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Protein

Fructose-1,6-bisphosphatase/inositol-1-monophosphatase

Gene

suhB

Organism
Aquifex aeolicus (strain VF5)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Phosphatase with broad specificity; it can dephosphorylate fructose 1,6-bisphosphate, and both D and L isomers of inositol-1-phosphate (I-1-P).By similarity

Catalytic activityi

D-fructose 1,6-bisphosphate + H2O = D-fructose 6-phosphate + phosphate.By similarity
Myo-inositol phosphate + H2O = myo-inositol + phosphate.By similarity

Cofactori

Mg2+By similarity

Pathwayi: gluconeogenesis

This protein is involved in the pathway gluconeogenesis, which is part of Carbohydrate biosynthesis.
View all proteins of this organism that are known to be involved in the pathway gluconeogenesis and in Carbohydrate biosynthesis.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi70 – 701Magnesium 1By similarity
Metal bindingi86 – 861Magnesium 1By similarity
Metal bindingi86 – 861Magnesium 2By similarity
Metal bindingi88 – 881Magnesium 1; via carbonyl oxygenBy similarity
Metal bindingi89 – 891Magnesium 2By similarity
Binding sitei185 – 1851SubstrateBy similarity
Binding sitei190 – 1901Substrate; via amide nitrogenBy similarity
Metal bindingi214 – 2141Magnesium 2By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Carbohydrate metabolism, Gluconeogenesis

Keywords - Ligandi

Magnesium, Metal-binding

Enzyme and pathway databases

BioCyciAAEO224324:GJBH-1421-MONOMER.
UniPathwayiUPA00138.

Names & Taxonomyi

Protein namesi
Recommended name:
Fructose-1,6-bisphosphatase/inositol-1-monophosphatase (EC:3.1.3.11By similarity, EC:3.1.3.25By similarity)
Short name:
FBPase/IMPase
Alternative name(s):
Inositol-1-phosphatase
Short name:
I-1-Pase
Gene namesi
Name:suhB
Synonyms:imp2
Ordered Locus Names:aq_1983
OrganismiAquifex aeolicus (strain VF5)
Taxonomic identifieri224324 [NCBI]
Taxonomic lineageiBacteriaAquificaeAquificalesAquificaceaeAquifex
Proteomesi
  • UP000000798 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 264264Fructose-1,6-bisphosphatase/inositol-1-monophosphatasePRO_0000142553Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi224324.aq_1983.

Structurei

Secondary structure

1
264
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi4 – 2522Combined sources
Helixi45 – 6117Combined sources
Beta strandi65 – 684Combined sources
Beta strandi81 – 899Combined sources
Helixi91 – 966Combined sources
Beta strandi102 – 1098Combined sources
Beta strandi112 – 1209Combined sources
Turni121 – 1244Combined sources
Beta strandi125 – 1306Combined sources
Turni131 – 1333Combined sources
Beta strandi134 – 1374Combined sources
Beta strandi140 – 1423Combined sources
Helixi150 – 1523Combined sources
Beta strandi154 – 1585Combined sources
Helixi167 – 18014Combined sources
Beta strandi181 – 1866Combined sources
Helixi190 – 1989Combined sources
Beta strandi201 – 21010Combined sources
Helixi212 – 22413Combined sources
Beta strandi228 – 2336Combined sources
Beta strandi237 – 2459Combined sources
Helixi246 – 25914Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2PCRX-ray2.60A/B/C/D1-264[»]
ProteinModelPortaliO67791.
SMRiO67791. Positions 1-263.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO67791.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni89 – 913Substrate bindingBy similarity

Sequence similaritiesi

Belongs to the inositol monophosphatase family.Curated

Phylogenomic databases

eggNOGiENOG4105ECY. Bacteria.
COG0483. LUCA.
HOGENOMiHOG000282238.
InParanoidiO67791.
KOiK01092.
OMAiYDPSRND.
OrthoDBiEOG6QK4W4.

Family and domain databases

InterProiIPR020583. Inositol_monoP_metal-BS.
IPR000760. Inositol_monophosphatase.
IPR022337. Inositol_monophosphatase_SuhB.
[Graphical view]
PANTHERiPTHR20854. PTHR20854. 1 hit.
PfamiPF00459. Inositol_P. 1 hit.
[Graphical view]
PRINTSiPR00377. IMPHPHTASES.
PR01959. SBIMPHPHTASE.
PROSITEiPS00629. IMP_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O67791-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MENLKKYLEV AKIAALAGGQ VLKENFGKVK KENIEEKGEK DFVSYVDKTS
60 70 80 90 100
EERIKEVILK FFPDHEVVGE EMGAEGSGSE YRWFIDPLDG TKNYINGFPI
110 120 130 140 150
FAVSVGLVKG EEPIVGAVYL PYFDKLYWGA KGLGAYVNGK RIKVKDNESL
160 170 180 190 200
KHAGVVYGFP SRSRRDISIY LNIFKDVFYE VGSMRRPGAA AVDLCMVAEG
210 220 230 240 250
IFDGMMEFEM KPWDITAGLV ILKEAGGVYT LVGEPFGVSD IIAGNKALHD
260
FILQVAKKYM EVAV
Length:264
Mass (Da):29,336
Last modified:August 1, 1998 - v1
Checksum:i10F32D1D3B81B76A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000657 Genomic DNA. Translation: AAC07753.1.
PIRiC70470.
RefSeqiNP_214360.1. NC_000918.1.
WP_010881296.1. NC_000918.1.

Genome annotation databases

EnsemblBacteriaiAAC07753; AAC07753; aq_1983.
GeneIDi1193688.
KEGGiaae:aq_1983.
PATRICi20960876. VBIAquAeo85532_1533.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000657 Genomic DNA. Translation: AAC07753.1.
PIRiC70470.
RefSeqiNP_214360.1. NC_000918.1.
WP_010881296.1. NC_000918.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2PCRX-ray2.60A/B/C/D1-264[»]
ProteinModelPortaliO67791.
SMRiO67791. Positions 1-263.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi224324.aq_1983.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC07753; AAC07753; aq_1983.
GeneIDi1193688.
KEGGiaae:aq_1983.
PATRICi20960876. VBIAquAeo85532_1533.

Phylogenomic databases

eggNOGiENOG4105ECY. Bacteria.
COG0483. LUCA.
HOGENOMiHOG000282238.
InParanoidiO67791.
KOiK01092.
OMAiYDPSRND.
OrthoDBiEOG6QK4W4.

Enzyme and pathway databases

UniPathwayiUPA00138.
BioCyciAAEO224324:GJBH-1421-MONOMER.

Miscellaneous databases

EvolutionaryTraceiO67791.

Family and domain databases

InterProiIPR020583. Inositol_monoP_metal-BS.
IPR000760. Inositol_monophosphatase.
IPR022337. Inositol_monophosphatase_SuhB.
[Graphical view]
PANTHERiPTHR20854. PTHR20854. 1 hit.
PfamiPF00459. Inositol_P. 1 hit.
[Graphical view]
PRINTSiPR00377. IMPHPHTASES.
PR01959. SBIMPHPHTASE.
PROSITEiPS00629. IMP_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: VF5.
  2. "Crystal structure of myo-inositol-1(or 4)-monophosphatase (aq_1983) from Aquifex aeolicus VF5."
    RIKEN structural genomics initiative (RSGI)
    Submitted (FEB-2009) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (2.6 ANGSTROMS).

Entry informationi

Entry nameiBSUHB_AQUAE
AccessioniPrimary (citable) accession number: O67791
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: August 1, 1998
Last modified: February 17, 2016
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.