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O67619

- PANE_AQUAE

UniProt

O67619 - PANE_AQUAE

Protein

Putative 2-dehydropantoate 2-reductase

Gene

aq_1727

Organism
Aquifex aeolicus (strain VF5)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 99 (01 Oct 2014)
      Sequence version 1 (01 Aug 1998)
      Previous versions | rss
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    Functioni

    Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid.By similarity

    Catalytic activityi

    (R)-pantoate + NADP+ = 2-dehydropantoate + NADPH.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei100 – 1001NADP; via amide nitrogenBy similarity
    Binding sitei100 – 1001SubstrateBy similarity
    Active sitei184 – 1841Proton donorBy similarity
    Binding sitei188 – 1881SubstrateBy similarity
    Binding sitei192 – 1921SubstrateBy similarity
    Binding sitei259 – 2591SubstrateBy similarity
    Binding sitei270 – 2701NADPBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi9 – 146NADPBy similarity

    GO - Molecular functioni

    1. 2-dehydropantoate 2-reductase activity Source: UniProtKB-EC
    2. NADP binding Source: InterPro

    GO - Biological processi

    1. pantothenate biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Pantothenate biosynthesis

    Keywords - Ligandi

    NADP

    Enzyme and pathway databases

    BioCyciAAEO224324:GJBH-1236-MONOMER.
    UniPathwayiUPA00028; UER00004.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Putative 2-dehydropantoate 2-reductase (EC:1.1.1.169)
    Alternative name(s):
    Ketopantoate reductase
    Short name:
    KPA reductase
    Short name:
    KPR
    Gene namesi
    Ordered Locus Names:aq_1727
    OrganismiAquifex aeolicus (strain VF5)
    Taxonomic identifieri224324 [NCBI]
    Taxonomic lineageiBacteriaAquificaeAquificalesAquificaceaeAquifex
    ProteomesiUP000000798: Chromosome

    Subcellular locationi

    Cytoplasm Curated

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 310310Putative 2-dehydropantoate 2-reductasePRO_0000157310Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi224324.aq_1727.

    Structurei

    3D structure databases

    ProteinModelPortaliO67619.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ketopantoate reductase family.Curated

    Phylogenomic databases

    eggNOGiCOG1893.
    HOGENOMiHOG000050222.
    KOiK00077.
    OMAiAYDACER.
    OrthoDBiEOG6P5ZHG.

    Family and domain databases

    Gene3Di1.10.1040.10. 1 hit.
    3.40.50.720. 1 hit.
    InterProiIPR008927. 6-PGluconate_DH_C-like.
    IPR003710. ApbA.
    IPR013328. DH_multihelical.
    IPR013752. KPA_reductase.
    IPR013332. KPR_N.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view]
    PfamiPF02558. ApbA. 1 hit.
    PF08546. ApbA_C. 1 hit.
    [Graphical view]
    SUPFAMiSSF48179. SSF48179. 1 hit.
    TIGRFAMsiTIGR00745. apbA_panE. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    O67619-1 [UniParc]FASTAAdd to Basket

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    MVMKFLIVGV GAIGSAYLAF LTRAGHEAAG LVRRNPVNRI KVEGIWGEFE    50
    IPVKTFTKVE EVPFIPDIVI ISVKSYDTEE ALKKVKPVVG ENTFIMIAQN 100
    GYGNYEKAVE IYGEGKVILS RIIFGSKVIK PGHIRITVSA DEVVIGDPSG 150
    KIDEEFLKNL ARTFTEAGIP TRYERDVYKY LVDKIIYNSA LNPLGALFEV 200
    NYGSLAENPH TKELMNRVID EIFQVIEKAK LPCFWKSADE YKKVFYEKLI 250
    PPTAEHYPSM LEDVKKGKTE IEALNGAIVE LGKKYGVSTP TNEFITKMVK 300
    AKELFNLKDT 310
    Length:310
    Mass (Da):34,776
    Last modified:August 1, 1998 - v1
    Checksum:iE59FB12901C0ABE0
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE000657 Genomic DNA. Translation: AAC07585.1.
    PIRiA70449.
    RefSeqiNP_214185.1. NC_000918.1.

    Genome annotation databases

    EnsemblBacteriaiAAC07585; AAC07585; aq_1727.
    GeneIDi1193334.
    KEGGiaae:aq_1727.
    PATRICi20960444. VBIAquAeo85532_1327.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE000657 Genomic DNA. Translation: AAC07585.1 .
    PIRi A70449.
    RefSeqi NP_214185.1. NC_000918.1.

    3D structure databases

    ProteinModelPortali O67619.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 224324.aq_1727.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAC07585 ; AAC07585 ; aq_1727 .
    GeneIDi 1193334.
    KEGGi aae:aq_1727.
    PATRICi 20960444. VBIAquAeo85532_1327.

    Phylogenomic databases

    eggNOGi COG1893.
    HOGENOMi HOG000050222.
    KOi K00077.
    OMAi AYDACER.
    OrthoDBi EOG6P5ZHG.

    Enzyme and pathway databases

    UniPathwayi UPA00028 ; UER00004 .
    BioCyci AAEO224324:GJBH-1236-MONOMER.

    Family and domain databases

    Gene3Di 1.10.1040.10. 1 hit.
    3.40.50.720. 1 hit.
    InterProi IPR008927. 6-PGluconate_DH_C-like.
    IPR003710. ApbA.
    IPR013328. DH_multihelical.
    IPR013752. KPA_reductase.
    IPR013332. KPR_N.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view ]
    Pfami PF02558. ApbA. 1 hit.
    PF08546. ApbA_C. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48179. SSF48179. 1 hit.
    TIGRFAMsi TIGR00745. apbA_panE. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: VF5.

    Entry informationi

    Entry nameiPANE_AQUAE
    AccessioniPrimary (citable) accession number: O67619
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 15, 1998
    Last sequence update: August 1, 1998
    Last modified: October 1, 2014
    This is version 99 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3