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O67740

- GCSPB_AQUAE

UniProt

O67740 - GCSPB_AQUAE

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Protein

Probable glycine dehydrogenase (decarboxylating) subunit 2

Gene
gcvPB, gcsP1, aq_1903
Organism
Aquifex aeolicus (strain VF5)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

Cofactori

Pyridoxal phosphate By similarity.UniRule annotation

GO - Molecular functioni

  1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciAAEO224324:GJBH-1363-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable glycine dehydrogenase (decarboxylating) subunit 2 (EC:1.4.4.2)
Alternative name(s):
Glycine cleavage system P-protein subunit 2
Glycine decarboxylase subunit 2
Glycine dehydrogenase (aminomethyl-transferring) subunit 2
Gene namesi
Name:gcvPB
Synonyms:gcsP1
Ordered Locus Names:aq_1903
OrganismiAquifex aeolicus (strain VF5)
Taxonomic identifieri224324 [NCBI]
Taxonomic lineageiBacteriaAquificaeAquificalesAquificaceaeAquifex
ProteomesiUP000000798: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 482482Probable glycine dehydrogenase (decarboxylating) subunit 2UniRule annotationPRO_0000166993Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei267 – 2671N6-(pyridoxal phosphate)lysine By similarity

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits By similarity.

Protein-protein interaction databases

STRINGi224324.aq_1903.

Structurei

3D structure databases

ProteinModelPortaliO67740.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1003.
HOGENOMiHOG000239368.
KOiK00283.
OMAiWTGLMMI.
OrthoDBiEOG6HMXDX.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
HAMAPiMF_00713. GcvPB.
InterProiIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR023012. GDC_P_su2.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.

Sequencei

Sequence statusi: Complete.

O67740-1 [UniParc]FASTAAdd to Basket

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MELIFEKSKK GRKGYKLPEL DVEEVNIKEY LPEEYLREEL DFPEVSELDV    50
VRHYTNLSHL NYAVDTTMVP LGSCTMKYNP RINEELVNKK EFLNVHPLTP 100
EEYIQPLLKL VYELKELLKE LGGFAEVSLQ PAAGAHGELL GLLLIHAYHQ 150
DRGNKEKKVV LIPDSAHGTN PASAAICGFD IKVVKSDKKG ELDFEDFIKK 200
LDERVAALMI TNPNTLGIFE RKIKEIAEEL HKRDALLYMD GANFNALVGR 250
FKPGEWGVDV MHFNLHKTFS TPHGGGGPGA GPVGVSERLK PYLPVPQIEY 300
DGKKYYLNWN IEKSVGKILA FHGHFLVWLK ALAYILTYGK DIKKVSEYAV 350
LNARYLKHLL KGVFKDPYPE SPCMHEFVLS ATNLTKYGVR ASDVAKRILD 400
YGFYAPTMYF PLIVREALMI EPTETENPDT LKKFALILRK IVKEAKEKPE 450
ILKKAPHRTP VRRIKEAEAN RNLILKFKDI KE 482
Length:482
Mass (Da):54,973
Last modified:August 1, 1998 - v1
Checksum:iD4D2BE9C407992EE
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE000657 Genomic DNA. Translation: AAC07701.1.
PIRiH70463.
RefSeqiNP_214308.1. NC_000918.1.

Genome annotation databases

EnsemblBacteriaiAAC07701; AAC07701; aq_1903.
GeneIDi1193545.
KEGGiaae:aq_1903.
PATRICi20960746. VBIAquAeo85532_1474.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE000657 Genomic DNA. Translation: AAC07701.1 .
PIRi H70463.
RefSeqi NP_214308.1. NC_000918.1.

3D structure databases

ProteinModelPortali O67740.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 224324.aq_1903.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAC07701 ; AAC07701 ; aq_1903 .
GeneIDi 1193545.
KEGGi aae:aq_1903.
PATRICi 20960746. VBIAquAeo85532_1474.

Phylogenomic databases

eggNOGi COG1003.
HOGENOMi HOG000239368.
KOi K00283.
OMAi WTGLMMI.
OrthoDBi EOG6HMXDX.

Enzyme and pathway databases

BioCyci AAEO224324:GJBH-1363-MONOMER.

Family and domain databases

Gene3Di 3.40.640.10. 1 hit.
HAMAPi MF_00713. GcvPB.
InterProi IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR023012. GDC_P_su2.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view ]
PANTHERi PTHR11773. PTHR11773. 1 hit.
Pfami PF02347. GDC-P. 1 hit.
[Graphical view ]
SUPFAMi SSF53383. SSF53383. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: VF5.

Entry informationi

Entry nameiGCSPB_AQUAE
AccessioniPrimary (citable) accession number: O67740
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 3, 2003
Last sequence update: August 1, 1998
Last modified: May 14, 2014
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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