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Protein

Formyltetrahydrofolate deformylase

Gene

purU

Organism
Aquifex aeolicus (strain VF5)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4).UniRule annotation

Catalytic activityi

10-formyltetrahydrofolate + H2O = formate + tetrahydrofolate.UniRule annotation

Pathwayi: IMP biosynthesis via de novo pathway

This protein is involved in step 1 of the subpathway that synthesizes formate from 10-formyl-5,6,7,8-tetrahydrofolate.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Formyltetrahydrofolate deformylase (purU)
This subpathway is part of the pathway IMP biosynthesis via de novo pathway, which is itself part of Purine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes formate from 10-formyl-5,6,7,8-tetrahydrofolate, the pathway IMP biosynthesis via de novo pathway and in Purine metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei227UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolaseUniRule annotation
Biological processOne-carbon metabolismUniRule annotation, Purine biosynthesisUniRule annotation

Enzyme and pathway databases

UniPathwayiUPA00074; UER00170.

Names & Taxonomyi

Protein namesi
Recommended name:
Formyltetrahydrofolate deformylaseUniRule annotation (EC:3.5.1.10UniRule annotation)
Alternative name(s):
Formyl-FH(4) hydrolaseUniRule annotation
Gene namesi
Name:purUUniRule annotationImported
Ordered Locus Names:aq_1818Imported
OrganismiAquifex aeolicus (strain VF5)Imported
Taxonomic identifieri224324 [NCBI]
Taxonomic lineageiBacteriaAquificaeAquificalesAquificaceaeAquifex
Proteomesi
  • UP000000798 Componenti: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi224324.aq_1818.

Structurei

3D structure databases

ProteinModelPortaliO67681.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini5 – 94ACTInterPro annotationAdd BLAST90

Sequence similaritiesi

Belongs to the PurU family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CIY. Bacteria.
COG0788. LUCA.
HOGENOMiHOG000033576.
InParanoidiO67681.
KOiK01433.
OMAiHADHHTD.
OrthoDBiPOG091H03FX.

Family and domain databases

Gene3Di3.40.50.170. 1 hit.
HAMAPiMF_01927. PurU. 1 hit.
InterProiView protein in InterPro
IPR002912. ACT_dom.
IPR002376. Formyl_transf_N.
IPR036477. Formyl_transf_N_sf.
IPR004810. PurU.
PANTHERiPTHR42706. PTHR42706. 1 hit.
PfamiView protein in Pfam
PF01842. ACT. 1 hit.
PF00551. Formyl_trans_N. 1 hit.
PRINTSiPR01575. FFH4HYDRLASE.
SUPFAMiSSF53328. SSF53328. 1 hit.
TIGRFAMsiTIGR00655. PurU. 1 hit.
PROSITEiView protein in PROSITE
PS51671. ACT. 1 hit.

Sequencei

Sequence statusi: Complete.

O67681-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQNAILLVSC PDRKGLVKEI SSFIADNGGN IVSFDQHIDE QTKTFLARVE
60 70 80 90 100
WSLEDFKIPR EKIENEFKKV AQKFSMNFQI SFSDYVKKVA IFVSKQEHCF
110 120 130 140 150
YDLMHRFYSG ELKGEVKLVI SNHEKARKTA EFFGVPFYHI PKTKENKLEA
160 170 180 190 200
EKRELELLKE YGVELVVLAR YMQILSPKFV KEYENKIINI HHSFLPAFPG
210 220 230 240 250
AKPYERAFGK GVKIIGATAH YVTEELDEGP IIEQDVVRVS HKDSLEDFIR
260 270 280
KGKDIEKVVL ARAVKWHLED KILVYNGKTV VFE
Length:283
Mass (Da):32,819
Last modified:August 1, 1998 - v1
Checksum:iF449B5DAFE31D26A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000657 Genomic DNA. Translation: AAC07636.1.
PIRiG70456.
RefSeqiNP_214247.1. NC_000918.1.
WP_010881184.1. NC_000918.1.

Genome annotation databases

EnsemblBacteriaiAAC07636; AAC07636; aq_1818.
GeneIDi1193488.
KEGGiaae:aq_1818.
PATRICifig|224324.8.peg.1404.

Similar proteinsi

Entry informationi

Entry nameiO67681_AQUAE
AccessioniPrimary (citable) accession number: O67681
Entry historyiIntegrated into UniProtKB/TrEMBL: August 1, 1998
Last sequence update: August 1, 1998
Last modified: October 25, 2017
This is version 105 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported