinic acid dehydratase
PRO_0000140491Add
BLAST

Proteomic databases

PRIDEiO67876.

Interactioni

Subunit structurei

Homooctamer By similarity.

Protein-protein interaction databases

STRINGi224324.aq_2109.

Structurei

3D structure databases

ProteinModelPortaliO67876.
SMRiO67876. Positions 9-325.

Family & Domainsi

Sequence similaritiesi

Belongs to the ALADH family.

Phylogenomic databases

eggNOGiCOG0113.
HOGENOMiHOG000020323.
KOiK01698.
OMAiDMILTYF.
OrthoDBiEOG6VXFCB.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
InterProiIPR013785. Aldolase_TIM.
IPR001731. Porphobilinogen_synth.
[Graphical view]
PANTHERiPTHR11458. PTHR11458. 1 hit.
PfamiPF00490. ALAD. 1 hit.
[Graphical view]
PIRSFiPIRSF001415. Porphbilin_synth. 1 hit.
PRINTSiPR00144. DALDHYDRTASE.
SMARTiSM01004. ALAD. 1 hit.
[Graphical view]
PROSITEiPS00169. D_ALA_DEHYDRATASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O67876-1 [UniParc]FASTAAdd to Basket

« Hide

MIVGRFPSSR PRRLRRNENI RRLVRETHLT LDDLIYPIFV RWGENVVEEV    50
PSMPGVYRYS VDKVVDAVKE VRDLGIPAII LFGIPEHKDE VGSDTWSEEG 100
IIQRALRKIK KEVPDIYVIT DVCFCEYTTH GHCGVLHDHD VENDLTLENL 150
KKQVVSHAEN GADMVAPSGM MDGMVKVIRE ALDEAGFKHI PIMAYSAKFA 200
SAYYGPFREA AESAPAFGDR RTYQMDPANS REALKEVLMD VEEGADVVMV 250
KPALAYLDII AKVKENVLVP VCAYNVSGEY SLIKAAGKLG WIDEKKVMWE 300
TLLSIKRAGA DMIITYFAKD AARMIIEGEV 330
Length:330
Mass (Da):37,091
Last modified:August 1, 1998 - v1
Checksum:iAC70D2063D9C7457
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE000657 Genomic DNA. Translation: AAC07837.1.
PIRiH70480.
RefSeqiNP_214445.1. NC_000918.1.

Genome annotation databases

EnsemblBacteriaiAAC07837; AAC07837; aq_2109.
GeneIDi1193865.
KEGGiaae:aq_2109.
PATRICi20961068. VBIAquAeo85532_1627.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE000657 Genomic DNA. Translation: AAC07837.1 .
PIRi H70480.
RefSeqi NP_214445.1. NC_000918.1.

3D structure databases

ProteinModelPortali O67876.
SMRi O67876. Positions 9-325.
ModBasei Search...

Protein-protein interaction databases

STRINGi 224324.aq_2109.

Proteomic databases

PRIDEi O67876.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAC07837 ; AAC07837 ; aq_2109 .
GeneIDi 1193865.
KEGGi aae:aq_2109.
PATRICi 20961068. VBIAquAeo85532_1627.

Phylogenomic databases

eggNOGi COG0113.
HOGENOMi HOG000020323.
KOi K01698.
OMAi DMILTYF.
OrthoDBi EOG6VXFCB.

Enzyme and pathway databases

UniPathwayi UPA00251 ; UER00318 .
BioCyci AAEO224324:GJBH-1508-MONOMER.

Family and domain databases

Gene3Di 3.20.20.70. 1 hit.
InterProi IPR013785. Aldolase_TIM.
IPR001731. Porphobilinogen_synth.
[Graphical view ]
PANTHERi PTHR11458. PTHR11458. 1 hit.
Pfami PF00490. ALAD. 1 hit.
[Graphical view ]
PIRSFi PIRSF001415. Porphbilin_synth. 1 hit.
PRINTSi PR00144. DALDHYDRTASE.
SMARTi SM01004. ALAD. 1 hit.
[Graphical view ]
PROSITEi PS00169. D_ALA_DEHYDRATASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: VF5.

Entry informationi

Entry nameiHEM2_AQUAE
AccessioniPrimary (citable) accession number: O67876
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: August 1, 1998
Last modified: May 14, 2014
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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