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O67772

- THID_AQUAE

UniProt

O67772 - THID_AQUAE

Protein

Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase

Gene

thiD

Organism
Aquifex aeolicus (strain VF5)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 87 (01 Oct 2014)
      Sequence version 1 (01 Aug 1998)
      Previous versions | rss
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    Functioni

    Catalyzes the phosphorylation of hydroxymethylpyrimidine phosphate (HMP-P) to HMP-PP, and of HMP to HMP-P.By similarity

    Catalytic activityi

    ATP + 4-amino-5-hydroxymethyl-2-methylpyrimidine = ADP + 4-amino-5-phosphonooxymethyl-2-methylpyrimidine.
    ATP + 4-amino-2-methyl-5-phosphomethylpyrimidine = ADP + 4-amino-2-methyl-5-diphosphomethylpyrimidine.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei41 – 411SubstrateBy similarity

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. hydroxymethylpyrimidine kinase activity Source: UniProtKB-EC
    3. phosphomethylpyrimidine kinase activity Source: UniProtKB-EC

    GO - Biological processi

    1. thiamine biosynthetic process Source: UniProtKB-KW
    2. thiamine diphosphate biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Biological processi

    Thiamine biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciAAEO224324:GJBH-1402-MONOMER.
    UniPathwayiUPA00060; UER00137.
    UPA00060; UER00138.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase (EC:2.7.1.49, EC:2.7.4.7)
    Alternative name(s):
    Hydroxymethylpyrimidine kinase
    Short name:
    HMP kinase
    Hydroxymethylpyrimidine phosphate kinase
    Short name:
    HMP-P kinase
    Short name:
    HMP-phosphate kinase
    Short name:
    HMPP kinase
    Gene namesi
    Name:thiD
    Ordered Locus Names:aq_1960
    OrganismiAquifex aeolicus (strain VF5)
    Taxonomic identifieri224324 [NCBI]
    Taxonomic lineageiBacteriaAquificaeAquificalesAquificaceaeAquifex
    ProteomesiUP000000798: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 255255Hydroxymethylpyrimidine/phosphomethylpyrimidine kinasePRO_0000192016Add
    BLAST

    Proteomic databases

    PRIDEiO67772.

    Interactioni

    Protein-protein interaction databases

    STRINGi224324.aq_1960.

    Structurei

    3D structure databases

    ProteinModelPortaliO67772.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ThiD family.Curated

    Phylogenomic databases

    eggNOGiCOG0351.
    HOGENOMiHOG000225273.
    KOiK00941.
    OMAiTNHWAYS.
    OrthoDBiEOG6XWV53.

    Family and domain databases

    Gene3Di3.40.1190.20. 1 hit.
    InterProiIPR004399. HMP/HMP-P_kinase.
    IPR013749. PM/HMP-P_kinase-1.
    IPR029056. Ribokinase-like.
    [Graphical view]
    PfamiPF08543. Phos_pyr_kin. 1 hit.
    [Graphical view]
    SUPFAMiSSF53613. SSF53613. 1 hit.
    TIGRFAMsiTIGR00097. HMP-P_kinase. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    O67772-1 [UniParc]FASTAAdd to Basket

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    MIALSIAGFD NSGGAGTLAD IRTFKHFGIY GVAVITALAV QNTQKVYEVF    50
    PIPPDVVKEE LKAIFEDFPI KGVKIGMLAN KEIAEVVYET LKSKKTNFIV 100
    LDPVFRSKSG RELLSEEGVE FLKSEFIKIV DLITPNVPEA EILCGEEIKS 150
    LEDVKNCAQK IYSLGAKSVL IKGGHLKGNY AIDILYDGKS FYEFKAPKIA 200
    GKTPRGTGCV YSSAILANYL RHKDLIKAIK TAKDFITEAI KNSKKLGKGY 250
    EIMDF 255
    Length:255
    Mass (Da):28,066
    Last modified:August 1, 1998 - v1
    Checksum:i95A4CA5F662F708F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE000657 Genomic DNA. Translation: AAC07733.1.
    PIRiH70467.
    RefSeqiNP_214341.1. NC_000918.1.

    Genome annotation databases

    EnsemblBacteriaiAAC07733; AAC07733; aq_1960.
    GeneIDi1193669.
    KEGGiaae:aq_1960.
    PATRICi20960832. VBIAquAeo85532_1511.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE000657 Genomic DNA. Translation: AAC07733.1 .
    PIRi H70467.
    RefSeqi NP_214341.1. NC_000918.1.

    3D structure databases

    ProteinModelPortali O67772.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 224324.aq_1960.

    Proteomic databases

    PRIDEi O67772.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAC07733 ; AAC07733 ; aq_1960 .
    GeneIDi 1193669.
    KEGGi aae:aq_1960.
    PATRICi 20960832. VBIAquAeo85532_1511.

    Phylogenomic databases

    eggNOGi COG0351.
    HOGENOMi HOG000225273.
    KOi K00941.
    OMAi TNHWAYS.
    OrthoDBi EOG6XWV53.

    Enzyme and pathway databases

    UniPathwayi UPA00060 ; UER00137 .
    UPA00060 ; UER00138 .
    BioCyci AAEO224324:GJBH-1402-MONOMER.

    Family and domain databases

    Gene3Di 3.40.1190.20. 1 hit.
    InterProi IPR004399. HMP/HMP-P_kinase.
    IPR013749. PM/HMP-P_kinase-1.
    IPR029056. Ribokinase-like.
    [Graphical view ]
    Pfami PF08543. Phos_pyr_kin. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53613. SSF53613. 1 hit.
    TIGRFAMsi TIGR00097. HMP-P_kinase. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: VF5.

    Entry informationi

    Entry nameiTHID_AQUAE
    AccessioniPrimary (citable) accession number: O67772
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: August 1, 1998
    Last modified: October 1, 2014
    This is version 87 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3