ID   ARGC_AQUAE              Reviewed;         340 AA.
AC   O67724;
DT   01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1998, sequence version 1.
DT   16-JUN-2009, entry version 65.
DE   RecName: Full=N-acetyl-gamma-glutamyl-phosphate reductase;
DE            Short=AGPR;
DE            EC=1.2.1.38;
DE   AltName: Full=N-acetyl-glutamate semialdehyde dehydrogenase;
DE            Short=NAGSA dehydrogenase;
GN   Name=argC; OrderedLocusNames=aq_1879;
OS   Aquifex aeolicus.
OC   Bacteria; Aquificae; Aquificales; Aquificaceae; Aquifex.
OX   NCBI_TaxID=63363;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=VF5;
RX   MEDLINE=98196666; PubMed=9537320; DOI=10.1038/32831;
RA   Deckert G., Warren P.V., Gaasterland T., Young W.G., Lenox A.L.,
RA   Graham D.E., Overbeek R., Snead M.A., Keller M., Aujay M., Huber R.,
RA   Feldman R.A., Short J.M., Olsen G.J., Swanson R.V.;
RT   "The complete genome of the hyperthermophilic bacterium Aquifex
RT   aeolicus.";
RL   Nature 392:353-358(1998).
CC   -!- CATALYTIC ACTIVITY: N-acetyl-L-glutamate 5-semialdehyde + NADP(+)
CC       + phosphate = N-acetyl-5-glutamyl phosphate + NADPH.
CC   -!- PATHWAY: Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-
CC       acetyl-L-ornithine from L-glutamate: step 3/4.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm (Probable).
CC   -!- SIMILARITY: Belongs to the NAGSA dehydrogenase family. Type 1
CC       subfamily.
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DR   EMBL; AE000657; AAC07684.1; -; Genomic_DNA.
DR   PIR; B70462; B70462.
DR   RefSeq; NP_214292.1; -.
DR   GeneID; 1193531; -.
DR   GenomeReviews; AE000657_GR; aq_1879.
DR   KEGG; aae:aq_1879; -.
DR   NMPDR; fig|224324.1.peg.1307; -.
DR   HOGENOM; O67724; -.
DR   OMA; O67724; VCRIAVH.
DR   BioCyc; AAEO224324:AQ_1879-MON; -.
DR   BRENDA; 1.2.1.38; 189781.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0003942; F:N-acetyl-gamma-glutamyl-phosphate reductase...; IEA:HAMAP.
DR   GO; GO:0051287; F:NAD or NADH binding; IEA:InterPro.
DR   GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR   GO; GO:0006526; P:arginine biosynthetic process; IEA:HAMAP.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   HAMAP; MF_00150; -; 1.
DR   InterPro; IPR000706; AGPR_act_site.
DR   InterPro; IPR000534; Semialdehyde_DH_NAD-bd.
DR   InterPro; IPR012280; Semialdhyde_DH_C.
DR   Pfam; PF01118; Semialdhyde_dh; 1.
DR   Pfam; PF02774; Semialdhyde_dhC; 1.
DR   ProDom; PD003765; AGPR_act_site; 1.
DR   TIGRFAMs; TIGR01850; argC; 1.
DR   PROSITE; PS01224; ARGC; 1.
PE   3: Inferred from homology;
KW   Amino-acid biosynthesis; Arginine biosynthesis; Complete proteome;
KW   Cytoplasm; NADP; Oxidoreductase.
FT   CHAIN         1    340       N-acetyl-gamma-glutamyl-phosphate
FT                                reductase.
FT                                /FTId=PRO_0000112375.
FT   ACT_SITE    151    151       By similarity.
SQ   SEQUENCE   340 AA;  38958 MW;  A7BADB7A186AB653 CRC64;
     MEQTLRVSVF GATGYTGIEL LRSLLTHPHF EVKNLISQSY KGKKVREVLP FFSNTYISEI
     EFLEEPVEDY ELAFLCLPHE VSYEIVPKLL SQGKKVVDLS GAYRIKSPKA YEEFYGFKHE
     REDILQRAVY GLPEVFREEI KNSDLVANPG CYPTATLLAI YPFLKERVGI ESVIVHALSG
     VSGAGRKPKQ QFHFPEMTEN FFNYAVEKHR HTPEMEDVIR RVYGREVKVR FTPTVVPTSR
     GMISTVYLKS EKLNVKELFK EVYEDEIFVK VVDEPPQTKW VLGTNYCFIY PHYDERTGYY
     VIISAIDNLG KGASLQAVQN ANLMFGLAED DGLLQLPVFP
//