SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

O67610

- FABG_AQUAE

UniProt

O67610 - FABG_AQUAE

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

3-oxoacyl-[acyl-carrier-protein] reductase FabG

Gene
fabG, aq_1716
Organism
Aquifex aeolicus (strain VF5)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Catalyzes the NADPH-dependent reduction of beta-ketoacyl-ACP substrates to beta-hydroxyacyl-ACP products, the first reductive step in the elongation cycle of fatty acid biosynthesis By similarity.

Catalytic activityi

(3R)-3-hydroxyacyl-[acyl-carrier-protein] + NADP+ = 3-oxoacyl-[acyl-carrier-protein] + NADPH.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei39 – 391NADP By similarity
Binding sitei92 – 921NADP; via carbonyl oxygen By similarity
Binding sitei144 – 1441Substrate By similarity
Active sitei157 – 1571Proton acceptor By similarity
Binding sitei190 – 1901NADP; via amide nitrogen and carbonyl oxygen By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi14 – 174NADP By similarity
Nucleotide bindingi65 – 662NADP By similarity
Nucleotide bindingi157 – 1615NADP By similarity

GO - Molecular functioni

  1. 3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity Source: UniProtKB
  2. NAD binding Source: InterPro
  3. NADP binding Source: UniProtKB

GO - Biological processi

  1. fatty acid elongation Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Fatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism

Keywords - Ligandi

NADP

Enzyme and pathway databases

BioCyciAAEO224324:GJBH-1227-MONOMER.
RETL1328306-WGS:GSTH-6822-MONOMER.
UniPathwayiUPA00094.

Names & Taxonomyi

Protein namesi
Recommended name:
3-oxoacyl-[acyl-carrier-protein] reductase FabG (EC:1.1.1.100)
Alternative name(s):
3-ketoacyl-acyl carrier protein reductase
Beta-Ketoacyl-acyl carrier protein reductase
Beta-ketoacyl-ACP reductase
Gene namesi
Name:fabG
Ordered Locus Names:aq_1716
OrganismiAquifex aeolicus (strain VF5)
Taxonomic identifieri224324 [NCBI]
Taxonomic lineageiBacteriaAquificaeAquificalesAquificaceaeAquifex
ProteomesiUP000000798: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 2482483-oxoacyl-[acyl-carrier-protein] reductase FabGPRO_0000054664Add
BLAST

Interactioni

Subunit structurei

Homotetramer.1 Publication

Protein-protein interaction databases

STRINGi224324.aq_1716.

Structurei

Secondary structure

1
248
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi9 – 124
Helixi18 – 2912
Beta strandi33 – 408
Helixi41 – 5515
Beta strandi59 – 635
Helixi69 – 8214
Beta strandi87 – 915
Helixi101 – 1033
Helixi106 – 11611
Helixi118 – 12710
Helixi129 – 1346
Beta strandi137 – 1426
Helixi145 – 1495
Helixi155 – 17521
Helixi176 – 1783
Beta strandi180 – 1878
Helixi193 – 1975
Helixi200 – 2089
Helixi218 – 22912
Helixi231 – 2333
Beta strandi240 – 2445

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2P68X-ray1.84A/B1-248[»]
2PNFX-ray1.80A/B1-248[»]
ProteinModelPortaliO67610.
SMRiO67610. Positions 1-248.

Miscellaneous databases

EvolutionaryTraceiO67610.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1028.
KOiK00059.
OMAiDEFGAID.
OrthoDBiEOG6N3CR8.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR011284. 3oxo_ACP_reduc.
IPR002198. DH_sc/Rdtase_SDR.
IPR002347. Glc/ribitol_DH.
IPR016040. NAD(P)-bd_dom.
IPR020904. Sc_DH/Rdtase_CS.
[Graphical view]
PfamiPF00106. adh_short. 1 hit.
[Graphical view]
PIRSFiPIRSF000126. 11-beta-HSD1. 1 hit.
PRINTSiPR00081. GDHRDH.
PR00080. SDRFAMILY.
TIGRFAMsiTIGR01830. 3oxo_ACP_reduc. 1 hit.
PROSITEiPS00061. ADH_SHORT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O67610-1 [UniParc]FASTAAdd to Basket

« Hide

MEIKLQGKVS LVTGSTRGIG RAIAEKLASA GSTVIITGTS GERAKAVAEE    50
IANKYGVKAH GVEMNLLSEE SINKAFEEIY NLVDGIDILV NNAGITRDKL 100
FLRMSLLDWE EVLKVNLTGT FLVTQNSLRK MIKQRWGRIV NISSVVGFTG 150
NVGQVNYSTT KAGLIGFTKS LAKELAPRNV LVNAVAPGFI ETDMTAVLSE 200
EIKQKYKEQI PLGRFGSPEE VANVVLFLCS ELASYITGEV IHVNGGMF 248
Length:248
Mass (Da):26,867
Last modified:August 1, 1998 - v1
Checksum:i5CFD9EB9AD83F2C5
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE000657 Genomic DNA. Translation: AAC07575.1.
PIRiH70447.
RefSeqiNP_214176.1. NC_000918.1.

Genome annotation databases

EnsemblBacteriaiAAC07575; AAC07575; aq_1716.
GeneIDi1193325.
KEGGiaae:aq_1716.
PATRICi20960424. VBIAquAeo85532_1317.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE000657 Genomic DNA. Translation: AAC07575.1 .
PIRi H70447.
RefSeqi NP_214176.1. NC_000918.1.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2P68 X-ray 1.84 A/B 1-248 [» ]
2PNF X-ray 1.80 A/B 1-248 [» ]
ProteinModelPortali O67610.
SMRi O67610. Positions 1-248.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 224324.aq_1716.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAC07575 ; AAC07575 ; aq_1716 .
GeneIDi 1193325.
KEGGi aae:aq_1716.
PATRICi 20960424. VBIAquAeo85532_1317.

Phylogenomic databases

eggNOGi COG1028.
KOi K00059.
OMAi DEFGAID.
OrthoDBi EOG6N3CR8.

Enzyme and pathway databases

UniPathwayi UPA00094 .
BioCyci AAEO224324:GJBH-1227-MONOMER.
RETL1328306-WGS:GSTH-6822-MONOMER.

Miscellaneous databases

EvolutionaryTracei O67610.

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
InterProi IPR011284. 3oxo_ACP_reduc.
IPR002198. DH_sc/Rdtase_SDR.
IPR002347. Glc/ribitol_DH.
IPR016040. NAD(P)-bd_dom.
IPR020904. Sc_DH/Rdtase_CS.
[Graphical view ]
Pfami PF00106. adh_short. 1 hit.
[Graphical view ]
PIRSFi PIRSF000126. 11-beta-HSD1. 1 hit.
PRINTSi PR00081. GDHRDH.
PR00080. SDRFAMILY.
TIGRFAMsi TIGR01830. 3oxo_ACP_reduc. 1 hit.
PROSITEi PS00061. ADH_SHORT. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: VF5.
  2. "Crystal structure of aq_1716 from Aquifex aeolicus VF5."
    Southeast collaboratory for structural genomics (SECSG)
    Submitted (APR-2007) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (1.84 ANGSTROMS), SUBUNIT.

Entry informationi

Entry nameiFABG_AQUAE
AccessioniPrimary (citable) accession number: O67610
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: August 1, 1998
Last modified: July 9, 2014
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi