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Protein

Putative 2-dehydropantoate 2-reductase

Gene

aq_1727

Organism
Aquifex aeolicus (strain VF5)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid.By similarity

Catalytic activityi

(R)-pantoate + NADP+ = 2-dehydropantoate + NADPH.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei100 – 1001NADP; via amide nitrogenBy similarity
Binding sitei100 – 1001SubstrateBy similarity
Active sitei184 – 1841Proton donorBy similarity
Binding sitei188 – 1881SubstrateBy similarity
Binding sitei192 – 1921SubstrateBy similarity
Binding sitei259 – 2591SubstrateBy similarity
Binding sitei270 – 2701NADPBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi9 – 146NADPBy similarity

GO - Molecular functioni

  1. 2-dehydropantoate 2-reductase activity Source: UniProtKB-EC
  2. NADP binding Source: InterPro

GO - Biological processi

  1. pantothenate biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Pantothenate biosynthesis

Keywords - Ligandi

NADP

Enzyme and pathway databases

BioCyciAAEO224324:GJBH-1236-MONOMER.
UniPathwayiUPA00028; UER00004.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative 2-dehydropantoate 2-reductase (EC:1.1.1.169)
Alternative name(s):
Ketopantoate reductase
Short name:
KPA reductase
Short name:
KPR
Gene namesi
Ordered Locus Names:aq_1727
OrganismiAquifex aeolicus (strain VF5)
Taxonomic identifieri224324 [NCBI]
Taxonomic lineageiBacteriaAquificaeAquificalesAquificaceaeAquifex
ProteomesiUP000000798 Componenti: Chromosome

Subcellular locationi

Cytoplasm Curated

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 310310Putative 2-dehydropantoate 2-reductasePRO_0000157310Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi224324.aq_1727.

Structurei

3D structure databases

ProteinModelPortaliO67619.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ketopantoate reductase family.Curated

Phylogenomic databases

eggNOGiCOG1893.
HOGENOMiHOG000050222.
InParanoidiO67619.
KOiK00077.
OMAiNILGTMW.
OrthoDBiEOG6P5ZHG.

Family and domain databases

Gene3Di1.10.1040.10. 1 hit.
3.40.50.720. 1 hit.
InterProiIPR008927. 6-PGluconate_DH_C-like.
IPR003710. ApbA.
IPR013328. DH_multihelical.
IPR013752. KPA_reductase.
IPR013332. KPR_N.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamiPF02558. ApbA. 1 hit.
PF08546. ApbA_C. 1 hit.
[Graphical view]
SUPFAMiSSF48179. SSF48179. 1 hit.
TIGRFAMsiTIGR00745. apbA_panE. 1 hit.

Sequencei

Sequence statusi: Complete.

O67619-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVMKFLIVGV GAIGSAYLAF LTRAGHEAAG LVRRNPVNRI KVEGIWGEFE
60 70 80 90 100
IPVKTFTKVE EVPFIPDIVI ISVKSYDTEE ALKKVKPVVG ENTFIMIAQN
110 120 130 140 150
GYGNYEKAVE IYGEGKVILS RIIFGSKVIK PGHIRITVSA DEVVIGDPSG
160 170 180 190 200
KIDEEFLKNL ARTFTEAGIP TRYERDVYKY LVDKIIYNSA LNPLGALFEV
210 220 230 240 250
NYGSLAENPH TKELMNRVID EIFQVIEKAK LPCFWKSADE YKKVFYEKLI
260 270 280 290 300
PPTAEHYPSM LEDVKKGKTE IEALNGAIVE LGKKYGVSTP TNEFITKMVK
310
AKELFNLKDT
Length:310
Mass (Da):34,776
Last modified:July 31, 1998 - v1
Checksum:iE59FB12901C0ABE0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000657 Genomic DNA. Translation: AAC07585.1.
PIRiA70449.
RefSeqiNP_214185.1. NC_000918.1.

Genome annotation databases

EnsemblBacteriaiAAC07585; AAC07585; aq_1727.
GeneIDi1193334.
KEGGiaae:aq_1727.
PATRICi20960444. VBIAquAeo85532_1327.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000657 Genomic DNA. Translation: AAC07585.1.
PIRiA70449.
RefSeqiNP_214185.1. NC_000918.1.

3D structure databases

ProteinModelPortaliO67619.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi224324.aq_1727.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC07585; AAC07585; aq_1727.
GeneIDi1193334.
KEGGiaae:aq_1727.
PATRICi20960444. VBIAquAeo85532_1327.

Phylogenomic databases

eggNOGiCOG1893.
HOGENOMiHOG000050222.
InParanoidiO67619.
KOiK00077.
OMAiNILGTMW.
OrthoDBiEOG6P5ZHG.

Enzyme and pathway databases

UniPathwayiUPA00028; UER00004.
BioCyciAAEO224324:GJBH-1236-MONOMER.

Family and domain databases

Gene3Di1.10.1040.10. 1 hit.
3.40.50.720. 1 hit.
InterProiIPR008927. 6-PGluconate_DH_C-like.
IPR003710. ApbA.
IPR013328. DH_multihelical.
IPR013752. KPA_reductase.
IPR013332. KPR_N.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamiPF02558. ApbA. 1 hit.
PF08546. ApbA_C. 1 hit.
[Graphical view]
SUPFAMiSSF48179. SSF48179. 1 hit.
TIGRFAMsiTIGR00745. apbA_panE. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: VF5.

Entry informationi

Entry nameiPANE_AQUAE
AccessioniPrimary (citable) accession number: O67619
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 14, 1998
Last sequence update: July 31, 1998
Last modified: January 6, 2015
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.