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Protein

Formyltetrahydrofolate deformylase

Gene

purU

Organism
Aquifex aeolicus (strain VF5)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4).UniRule annotation

Catalytic activityi

10-formyltetrahydrofolate + H2O = formate + tetrahydrofolate.UniRule annotation

Pathwayi: IMP biosynthesis via de novo pathway

This protein is involved in step 1 of the subpathway that synthesizes formate from 10-formyl-5,6,7,8-tetrahydrofolate.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Formyltetrahydrofolate deformylase (purU)
This subpathway is part of the pathway IMP biosynthesis via de novo pathway, which is itself part of Purine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes formate from 10-formyl-5,6,7,8-tetrahydrofolate, the pathway IMP biosynthesis via de novo pathway and in Purine metabolism.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei227 – 2271UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

HydrolaseUniRule annotation

Keywords - Biological processi

One-carbon metabolismUniRule annotation, Purine biosynthesisUniRule annotation

Enzyme and pathway databases

BioCyciAAEO224324:GJBH-1302-MONOMER.
UniPathwayiUPA00074; UER00170.

Names & Taxonomyi

Protein namesi
Recommended name:
Formyltetrahydrofolate deformylaseUniRule annotation (EC:3.5.1.10UniRule annotation)
Alternative name(s):
Formyl-FH(4) hydrolaseUniRule annotation
Gene namesi
Name:purUUniRule annotationImported
Ordered Locus Names:aq_1818Imported
OrganismiAquifex aeolicus (strain VF5)Imported
Taxonomic identifieri224324 [NCBI]
Taxonomic lineageiBacteriaAquificaeAquificalesAquificaceaeAquifex
Proteomesi
  • UP000000798 Componenti: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi224324.aq_1818.

Structurei

3D structure databases

ProteinModelPortaliO67681.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini5 – 9490ACTInterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the PurU family.UniRule annotation
Contains 1 ACT domain.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CIY. Bacteria.
COG0788. LUCA.
HOGENOMiHOG000033576.
InParanoidiO67681.
KOiK01433.
OMAiTLCEAMS.
OrthoDBiEOG615VP4.

Family and domain databases

Gene3Di3.40.50.170. 1 hit.
HAMAPiMF_01927. PurU.
InterProiIPR002912. ACT_dom.
IPR002376. Formyl_transf_N.
IPR004810. PurU.
[Graphical view]
PANTHERiPTHR10520:SF7. PTHR10520:SF7. 1 hit.
PfamiPF01842. ACT. 1 hit.
PF00551. Formyl_trans_N. 1 hit.
[Graphical view]
PRINTSiPR01575. FFH4HYDRLASE.
SUPFAMiSSF53328. SSF53328. 1 hit.
TIGRFAMsiTIGR00655. PurU. 1 hit.
PROSITEiPS51671. ACT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O67681-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQNAILLVSC PDRKGLVKEI SSFIADNGGN IVSFDQHIDE QTKTFLARVE
60 70 80 90 100
WSLEDFKIPR EKIENEFKKV AQKFSMNFQI SFSDYVKKVA IFVSKQEHCF
110 120 130 140 150
YDLMHRFYSG ELKGEVKLVI SNHEKARKTA EFFGVPFYHI PKTKENKLEA
160 170 180 190 200
EKRELELLKE YGVELVVLAR YMQILSPKFV KEYENKIINI HHSFLPAFPG
210 220 230 240 250
AKPYERAFGK GVKIIGATAH YVTEELDEGP IIEQDVVRVS HKDSLEDFIR
260 270 280
KGKDIEKVVL ARAVKWHLED KILVYNGKTV VFE
Length:283
Mass (Da):32,819
Last modified:August 1, 1998 - v1
Checksum:iF449B5DAFE31D26A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000657 Genomic DNA. Translation: AAC07636.1.
PIRiG70456.
RefSeqiNP_214247.1. NC_000918.1.
WP_010881184.1. NC_000918.1.

Genome annotation databases

EnsemblBacteriaiAAC07636; AAC07636; aq_1818.
GeneIDi1193488.
KEGGiaae:aq_1818.
PATRICi20960606. VBIAquAeo85532_1404.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000657 Genomic DNA. Translation: AAC07636.1.
PIRiG70456.
RefSeqiNP_214247.1. NC_000918.1.
WP_010881184.1. NC_000918.1.

3D structure databases

ProteinModelPortaliO67681.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi224324.aq_1818.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC07636; AAC07636; aq_1818.
GeneIDi1193488.
KEGGiaae:aq_1818.
PATRICi20960606. VBIAquAeo85532_1404.

Phylogenomic databases

eggNOGiENOG4105CIY. Bacteria.
COG0788. LUCA.
HOGENOMiHOG000033576.
InParanoidiO67681.
KOiK01433.
OMAiTLCEAMS.
OrthoDBiEOG615VP4.

Enzyme and pathway databases

UniPathwayiUPA00074; UER00170.
BioCyciAAEO224324:GJBH-1302-MONOMER.

Family and domain databases

Gene3Di3.40.50.170. 1 hit.
HAMAPiMF_01927. PurU.
InterProiIPR002912. ACT_dom.
IPR002376. Formyl_transf_N.
IPR004810. PurU.
[Graphical view]
PANTHERiPTHR10520:SF7. PTHR10520:SF7. 1 hit.
PfamiPF01842. ACT. 1 hit.
PF00551. Formyl_trans_N. 1 hit.
[Graphical view]
PRINTSiPR01575. FFH4HYDRLASE.
SUPFAMiSSF53328. SSF53328. 1 hit.
TIGRFAMsiTIGR00655. PurU. 1 hit.
PROSITEiPS51671. ACT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: VF5Imported.

Entry informationi

Entry nameiO67681_AQUAE
AccessioniPrimary (citable) accession number: O67681
Entry historyi
Integrated into UniProtKB/TrEMBL: August 1, 1998
Last sequence update: August 1, 1998
Last modified: June 8, 2016
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.