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Protein

Dephospho-CoA kinase

Gene

coaE

Organism
Aquifex aeolicus (strain VF5)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A.By similarity

Catalytic activityi

ATP + 3'-dephospho-CoA = ADP + CoA.

Pathwayi: coenzyme A biosynthesis

This protein is involved in step 5 of the subpathway that synthesizes CoA from (R)-pantothenate.
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. Type III pantothenate kinase (coaX)
  2. no protein annotated in this organism
  3. no protein annotated in this organism
  4. Phosphopantetheine adenylyltransferase (coaD)
  5. Dephospho-CoA kinase (coaE)
This subpathway is part of the pathway coenzyme A biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes CoA from (R)-pantothenate, the pathway coenzyme A biosynthesis and in Cofactor biosynthesis.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi8 – 15ATPSequence analysis8

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Coenzyme A biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00241; UER00356.

Names & Taxonomyi

Protein namesi
Recommended name:
Dephospho-CoA kinase (EC:2.7.1.24)
Alternative name(s):
Dephosphocoenzyme A kinase
Gene namesi
Name:coaE
Ordered Locus Names:aq_1985
OrganismiAquifex aeolicus (strain VF5)
Taxonomic identifieri224324 [NCBI]
Taxonomic lineageiBacteriaAquificaeAquificalesAquificaceaeAquifex
Proteomesi
  • UP000000798 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001729001 – 196Dephospho-CoA kinaseAdd BLAST196

Interactioni

Protein-protein interaction databases

STRINGi224324.aq_1985.

Structurei

Secondary structure

1196
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi3 – 8Combined sources6
Helixi14 – 23Combined sources10
Beta strandi27 – 30Combined sources4
Helixi31 – 36Combined sources6
Helixi37 – 39Combined sources3
Beta strandi40 – 43Combined sources4
Helixi44 – 53Combined sources10
Turni55 – 58Combined sources4
Helixi66 – 71Combined sources6
Helixi77 – 91Combined sources15
Turni92 – 94Combined sources3
Helixi95 – 101Combined sources7
Beta strandi108 – 111Combined sources4
Turni116 – 119Combined sources4
Helixi121 – 123Combined sources3
Beta strandi124 – 130Combined sources7
Helixi134 – 143Combined sources10
Helixi148 – 155Combined sources8
Helixi161 – 164Combined sources4
Helixi165 – 167Combined sources3
Beta strandi169 – 171Combined sources3
Helixi178 – 190Combined sources13

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2IF2X-ray3.00A/B/C1-196[»]
ProteinModelPortaliO67792.
SMRiO67792.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO67792.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini3 – 196DPCKAdd BLAST194

Sequence similaritiesi

Belongs to the CoaE family.Curated

Phylogenomic databases

eggNOGiENOG4108ZQD. Bacteria.
COG0237. LUCA.
HOGENOMiHOG000020768.
InParanoidiO67792.
KOiK00859.
OMAiIIHPLVQ.
OrthoDBiPOG091H02KX.

Family and domain databases

CDDicd02022. DPCK. 1 hit.
Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_00376. Dephospho_CoA_kinase. 1 hit.
InterProiIPR001977. Depp_CoAkinase.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01121. CoaE. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00152. TIGR00152. 1 hit.
PROSITEiPS51219. DPCK. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O67792-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKRIGLTGNI GCGKSTVAQM FRELGAYVLD ADKLIHSFYR KGHPVYEEVV
60 70 80 90 100
KTFGKGILDE EGNIDRKKLA DIVFKDEEKL RKLEEITHRA LYKEIEKITK
110 120 130 140 150
NLSEDTLFIL EASLLVEKGT YKNYDKLIVV YAPYEVCKER AIKRGMSEED
160 170 180 190
FERRWKKQMP IEEKVKYADY VIDNSGSIEE TYKQVKKVYE ELTRDP
Length:196
Mass (Da):22,930
Last modified:August 1, 1998 - v1
Checksum:iDD691CBCD7B1C0E2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000657 Genomic DNA. Translation: AAC07761.1.
PIRiD70470.
RefSeqiNP_214361.1. NC_000918.1.
WP_010881297.1. NC_000918.1.

Genome annotation databases

EnsemblBacteriaiAAC07761; AAC07761; aq_1985.
GeneIDi1193689.
KEGGiaae:aq_1985.
PATRICi20960878. VBIAquAeo85532_1534.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000657 Genomic DNA. Translation: AAC07761.1.
PIRiD70470.
RefSeqiNP_214361.1. NC_000918.1.
WP_010881297.1. NC_000918.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2IF2X-ray3.00A/B/C1-196[»]
ProteinModelPortaliO67792.
SMRiO67792.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi224324.aq_1985.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC07761; AAC07761; aq_1985.
GeneIDi1193689.
KEGGiaae:aq_1985.
PATRICi20960878. VBIAquAeo85532_1534.

Phylogenomic databases

eggNOGiENOG4108ZQD. Bacteria.
COG0237. LUCA.
HOGENOMiHOG000020768.
InParanoidiO67792.
KOiK00859.
OMAiIIHPLVQ.
OrthoDBiPOG091H02KX.

Enzyme and pathway databases

UniPathwayiUPA00241; UER00356.

Miscellaneous databases

EvolutionaryTraceiO67792.

Family and domain databases

CDDicd02022. DPCK. 1 hit.
Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_00376. Dephospho_CoA_kinase. 1 hit.
InterProiIPR001977. Depp_CoAkinase.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01121. CoaE. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00152. TIGR00152. 1 hit.
PROSITEiPS51219. DPCK. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCOAE_AQUAE
AccessioniPrimary (citable) accession number: O67792
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 2001
Last sequence update: August 1, 1998
Last modified: November 2, 2016
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.