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Protein

GTPase Obg

Gene

obg

Organism
Aquifex aeolicus (strain VF5)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control.UniRule annotation

Cofactori

Mg2+UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi174 – 1741MagnesiumUniRule annotation
Metal bindingi194 – 1941MagnesiumUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi167 – 1748GTPUniRule annotation
Nucleotide bindingi192 – 1965GTPUniRule annotation
Nucleotide bindingi214 – 2174GTPUniRule annotation
Nucleotide bindingi284 – 2874GTPUniRule annotation
Nucleotide bindingi313 – 3153GTPUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

GTP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciAAEO224324:GJBH-1481-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
GTPase ObgUniRule annotation (EC:3.6.5.-UniRule annotation)
Alternative name(s):
GTP-binding protein ObgUniRule annotation
Gene namesi
Name:obgUniRule annotation
Ordered Locus Names:aq_2069
OrganismiAquifex aeolicus (strain VF5)
Taxonomic identifieri224324 [NCBI]
Taxonomic lineageiBacteriaAquificaeAquificalesAquificaceaeAquifex
Proteomesi
  • UP000000798 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 343343GTPase ObgPRO_0000385702Add
BLAST

Proteomic databases

PRIDEiO67849.

Interactioni

Subunit structurei

Monomer.UniRule annotation

Protein-protein interaction databases

STRINGi224324.aq_2069.

Structurei

3D structure databases

ProteinModelPortaliO67849.
SMRiO67849. Positions 3-335.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini161 – 332172OBG-type GUniRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.UniRule annotation
Contains 1 OBG-type G (guanine nucleotide-binding) domain.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C9R. Bacteria.
COG0536. LUCA.
HOGENOMiHOG000019084.
InParanoidiO67849.
KOiK03979.
OMAiTAIYDAD.
OrthoDBiEOG6H1Q1M.

Family and domain databases

Gene3Di2.70.210.12. 1 hit.
3.40.50.300. 1 hit.
HAMAPiMF_01454. GTPase_Obg.
InterProiIPR031167. G_OBG.
IPR014100. GTP-bd_Obg/CgtA.
IPR006169. GTP1_OBG_dom.
IPR006073. GTP_binding_domain.
IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
[Graphical view]
PANTHERiPTHR11702:SF3. PTHR11702:SF3. 1 hit.
PfamiPF01018. GTP1_OBG. 1 hit.
PF01926. MMR_HSR1. 1 hit.
[Graphical view]
PIRSFiPIRSF002401. GTP_bd_Obg/CgtA. 1 hit.
PRINTSiPR00326. GTP1OBG.
SUPFAMiSSF52540. SSF52540. 1 hit.
SSF82051. SSF82051. 1 hit.
TIGRFAMsiTIGR02729. Obg_CgtA. 1 hit.
TIGR00231. small_GTP. 1 hit.
PROSITEiPS51710. G_OBG. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O67849-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEKFVDRVKI FVKGGKGGDG AVAFLREKYR PKGGPAGGDG GKGGDVILVA
60 70 80 90 100
TSSKHTLLDF KYKKHYIAQN GEPGKGKKMH GKDGEDLIIY VPVGTVVKDA
110 120 130 140 150
QTGEVICDLV KEGQKCIVAK GGKGGRGNAR FATPTNQAPT YAEKGQKGEE
160 170 180 190 200
RWIILELKLI ADVGLVGFPN AGKSTLLSRL TRAKPKIADY PFTTLSPNLG
210 220 230 240 250
VMELDWERRL VIADIPGLIE DAHKGAGLGH EFLRHIERTK FLAHVIDVSD
260 270 280 290 300
FREREPVQAF EAINRELELY SPKLAQKPQI VVANKIDALS DRSLLSELEK
310 320 330 340
YFKEKGYEFY AVSALTGEGI EELKEGLWKK YEEIRDKESA QVT
Length:343
Mass (Da):37,796
Last modified:August 1, 1998 - v1
Checksum:iC0A0EE71632A5699
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000657 Genomic DNA. Translation: AAC07816.1.
PIRiE70477.
RefSeqiNP_214418.1. NC_000918.1.
WP_010881354.1. NC_000918.1.

Genome annotation databases

EnsemblBacteriaiAAC07816; AAC07816; aq_2069.
GeneIDi1193838.
KEGGiaae:aq_2069.
PATRICi20961004. VBIAquAeo85532_1595.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000657 Genomic DNA. Translation: AAC07816.1.
PIRiE70477.
RefSeqiNP_214418.1. NC_000918.1.
WP_010881354.1. NC_000918.1.

3D structure databases

ProteinModelPortaliO67849.
SMRiO67849. Positions 3-335.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi224324.aq_2069.

Proteomic databases

PRIDEiO67849.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC07816; AAC07816; aq_2069.
GeneIDi1193838.
KEGGiaae:aq_2069.
PATRICi20961004. VBIAquAeo85532_1595.

Phylogenomic databases

eggNOGiENOG4105C9R. Bacteria.
COG0536. LUCA.
HOGENOMiHOG000019084.
InParanoidiO67849.
KOiK03979.
OMAiTAIYDAD.
OrthoDBiEOG6H1Q1M.

Enzyme and pathway databases

BioCyciAAEO224324:GJBH-1481-MONOMER.

Family and domain databases

Gene3Di2.70.210.12. 1 hit.
3.40.50.300. 1 hit.
HAMAPiMF_01454. GTPase_Obg.
InterProiIPR031167. G_OBG.
IPR014100. GTP-bd_Obg/CgtA.
IPR006169. GTP1_OBG_dom.
IPR006073. GTP_binding_domain.
IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
[Graphical view]
PANTHERiPTHR11702:SF3. PTHR11702:SF3. 1 hit.
PfamiPF01018. GTP1_OBG. 1 hit.
PF01926. MMR_HSR1. 1 hit.
[Graphical view]
PIRSFiPIRSF002401. GTP_bd_Obg/CgtA. 1 hit.
PRINTSiPR00326. GTP1OBG.
SUPFAMiSSF52540. SSF52540. 1 hit.
SSF82051. SSF82051. 1 hit.
TIGRFAMsiTIGR02729. Obg_CgtA. 1 hit.
TIGR00231. small_GTP. 1 hit.
PROSITEiPS51710. G_OBG. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: VF5.

Entry informationi

Entry nameiOBG_AQUAE
AccessioniPrimary (citable) accession number: O67849
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 13, 2009
Last sequence update: August 1, 1998
Last modified: December 9, 2015
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.