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Protein

Acyl carrier protein

Gene

acpP

Organism
Aquifex aeolicus (strain VF5)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Carrier of the growing fatty acid chain in fatty acid biosynthesis.UniRule annotation

Pathwayi: fatty acid biosynthesis

This protein is involved in the pathway fatty acid biosynthesis, which is part of Lipid metabolism.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway fatty acid biosynthesis and in Lipid metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processFatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism

Enzyme and pathway databases

BioCyciAAEO224324:G1G15-1222-MONOMER
UniPathwayiUPA00094

Names & Taxonomyi

Protein namesi
Recommended name:
Acyl carrier proteinUniRule annotation
Short name:
ACPUniRule annotation
Gene namesi
Name:acpPUniRule annotation
Ordered Locus Names:aq_1716.1
ORF Names:aq_1717A
OrganismiAquifex aeolicus (strain VF5)
Taxonomic identifieri224324 [NCBI]
Taxonomic lineageiBacteriaAquificaeAquificalesAquificaceaeAquifex
Proteomesi
  • UP000000798 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001800941 – 78Acyl carrier proteinAdd BLAST78

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei36O-(pantetheine 4'-phosphoryl)serinePROSITE-ProRule annotation1

Post-translational modificationi

4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by AcpS. This modification is essential for activity because fatty acids are bound in thioester linkage to the sulfhydryl of the prosthetic group.UniRule annotation

Keywords - PTMi

Phosphopantetheine, Phosphoprotein

Interactioni

Protein-protein interaction databases

STRINGi224324.aq_1717a

Structurei

Secondary structure

178
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi3 – 15Combined sources13
Helixi19 – 21Combined sources3
Turni28 – 32Combined sources5
Helixi36 – 50Combined sources15
Helixi56 – 60Combined sources5
Helixi65 – 75Combined sources11

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2EHSX-ray1.30A2-78[»]
2EHTX-ray1.40A2-78[»]
ProteinModelPortaliO67611
SMRiO67611
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO67611

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 76CarrierPROSITE-ProRule annotationAdd BLAST76

Sequence similaritiesi

Belongs to the acyl carrier protein (ACP) family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105VNB Bacteria
COG0236 LUCA
HOGENOMiHOG000178184
InParanoidiO67611
KOiK02078
OMAiDQIKPES
OrthoDBiPOG091H00VW

Family and domain databases

Gene3Di1.10.1200.10, 1 hit
HAMAPiMF_01217 Acyl_carrier, 1 hit
InterProiView protein in InterPro
IPR036736 ACP-like_sf
IPR003231 Acyl_carrier
IPR020806 PKS_PP-bd
IPR009081 PP-bd_ACP
IPR006162 Ppantetheine_attach_site
PfamiView protein in Pfam
PF00550 PP-binding, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD000887 PD000887, 1 hit
SMARTiView protein in SMART
SM00823 PKS_PP, 1 hit
SUPFAMiSSF47336 SSF47336, 1 hit
TIGRFAMsiTIGR00517 acyl_carrier, 1 hit
PROSITEiView protein in PROSITE
PS50075 CARRIER, 1 hit
PS00012 PHOSPHOPANTETHEINE, 1 hit

Sequencei

Sequence statusi: Complete.

O67611-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLEERVKEI IAEQLGVEKE KITPEAKFVE DLGADSLDVV ELIMAFEEEF
60 70
GIEIPDEDAE KIQTVGDVIN YLKEKVGG
Length:78
Mass (Da):8,711
Last modified:August 1, 1998 - v1
Checksum:i21E3B7D77157EB35
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000657 Genomic DNA Translation: AAC07567.1
PIRiA70448
RefSeqiNP_214177.1, NC_000918.1
WP_010881114.1, NC_000918.1

Genome annotation databases

EnsemblBacteriaiAAC07567; AAC07567; aq_1717a
GeneIDi1193326
KEGGiaae:aq_1717a
PATRICifig|224324.8.peg.1318

Similar proteinsi

Entry informationi

Entry nameiACP_AQUAE
AccessioniPrimary (citable) accession number: O67611
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: August 1, 1998
Last modified: March 28, 2018
This is version 112 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

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