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O67791 (SUHB_AQUAE) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 72. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Inositol-1-monophosphatase
Short name=I-1-Pase
Short name=IMPase
Short name=Inositol-1-phosphatase
EC=3.1.3.25
Gene names
Name:suhB
Synonyms:imp2
Ordered Locus Names:aq_1983
OrganismAquifex aeolicus (strain VF5)
Taxonomic identifier224324 [NCBI]
Taxonomic lineageBacteria › Aquificae › Aquificales › Aquificaceae › Aquifex

Protein attributes

Sequence length264 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Catalytic activity

Myo-inositol phosphate + H2O = myo-inositol + phosphate.

Cofactor

Magnesium By similarity.

Sequence similarities

Belongs to the inositol monophosphatase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 264264Inositol-1-monophosphatase
PRO_0000142553

Regions

Region88 – 914Substrate binding By similarity

Sites

Metal binding701Magnesium 1 By similarity
Metal binding861Magnesium 1 By similarity
Metal binding861Magnesium 2 By similarity
Metal binding881Magnesium 1; via carbonyl oxygen By similarity
Metal binding891Magnesium 2 By similarity
Metal binding2141Magnesium 2 By similarity
Binding site701Substrate By similarity
Binding site1571Substrate By similarity
Binding site1851Substrate By similarity
Binding site2141Substrate By similarity

Secondary structure

1 ....................................... 264
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
O67791 [UniParc].

Last modified August 1, 1998. Version 1.
Checksum: 10F32D1D3B81B76A

FASTA26429,336
        10         20         30         40         50         60 
MENLKKYLEV AKIAALAGGQ VLKENFGKVK KENIEEKGEK DFVSYVDKTS EERIKEVILK 

        70         80         90        100        110        120 
FFPDHEVVGE EMGAEGSGSE YRWFIDPLDG TKNYINGFPI FAVSVGLVKG EEPIVGAVYL 

       130        140        150        160        170        180 
PYFDKLYWGA KGLGAYVNGK RIKVKDNESL KHAGVVYGFP SRSRRDISIY LNIFKDVFYE 

       190        200        210        220        230        240 
VGSMRRPGAA AVDLCMVAEG IFDGMMEFEM KPWDITAGLV ILKEAGGVYT LVGEPFGVSD 

       250        260 
IIAGNKALHD FILQVAKKYM EVAV

« Hide

References

« Hide 'large scale' references
[1]"The complete genome of the hyperthermophilic bacterium Aquifex aeolicus."
Deckert G., Warren P.V., Gaasterland T., Young W.G., Lenox A.L., Graham D.E., Overbeek R., Snead M.A., Keller M., Aujay M., Huber R., Feldman R.A., Short J.M., Olsen G.J., Swanson R.V.
Nature 392:353-358(1998) [PubMed: 9537320] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: VF5.
[2]"Crystal structure of myo-inositol-1(or 4)-monophosphatase (aq_1983) from Aquifex aeolicus VF5."
RIKEN structural genomics initiative (RSGI)
Submitted (FEB-2009) to the PDB data bank
Cited for: X-RAY CRYSTALLOGRAPHY (2.6 ANGSTROMS).
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AE000657 Genomic DNA. Translation: AAC07753.1.
PIRC70470.
RefSeqNP_214360.1. NC_000918.1.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
2PCRX-ray2.60A/B/C/D1-264[»]
ProteinModelPortalO67791.
SMRO67791. Positions 1-263.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID1193688.
GenomeReviewsGene locus aq_1983 in contig AE000657_GR.
KEGGaae:aq_1983.
NMPDRfig|224324.1.peg.1375.
PATRIC20960876. VBIAquAeo85532_1533.

Phylogenomic databases

HOGENOMHBG730251.
OMATHKTRGV.
PhylomeDBO67791.
ProtClustDBCLSK2299891.

Enzyme and pathway databases

BioCycAAEO224324:AQ_1983-MONOMER.

Family and domain databases

InterProIPR020583. Inositol_monoP_metal-BS.
IPR000760. Inositol_monophosphatase.
IPR022337. Inositol_monophosphatase_SuhB.
[Graphical view]
KOK01092.
PANTHERPTHR20854. Inositol_P. 1 hit.
PfamPF00459. Inositol_P. 1 hit.
[Graphical view]
PRINTSPR00377. IMPHPHTASES.
PR01959. SBIMPHPHTASE.
PROSITEPS00629. IMP_1. 1 hit.
PS00630. IMP_2. False negative.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSUHB_AQUAE
AccessionPrimary (citable) accession number: O67791
Entry history
Integrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: August 1, 1998
Last modified: January 25, 2012
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

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