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O67619

- PANE_AQUAE

UniProt

O67619 - PANE_AQUAE

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Protein
Putative 2-dehydropantoate 2-reductase
Gene
aq_1727
Organism
Aquifex aeolicus (strain VF5)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid By similarity.

Catalytic activityi

(R)-pantoate + NADP+ = 2-dehydropantoate + NADPH.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei100 – 1001NADP; via amide nitrogen By similarity
Binding sitei100 – 1001Substrate By similarity
Active sitei184 – 1841Proton donor By similarity
Binding sitei188 – 1881Substrate By similarity
Binding sitei192 – 1921Substrate By similarity
Binding sitei259 – 2591Substrate By similarity
Binding sitei270 – 2701NADP By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi9 – 146NADP By similarity

GO - Molecular functioni

  1. 2-dehydropantoate 2-reductase activity Source: UniProtKB-EC
  2. NADP binding Source: InterPro

GO - Biological processi

  1. pantothenate biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Pantothenate biosynthesis

Keywords - Ligandi

NADP

Enzyme and pathway databases

BioCyciAAEO224324:GJBH-1236-MONOMER.
UniPathwayiUPA00028; UER00004.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative 2-dehydropantoate 2-reductase (EC:1.1.1.169)
Alternative name(s):
Ketopantoate reductase
Short name:
KPA reductase
Short name:
KPR
Gene namesi
Ordered Locus Names:aq_1727
OrganismiAquifex aeolicus (strain VF5)
Taxonomic identifieri224324 [NCBI]
Taxonomic lineageiBacteriaAquificaeAquificalesAquificaceaeAquifex
ProteomesiUP000000798: Chromosome

Subcellular locationi

Cytoplasm Reviewed prediction

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 310310Putative 2-dehydropantoate 2-reductase
PRO_0000157310Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi224324.aq_1727.

Structurei

3D structure databases

ProteinModelPortaliO67619.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1893.
HOGENOMiHOG000050222.
KOiK00077.
OMAiAYDACER.
OrthoDBiEOG6P5ZHG.

Family and domain databases

Gene3Di1.10.1040.10. 1 hit.
3.40.50.720. 1 hit.
InterProiIPR008927. 6-PGluconate_DH_C-like.
IPR003710. ApbA.
IPR013328. DH_multihelical.
IPR013752. KPA_reductase.
IPR013332. KPR_N.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamiPF02558. ApbA. 1 hit.
PF08546. ApbA_C. 1 hit.
[Graphical view]
SUPFAMiSSF48179. SSF48179. 1 hit.
TIGRFAMsiTIGR00745. apbA_panE. 1 hit.

Sequencei

Sequence statusi: Complete.

O67619-1 [UniParc]FASTAAdd to Basket

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MVMKFLIVGV GAIGSAYLAF LTRAGHEAAG LVRRNPVNRI KVEGIWGEFE    50
IPVKTFTKVE EVPFIPDIVI ISVKSYDTEE ALKKVKPVVG ENTFIMIAQN 100
GYGNYEKAVE IYGEGKVILS RIIFGSKVIK PGHIRITVSA DEVVIGDPSG 150
KIDEEFLKNL ARTFTEAGIP TRYERDVYKY LVDKIIYNSA LNPLGALFEV 200
NYGSLAENPH TKELMNRVID EIFQVIEKAK LPCFWKSADE YKKVFYEKLI 250
PPTAEHYPSM LEDVKKGKTE IEALNGAIVE LGKKYGVSTP TNEFITKMVK 300
AKELFNLKDT 310
Length:310
Mass (Da):34,776
Last modified:August 1, 1998 - v1
Checksum:iE59FB12901C0ABE0
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE000657 Genomic DNA. Translation: AAC07585.1.
PIRiA70449.
RefSeqiNP_214185.1. NC_000918.1.

Genome annotation databases

EnsemblBacteriaiAAC07585; AAC07585; aq_1727.
GeneIDi1193334.
KEGGiaae:aq_1727.
PATRICi20960444. VBIAquAeo85532_1327.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE000657 Genomic DNA. Translation: AAC07585.1 .
PIRi A70449.
RefSeqi NP_214185.1. NC_000918.1.

3D structure databases

ProteinModelPortali O67619.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 224324.aq_1727.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAC07585 ; AAC07585 ; aq_1727 .
GeneIDi 1193334.
KEGGi aae:aq_1727.
PATRICi 20960444. VBIAquAeo85532_1327.

Phylogenomic databases

eggNOGi COG1893.
HOGENOMi HOG000050222.
KOi K00077.
OMAi AYDACER.
OrthoDBi EOG6P5ZHG.

Enzyme and pathway databases

UniPathwayi UPA00028 ; UER00004 .
BioCyci AAEO224324:GJBH-1236-MONOMER.

Family and domain databases

Gene3Di 1.10.1040.10. 1 hit.
3.40.50.720. 1 hit.
InterProi IPR008927. 6-PGluconate_DH_C-like.
IPR003710. ApbA.
IPR013328. DH_multihelical.
IPR013752. KPA_reductase.
IPR013332. KPR_N.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
Pfami PF02558. ApbA. 1 hit.
PF08546. ApbA_C. 1 hit.
[Graphical view ]
SUPFAMi SSF48179. SSF48179. 1 hit.
TIGRFAMsi TIGR00745. apbA_panE. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: VF5.

Entry informationi

Entry nameiPANE_AQUAE
AccessioniPrimary (citable) accession number: O67619
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: August 1, 1998
Last modified: September 3, 2014
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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