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O67655

- MDH1_AQUAE

UniProt

O67655 - MDH1_AQUAE

Protein

Malate dehydrogenase 1

Gene

mdh1

Organism
Aquifex aeolicus (strain VF5)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 105 (01 Oct 2014)
      Sequence version 1 (01 Aug 1998)
      Previous versions | rss
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    Functioni

    Catalyzes the reversible oxidation of malate to oxaloacetate.By similarity

    Catalytic activityi

    (S)-malate + NAD+ = oxaloacetate + NADH.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei35 – 351NADBy similarity
    Binding sitei97 – 971SubstrateBy similarity
    Binding sitei103 – 1031SubstrateBy similarity
    Binding sitei110 – 1101NADBy similarity
    Binding sitei135 – 1351SubstrateBy similarity
    Binding sitei166 – 1661SubstrateBy similarity
    Active sitei190 – 1901Proton acceptorBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi11 – 166NADBy similarity
    Nucleotide bindingi133 – 1353NADBy similarity

    GO - Molecular functioni

    1. L-malate dehydrogenase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. cellular carbohydrate metabolic process Source: InterPro
    2. malate metabolic process Source: InterPro
    3. tricarboxylic acid cycle Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Tricarboxylic acid cycle

    Keywords - Ligandi

    NAD

    Enzyme and pathway databases

    BioCyciAAEO224324:GJBH-1276-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Malate dehydrogenase 1 (EC:1.1.1.37)
    Gene namesi
    Name:mdh1
    Synonyms:mdh
    Ordered Locus Names:aq_1782
    OrganismiAquifex aeolicus (strain VF5)
    Taxonomic identifieri224324 [NCBI]
    Taxonomic lineageiBacteriaAquificaeAquificalesAquificaceaeAquifex
    ProteomesiUP000000798: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 335335Malate dehydrogenase 1PRO_0000113422Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi224324.aq_1782.

    Structurei

    3D structure databases

    ProteinModelPortaliO67655.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the LDH/MDH superfamily. MDH type 3 family.Curated

    Phylogenomic databases

    eggNOGiCOG0039.
    HOGENOMiHOG000213794.
    KOiK00024.
    OMAiYGQNDIC.
    OrthoDBiEOG6091FG.

    Family and domain databases

    Gene3Di3.40.50.720. 1 hit.
    3.90.110.10. 1 hit.
    HAMAPiMF_00487. Malate_dehydrog_3.
    InterProiIPR001557. L-lactate/malate_DH.
    IPR022383. Lactate/malate_DH_C.
    IPR001236. Lactate/malate_DH_N.
    IPR015955. Lactate_DH/Glyco_Ohase_4_C.
    IPR011275. Malate_DH_type3.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view]
    PANTHERiPTHR11540. PTHR11540. 1 hit.
    PfamiPF02866. Ldh_1_C. 1 hit.
    PF00056. Ldh_1_N. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000102. Lac_mal_DH. 1 hit.
    PRINTSiPR00086. LLDHDRGNASE.
    SUPFAMiSSF56327. SSF56327. 1 hit.
    TIGRFAMsiTIGR01763. MalateDH_bact. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    O67655-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRMKKTVAVI GAGNVGEHVA SLILLKNLAN VKMFDLPRKT EEKVFEPVKG    50
    KALDMKQMLA AMDIDARVEG YTVTPEGEGY EPLEGSDIVV ITAGFPRRPG 100
    MSREDLLEAN IRIISVIADR IKRYAPDAIV IVVTNPVDVM TYVAYKLLNF 150
    PKNRVMGMAG VLDSARFKTF ISEELMVSPK DIHAYVIGGH GDEMVPLISI 200
    SNVGGIPLKD LLPKEKLEKI IERTRFGGGE IVNLMGTSAY YAPAAAIVDM 250
    IEALVQNSKR ILPCSVYLDG EAGEYYGVQG FCVGVPVKLG SNGVEEIIKV 300
    PMIEEEREMW RRSVESVKKT VEVAEGILSA GSSRQ 335
    Length:335
    Mass (Da):36,675
    Last modified:August 1, 1998 - v1
    Checksum:iE02FA4C339237118
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE000657 Genomic DNA. Translation: AAC07619.1.
    PIRiE70453.
    RefSeqiNP_214221.1. NC_000918.1.

    Genome annotation databases

    EnsemblBacteriaiAAC07619; AAC07619; aq_1782.
    GeneIDi1193462.
    KEGGiaae:aq_1782.
    PATRICi20960554. VBIAquAeo85532_1378.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE000657 Genomic DNA. Translation: AAC07619.1 .
    PIRi E70453.
    RefSeqi NP_214221.1. NC_000918.1.

    3D structure databases

    ProteinModelPortali O67655.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 224324.aq_1782.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAC07619 ; AAC07619 ; aq_1782 .
    GeneIDi 1193462.
    KEGGi aae:aq_1782.
    PATRICi 20960554. VBIAquAeo85532_1378.

    Phylogenomic databases

    eggNOGi COG0039.
    HOGENOMi HOG000213794.
    KOi K00024.
    OMAi YGQNDIC.
    OrthoDBi EOG6091FG.

    Enzyme and pathway databases

    BioCyci AAEO224324:GJBH-1276-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.720. 1 hit.
    3.90.110.10. 1 hit.
    HAMAPi MF_00487. Malate_dehydrog_3.
    InterProi IPR001557. L-lactate/malate_DH.
    IPR022383. Lactate/malate_DH_C.
    IPR001236. Lactate/malate_DH_N.
    IPR015955. Lactate_DH/Glyco_Ohase_4_C.
    IPR011275. Malate_DH_type3.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view ]
    PANTHERi PTHR11540. PTHR11540. 1 hit.
    Pfami PF02866. Ldh_1_C. 1 hit.
    PF00056. Ldh_1_N. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000102. Lac_mal_DH. 1 hit.
    PRINTSi PR00086. LLDHDRGNASE.
    SUPFAMi SSF56327. SSF56327. 1 hit.
    TIGRFAMsi TIGR01763. MalateDH_bact. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: VF5.

    Entry informationi

    Entry nameiMDH1_AQUAE
    AccessioniPrimary (citable) accession number: O67655
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 1, 2001
    Last sequence update: August 1, 1998
    Last modified: October 1, 2014
    This is version 105 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3