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Protein

Protein translocase subunit SecA

Gene

secA

Organism
Aquifex aeolicus (strain VF5)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.UniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi111 – 1188ATPUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Protein transport, Translocation, Transport

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciAAEO224324:GJBH-1341-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein translocase subunit SecAUniRule annotation
Gene namesi
Name:secAUniRule annotation
Ordered Locus Names:aq_1870
OrganismiAquifex aeolicus (strain VF5)
Taxonomic identifieri224324 [NCBI]
Taxonomic lineageiBacteriaAquificaeAquificalesAquificaceaeAquifex
Proteomesi
  • UP000000798 Componenti: Chromosome

Subcellular locationi

  • Cell inner membrane UniRule annotation; Peripheral membrane protein UniRule annotation; Cytoplasmic side UniRule annotation
  • Cytoplasm UniRule annotation

  • Note: Distribution is 50-50.UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Cytoplasm, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 984984Protein translocase subunit SecAPRO_0000109574Add
BLAST

Proteomic databases

PRIDEiO67718.

Interactioni

Subunit structurei

Monomer and homodimer. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.UniRule annotation

Protein-protein interaction databases

STRINGi224324.aq_1870.

Structurei

3D structure databases

ProteinModelPortaliO67718.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the SecA family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CI6. Bacteria.
COG0653. LUCA.
HOGENOMiHOG000218168.
InParanoidiO67718.
KOiK03070.
OMAiIATERHE.
OrthoDBiEOG654P48.

Family and domain databases

Gene3Di1.10.3060.10. 1 hit.
3.40.50.300. 5 hits.
3.90.1440.10. 1 hit.
HAMAPiMF_01382. SecA.
InterProiIPR027417. P-loop_NTPase.
IPR000185. SecA.
IPR020937. SecA_CS.
IPR011115. SecA_DEAD.
IPR014018. SecA_motor_DEAD.
IPR011130. SecA_preprotein_X-link_dom.
IPR011116. SecA_Wing/Scaffold.
[Graphical view]
PfamiPF07517. SecA_DEAD. 1 hit.
PF01043. SecA_PP_bind. 1 hit.
PF07516. SecA_SW. 1 hit.
[Graphical view]
PRINTSiPR00906. SECA.
SMARTiSM00957. SecA_DEAD. 1 hit.
SM00958. SecA_PP_bind. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 5 hits.
SSF81767. SSF81767. 1 hit.
SSF81886. SSF81886. 1 hit.
PROSITEiPS01312. SECA. 1 hit.
PS51196. SECA_MOTOR_DEAD. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O67718-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLGWIAKKII GTKNEREVKR LRKFVNQINE LEKELDALTN KELVELAQEL
60 70 80 90 100
HDKIRFDEEL KERVIKGEIT PEVIKAFALV REAAKRTLGL RHFDVQLIGG
110 120 130 140 150
LVLHEGKIAE MKTGEGKTLV ATSPAVVNGM TDEGVHIVTV NDYLARRDAQ
160 170 180 190 200
WMGPIYKFLG LEVGVINSDG KTYLVEWVDP EKVKEAIEND VRVWPKGYYE
210 220 230 240 250
EILPSEKVNI DAKKTYFTTL KEAEHRRKAY EAHITYGTNN EFGFDYLRDN
260 270 280 290 300
LAFSKEEIVQ VKGHNYAIVD EVDSILIDEA RTPLIISGPA QIDSQIYHVA
310 320 330 340 350
DAVVRKLKKD KDFTVDEKNR TVNLTEQGIK KVEKMLGIDN LYDLKHVDLL
360 370 380 390 400
HAILQSIRAH HLFKKDVHYI VRDGEVLIVD EFTGRVLPGR RWSDGLHQAI
410 420 430 440 450
EVKEGVPVKE ENQTLASITF QNYFKLYRKL AGMTGTAETE ALEFKEIYGL
460 470 480 490 500
DVVVIPTHKP MIRKDHPDLV FKTKEEKWER VVEEVLLNHI FGRPVLVGTV
510 520 530 540 550
SIEDNEKLSS LLKNKKLLKE IANRNSFKRR LEETAKNLGV SPEEVQKKLE
560 570 580 590 600
EVLKKGIPHN VLNAKHHERE AEIIAQAGRV GAVTIATNMA GRGTDILLGG
610 620 630 640 650
NPEYLAKQML KEKGINPEEA TEEQFREALR EAYRITEEEK EKVKKLGGLL
660 670 680 690 700
VIGTERHESR RIDNQLRGRA GRQGDPGESR FIVSLEDDLL RLFGGERVSK
710 720 730 740 750
LMDMLKIERG EPIESRMVSK ALENAQKRVE AQNFQIRKRL YEFDSVMNIQ
760 770 780 790 800
RDVVYTLRRQ LLEGENVHEK IKEFLKDIIT QKVNELLPED DPELWDLEPL
810 820 830 840 850
KAFLKELTGR EVEIPQVRDK EELIQKLYEE LLKIYEEKEK EIGSPEAMRE
860 870 880 890 900
LERVILLNLL DNAWREHLHT LDRLREGIYL RGYAGKDPLI EYKREAYELF
910 920 930 940 950
ENMMENVKLN TLMTLFNVQI KSEEEIKEVE HEEEKKHQRL LEEAELQGVQ
960 970 980
GKSDKKPRPK TLKERLKEER LRKRKLKAKK KEQE
Length:984
Mass (Da):113,976
Last modified:August 1, 1998 - v1
Checksum:iAE23834D330DED84
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000657 Genomic DNA. Translation: AAC07677.1.
PIRiD70461.
RefSeqiNP_214286.1. NC_000918.1.
WP_010881222.1. NC_000918.1.

