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Protein

Dephospho-CoA kinase

Gene

coaE

Organism
Aquifex aeolicus (strain VF5)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A.By similarity

Catalytic activityi

ATP + 3'-dephospho-CoA = ADP + CoA.

Pathwayi: coenzyme A biosynthesis

This protein is involved in step 5 of the subpathway that synthesizes CoA from (R)-pantothenate.
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. Type III pantothenate kinase (coaX)
  2. no protein annotated in this organism
  3. no protein annotated in this organism
  4. Phosphopantetheine adenylyltransferase (coaD)
  5. Dephospho-CoA kinase (coaE)
This subpathway is part of the pathway coenzyme A biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes CoA from (R)-pantothenate, the pathway coenzyme A biosynthesis and in Cofactor biosynthesis.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi8 – 158ATPSequence analysis

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Coenzyme A biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciAAEO224324:GJBH-1422-MONOMER.
UniPathwayiUPA00241; UER00356.

Names & Taxonomyi

Protein namesi
Recommended name:
Dephospho-CoA kinase (EC:2.7.1.24)
Alternative name(s):
Dephosphocoenzyme A kinase
Gene namesi
Name:coaE
Ordered Locus Names:aq_1985
OrganismiAquifex aeolicus (strain VF5)
Taxonomic identifieri224324 [NCBI]
Taxonomic lineageiBacteriaAquificaeAquificalesAquificaceaeAquifex
Proteomesi
  • UP000000798 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 196196Dephospho-CoA kinasePRO_0000172900Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi224324.aq_1985.

Structurei

Secondary structure

1
196
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi3 – 86Combined sources
Helixi14 – 2310Combined sources
Beta strandi27 – 304Combined sources
Helixi31 – 366Combined sources
Helixi37 – 393Combined sources
Beta strandi40 – 434Combined sources
Helixi44 – 5310Combined sources
Turni55 – 584Combined sources
Helixi66 – 716Combined sources
Helixi77 – 9115Combined sources
Turni92 – 943Combined sources
Helixi95 – 1017Combined sources
Beta strandi108 – 1114Combined sources
Turni116 – 1194Combined sources
Helixi121 – 1233Combined sources
Beta strandi124 – 1307Combined sources
Helixi134 – 14310Combined sources
Helixi148 – 1558Combined sources
Helixi161 – 1644Combined sources
Helixi165 – 1673Combined sources
Beta strandi169 – 1713Combined sources
Helixi178 – 19013Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2IF2X-ray3.00A/B/C1-196[»]
ProteinModelPortaliO67792.
SMRiO67792. Positions 1-194.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO67792.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini3 – 196194DPCKAdd
BLAST

Sequence similaritiesi

Belongs to the CoaE family.Curated

Phylogenomic databases

eggNOGiENOG4108ZQD. Bacteria.
COG0237. LUCA.
HOGENOMiHOG000020768.
InParanoidiO67792.
KOiK00859.
OMAiMILSRQT.
OrthoDBiEOG6HTP3H.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_00376. Dephospho_CoA_kinase.
InterProiIPR001977. Depp_CoAkinase.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01121. CoaE. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00152. TIGR00152. 1 hit.
PROSITEiPS51219. DPCK. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O67792-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKRIGLTGNI GCGKSTVAQM FRELGAYVLD ADKLIHSFYR KGHPVYEEVV
60 70 80 90 100
KTFGKGILDE EGNIDRKKLA DIVFKDEEKL RKLEEITHRA LYKEIEKITK
110 120 130 140 150
NLSEDTLFIL EASLLVEKGT YKNYDKLIVV YAPYEVCKER AIKRGMSEED
160 170 180 190
FERRWKKQMP IEEKVKYADY VIDNSGSIEE TYKQVKKVYE ELTRDP
Length:196
Mass (Da):22,930
Last modified:August 1, 1998 - v1
Checksum:iDD691CBCD7B1C0E2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000657 Genomic DNA. Translation: AAC07761.1.
PIRiD70470.
RefSeqiNP_214361.1. NC_000918.1.
WP_010881297.1. NC_000918.1.

Genome annotation databases

EnsemblBacteriaiAAC07761; AAC07761; aq_1985.
GeneIDi1193689.
KEGGiaae:aq_1985.
PATRICi20960878. VBIAquAeo85532_1534.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000657 Genomic DNA. Translation: AAC07761.1.
PIRiD70470.
RefSeqiNP_214361.1. NC_000918.1.
WP_010881297.1. NC_000918.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2IF2X-ray3.00A/B/C1-196[»]
ProteinModelPortaliO67792.
SMRiO67792. Positions 1-194.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi224324.aq_1985.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC07761; AAC07761; aq_1985.
GeneIDi1193689.
KEGGiaae:aq_1985.
PATRICi20960878. VBIAquAeo85532_1534.

Phylogenomic databases

eggNOGiENOG4108ZQD. Bacteria.
COG0237. LUCA.
HOGENOMiHOG000020768.
InParanoidiO67792.
KOiK00859.
OMAiMILSRQT.
OrthoDBiEOG6HTP3H.

Enzyme and pathway databases

UniPathwayiUPA00241; UER00356.
BioCyciAAEO224324:GJBH-1422-MONOMER.

Miscellaneous databases

EvolutionaryTraceiO67792.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_00376. Dephospho_CoA_kinase.
InterProiIPR001977. Depp_CoAkinase.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01121. CoaE. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00152. TIGR00152. 1 hit.
PROSITEiPS51219. DPCK. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: VF5.

Entry informationi

Entry nameiCOAE_AQUAE
AccessioniPrimary (citable) accession number: O67792
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 2001
Last sequence update: August 1, 1998
Last modified: February 17, 2016
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.