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Protein

Transcription termination/antitermination protein NusG

Gene

nusG

Organism
Aquifex aeolicus (strain VF5)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Participates in transcription elongation, termination and antitermination.UniRule annotation

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription antitermination, Transcription regulation, Transcription termination

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription termination/antitermination protein NusGUniRule annotation
Gene namesi
Name:nusGUniRule annotation
Ordered Locus Names:aq_1931
OrganismiAquifex aeolicus (strain VF5)
Taxonomic identifieri224324 [NCBI]
Taxonomic lineageiBacteriaAquificaeAquificalesAquificaceaeAquifex
Proteomesi
  • UP000000798 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Chemistry databases

DrugBankiDB02325. Isopropyl Alcohol.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001139141 – 248Transcription termination/antitermination protein NusGAdd BLAST248

Interactioni

Subunit structurei

Monomer (PubMed:12198166). Homodimer (PubMed:12600194).2 Publications

Protein-protein interaction databases

STRINGi224324.aq_1931.

Structurei

Secondary structure

1248
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi12 – 18Combined sources7
Helixi23 – 36Combined sources14
Helixi40 – 42Combined sources3
Beta strandi43 – 47Combined sources5
Beta strandi49 – 58Combined sources10
Beta strandi61 – 71Combined sources11
Beta strandi73 – 78Combined sources6
Beta strandi80 – 88Combined sources9
Beta strandi93 – 97Combined sources5
Helixi103 – 106Combined sources4
Beta strandi116 – 119Combined sources4
Turni120 – 123Combined sources4
Beta strandi124 – 131Combined sources8
Beta strandi133 – 135Combined sources3
Beta strandi138 – 143Combined sources6
Helixi147 – 154Combined sources8
Beta strandi159 – 162Combined sources4
Beta strandi164 – 169Combined sources6
Helixi174 – 183Combined sources10
Beta strandi200 – 203Combined sources4
Turni207 – 210Combined sources4
Beta strandi212 – 219Combined sources8
Turni220 – 223Combined sources4
Beta strandi224 – 231Combined sources8
Beta strandi234 – 241Combined sources8
Beta strandi244 – 248Combined sources5

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1M1GX-ray2.00A/B/C/D1-248[»]
1M1HX-ray1.95A1-248[»]
1NPPX-ray2.00A/B/C/D1-248[»]
1NPRX-ray2.21A1-248[»]
ProteinModelPortaliO67757.
SMRiO67757.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO67757.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini197 – 227KOWUniRule annotationAdd BLAST31

Domaini

Contains an N-terminal RNP-like domain, a C-terminal element with a KOW sequence motif and a species-specific immunoglobulin-like fold.1 Publication

Sequence similaritiesi

Belongs to the NusG family.UniRule annotation
Contains 1 KOW domain.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107WP1. Bacteria.
COG0250. LUCA.
HOGENOMiHOG000219265.
InParanoidiO67757.
KOiK02601.
OMAiIEGPFMN.
OrthoDBiPOG091H02IB.

Family and domain databases

Gene3Di2.30.30.30. 1 hit.
2.60.320.10. 1 hit.
3.30.70.940. 2 hits.
HAMAPiMF_00948. NusG. 1 hit.
InterProiIPR005824. KOW.
IPR006645. NGN_dom.
IPR024045. NusG_dom2.
IPR014722. Rib_L2_dom2.
IPR001062. Transcrpt_antiterm_NusG.
IPR015869. Transcrpt_antiterm_NusG_bac_CS.
IPR008991. Translation_prot_SH3-like.
[Graphical view]
PfamiPF00467. KOW. 1 hit.
PF02357. NusG. 1 hit.
PF07009. NusG_II. 1 hit.
[Graphical view]
PRINTSiPR00338. NUSGTNSCPFCT.
SMARTiSM00739. KOW. 1 hit.
SM00738. NGN. 1 hit.
[Graphical view]
SUPFAMiSSF50104. SSF50104. 1 hit.
SSF82679. SSF82679. 2 hits.
TIGRFAMsiTIGR00922. nusG. 1 hit.
PROSITEiPS01014. NUSG. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O67757-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSEQQVQELE KKWYALQVEP GKENEAKENL LKVLELEGLK DLVDEVIVPA
60 70 80 90 100
EEKVVIRAQG KEKYRLSLKG NARDISVLGK KGVTTFRIEN GEVKVVESVE
110 120 130 140 150
GDTCVNAPPI SKPGQKITCK ENKTEAKIVL DNKIFPGYIL IKAHMNDKLL
160 170 180 190 200
MAIEKTPHVF RPVMVGGKPV PLKEEEVQNI LNQIKRGVKP SKVEFEKGDQ
210 220 230 240
VRVIEGPFMN FTGTVEEVHP EKRKLTVMIS IFGRMTPVEL DFDQVEKI
Length:248
Mass (Da):27,999
Last modified:August 1, 1998 - v1
Checksum:iCECE083CA19D8482
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000657 Genomic DNA. Translation: AAC07722.1.
PIRiA70466.
RefSeqiNP_214326.1. NC_000918.1.
WP_010881262.1. NC_000918.1.

Genome annotation databases

EnsemblBacteriaiAAC07722; AAC07722; aq_1931.
GeneIDi1193654.
KEGGiaae:aq_1931.
PATRICi20960800. VBIAquAeo85532_1496.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000657 Genomic DNA. Translation: AAC07722.1.
PIRiA70466.
RefSeqiNP_214326.1. NC_000918.1.
WP_010881262.1. NC_000918.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1M1GX-ray2.00A/B/C/D1-248[»]
1M1HX-ray1.95A1-248[»]
1NPPX-ray2.00A/B/C/D1-248[»]
1NPRX-ray2.21A1-248[»]
ProteinModelPortaliO67757.
SMRiO67757.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi224324.aq_1931.

Chemistry databases

DrugBankiDB02325. Isopropyl Alcohol.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC07722; AAC07722; aq_1931.
GeneIDi1193654.
KEGGiaae:aq_1931.
PATRICi20960800. VBIAquAeo85532_1496.

Phylogenomic databases

eggNOGiENOG4107WP1. Bacteria.
COG0250. LUCA.
HOGENOMiHOG000219265.
InParanoidiO67757.
KOiK02601.
OMAiIEGPFMN.
OrthoDBiPOG091H02IB.

Miscellaneous databases

EvolutionaryTraceiO67757.

Family and domain databases

Gene3Di2.30.30.30. 1 hit.
2.60.320.10. 1 hit.
3.30.70.940. 2 hits.
HAMAPiMF_00948. NusG. 1 hit.
InterProiIPR005824. KOW.
IPR006645. NGN_dom.
IPR024045. NusG_dom2.
IPR014722. Rib_L2_dom2.
IPR001062. Transcrpt_antiterm_NusG.
IPR015869. Transcrpt_antiterm_NusG_bac_CS.
IPR008991. Translation_prot_SH3-like.
[Graphical view]
PfamiPF00467. KOW. 1 hit.
PF02357. NusG. 1 hit.
PF07009. NusG_II. 1 hit.
[Graphical view]
PRINTSiPR00338. NUSGTNSCPFCT.
SMARTiSM00739. KOW. 1 hit.
SM00738. NGN. 1 hit.
[Graphical view]
SUPFAMiSSF50104. SSF50104. 1 hit.
SSF82679. SSF82679. 2 hits.
TIGRFAMsiTIGR00922. nusG. 1 hit.
PROSITEiPS01014. NUSG. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiNUSG_AQUAE
AccessioniPrimary (citable) accession number: O67757
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: August 1, 1998
Last modified: November 2, 2016
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.