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O67646

- SYLB_AQUAE

UniProt

O67646 - SYLB_AQUAE

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Protein
Leucine--tRNA ligase subunit beta
Gene
leuS', aq_1770
Organism
Aquifex aeolicus (strain VF5)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei48 – 481ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. leucine-tRNA ligase activity Source: UniProtKB-EC
Complete GO annotation...

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciAAEO224324:GJBH-1267-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligase subunit beta (EC:6.1.1.4)
Alternative name(s):
Leucyl-tRNA synthetase subunit beta
Short name:
LeuRS
Gene namesi
Name:leuS'
Ordered Locus Names:aq_1770
OrganismiAquifex aeolicus (strain VF5)
Taxonomic identifieri224324 [NCBI]
Taxonomic lineageiBacteriaAquificaeAquificalesAquificaceaeAquifex
ProteomesiUP000000798: Chromosome

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 289289Leucine--tRNA ligase subunit beta
PRO_0000151963Add
BLAST

Interactioni

Subunit structurei

Seems to consist of an alpha chain and a beta chain.

Protein-protein interaction databases

STRINGi224324.aq_1770.

Structurei

3D structure databases

ProteinModelPortaliO67646.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi45 – 495"KMSKS" region

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000248928.
KOiK01869.
OMAiSKSKHNT.
OrthoDBiEOG6SZ1G3.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 1 hit.
InterProiIPR002302. Leu-tRNA-ligase.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view]
SUPFAMiSSF47323. SSF47323. 1 hit.

Sequencei

Sequence statusi: Complete.

O67646-1 [UniParc]FASTAAdd to Basket

« Hide

MKIKDFLQEN KISVGDNAIF LLEKLGIKDE NLIKFLEREI GESAKMSKSK    50
ANVVDPEEAV EKYGADTVRL YILFAAPPEQ DFEWTDEGIQ GAYRFLQRYW 100
NFVNKHLEKI KNLTYTVEEL RNVQGKAKEV RREIHQTIAD YRRDFEERYQ 150
FNTAIAKIMK LLNTLQDFSP QTEQDYKVLR EGIETITLLL SPITPHIAEE 200
VWEMLGNEGF IINQPIPEPD PEALKVEEIE IPVQVNGKLR ARVKVPADAD 250
EETVKNIVLS DERVQKWVQG KEVKKFIYVK GKLVNVVVK 289
Length:289
Mass (Da):33,536
Last modified:August 1, 1998 - v1
Checksum:i585B825AC6E3F606
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE000657 Genomic DNA. Translation: AAC07608.1.
PIRiD70452.
RefSeqiNP_214212.1. NC_000918.1.

Genome annotation databases

EnsemblBacteriaiAAC07608; AAC07608; aq_1770.
GeneIDi1193361.
KEGGiaae:aq_1770.
PATRICi20960530. VBIAquAeo85532_1366.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE000657 Genomic DNA. Translation: AAC07608.1 .
PIRi D70452.
RefSeqi NP_214212.1. NC_000918.1.

3D structure databases

ProteinModelPortali O67646.
ModBasei Search...

Protein-protein interaction databases

STRINGi 224324.aq_1770.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAC07608 ; AAC07608 ; aq_1770 .
GeneIDi 1193361.
KEGGi aae:aq_1770.
PATRICi 20960530. VBIAquAeo85532_1366.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000248928.
KOi K01869.
OMAi SKSKHNT.
OrthoDBi EOG6SZ1G3.

Enzyme and pathway databases

BioCyci AAEO224324:GJBH-1267-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 1 hit.
InterProi IPR002302. Leu-tRNA-ligase.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
[Graphical view ]
PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
Pfami PF08264. Anticodon_1. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view ]
SUPFAMi SSF47323. SSF47323. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: VF5.

Entry informationi

Entry nameiSYLB_AQUAE
AccessioniPrimary (citable) accession number: O67646
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: August 1, 1998
Last modified: May 14, 2014
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi