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Protein

Type III pantothenate kinase

Gene

coaX

Organism
Aquifex aeolicus (strain VF5)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis.UniRule annotation

Catalytic activityi

ATP + (R)-pantothenate = ADP + (R)-4'-phosphopantothenate.UniRule annotation

Cofactori

NH4(+)UniRule annotation, K+UniRule annotationNote: A monovalent cation. Ammonium or potassium.UniRule annotation

Pathwayi: coenzyme A biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes CoA from (R)-pantothenate.UniRule annotation
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. Type III pantothenate kinase (coaX)
  2. Coenzyme A biosynthesis bifunctional protein CoaBC (dfp)
  3. Coenzyme A biosynthesis bifunctional protein CoaBC (dfp)
  4. Phosphopantetheine adenylyltransferase (coaD)
  5. Dephospho-CoA kinase (coaE)
This subpathway is part of the pathway coenzyme A biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes CoA from (R)-pantothenate, the pathway coenzyme A biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei78SubstrateUniRule annotation1
Active sitei87Proton acceptorUniRule annotation1
Binding sitei110ATPUniRule annotation1
Binding sitei161SubstrateUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi7 – 14ATPUniRule annotation8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
Biological processCoenzyme A biosynthesis
LigandATP-binding, Nucleotide-binding, Potassium

Enzyme and pathway databases

UniPathwayiUPA00241; UER00352.

Names & Taxonomyi

Protein namesi
Recommended name:
Type III pantothenate kinaseUniRule annotation (EC:2.7.1.33UniRule annotation)
Alternative name(s):
PanK-IIIUniRule annotation
Pantothenic acid kinaseUniRule annotation
Gene namesi
Name:coaXUniRule annotation
Ordered Locus Names:aq_1924
OrganismiAquifex aeolicus (strain VF5)
Taxonomic identifieri224324 [NCBI]
Taxonomic lineageiBacteriaAquificaeAquificalesAquificaceaeAquifex
Proteomesi
  • UP000000798 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002708591 – 229Type III pantothenate kinaseAdd BLAST229

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi224324.aq_1924.

Structurei

3D structure databases

ProteinModelPortaliO67753.
SMRiO67753.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni85 – 88Substrate bindingUniRule annotation4

Sequence similaritiesi

Belongs to the type III pantothenate kinase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CGM. Bacteria.
COG1521. LUCA.
HOGENOMiHOG000111872.
InParanoidiO67753.
KOiK03525.
OMAiDFITHEC.
OrthoDBiPOG091H01V7.

Family and domain databases

HAMAPiMF_01274. Pantothen_kinase_3. 1 hit.
InterProiView protein in InterPro
IPR004619. Type_III_PanK.
PANTHERiPTHR34265. PTHR34265. 1 hit.
PfamiView protein in Pfam
PF03309. Pan_kinase. 1 hit.
TIGRFAMsiTIGR00671. baf. 1 hit.

Sequencei

Sequence statusi: Complete.

O67753-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRFLTVDVGN SSVDIALWEG KKVKDFLKLS HEEFLKEEFP KLKALGISVK
60 70 80 90 100
QSFSEKVRGK IPKIKFLKKE NFPIQVDYKT PETLGTDRVA LAYSAKKFYG
110 120 130 140 150
KNVVVISAGT ALVIDLVLEG KFKGGFITLG LGKKLKILSD LAEGIPEFFP
160 170 180 190 200
EEVEIFLGRS TRECVLGGAY RESTEFIKST LKLWRKVFKR KFKVVITGGE
210 220
GKYFSKFGIY DPLLVHRGMR NLLYLYHRI
Length:229
Mass (Da):26,068
Last modified:August 1, 1998 - v1
Checksum:i64C347A285FABE9A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000657 Genomic DNA. Translation: AAC07720.1.
PIRiE70465.
RefSeqiNP_214321.1. NC_000918.1.
WP_010881257.1. NC_000918.1.

Genome annotation databases

EnsemblBacteriaiAAC07720; AAC07720; aq_1924.
GeneIDi1193650.
KEGGiaae:aq_1924.

Entry informationi

Entry nameiCOAX_AQUAE
AccessioniPrimary (citable) accession number: O67753
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: August 1, 1998
Last modified: June 7, 2017
This is version 88 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families