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Protein

Malate dehydrogenase 1

Gene

mdh1

Organism
Aquifex aeolicus (strain VF5)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the reversible oxidation of malate to oxaloacetate.By similarity

Catalytic activityi

(S)-malate + NAD+ = oxaloacetate + NADH.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei35 – 351NADBy similarity
Binding sitei97 – 971SubstrateBy similarity
Binding sitei103 – 1031SubstrateBy similarity
Binding sitei110 – 1101NADBy similarity
Binding sitei135 – 1351SubstrateBy similarity
Binding sitei166 – 1661SubstrateBy similarity
Active sitei190 – 1901Proton acceptorBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi11 – 166NADBy similarity
Nucleotide bindingi133 – 1353NADBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Tricarboxylic acid cycle

Keywords - Ligandi

NAD

Enzyme and pathway databases

BioCyciAAEO224324:GJBH-1276-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Malate dehydrogenase 1 (EC:1.1.1.37)
Gene namesi
Name:mdh1
Synonyms:mdh
Ordered Locus Names:aq_1782
OrganismiAquifex aeolicus (strain VF5)
Taxonomic identifieri224324 [NCBI]
Taxonomic lineageiBacteriaAquificaeAquificalesAquificaceaeAquifex
ProteomesiUP000000798 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 335335Malate dehydrogenase 1PRO_0000113422Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi224324.aq_1782.

Structurei

3D structure databases

ProteinModelPortaliO67655.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the LDH/MDH superfamily. MDH type 3 family.Curated

Phylogenomic databases

eggNOGiCOG0039.
HOGENOMiHOG000213794.
InParanoidiO67655.
KOiK00024.
OMAiGESMFPV.
OrthoDBiEOG6091FG.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
3.90.110.10. 1 hit.
HAMAPiMF_00487. Malate_dehydrog_3.
InterProiIPR001557. L-lactate/malate_DH.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR011275. Malate_DH_type3.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR11540. PTHR11540. 1 hit.
PfamiPF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000102. Lac_mal_DH. 1 hit.
PRINTSiPR00086. LLDHDRGNASE.
SUPFAMiSSF56327. SSF56327. 1 hit.
TIGRFAMsiTIGR01763. MalateDH_bact. 1 hit.

Sequencei

Sequence statusi: Complete.

O67655-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRMKKTVAVI GAGNVGEHVA SLILLKNLAN VKMFDLPRKT EEKVFEPVKG
60 70 80 90 100
KALDMKQMLA AMDIDARVEG YTVTPEGEGY EPLEGSDIVV ITAGFPRRPG
110 120 130 140 150
MSREDLLEAN IRIISVIADR IKRYAPDAIV IVVTNPVDVM TYVAYKLLNF
160 170 180 190 200
PKNRVMGMAG VLDSARFKTF ISEELMVSPK DIHAYVIGGH GDEMVPLISI
210 220 230 240 250
SNVGGIPLKD LLPKEKLEKI IERTRFGGGE IVNLMGTSAY YAPAAAIVDM
260 270 280 290 300
IEALVQNSKR ILPCSVYLDG EAGEYYGVQG FCVGVPVKLG SNGVEEIIKV
310 320 330
PMIEEEREMW RRSVESVKKT VEVAEGILSA GSSRQ
Length:335
Mass (Da):36,675
Last modified:August 1, 1998 - v1
Checksum:iE02FA4C339237118
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000657 Genomic DNA. Translation: AAC07619.1.
PIRiE70453.
RefSeqiNP_214221.1. NC_000918.1.
WP_010881158.1. NC_000918.1.

Genome annotation databases

EnsemblBacteriaiAAC07619; AAC07619; aq_1782.
GeneIDi1193462.
KEGGiaae:aq_1782.
PATRICi20960554. VBIAquAeo85532_1378.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000657 Genomic DNA. Translation: AAC07619.1.
PIRiE70453.
RefSeqiNP_214221.1. NC_000918.1.
WP_010881158.1. NC_000918.1.

3D structure databases

ProteinModelPortaliO67655.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi224324.aq_1782.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC07619; AAC07619; aq_1782.
GeneIDi1193462.
KEGGiaae:aq_1782.
PATRICi20960554. VBIAquAeo85532_1378.

Phylogenomic databases

eggNOGiCOG0039.
HOGENOMiHOG000213794.
InParanoidiO67655.
KOiK00024.
OMAiGESMFPV.
OrthoDBiEOG6091FG.

Enzyme and pathway databases

BioCyciAAEO224324:GJBH-1276-MONOMER.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
3.90.110.10. 1 hit.
HAMAPiMF_00487. Malate_dehydrog_3.
InterProiIPR001557. L-lactate/malate_DH.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR011275. Malate_DH_type3.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR11540. PTHR11540. 1 hit.
PfamiPF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000102. Lac_mal_DH. 1 hit.
PRINTSiPR00086. LLDHDRGNASE.
SUPFAMiSSF56327. SSF56327. 1 hit.
TIGRFAMsiTIGR01763. MalateDH_bact. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: VF5.

Entry informationi

Entry nameiMDH1_AQUAE
AccessioniPrimary (citable) accession number: O67655
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 2001
Last sequence update: August 1, 1998
Last modified: July 22, 2015
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.