O67724 (ARGC_AQUAE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
N-acetyl-gamma-glutamyl-phosphate reductase
Short name=AGPR
EC=1.2.1.38

Alternative name(s):
N-acetyl-glutamate semialdehyde dehydrogenase
Short name=NAGSA dehydrogenase

Gene names

Name:	argC
Ordered Locus Names:	aq_1879

Organism

Aquifex aeolicus (strain VF5)

Taxonomic identifier

224324 [NCBI]

Taxonomic lineage

Bacteria › Aquificae › Aquificales › Aquificaceae › Aquifex

Protein attributes

Sequence length	340 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	N-acetyl-L-glutamate 5-semialdehyde + NADP+ + phosphate = N-acetyl-5-glutamyl phosphate + NADPH. HAMAP MF_00150
Pathway	Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 3/4. HAMAP MF_00150
Subcellular location	Cytoplasm Probable HAMAP MF_00150.
Sequence similarities	Belongs to the NAGSA dehydrogenase family. Type 1 subfamily.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Arginine biosynthesis
Cellular component	Cytoplasm
Ligand	NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	arginine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	N-acetyl-gamma-glutamyl-phosphate reductase activity Inferred from electronic annotation. Source: EC NAD binding Inferred from electronic annotation. Source: InterPro protein dimerization activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 340	340	N-acetyl-gamma-glutamyl-phosphate reductase HAMAP MF_00150		PRO_0000112375
Sites
	Active site	151	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	O67724 [UniParc]. Last modified August 1, 1998. Version 1. Checksum: A7BADB7A186AB653	FASTA	340	38,958
	10 20 30 40 50 60 MEQTLRVSVF GATGYTGIEL LRSLLTHPHF EVKNLISQSY KGKKVREVLP FFSNTYISEI 70 80 90 100 110 120 EFLEEPVEDY ELAFLCLPHE VSYEIVPKLL SQGKKVVDLS GAYRIKSPKA YEEFYGFKHE 130 140 150 160 170 180 REDILQRAVY GLPEVFREEI KNSDLVANPG CYPTATLLAI YPFLKERVGI ESVIVHALSG 190 200 210 220 230 240 VSGAGRKPKQ QFHFPEMTEN FFNYAVEKHR HTPEMEDVIR RVYGREVKVR FTPTVVPTSR 250 260 270 280 290 300 GMISTVYLKS EKLNVKELFK EVYEDEIFVK VVDEPPQTKW VLGTNYCFIY PHYDERTGYY 310 320 330 340 VIISAIDNLG KGASLQAVQN ANLMFGLAED DGLLQLPVFP

References

[1]

"The complete genome of the hyperthermophilic bacterium Aquifex aeolicus." Deckert G., Warren P.V., Gaasterland T., Young W.G., Lenox A.L., Graham D.E., Overbeek R., Snead M.A., Keller M., Aujay M., Huber R., Feldman R.A., Short J.M., Olsen G.J., Swanson R.V. Nature 392:353-358(1998) [PubMed: 9537320] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: VF5.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE000657 Genomic DNA. Translation: AAC07684.1.
PIR	B70462.
RefSeq	NP_214292.1. NC_000918.1.
3D structure databases
ProteinModelPortal	O67724.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1193531.
GenomeReviews	Gene locus aq_1879 in contig AE000657_GR.
KEGG	aae:aq_1879.
NMPDR	fig|224324.1.peg.1307.
PATRIC	20960712. VBIAquAeo85532_1457.
Phylogenomic databases
HOGENOM	HBG294213.
OMA	VCRIAVH.
PhylomeDB	O67724.
ProtClustDB	CLSK2299858.
Enzyme and pathway databases
BioCyc	AAEO224324:AQ_1879-MONOMER.
Family and domain databases
HAMAP	MF_00150. ArgC_type1. [Tree]
InterPro	IPR023013. AGPR_AS. IPR000706. AGPR_type-1. IPR016040. NAD(P)-bd_dom. IPR000534. Semialdehyde_DH_NAD-bd. IPR012280. Semialdhyde_DH_dimer_dom. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
KO	K00145.
Pfam	PF01118. Semialdhyde_dh. 1 hit. PF02774. Semialdhyde_dhC. 1 hit. [Graphical view]
SMART	SM00859. Semialdhyde_dh. 1 hit. [Graphical view]
TIGRFAMs	TIGR01850. ArgC. 1 hit.
PROSITE	PS01224. ARGC. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ARGC_AQUAE

Accession

Primary (citable) accession number: O67724

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 1, 2000
Last sequence update:	August 1, 1998
Last modified:	January 25, 2012
This is version 84 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program