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Protein

Leucine--tRNA ligase subunit beta

Gene

leuS'

Organism
Aquifex aeolicus (strain VF5)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei48 – 481ATPBy similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. leucine-tRNA ligase activity Source: UniProtKB-EC

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciAAEO224324:GJBH-1267-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligase subunit beta (EC:6.1.1.4)
Alternative name(s):
Leucyl-tRNA synthetase subunit beta
Short name:
LeuRS
Gene namesi
Name:leuS'
Ordered Locus Names:aq_1770
OrganismiAquifex aeolicus (strain VF5)
Taxonomic identifieri224324 [NCBI]
Taxonomic lineageiBacteriaAquificaeAquificalesAquificaceaeAquifex
ProteomesiUP000000798: Chromosome

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 289289Leucine--tRNA ligase subunit betaPRO_0000151963Add
BLAST

Interactioni

Subunit structurei

Seems to consist of an alpha chain and a beta chain.

Protein-protein interaction databases

STRINGi224324.aq_1770.

Structurei

3D structure databases

ProteinModelPortaliO67646.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi45 – 495"KMSKS" region

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000248928.
InParanoidiO67646.
KOiK01869.
OMAiSKSKHNT.
OrthoDBiEOG6SZ1G3.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 1 hit.
InterProiIPR002302. Leu-tRNA-ligase.
IPR013155. M/V/L/I-tRNA-synth_anticd-bd.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view]
SUPFAMiSSF47323. SSF47323. 1 hit.

Sequencei

Sequence statusi: Complete.

O67646-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKIKDFLQEN KISVGDNAIF LLEKLGIKDE NLIKFLEREI GESAKMSKSK
60 70 80 90 100
ANVVDPEEAV EKYGADTVRL YILFAAPPEQ DFEWTDEGIQ GAYRFLQRYW
110 120 130 140 150
NFVNKHLEKI KNLTYTVEEL RNVQGKAKEV RREIHQTIAD YRRDFEERYQ
160 170 180 190 200
FNTAIAKIMK LLNTLQDFSP QTEQDYKVLR EGIETITLLL SPITPHIAEE
210 220 230 240 250
VWEMLGNEGF IINQPIPEPD PEALKVEEIE IPVQVNGKLR ARVKVPADAD
260 270 280
EETVKNIVLS DERVQKWVQG KEVKKFIYVK GKLVNVVVK
Length:289
Mass (Da):33,536
Last modified:August 1, 1998 - v1
Checksum:i585B825AC6E3F606
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000657 Genomic DNA. Translation: AAC07608.1.
PIRiD70452.
RefSeqiNP_214212.1. NC_000918.1.

Genome annotation databases

EnsemblBacteriaiAAC07608; AAC07608; aq_1770.
GeneIDi1193361.
KEGGiaae:aq_1770.
PATRICi20960530. VBIAquAeo85532_1366.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000657 Genomic DNA. Translation: AAC07608.1.
PIRiD70452.
RefSeqiNP_214212.1. NC_000918.1.

3D structure databases

ProteinModelPortaliO67646.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi224324.aq_1770.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC07608; AAC07608; aq_1770.
GeneIDi1193361.
KEGGiaae:aq_1770.
PATRICi20960530. VBIAquAeo85532_1366.

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000248928.
InParanoidiO67646.
KOiK01869.
OMAiSKSKHNT.
OrthoDBiEOG6SZ1G3.

Enzyme and pathway databases

BioCyciAAEO224324:GJBH-1267-MONOMER.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 1 hit.
InterProiIPR002302. Leu-tRNA-ligase.
IPR013155. M/V/L/I-tRNA-synth_anticd-bd.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view]
SUPFAMiSSF47323. SSF47323. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: VF5.

Entry informationi

Entry nameiSYLB_AQUAE
AccessioniPrimary (citable) accession number: O67646
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: August 1, 1998
Last modified: February 4, 2015
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.