O67657 (TRPC_AQUAE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Indole-3-glycerol phosphate synthase
Short name=IGPS
EC=4.1.1.48

Gene names

Name:	trpC
Ordered Locus Names:	aq_1787

Organism

Aquifex aeolicus (strain VF5)

Taxonomic identifier

224324 [NCBI]

Taxonomic lineage

Bacteria › Aquificae › Aquificales › Aquificaceae › Aquifex

Protein attributes

Sequence length	257 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate = 1-C-(3-indolyl)-glycerol 3-phosphate + CO2 + H2O. HAMAP MF_00134_B
Pathway	Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 4/5. HAMAP MF_00134_B
Sequence similarities	Belongs to the TrpC family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis Tryptophan biosynthesis
Molecular function	Decarboxylase Lyase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	tryptophan biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	indole-3-glycerol-phosphate synthase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 257	257	Indole-3-glycerol phosphate synthase HAMAP MF_00134_B		PRO_0000154206

Sequences

	Sequence		Length	Mass (Da)
	O67657 [UniParc]. Last modified August 1, 1998. Version 1. Checksum: 3AD9432C7E188EC5	FASTA	257	29,188
	10 20 30 40 50 60 MGFLEEVRSY KESQIDTSPE YLRKLEELIE ERKEFYDFEK ALTSCGTKII AEVKKASPSE 70 80 90 100 110 120 GNIKEVNPEE QAKLYEKAGA IAISVLTDEK YFKGSLEDLR NVRESVKLPL LRKDFTVHKV 130 140 150 160 170 180 QILEAKAYGA DIVLLIVRML SDKELKELLD FSEELGLSPL VEVFTLDEAK RALDAGAKII 190 200 210 220 230 240 GINNRDLETF KVDINKTKEL APKIKDLGAK FVISESGISK REEILELMNY QVDGFLIGTS 250 LMKSENPYRK LKELLGF

References

[1]	"The complete genome of the hyperthermophilic bacterium Aquifex aeolicus." Deckert G., Warren P.V., Gaasterland T., Young W.G., Lenox A.L., Graham D.E., Overbeek R., Snead M.A., Keller M., Aujay M., Huber R., Feldman R.A., Short J.M., Olsen G.J., Swanson R.V. Nature 392:353-358(1998) [PubMed: 9537320] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: VF5.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE000657 Genomic DNA. Translation: AAC07616.1.
PIR	G70453.
RefSeq	NP_214223.1. NC_000918.1.
3D structure databases
ProteinModelPortal	O67657.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1193464.
GenomeReviews	Gene locus aq_1787 in contig AE000657_GR.
KEGG	aae:aq_1787.
NMPDR	fig|224324.1.peg.1238.
PATRIC	20960558. VBIAquAeo85532_1380.
Phylogenomic databases
HOGENOM	HBG540956.
OMA	LEYAVPH.
PhylomeDB	O67657.
ProtClustDB	PRK00278.
Enzyme and pathway databases
BioCyc	AAEO224324:AQ_1787-MONOMER.
Family and domain databases
HAMAP	MF_00134_B. IGPS_B. [Tree]
InterPro	IPR013785. Aldolase_TIM. IPR013798. Indole-3-glycerol_P_synth. IPR001468. Indole-3-GlycerolPSynthase_CS. IPR011060. RibuloseP-bd_barrel. [Graphical view]
Gene3D	G3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
KO	K01609.
Pfam	PF00218. IGPS. 1 hit. [Graphical view]
SUPFAM	SSF51366. RibP_bind_barrel. 1 hit.
PROSITE	PS00614. IGPS. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

TRPC_AQUAE

Accession

Primary (citable) accession number: O67657

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	August 1, 1998
Last modified:	January 25, 2012
This is version 71 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program