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Protein
Submitted name:

Prephenate dehydrogenase

Gene

tyrA

Organism
Aquifex aeolicus (strain VF5)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei62NADCombined sources1
Binding sitei67NADCombined sources1
Binding sitei99NAD; via carbonyl oxygenCombined sources1
Binding sitei126NADCombined sources1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi40 – 41NADCombined sources2
Nucleotide bindingi151 – 156NADCombined sources6

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

NADCombined sources, Nucleotide-bindingCombined sources

Enzyme and pathway databases

BRENDAi1.3.1.12. 396.

Names & Taxonomyi

Protein namesi
Submitted name:
Prephenate dehydrogenaseImported
Gene namesi
Name:tyrAImported
Ordered Locus Names:aq_1755Imported
OrganismiAquifex aeolicus (strain VF5)Imported
Taxonomic identifieri224324 [NCBI]
Taxonomic lineageiBacteriaAquificaeAquificalesAquificaceaeAquifex
Proteomesi
  • UP000000798 Componenti: Chromosome

PTM / Processingi

Proteomic databases

PRIDEiO67636.

Interactioni

Protein-protein interaction databases

STRINGi224324.aq_1755.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2G5CX-ray1.90A/B/C/D30-310[»]
3GGGX-ray2.21A/B/C/D19-311[»]
3GGOX-ray2.15A/B/C/D19-311[»]
3GGPX-ray2.25A/B/C/D19-311[»]
ProteinModelPortaliO67636.
SMRiO67636.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO67636.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini31 – 311Prephenate/arogenate dehydrogenaseInterPro annotationAdd BLAST281

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili274 – 309Sequence analysisAdd BLAST36

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiENOG4105EVN. Bacteria.
COG0287. LUCA.
HOGENOMiHOG000043493.
InParanoidiO67636.
KOiK04517.
OMAiMWRDICL.
OrthoDBiPOG091H02BW.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR008927. 6-PGluconate_DH_C-like.
IPR016040. NAD(P)-bd_dom.
IPR003099. Prephen_DH.
[Graphical view]
PfamiPF02153. PDH. 1 hit.
[Graphical view]
SUPFAMiSSF48179. SSF48179. 1 hit.
SSF51735. SSF51735. 1 hit.
PROSITEiPS51176. PDH_ADH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O67636-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAILSSMFNP SPPQGFCKKN IIKILKSLSM QNVLIVGVGF MGGSFAKSLR
60 70 80 90 100
RSGFKGKIYG YDINPESISK AVDLGIIDEG TTSIAKVEDF SPDFVMLSSP
110 120 130 140 150
VRTFREIAKK LSYILSEDAT VTDQGSVKGK LVYDLENILG KRFVGGHPIA
160 170 180 190 200
GTEKSGVEYS LDNLYEGKKV ILTPTKKTDK KRLKLVKRVW EDVGGVVEYM
210 220 230 240 250
SPELHDYVFG VVSHLPHAVA FALVDTLIHM STPEVDLFKY PGGGFKDFTR
260 270 280 290 300
IAKSDPIMWR DIFLENKENV MKAIEGFEKS LNHLKELIVR EAEEELVEYL
310
KEVKIKRMEI D
Length:311
Mass (Da):34,850
Last modified:August 1, 1998 - v1
Checksum:iCCA6DA3EFC7A18CD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000657 Genomic DNA. Translation: AAC07589.1.
PIRiB70451.
RefSeqiNP_214202.1. NC_000918.1.
WP_010881139.1. NC_000918.1.

Genome annotation databases

EnsemblBacteriaiAAC07589; AAC07589; aq_1755.
GeneIDi1193351.
KEGGiaae:aq_1755.
PATRICi20960500. VBIAquAeo85532_1354.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000657 Genomic DNA. Translation: AAC07589.1.
PIRiB70451.
RefSeqiNP_214202.1. NC_000918.1.
WP_010881139.1. NC_000918.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2G5CX-ray1.90A/B/C/D30-310[»]
3GGGX-ray2.21A/B/C/D19-311[»]
3GGOX-ray2.15A/B/C/D19-311[»]
3GGPX-ray2.25A/B/C/D19-311[»]
ProteinModelPortaliO67636.
SMRiO67636.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi224324.aq_1755.

Proteomic databases

PRIDEiO67636.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC07589; AAC07589; aq_1755.
GeneIDi1193351.
KEGGiaae:aq_1755.
PATRICi20960500. VBIAquAeo85532_1354.

Phylogenomic databases

eggNOGiENOG4105EVN. Bacteria.
COG0287. LUCA.
HOGENOMiHOG000043493.
InParanoidiO67636.
KOiK04517.
OMAiMWRDICL.
OrthoDBiPOG091H02BW.

Enzyme and pathway databases

BRENDAi1.3.1.12. 396.

Miscellaneous databases

EvolutionaryTraceiO67636.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR008927. 6-PGluconate_DH_C-like.
IPR016040. NAD(P)-bd_dom.
IPR003099. Prephen_DH.
[Graphical view]
PfamiPF02153. PDH. 1 hit.
[Graphical view]
SUPFAMiSSF48179. SSF48179. 1 hit.
SSF51735. SSF51735. 1 hit.
PROSITEiPS51176. PDH_ADH. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiO67636_AQUAE
AccessioniPrimary (citable) accession number: O67636
Entry historyi
Integrated into UniProtKB/TrEMBL: August 1, 1998
Last sequence update: August 1, 1998
Last modified: November 2, 2016
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.