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Protein

Putative 2-dehydropantoate 2-reductase

Gene

aq_1727

Organism
Aquifex aeolicus (strain VF5)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid.By similarity

Catalytic activityi

(R)-pantoate + NADP+ = 2-dehydropantoate + NADPH.

Pathwayi: (R)-pantothenate biosynthesis

This protein is involved in step 2 of the subpathway that synthesizes (R)-pantoate from 3-methyl-2-oxobutanoate.
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. 3-methyl-2-oxobutanoate hydroxymethyltransferase (panB)
  2. Putative 2-dehydropantoate 2-reductase (aq_1727)
This subpathway is part of the pathway (R)-pantothenate biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes (R)-pantoate from 3-methyl-2-oxobutanoate, the pathway (R)-pantothenate biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei100NADP; via amide nitrogenBy similarity1
Binding sitei100SubstrateBy similarity1
Active sitei184Proton donorBy similarity1
Binding sitei188SubstrateBy similarity1
Binding sitei192SubstrateBy similarity1
Binding sitei259SubstrateBy similarity1
Binding sitei270NADPBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi9 – 14NADPBy similarity6

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processPantothenate biosynthesis
LigandNADP

Enzyme and pathway databases

BioCyciAAEO224324:G1G15-1230-MONOMER
UniPathwayiUPA00028; UER00004

Names & Taxonomyi

Protein namesi
Recommended name:
Putative 2-dehydropantoate 2-reductase (EC:1.1.1.169)
Alternative name(s):
Ketopantoate reductase
Short name:
KPA reductase
Short name:
KPR
Gene namesi
Ordered Locus Names:aq_1727
OrganismiAquifex aeolicus (strain VF5)
Taxonomic identifieri224324 [NCBI]
Taxonomic lineageiBacteriaAquificaeAquificalesAquificaceaeAquifex
Proteomesi
  • UP000000798 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001573101 – 310Putative 2-dehydropantoate 2-reductaseAdd BLAST310

Interactioni

Protein-protein interaction databases

STRINGi224324.aq_1727

Structurei

3D structure databases

ProteinModelPortaliO67619
SMRiO67619
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ketopantoate reductase family.Curated

Phylogenomic databases

eggNOGiENOG4108JZF Bacteria
COG1893 LUCA
HOGENOMiHOG000050222
InParanoidiO67619
KOiK00077
OMAiLTVLHDC
OrthoDBiPOG091H01MS

Family and domain databases

Gene3Di1.10.1040.10, 1 hit
InterProiView protein in InterPro
IPR008927 6-PGluconate_DH-like_C_sf
IPR013328 6PGD_dom2
IPR003710 ApbA
IPR013752 KPA_reductase
IPR013332 KPR_N
IPR036291 NAD(P)-bd_dom_sf
PfamiView protein in Pfam
PF02558 ApbA, 1 hit
PF08546 ApbA_C, 1 hit
SUPFAMiSSF48179 SSF48179, 1 hit
SSF51735 SSF51735, 1 hit
TIGRFAMsiTIGR00745 apbA_panE, 1 hit

Sequencei

Sequence statusi: Complete.

O67619-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVMKFLIVGV GAIGSAYLAF LTRAGHEAAG LVRRNPVNRI KVEGIWGEFE
60 70 80 90 100
IPVKTFTKVE EVPFIPDIVI ISVKSYDTEE ALKKVKPVVG ENTFIMIAQN
110 120 130 140 150
GYGNYEKAVE IYGEGKVILS RIIFGSKVIK PGHIRITVSA DEVVIGDPSG
160 170 180 190 200
KIDEEFLKNL ARTFTEAGIP TRYERDVYKY LVDKIIYNSA LNPLGALFEV
210 220 230 240 250
NYGSLAENPH TKELMNRVID EIFQVIEKAK LPCFWKSADE YKKVFYEKLI
260 270 280 290 300
PPTAEHYPSM LEDVKKGKTE IEALNGAIVE LGKKYGVSTP TNEFITKMVK
310
AKELFNLKDT
Length:310
Mass (Da):34,776
Last modified:August 1, 1998 - v1
Checksum:iE59FB12901C0ABE0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000657 Genomic DNA Translation: AAC07585.1
PIRiA70449
RefSeqiNP_214185.1, NC_000918.1
WP_010881122.1, NC_000918.1

Genome annotation databases

EnsemblBacteriaiAAC07585; AAC07585; aq_1727
GeneIDi1193334
KEGGiaae:aq_1727
PATRICifig|224324.8.peg.1327

Similar proteinsi

Entry informationi

Entry nameiPANE_AQUAE
AccessioniPrimary (citable) accession number: O67619
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: August 1, 1998
Last modified: April 25, 2018
This is version 119 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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