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Protein

Fructose-1,6-bisphosphatase/inositol-1-monophosphatase

Gene

suhB

Organism
Aquifex aeolicus (strain VF5)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Phosphatase with broad specificity; it can dephosphorylate fructose 1,6-bisphosphate, and both D and L isomers of inositol-1-phosphate (I-1-P).By similarity

Catalytic activityi

D-fructose 1,6-bisphosphate + H2O = D-fructose 6-phosphate + phosphate.By similarity
Myo-inositol phosphate + H2O = myo-inositol + phosphate.By similarity

Cofactori

Mg2+By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi70Magnesium 1By similarity1
Metal bindingi86Magnesium 1By similarity1
Metal bindingi86Magnesium 2By similarity1
Metal bindingi88Magnesium 1; via carbonyl oxygenBy similarity1
Metal bindingi89Magnesium 2By similarity1
Binding sitei185SubstrateBy similarity1
Binding sitei190Substrate; via amide nitrogenBy similarity1
Metal bindingi214Magnesium 2By similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Carbohydrate metabolism

Keywords - Ligandi

Magnesium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Fructose-1,6-bisphosphatase/inositol-1-monophosphatase (EC:3.1.3.11By similarity, EC:3.1.3.25By similarity)
Short name:
FBPase/IMPase
Alternative name(s):
Inositol-1-phosphatase
Short name:
I-1-Pase
Gene namesi
Name:suhB
Synonyms:imp2
Ordered Locus Names:aq_1983
OrganismiAquifex aeolicus (strain VF5)
Taxonomic identifieri224324 [NCBI]
Taxonomic lineageiBacteriaAquificaeAquificalesAquificaceaeAquifex
Proteomesi
  • UP000000798 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001425531 – 264Fructose-1,6-bisphosphatase/inositol-1-monophosphataseAdd BLAST264

Interactioni

Protein-protein interaction databases

STRINGi224324.aq_1983.

Structurei

Secondary structure

1264
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi4 – 25Combined sources22
Helixi45 – 61Combined sources17
Beta strandi65 – 68Combined sources4
Beta strandi81 – 89Combined sources9
Helixi91 – 96Combined sources6
Beta strandi102 – 109Combined sources8
Beta strandi112 – 120Combined sources9
Turni121 – 124Combined sources4
Beta strandi125 – 130Combined sources6
Turni131 – 133Combined sources3
Beta strandi134 – 137Combined sources4
Beta strandi140 – 142Combined sources3
Helixi150 – 152Combined sources3
Beta strandi154 – 158Combined sources5
Helixi167 – 180Combined sources14
Beta strandi181 – 186Combined sources6
Helixi190 – 198Combined sources9
Beta strandi201 – 210Combined sources10
Helixi212 – 224Combined sources13
Beta strandi228 – 233Combined sources6
Beta strandi237 – 245Combined sources9
Helixi246 – 259Combined sources14

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2PCRX-ray2.60A/B/C/D1-264[»]
ProteinModelPortaliO67791.
SMRiO67791.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO67791.

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni89 – 91Substrate bindingBy similarity3

Sequence similaritiesi

Belongs to the inositol monophosphatase family.Curated

Phylogenomic databases

eggNOGiENOG4105ECY. Bacteria.
COG0483. LUCA.
HOGENOMiHOG000282238.
InParanoidiO67791.
KOiK01092.
OMAiYDPSRND.
OrthoDBiPOG091H061V.

Family and domain databases

CDDicd01639. IMPase. 1 hit.
InterProiIPR033942. IMPase.
IPR020583. Inositol_monoP_metal-BS.
IPR000760. Inositol_monophosphatase-like.
IPR022337. Inositol_monophosphatase_SuhB.
[Graphical view]
PANTHERiPTHR20854. PTHR20854. 1 hit.
PfamiPF00459. Inositol_P. 1 hit.
[Graphical view]
PRINTSiPR00377. IMPHPHTASES.
PR01959. SBIMPHPHTASE.
PROSITEiPS00629. IMP_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O67791-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MENLKKYLEV AKIAALAGGQ VLKENFGKVK KENIEEKGEK DFVSYVDKTS
60 70 80 90 100
EERIKEVILK FFPDHEVVGE EMGAEGSGSE YRWFIDPLDG TKNYINGFPI
110 120 130 140 150
FAVSVGLVKG EEPIVGAVYL PYFDKLYWGA KGLGAYVNGK RIKVKDNESL
160 170 180 190 200
KHAGVVYGFP SRSRRDISIY LNIFKDVFYE VGSMRRPGAA AVDLCMVAEG
210 220 230 240 250
IFDGMMEFEM KPWDITAGLV ILKEAGGVYT LVGEPFGVSD IIAGNKALHD
260
FILQVAKKYM EVAV
Length:264
Mass (Da):29,336
Last modified:August 1, 1998 - v1
Checksum:i10F32D1D3B81B76A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000657 Genomic DNA. Translation: AAC07753.1.
PIRiC70470.
RefSeqiNP_214360.1. NC_000918.1.
WP_010881296.1. NC_000918.1.

Genome annotation databases

EnsemblBacteriaiAAC07753; AAC07753; aq_1983.
GeneIDi1193688.
KEGGiaae:aq_1983.
PATRICi20960876. VBIAquAeo85532_1533.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000657 Genomic DNA. Translation: AAC07753.1.
PIRiC70470.
RefSeqiNP_214360.1. NC_000918.1.
WP_010881296.1. NC_000918.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2PCRX-ray2.60A/B/C/D1-264[»]
ProteinModelPortaliO67791.
SMRiO67791.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi224324.aq_1983.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC07753; AAC07753; aq_1983.
GeneIDi1193688.
KEGGiaae:aq_1983.
PATRICi20960876. VBIAquAeo85532_1533.

Phylogenomic databases

eggNOGiENOG4105ECY. Bacteria.
COG0483. LUCA.
HOGENOMiHOG000282238.
InParanoidiO67791.
KOiK01092.
OMAiYDPSRND.
OrthoDBiPOG091H061V.

Miscellaneous databases

EvolutionaryTraceiO67791.

Family and domain databases

CDDicd01639. IMPase. 1 hit.
InterProiIPR033942. IMPase.
IPR020583. Inositol_monoP_metal-BS.
IPR000760. Inositol_monophosphatase-like.
IPR022337. Inositol_monophosphatase_SuhB.
[Graphical view]
PANTHERiPTHR20854. PTHR20854. 1 hit.
PfamiPF00459. Inositol_P. 1 hit.
[Graphical view]
PRINTSiPR00377. IMPHPHTASES.
PR01959. SBIMPHPHTASE.
PROSITEiPS00629. IMP_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiBSUHB_AQUAE
AccessioniPrimary (citable) accession number: O67791
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: August 1, 1998
Last modified: November 30, 2016
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.