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O67772 (THID_AQUAE) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 85. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase

EC=2.7.1.49
EC=2.7.4.7
Alternative name(s):
Hydroxymethylpyrimidine kinase
Short name=HMP kinase
Hydroxymethylpyrimidine phosphate kinase
Short name=HMP-P kinase
Short name=HMP-phosphate kinase
Short name=HMPP kinase
Gene names
Name:thiD
Ordered Locus Names:aq_1960
OrganismAquifex aeolicus (strain VF5) [Reference proteome] [HAMAP]
Taxonomic identifier224324 [NCBI]
Taxonomic lineageBacteriaAquificaeAquificalesAquificaceaeAquifex

Protein attributes

Sequence length255 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the phosphorylation of hydroxymethylpyrimidine phosphate (HMP-P) to HMP-PP, and of HMP to HMP-P By similarity.

Catalytic activity

ATP + 4-amino-5-hydroxymethyl-2-methylpyrimidine = ADP + 4-amino-5-phosphonooxymethyl-2-methylpyrimidine.

ATP + 4-amino-2-methyl-5-phosphomethylpyrimidine = ADP + 4-amino-2-methyl-5-diphosphomethylpyrimidine.

Pathway

Cofactor biosynthesis; thiamine diphosphate biosynthesis; 4-amino-2-methyl-5-diphosphomethylpyrimidine from 5-amino-1-(5-phospho-D-ribosyl)imidazole: step 2/3.

Cofactor biosynthesis; thiamine diphosphate biosynthesis; 4-amino-2-methyl-5-diphosphomethylpyrimidine from 5-amino-1-(5-phospho-D-ribosyl)imidazole: step 3/3.

Sequence similarities

Belongs to the ThiD family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 255255Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase
PRO_0000192016

Sites

Binding site411Substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
O67772 [UniParc].

Last modified August 1, 1998. Version 1.
Checksum: 95A4CA5F662F708F

FASTA25528,066
        10         20         30         40         50         60 
MIALSIAGFD NSGGAGTLAD IRTFKHFGIY GVAVITALAV QNTQKVYEVF PIPPDVVKEE 

        70         80         90        100        110        120 
LKAIFEDFPI KGVKIGMLAN KEIAEVVYET LKSKKTNFIV LDPVFRSKSG RELLSEEGVE 

       130        140        150        160        170        180 
FLKSEFIKIV DLITPNVPEA EILCGEEIKS LEDVKNCAQK IYSLGAKSVL IKGGHLKGNY 

       190        200        210        220        230        240 
AIDILYDGKS FYEFKAPKIA GKTPRGTGCV YSSAILANYL RHKDLIKAIK TAKDFITEAI 

       250 
KNSKKLGKGY EIMDF 

« Hide

References

[1]"The complete genome of the hyperthermophilic bacterium Aquifex aeolicus."
Deckert G., Warren P.V., Gaasterland T., Young W.G., Lenox A.L., Graham D.E., Overbeek R., Snead M.A., Keller M., Aujay M., Huber R., Feldman R.A., Short J.M., Olsen G.J., Swanson R.V.
Nature 392:353-358(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: VF5.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE000657 Genomic DNA. Translation: AAC07733.1.
PIRH70467.
RefSeqNP_214341.1. NC_000918.1.

3D structure databases

ProteinModelPortalO67772.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING224324.aq_1960.

Proteomic databases

PRIDEO67772.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAC07733; AAC07733; aq_1960.
GeneID1193669.
KEGGaae:aq_1960.
PATRIC20960832. VBIAquAeo85532_1511.

Phylogenomic databases

eggNOGCOG0351.
HOGENOMHOG000225273.
KOK00941.
OMATNHWAYS.
OrthoDBEOG6XWV53.

Enzyme and pathway databases

BioCycAAEO224324:GJBH-1402-MONOMER.
UniPathwayUPA00060; UER00137.
UPA00060; UER00138.

Family and domain databases

Gene3D3.40.1190.20. 1 hit.
InterProIPR013749. HMP-P_kinase-1.
IPR004399. HMP-P_kinase-2.
IPR029056. Ribokinase-like.
[Graphical view]
PfamPF08543. Phos_pyr_kin. 1 hit.
[Graphical view]
SUPFAMSSF53613. SSF53613. 1 hit.
TIGRFAMsTIGR00097. HMP-P_kinase. 1 hit.
ProtoNetSearch...

Entry information

Entry nameTHID_AQUAE
AccessionPrimary (citable) accession number: O67772
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: August 1, 1998
Last modified: June 11, 2014
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways