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O67775

- PUR9_AQUAE

UniProt

O67775 - PUR9_AQUAE

Protein

Bifunctional purine biosynthesis protein PurH

Gene

purH

Organism
Aquifex aeolicus (strain VF5)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 91 (01 Oct 2014)
      Sequence version 1 (01 Aug 1998)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    10-formyltetrahydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide = tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.
    IMP + H2O = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.

    Pathwayi

    GO - Molecular functioni

    1. IMP cyclohydrolase activity Source: UniProtKB-HAMAP
    2. phosphoribosylaminoimidazolecarboxamide formyltransferase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. 'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Hydrolase, Transferase

    Keywords - Biological processi

    Purine biosynthesis

    Enzyme and pathway databases

    BioCyciAAEO224324:GJBH-1405-MONOMER.
    UniPathwayiUPA00074; UER00133.
    UPA00074; UER00135.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Bifunctional purine biosynthesis protein PurH
    Including the following 2 domains:
    Phosphoribosylaminoimidazolecarboxamide formyltransferase (EC:2.1.2.3)
    Alternative name(s):
    AICAR transformylase
    IMP cyclohydrolase (EC:3.5.4.10)
    Alternative name(s):
    ATIC
    IMP synthase
    Inosinicase
    Gene namesi
    Name:purH
    Ordered Locus Names:aq_1963
    OrganismiAquifex aeolicus (strain VF5)
    Taxonomic identifieri224324 [NCBI]
    Taxonomic lineageiBacteriaAquificaeAquificalesAquificaceaeAquifex
    ProteomesiUP000000798: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 506506Bifunctional purine biosynthesis protein PurHPRO_0000192068Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi224324.aq_1963.

    Structurei

    3D structure databases

    ProteinModelPortaliO67775.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domaini

    The IMP cyclohydrolase activity resides in the N-terminal region.By similarity

    Sequence similaritiesi

    Belongs to the PurH family.Curated

    Phylogenomic databases

    eggNOGiCOG0138.
    HOGENOMiHOG000230372.
    KOiK00602.
    OMAiRAFKTDP.
    OrthoDBiEOG6QCDFF.

    Family and domain databases

    Gene3Di3.40.140.20. 2 hits.
    3.40.50.1380. 1 hit.
    HAMAPiMF_00139. PurH.
    InterProiIPR024051. AICAR_Tfase_dom.
    IPR002695. AICARFT_IMPCHas.
    IPR016193. Cytidine_deaminase-like.
    IPR011607. MGS-like_dom.
    [Graphical view]
    PANTHERiPTHR11692. PTHR11692. 1 hit.
    PfamiPF01808. AICARFT_IMPCHas. 1 hit.
    PF02142. MGS. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000414. AICARFT_IMPCHas. 1 hit.
    SMARTiSM00798. AICARFT_IMPCHas. 1 hit.
    SM00851. MGS. 1 hit.
    [Graphical view]
    SUPFAMiSSF52335. SSF52335. 1 hit.
    SSF53927. SSF53927. 1 hit.
    TIGRFAMsiTIGR00355. purH. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    O67775-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRAIISVYRK EGIDKLAKAL QELGYEIVST GGTAKYLREK GISVKEVSEI    50
    TGFPEILEGR VKTLHPVVHG GILFRDWVEK DKEEIEKHGI KPIDVVVVNL 100
    YPFEEKLKEG LTDKDLMEFI DIGGPTLIRA AAKNFFRVVI LVDPEDYDWV 150
    IEKLKKGNLT LQDRAYLAWK AFSHTAYYDG VISQAFKKLY SIDTFGKEEA 200
    LPLKRMQKLR YGENPHQRGF LYENPLEDIG ITKAQVLQGK EMSFNNYLDA 250
    DSAVRLVAEF PNQTVCAIIK HNNPCGVALG SSVKEAFLRA KEADPVSAFG 300
    GIVAFNDKVD GETAKELTSM FLEVVIAPDY DEEALRELSR KKNLRVIRFF 350
    GFQHAFDVKK VSGGYLLQDE DTVLYEKLQV VTKREPTAEE MEDLLFAWKV 400
    VKHTKSNAVV IAKNGQTLGI GSGNVSRVDS LKCAINKAKE FGFDLKGAVV 450
    ASEAFFPFRD SIDIMAKEGI TAVIQPGGSI RDQEVIDACN EHGIAMIFTG 500
    LRHFKH 506
    Length:506
    Mass (Da):56,677
    Last modified:August 1, 1998 - v1
    Checksum:i46998C8B1B1FE694
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE000657 Genomic DNA. Translation: AAC07734.1.
    PIRiC70468.
    RefSeqiNP_214344.1. NC_000918.1.

    Genome annotation databases

    EnsemblBacteriaiAAC07734; AAC07734; aq_1963.
    GeneIDi1193672.
    KEGGiaae:aq_1963.
    PATRICi20960838. VBIAquAeo85532_1514.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE000657 Genomic DNA. Translation: AAC07734.1 .
    PIRi C70468.
    RefSeqi NP_214344.1. NC_000918.1.

    3D structure databases

    ProteinModelPortali O67775.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 224324.aq_1963.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAC07734 ; AAC07734 ; aq_1963 .
    GeneIDi 1193672.
    KEGGi aae:aq_1963.
    PATRICi 20960838. VBIAquAeo85532_1514.

    Phylogenomic databases

    eggNOGi COG0138.
    HOGENOMi HOG000230372.
    KOi K00602.
    OMAi RAFKTDP.
    OrthoDBi EOG6QCDFF.

    Enzyme and pathway databases

    UniPathwayi UPA00074 ; UER00133 .
    UPA00074 ; UER00135 .
    BioCyci AAEO224324:GJBH-1405-MONOMER.

    Family and domain databases

    Gene3Di 3.40.140.20. 2 hits.
    3.40.50.1380. 1 hit.
    HAMAPi MF_00139. PurH.
    InterProi IPR024051. AICAR_Tfase_dom.
    IPR002695. AICARFT_IMPCHas.
    IPR016193. Cytidine_deaminase-like.
    IPR011607. MGS-like_dom.
    [Graphical view ]
    PANTHERi PTHR11692. PTHR11692. 1 hit.
    Pfami PF01808. AICARFT_IMPCHas. 1 hit.
    PF02142. MGS. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000414. AICARFT_IMPCHas. 1 hit.
    SMARTi SM00798. AICARFT_IMPCHas. 1 hit.
    SM00851. MGS. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52335. SSF52335. 1 hit.
    SSF53927. SSF53927. 1 hit.
    TIGRFAMsi TIGR00355. purH. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: VF5.

    Entry informationi

    Entry nameiPUR9_AQUAE
    AccessioniPrimary (citable) accession number: O67775
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: August 1, 1998
    Last modified: October 1, 2014
    This is version 91 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Multifunctional enzyme, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3