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O67648 (LPXC_AQUAE) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 83. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase
EC=3.5.1.-
Alternative name(s):
UDP-3-O-acyl-GlcNAc deacetylase
Gene names
Name:lpxC
Synonyms:envA
Ordered Locus Names:aq_1772
OrganismAquifex aeolicus (strain VF5)
Taxonomic identifier224324 [NCBI]
Taxonomic lineageBacteria › Aquificae › Aquificales › Aquificaceae › Aquifex

Protein attributes

Sequence length282 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell By similarity. HAMAP MF_00388

Catalytic activity

UDP-3-O-(3-hydroxytetradecanoyl)-N-acetylglucosamine + H2O = UDP-3-O-(3-hydroxytetradecanoyl)-glucosamine + acetate. HAMAP MF_00388

Pathway

Glycolipid biosynthesis; lipid IV(A) biosynthesis; lipid IV(A) from (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] and UDP-N-acetyl-alpha-D-glucosamine: step 2/6. HAMAP MF_00388

Sequence similarities

Belongs to the LpxC family.

Ontologies

Keywords
   Biological processLipid A biosynthesis
Lipid synthesis
   Molecular functionHydrolase
   Technical term3D-structure
Complete proteome
Reference proteome
Gene Ontology (GO)
   Biological processlipid A biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular functionUDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 282282UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase HAMAP MF_00388
PRO_0000191917

Secondary structure

1 ........................................................ 282
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
O67648 [UniParc].

Last modified August 1, 1998. Version 1.
Checksum: 38EFE076144B5F27

FASTA28232,145
        10         20         30         40         50         60 
MGLEKTVKEK LSFEGVGIHT GEYSKLIIHP EKEGTGIRFF KNGVYIPARH EFVVHTNHST 

        70         80         90        100        110        120 
DLGFKGQRIK TVEHILSVLH LLEITNVTIE VIGNEIPILD GSGWEFYEAI RKNILNQNRE 

       130        140        150        160        170        180 
IDYFVVEEPI IVEDEGRLIK AEPSDTLEVT YEGEFKNFLG RQKFTFVEGN EEEIVLARTF 

       190        200        210        220        230        240 
CFDWEIEHIK KVGLGKGGSL KNTLVLGKDK VYNPEGLRYE NEPVRHKVFD LIGDLYLLGS 

       250        260        270        280 
PVKGKFYSFR GGHSLNVKLV KELAKKQKLT RDLPHLPSVQ AL

« Hide

References

[1]"The complete genome of the hyperthermophilic bacterium Aquifex aeolicus."
Deckert G., Warren P.V., Gaasterland T., Young W.G., Lenox A.L., Graham D.E., Overbeek R., Snead M.A., Keller M., Aujay M., Huber R., Feldman R.A., Short J.M., Olsen G.J., Swanson R.V.
Nature 392:353-358(1998) [PubMed: 9537320] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: VF5.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AE000657 Genomic DNA. Translation: AAC07605.1.
PIRF70452.
RefSeqNP_214214.1. NC_000918.1.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1P42X-ray2.00A/B2-271[»]
1XXENMR-A1-282[»]
1YH8X-ray2.70A/B2-271[»]
1YHCX-ray2.10A/B2-271[»]
2GO3X-ray2.00A/B1-255[»]
2GO4X-ray2.70A/B1-267[»]
2IERX-ray2.70A/B1-271[»]
2IESX-ray3.10A/B1-271[»]
2J65X-ray2.20A/B1-271[»]
2JT2NMR-A1-274[»]
2O3ZX-ray2.25A/B1-271[»]
3P3CX-ray1.25A2-275[»]
3P76X-ray1.93A1-271[»]
ProteinModelPortalO67648.
SMRO67648. Positions 3-270.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID1193363.
GenomeReviewsGene locus aq_1772 in contig AE000657_GR.
KEGGaae:aq_1772.
NMPDRfig|224324.1.peg.1229.
PATRIC20960534. VBIAquAeo85532_1368.

Phylogenomic databases

HOGENOMHBG482342.
OMAKAYKSGH.
PhylomeDBO67648.
ProtClustDBPRK13186.

Enzyme and pathway databases

BioCycAAEO224324:AQ_1772-MONOMER.

Family and domain databases

HAMAPMF_00388. LpxC.
[Tree]
InterProIPR020568. Ribosomal_S5_D2-typ_fold.
IPR004463. UDP-acyl_GlcNac_deAcase.
IPR011334. UDP-acyl_GlcNac_deAcase_C.
IPR015870. UDP-acyl_N-AcGlcN_deAcase_N.
[Graphical view]
Gene3DG3DSA:3.30.1700.10. UDP-acyl_N-AcGlcN_deAcase_C. 1 hit.
G3DSA:3.30.230.20. UDP-acyl_N-AcGlcN_deAcase_N. 1 hit.
KOK02535.
PfamPF03331. LpxC. 1 hit.
[Graphical view]
SUPFAMSSF54211. Ribosomal_S5_D2-typ_fold. 2 hits.
TIGRFAMsTIGR00325. LpxC. 1 hit.
ProtoNetSearch...

Entry information

Entry nameLPXC_AQUAE
AccessionPrimary (citable) accession number: O67648
Entry history
Integrated into UniProtKB/Swiss-Prot: June 1, 2001
Last sequence update: August 1, 1998
Last modified: January 25, 2012
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

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