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O67772

- THID_AQUAE

UniProt

O67772 - THID_AQUAE

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Protein

Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase

Gene

thiD

Organism
Aquifex aeolicus (strain VF5)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the phosphorylation of hydroxymethylpyrimidine phosphate (HMP-P) to HMP-PP, and of HMP to HMP-P.By similarity

Catalytic activityi

ATP + 4-amino-5-hydroxymethyl-2-methylpyrimidine = ADP + 4-amino-5-phosphonooxymethyl-2-methylpyrimidine.
ATP + 4-amino-2-methyl-5-phosphomethylpyrimidine = ADP + 4-amino-2-methyl-5-diphosphomethylpyrimidine.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei41 – 411SubstrateBy similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. hydroxymethylpyrimidine kinase activity Source: UniProtKB-EC
  3. phosphomethylpyrimidine kinase activity Source: UniProtKB-EC

GO - Biological processi

  1. thiamine biosynthetic process Source: UniProtKB-KW
  2. thiamine diphosphate biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Thiamine biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciAAEO224324:GJBH-1402-MONOMER.
UniPathwayiUPA00060; UER00137.
UPA00060; UER00138.

Names & Taxonomyi

Protein namesi
Recommended name:
Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase (EC:2.7.1.49, EC:2.7.4.7)
Alternative name(s):
Hydroxymethylpyrimidine kinase
Short name:
HMP kinase
Hydroxymethylpyrimidine phosphate kinase
Short name:
HMP-P kinase
Short name:
HMP-phosphate kinase
Short name:
HMPP kinase
Gene namesi
Name:thiD
Ordered Locus Names:aq_1960
OrganismiAquifex aeolicus (strain VF5)
Taxonomic identifieri224324 [NCBI]
Taxonomic lineageiBacteriaAquificaeAquificalesAquificaceaeAquifex
ProteomesiUP000000798: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 255255Hydroxymethylpyrimidine/phosphomethylpyrimidine kinasePRO_0000192016Add
BLAST

Proteomic databases

PRIDEiO67772.

Interactioni

Protein-protein interaction databases

STRINGi224324.aq_1960.

Structurei

3D structure databases

ProteinModelPortaliO67772.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ThiD family.Curated

Phylogenomic databases

eggNOGiCOG0351.
HOGENOMiHOG000225273.
InParanoidiO67772.
KOiK00941.
OMAiTNHWAYS.
OrthoDBiEOG6XWV53.

Family and domain databases

Gene3Di3.40.1190.20. 1 hit.
InterProiIPR004399. HMP/HMP-P_kinase.
IPR013749. PM/HMP-P_kinase-1.
IPR029056. Ribokinase-like.
[Graphical view]
PfamiPF08543. Phos_pyr_kin. 1 hit.
[Graphical view]
SUPFAMiSSF53613. SSF53613. 1 hit.
TIGRFAMsiTIGR00097. HMP-P_kinase. 1 hit.

Sequencei

Sequence statusi: Complete.

O67772-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MIALSIAGFD NSGGAGTLAD IRTFKHFGIY GVAVITALAV QNTQKVYEVF
60 70 80 90 100
PIPPDVVKEE LKAIFEDFPI KGVKIGMLAN KEIAEVVYET LKSKKTNFIV
110 120 130 140 150
LDPVFRSKSG RELLSEEGVE FLKSEFIKIV DLITPNVPEA EILCGEEIKS
160 170 180 190 200
LEDVKNCAQK IYSLGAKSVL IKGGHLKGNY AIDILYDGKS FYEFKAPKIA
210 220 230 240 250
GKTPRGTGCV YSSAILANYL RHKDLIKAIK TAKDFITEAI KNSKKLGKGY

EIMDF
Length:255
Mass (Da):28,066
Last modified:August 1, 1998 - v1
Checksum:i95A4CA5F662F708F
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE000657 Genomic DNA. Translation: AAC07733.1.
PIRiH70467.
RefSeqiNP_214341.1. NC_000918.1.

Genome annotation databases

EnsemblBacteriaiAAC07733; AAC07733; aq_1960.
GeneIDi1193669.
KEGGiaae:aq_1960.
PATRICi20960832. VBIAquAeo85532_1511.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE000657 Genomic DNA. Translation: AAC07733.1 .
PIRi H70467.
RefSeqi NP_214341.1. NC_000918.1.

3D structure databases

ProteinModelPortali O67772.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 224324.aq_1960.

Proteomic databases

PRIDEi O67772.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAC07733 ; AAC07733 ; aq_1960 .
GeneIDi 1193669.
KEGGi aae:aq_1960.
PATRICi 20960832. VBIAquAeo85532_1511.

Phylogenomic databases

eggNOGi COG0351.
HOGENOMi HOG000225273.
InParanoidi O67772.
KOi K00941.
OMAi TNHWAYS.
OrthoDBi EOG6XWV53.

Enzyme and pathway databases

UniPathwayi UPA00060 ; UER00137 .
UPA00060 ; UER00138 .
BioCyci AAEO224324:GJBH-1402-MONOMER.

Family and domain databases

Gene3Di 3.40.1190.20. 1 hit.
InterProi IPR004399. HMP/HMP-P_kinase.
IPR013749. PM/HMP-P_kinase-1.
IPR029056. Ribokinase-like.
[Graphical view ]
Pfami PF08543. Phos_pyr_kin. 1 hit.
[Graphical view ]
SUPFAMi SSF53613. SSF53613. 1 hit.
TIGRFAMsi TIGR00097. HMP-P_kinase. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: VF5.

Entry informationi

Entry nameiTHID_AQUAE
AccessioniPrimary (citable) accession number: O67772
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: August 1, 1998
Last modified: October 29, 2014
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3