Genome annotation databases

EnsemblBacteriaiAAC07677; AAC07677; aq_1870.
GeneIDi1193525.
KEGGiaae:aq_1870.
PATRICi20960698. VBIAquAeo85532_1450.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000657 Genomic DNA. Translation: AAC07677.1.
PIRiD70461.
RefSeqiNP_214286.1. NC_000918.1.
WP_010881222.1. NC_000918.1.

3D structure databases

ProteinModelPortaliO67718.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi224324.aq_1870.

Proteomic databases

PRIDEiO67718.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC07677; AAC07677; aq_1870.
GeneIDi1193525.
KEGGiaae:aq_1870.
PATRICi20960698. VBIAquAeo85532_1450.

Phylogenomic databases

eggNOGiENOG4105CI6. Bacteria.
COG0653. LUCA.
HOGENOMiHOG000218168.
InParanoidiO67718.
KOiK03070.
OMAiIATERHE.
OrthoDBiEOG654P48.

Enzyme and pathway databases

BioCyciAAEO224324:GJBH-1341-MONOMER.

Family and domain databases

Gene3Di1.10.3060.10. 1 hit.
3.40.50.300. 5 hits.
3.90.1440.10. 1 hit.
HAMAPiMF_01382. SecA.
InterProiIPR027417. P-loop_NTPase.
IPR000185. SecA.
IPR020937. SecA_CS.
IPR011115. SecA_DEAD.
IPR014018. SecA_motor_DEAD.
IPR011130. SecA_preprotein_X-link_dom.
IPR011116. SecA_Wing/Scaffold.
[Graphical view]
PfamiPF07517. SecA_DEAD. 1 hit.
PF01043. SecA_PP_bind. 1 hit.
PF07516. SecA_SW. 1 hit.
[Graphical view]
PRINTSiPR00906. SECA.
SMARTiSM00957. SecA_DEAD. 1 hit.
SM00958. SecA_PP_bind. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 5 hits.
SSF81767. SSF81767. 1 hit.
SSF81886. SSF81886. 1 hit.
PROSITEiPS01312. SECA. 1 hit.
PS51196. SECA_MOTOR_DEAD. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: VF5.

Entry informationi

Entry nameiSECA_AQUAE
AccessioniPrimary (citable) accession number: O67718
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: August 1, 1998
Last modified: November 11, 2015
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.