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Protein

Lipoprotein signal peptidase

Gene

lspA

Organism
Aquifex aeolicus (strain VF5)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

This protein specifically catalyzes the removal of signal peptides from prolipoproteins.By similarity

Catalytic activityi

Release of signal peptides from bacterial membrane prolipoproteins. Hydrolyzes -Xaa-Yaa-Zaa-|-(S,diacylglyceryl)Cys-, in which Xaa is hydrophobic (preferably Leu), and Yaa (Ala or Ser) and Zaa (Gly or Ala) have small, neutral side chains.

Pathwayi: lipoprotein biosynthesis (signal peptide cleavage)

This protein is involved in the pathway lipoprotein biosynthesis (signal peptide cleavage), which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway lipoprotein biosynthesis (signal peptide cleavage) and in Protein modification.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei111By similarity1
Active sitei138By similarity1

GO - Molecular functioni

Keywordsi

Molecular functionAspartyl protease, Hydrolase, Protease

Enzyme and pathway databases

BioCyciAAEO224324:G1G15-1311-MONOMER
UniPathwayiUPA00665

Protein family/group databases

MEROPSiA08.001

Names & Taxonomyi

Protein namesi
Recommended name:
Lipoprotein signal peptidase (EC:3.4.23.36)
Alternative name(s):
Prolipoprotein signal peptidase
Signal peptidase II
Short name:
SPase II
Gene namesi
Name:lspA
Synonyms:lsp
Ordered Locus Names:aq_1837
OrganismiAquifex aeolicus (strain VF5)
Taxonomic identifieri224324 [NCBI]
Taxonomic lineageiBacteriaAquificaeAquificalesAquificaceaeAquifex
Proteomesi
  • UP000000798 Componenti: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei10 – 30HelicalSequence analysisAdd BLAST21
Transmembranei68 – 88HelicalSequence analysisAdd BLAST21
Transmembranei98 – 118HelicalSequence analysisAdd BLAST21
Transmembranei130 – 150HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001787671 – 167Lipoprotein signal peptidaseAdd BLAST167

Interactioni

Protein-protein interaction databases

STRINGi224324.aq_1837

Structurei

3D structure databases

SMRiO67692
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase A8 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4108386 Bacteria
COG0597 LUCA
HOGENOMiHOG000096992
InParanoidiO67692
KOiK03101
OMAiWFIVGMR
OrthoDBiPOG091H059F

Family and domain databases

HAMAPiMF_00161 LspA, 1 hit
InterProiView protein in InterPro
IPR001872 Peptidase_A8
PANTHERiPTHR33695 PTHR33695, 1 hit
PfamiView protein in Pfam
PF01252 Peptidase_A8, 1 hit
PRINTSiPR00781 LIPOSIGPTASE
TIGRFAMsiTIGR00077 lspA, 1 hit
PROSITEiView protein in PROSITE
PS00855 SPASE_II, 1 hit

Sequencei

Sequence statusi: Complete.

O67692-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MENFLRKTAW LYLSIAVSVF LLDIITKNLA EKLFTTHVEV FPFLEFYLIY
60 70 80 90 100
NKGVAFGLLS ELPDPLRLPL LLITPVIALI ITFLYALYSG DRIVAISMGL
110 120 130 140 150
IGGGALGNLY DRLFLGMVRD FIHLHIGEYY WPAFNIADAS ISIGIALLIL
160
KYFFTKPALK NLVNRTR
Length:167
Mass (Da):18,919
Last modified:August 1, 1998 - v1
Checksum:iCFF42E4E8DE68FC3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000657 Genomic DNA Translation: AAC07652.1
PIRiB70458
RefSeqiNP_214259.1, NC_000918.1
WP_010881195.1, NC_000918.1

Genome annotation databases

EnsemblBacteriaiAAC07652; AAC07652; aq_1837
GeneIDi1193499
KEGGiaae:aq_1837

Similar proteinsi

Entry informationi

Entry nameiLSPA_AQUAE
AccessioniPrimary (citable) accession number: O67692
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: August 1, 1998
Last modified: March 28, 2018
This is version 116 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health