Reviewed, UniProtKB/Swiss-Prot O67781 (AAT_AQUAE)

Names and origin

Protein names

Recommended name:
    Aspartate aminotransferase
      Short name=AspAT
    EC=2.6.1.1
Alternative name(s):
    Transaminase A

Gene names

Name:	aspC
Ordered Locus Names:	aq_1969

Organism

Aquifex aeolicus [Complete proteome] [HAMAP]

Taxonomic identifier

63363 [NCBI]

Taxonomic lineage

Bacteria › Aquificae › Aquificales › Aquificaceae › Aquifex

Protein attributes

Sequence length	394 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	L-aspartate + 2-oxoglutarate = oxaloacetate + L-glutamate.
Cofactor	Pyridoxal phosphate By similarity.
Subunit structure	Homodimer By similarity.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	Pyridoxal phosphate
Molecular function	Aminotransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	biosynthetic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	1-aminocyclopropane-1-carboxylate synthase activity Inferred from electronic annotation. Source: InterPro L-aspartate:2-oxoglutarate aminotransferase activity Inferred from electronic annotation. Source: EC pyridoxal phosphate binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 394	394	Aspartate aminotransferase		PRO_0000123833
Amino acid modifications
	Modified residue	239	1	N6-(pyridoxal phosphate)lysine By similarity

Sequences

	Sequence		Length	Mass (Da)
	O67781-1 [UniParc]. Last modified August 1, 1998. Version 1. Checksum: E570B4FD080C56E1	FASTA	394	43,777
	10 20 30 40 50 60 MRKGLASRVS HLKPSPTLTI TAKAKELRAK GVDVIGFGAG EPDFDTPDFI KEACIRALRE 70 80 90 100 110 120 GKTKYAPSAG IPELREAIAE KLLKENKVEY KPSEIVVSAG AKMVLFLIFM AILDEGDEVL 130 140 150 160 170 180 LPSPYWVTYP EQIRFFGGVP VEVPLKKEKG FQLSLEDVKE KVTERTKAIV INSPNNPTGA 190 200 210 220 230 240 VYEEEELKKI AEFCVERGIF IISDECYEYF VYGDAKFVSP ASFSDEVKNI TFTVNAFSKS 250 260 270 280 290 300 YSMTGWRIGY VACPEEYAKV IASLNSQSVS NVTTFAQYGA LEALKNPKSK DFVNEMRNAF 310 320 330 340 350 360 ERRRDTAVEE LSKIPGMDVV KPEGAFYIFP DFSAYAEKLG GDVKLSEFLL EKAKVAVVPG 370 380 390 SAFGAPGFLR LSYALSEERL VEGIRRIKKA LEEI

References

[1]

"The complete genome of the hyperthermophilic bacterium Aquifex aeolicus." Deckert G., Warren P.V., Gaasterland T., Young W.G., Lenox A.L., Graham D.E., Overbeek R., Snead M.A., Keller M., Aujay M., Huber R., Feldman R.A., Short J.M., Olsen G.J., Swanson R.V. Nature 392:353-358(1998) [PubMed: 9537320] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: VF5.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE000657 Genomic DNA. Translation: AAC07746.1.
PIR	A70469.
RefSeq	NP_214350.1.
3D structure databases
HSSP	HSSP built from PDB template 1BKG based on UniProtKB Q56232.
ModBase	Search...
Genome annotation databases
GeneID	1193678.
GenomeReviews	Gene locus aq_1969 in contig AE000657_GR.
KEGG	aae:aq_1969.
NMPDR	fig|224324.1.peg.1365.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	O67781.
OMA	KNIRDAA.
Enzyme and pathway databases
BioCyc	AAEO224324:AQ_1969-MON.
BRENDA	2.6.1.1. 189781.
Family and domain databases
InterPro	IPR001176. ACC_synthase. IPR004839. Aminotransferase_I/II. IPR004838. NHTrfase_class1_PyrdxlP-BS. IPR015421. PyrdxlP-dep_Trfase_major_sub1. IPR015422. PyrdxlP-dep_Trfase_major_sub2. [Graphical view]
Gene3D	G3DSA:3.40.640.10. PyrdxlP-dep_Trfase_major_sub1. 1 hit. G3DSA:3.90.1150.10. PyrdxlP-dep_Trfase_major_sub2. 1 hit.
Pfam	PF00155. Aminotran_1_2. 1 hit. [Graphical view]
PRINTS	PR00753. ACCSYNTHASE.
PROSITE	PS00105. AA_TRANSFER_CLASS_1. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

AAT_AQUAE

Accession

Primary (citable) accession number: O67781

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	August 1, 1998
Last modified:	November 3, 2009
This is version 57 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)