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O67619 (PANE_AQUAE) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 94. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Putative 2-dehydropantoate 2-reductase
EC=1.1.1.169
Alternative name(s):
Ketopantoate reductase
Short name=KPA reductase
Short name=KPR
Gene names
Ordered Locus Names:aq_1727
OrganismAquifex aeolicus (strain VF5) [Reference proteome] [HAMAP]
Taxonomic identifier224324 [NCBI]
Taxonomic lineageBacteria › Aquificae › Aquificales › Aquificaceae › Aquifex ›

Protein attributes

Sequence length310 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid By similarity.

Catalytic activity

(R)-pantoate + NADP+ = 2-dehydropantoate + NADPH.

Pathway

Cofactor biosynthesis; (R)-pantothenate biosynthesis; (R)-pantoate from 3-methyl-2-oxobutanoate: step 2/2.

Subcellular location

Cytoplasm Potential.

Sequence similarities

Belongs to the ketopantoate reductase family.

Ontologies

Keywords
   Biological processPantothenate biosynthesis
   Cellular componentCytoplasm
   LigandNADP
   Molecular functionOxidoreductase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processpantothenate biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_function2-dehydropantoate 2-reductase activity

Inferred from electronic annotation. Source: EC

NADP binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 310310Putative 2-dehydropantoate 2-reductase
PRO_0000157310

Regions

Nucleotide binding9 – 146NADP By similarity

Sites

Active site1841Proton donor By similarity
Binding site1001NADP; via amide nitrogen By similarity
Binding site1001Substrate By similarity
Binding site1881Substrate By similarity
Binding site1921Substrate By similarity
Binding site2591Substrate By similarity
Binding site2701NADP By similarity

Sequences

Sequence LengthMass (Da)Tools
O67619 [UniParc].

Last modified August 1, 1998. Version 1.
Checksum: E59FB12901C0ABE0

FASTA31034,776
        10         20         30         40         50         60 
MVMKFLIVGV GAIGSAYLAF LTRAGHEAAG LVRRNPVNRI KVEGIWGEFE IPVKTFTKVE 

        70         80         90        100        110        120 
EVPFIPDIVI ISVKSYDTEE ALKKVKPVVG ENTFIMIAQN GYGNYEKAVE IYGEGKVILS 

       130        140        150        160        170        180 
RIIFGSKVIK PGHIRITVSA DEVVIGDPSG KIDEEFLKNL ARTFTEAGIP TRYERDVYKY 

       190        200        210        220        230        240 
LVDKIIYNSA LNPLGALFEV NYGSLAENPH TKELMNRVID EIFQVIEKAK LPCFWKSADE 

       250        260        270        280        290        300 
YKKVFYEKLI PPTAEHYPSM LEDVKKGKTE IEALNGAIVE LGKKYGVSTP TNEFITKMVK 

       310 
AKELFNLKDT

« Hide

References

[1]"The complete genome of the hyperthermophilic bacterium Aquifex aeolicus."
Deckert G., Warren P.V., Gaasterland T., Young W.G., Lenox A.L., Graham D.E., Overbeek R., Snead M.A., Keller M., Aujay M., Huber R., Feldman R.A., Short J.M., Olsen G.J., Swanson R.V.
Nature 392:353-358(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: VF5.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AE000657 Genomic DNA. Translation: AAC07585.1.
PIRA70449.
RefSeqNP_214185.1. NC_000918.1.

3D structure databases

ProteinModelPortalO67619.
ModBaseSearch...

Protein-protein interaction databases

STRING224324.aq_1727.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAC07585; AAC07585; aq_1727.
GeneID1193334.
KEGGaae:aq_1727.
PATRIC20960444. VBIAquAeo85532_1327.

Phylogenomic databases

eggNOGCOG1893.
HOGENOMHOG000050222.
KOK00077.
OMAAKMLYNC.
ProtClustDBCLSK692029.

Enzyme and pathway databases

BioCycAAEO224324:GJBH-1236-MONOMER.
UniPathwayUPA00028; UER00004.

Family and domain databases

Gene3D1.10.1040.10. 1 hit.
3.40.50.720. 1 hit.
InterProIPR008927. 6-PGluconate_DH_C-like.
IPR003710. ApbA.
IPR013752. ApbA_C.
IPR013332. ApbA_N.
IPR013328. DH_multihelical.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamPF02558. ApbA. 1 hit.
PF08546. ApbA_C. 1 hit.
[Graphical view]
SUPFAMSSF48179. 6DGDH_C_like. 1 hit.
TIGRFAMsTIGR00745. apbA_panE. 1 hit.
ProtoNetSearch...

Entry information

Entry namePANE_AQUAE
AccessionPrimary (citable) accession number: O67619
Entry history
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: August 1, 1998
Last modified: May 1, 2013
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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