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O67724 (ARGC_AQUAE) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 84. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
N-acetyl-gamma-glutamyl-phosphate reductase

Short name=AGPR
EC=1.2.1.38
Alternative name(s):
N-acetyl-glutamate semialdehyde dehydrogenase
Short name=NAGSA dehydrogenase
Gene names
Name:argC
Ordered Locus Names:aq_1879
OrganismAquifex aeolicus (strain VF5)
Taxonomic identifier224324 [NCBI]
Taxonomic lineageBacteriaAquificaeAquificalesAquificaceaeAquifex

Protein attributes

Sequence length340 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

N-acetyl-L-glutamate 5-semialdehyde + NADP+ + phosphate = N-acetyl-5-glutamyl phosphate + NADPH. HAMAP MF_00150

Pathway

Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 3/4. HAMAP MF_00150

Subcellular location

Cytoplasm Probable HAMAP MF_00150.

Sequence similarities

Belongs to the NAGSA dehydrogenase family. Type 1 subfamily.

Ontologies

Keywords
   Biological processAmino-acid biosynthesis
Arginine biosynthesis
   Cellular componentCytoplasm
   LigandNADP
   Molecular functionOxidoreductase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological processarginine biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionN-acetyl-gamma-glutamyl-phosphate reductase activity

Inferred from electronic annotation. Source: EC

NAD binding

Inferred from electronic annotation. Source: InterPro

protein dimerization activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 340340N-acetyl-gamma-glutamyl-phosphate reductase HAMAP MF_00150
PRO_0000112375

Sites

Active site1511 By similarity

Sequences

Sequence LengthMass (Da)Tools
O67724 [UniParc].

Last modified August 1, 1998. Version 1.
Checksum: A7BADB7A186AB653

FASTA34038,958
        10         20         30         40         50         60 
MEQTLRVSVF GATGYTGIEL LRSLLTHPHF EVKNLISQSY KGKKVREVLP FFSNTYISEI 

        70         80         90        100        110        120 
EFLEEPVEDY ELAFLCLPHE VSYEIVPKLL SQGKKVVDLS GAYRIKSPKA YEEFYGFKHE 

       130        140        150        160        170        180 
REDILQRAVY GLPEVFREEI KNSDLVANPG CYPTATLLAI YPFLKERVGI ESVIVHALSG 

       190        200        210        220        230        240 
VSGAGRKPKQ QFHFPEMTEN FFNYAVEKHR HTPEMEDVIR RVYGREVKVR FTPTVVPTSR 

       250        260        270        280        290        300 
GMISTVYLKS EKLNVKELFK EVYEDEIFVK VVDEPPQTKW VLGTNYCFIY PHYDERTGYY 

       310        320        330        340 
VIISAIDNLG KGASLQAVQN ANLMFGLAED DGLLQLPVFP 

« Hide

References

[1]"The complete genome of the hyperthermophilic bacterium Aquifex aeolicus."
Deckert G., Warren P.V., Gaasterland T., Young W.G., Lenox A.L., Graham D.E., Overbeek R., Snead M.A., Keller M., Aujay M., Huber R., Feldman R.A., Short J.M., Olsen G.J., Swanson R.V.
Nature 392:353-358(1998) [PubMed: 9537320] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: VF5.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE000657 Genomic DNA. Translation: AAC07684.1.
PIRB70462.
RefSeqNP_214292.1. NC_000918.1.

3D structure databases

ProteinModelPortalO67724.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID1193531.
GenomeReviewsGene locus aq_1879 in contig AE000657_GR.
KEGGaae:aq_1879.
NMPDRfig|224324.1.peg.1307.
PATRIC20960712. VBIAquAeo85532_1457.

Phylogenomic databases

HOGENOMHBG294213.
OMAVCRIAVH.
PhylomeDBO67724.
ProtClustDBCLSK2299858.

Enzyme and pathway databases

BioCycAAEO224324:AQ_1879-MONOMER.

Family and domain databases

HAMAPMF_00150. ArgC_type1.
[Tree]
InterProIPR023013. AGPR_AS.
IPR000706. AGPR_type-1.
IPR016040. NAD(P)-bd_dom.
IPR000534. Semialdehyde_DH_NAD-bd.
IPR012280. Semialdhyde_DH_dimer_dom.
[Graphical view]
Gene3DG3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
KOK00145.
PfamPF01118. Semialdhyde_dh. 1 hit.
PF02774. Semialdhyde_dhC. 1 hit.
[Graphical view]
SMARTSM00859. Semialdhyde_dh. 1 hit.
[Graphical view]
TIGRFAMsTIGR01850. ArgC. 1 hit.
PROSITEPS01224. ARGC. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameARGC_AQUAE
AccessionPrimary (citable) accession number: O67724
Entry history
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: August 1, 1998
Last modified: January 25, 2012
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families