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O67646

- SYLB_AQUAE

UniProt

O67646 - SYLB_AQUAE

Protein

Leucine--tRNA ligase subunit beta

Gene

leuS'

Organism
Aquifex aeolicus (strain VF5)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 92 (01 Oct 2014)
      Sequence version 1 (01 Aug 1998)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei48 – 481ATPBy similarity

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. leucine-tRNA ligase activity Source: UniProtKB-EC

    GO - Biological processi

    1. leucyl-tRNA aminoacylation Source: InterPro

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciAAEO224324:GJBH-1267-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Leucine--tRNA ligase subunit beta (EC:6.1.1.4)
    Alternative name(s):
    Leucyl-tRNA synthetase subunit beta
    Short name:
    LeuRS
    Gene namesi
    Name:leuS'
    Ordered Locus Names:aq_1770
    OrganismiAquifex aeolicus (strain VF5)
    Taxonomic identifieri224324 [NCBI]
    Taxonomic lineageiBacteriaAquificaeAquificalesAquificaceaeAquifex
    ProteomesiUP000000798: Chromosome

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 289289Leucine--tRNA ligase subunit betaPRO_0000151963Add
    BLAST

    Interactioni

    Subunit structurei

    Seems to consist of an alpha chain and a beta chain.

    Protein-protein interaction databases

    STRINGi224324.aq_1770.

    Structurei

    3D structure databases

    ProteinModelPortaliO67646.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi45 – 495"KMSKS" region

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0495.
    HOGENOMiHOG000248928.
    KOiK01869.
    OMAiSKSKHNT.
    OrthoDBiEOG6SZ1G3.

    Family and domain databases

    Gene3Di1.10.730.10. 1 hit.
    3.40.50.620. 1 hit.
    InterProiIPR002302. Leu-tRNA-ligase.
    IPR015413. Methionyl/Leucyl_tRNA_Synth.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    [Graphical view]
    PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
    PfamiPF08264. Anticodon_1. 1 hit.
    PF09334. tRNA-synt_1g. 1 hit.
    [Graphical view]
    SUPFAMiSSF47323. SSF47323. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    O67646-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKIKDFLQEN KISVGDNAIF LLEKLGIKDE NLIKFLEREI GESAKMSKSK    50
    ANVVDPEEAV EKYGADTVRL YILFAAPPEQ DFEWTDEGIQ GAYRFLQRYW 100
    NFVNKHLEKI KNLTYTVEEL RNVQGKAKEV RREIHQTIAD YRRDFEERYQ 150
    FNTAIAKIMK LLNTLQDFSP QTEQDYKVLR EGIETITLLL SPITPHIAEE 200
    VWEMLGNEGF IINQPIPEPD PEALKVEEIE IPVQVNGKLR ARVKVPADAD 250
    EETVKNIVLS DERVQKWVQG KEVKKFIYVK GKLVNVVVK 289
    Length:289
    Mass (Da):33,536
    Last modified:August 1, 1998 - v1
    Checksum:i585B825AC6E3F606
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE000657 Genomic DNA. Translation: AAC07608.1.
    PIRiD70452.
    RefSeqiNP_214212.1. NC_000918.1.

    Genome annotation databases

    EnsemblBacteriaiAAC07608; AAC07608; aq_1770.
    GeneIDi1193361.
    KEGGiaae:aq_1770.
    PATRICi20960530. VBIAquAeo85532_1366.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE000657 Genomic DNA. Translation: AAC07608.1 .
    PIRi D70452.
    RefSeqi NP_214212.1. NC_000918.1.

    3D structure databases

    ProteinModelPortali O67646.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 224324.aq_1770.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAC07608 ; AAC07608 ; aq_1770 .
    GeneIDi 1193361.
    KEGGi aae:aq_1770.
    PATRICi 20960530. VBIAquAeo85532_1366.

    Phylogenomic databases

    eggNOGi COG0495.
    HOGENOMi HOG000248928.
    KOi K01869.
    OMAi SKSKHNT.
    OrthoDBi EOG6SZ1G3.

    Enzyme and pathway databases

    BioCyci AAEO224324:GJBH-1267-MONOMER.

    Family and domain databases

    Gene3Di 1.10.730.10. 1 hit.
    3.40.50.620. 1 hit.
    InterProi IPR002302. Leu-tRNA-ligase.
    IPR015413. Methionyl/Leucyl_tRNA_Synth.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    [Graphical view ]
    PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
    Pfami PF08264. Anticodon_1. 1 hit.
    PF09334. tRNA-synt_1g. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47323. SSF47323. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: VF5.

    Entry informationi

    Entry nameiSYLB_AQUAE
    AccessioniPrimary (citable) accession number: O67646
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: August 1, 1998
    Last modified: October 1, 2014
    This is version 92 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3