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O67610 (FABG_AQUAE) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 88. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
3-oxoacyl-[acyl-carrier-protein] reductase FabG
EC=1.1.1.100
Alternative name(s):
3-ketoacyl-acyl carrier protein reductase
Beta-Ketoacyl-acyl carrier protein reductase
Beta-ketoacyl-ACP reductase
Gene names
Name:fabG
Ordered Locus Names:aq_1716
OrganismAquifex aeolicus (strain VF5) [Reference proteome] [HAMAP]
Taxonomic identifier224324 [NCBI]
Taxonomic lineageBacteria › Aquificae › Aquificales › Aquificaceae › Aquifex ›

Protein attributes

Sequence length248 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Catalyzes the NADPH-dependent reduction of beta-ketoacyl-ACP substrates to beta-hydroxyacyl-ACP products, the first reductive step in the elongation cycle of fatty acid biosynthesis By similarity.

Catalytic activity

(3R)-3-hydroxyacyl-[acyl-carrier-protein] + NADP+ = 3-oxoacyl-[acyl-carrier-protein] + NADPH.

Pathway

Lipid metabolism; fatty acid biosynthesis.

Subunit structure

Homotetramer. Ref.2

Sequence similarities

Belongs to the short-chain dehydrogenases/reductases (SDR) family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 2482483-oxoacyl-[acyl-carrier-protein] reductase FabG
PRO_0000054664

Regions

Nucleotide binding14 – 174NADP By similarity
Nucleotide binding65 – 662NADP By similarity
Nucleotide binding157 – 1615NADP By similarity

Sites

Active site1571Proton acceptor By similarity
Binding site391NADP By similarity
Binding site921NADP; via carbonyl oxygen By similarity
Binding site1441Substrate By similarity
Binding site1901NADP; via amide nitrogen and carbonyl oxygen By similarity

Secondary structure

1 ......................................... 248
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
O67610 [UniParc].

Last modified August 1, 1998. Version 1.
Checksum: 5CFD9EB9AD83F2C5

FASTA24826,867
        10         20         30         40         50         60 
MEIKLQGKVS LVTGSTRGIG RAIAEKLASA GSTVIITGTS GERAKAVAEE IANKYGVKAH 

        70         80         90        100        110        120 
GVEMNLLSEE SINKAFEEIY NLVDGIDILV NNAGITRDKL FLRMSLLDWE EVLKVNLTGT 

       130        140        150        160        170        180 
FLVTQNSLRK MIKQRWGRIV NISSVVGFTG NVGQVNYSTT KAGLIGFTKS LAKELAPRNV 

       190        200        210        220        230        240 
LVNAVAPGFI ETDMTAVLSE EIKQKYKEQI PLGRFGSPEE VANVVLFLCS ELASYITGEV 


IHVNGGMF

« Hide

References

« Hide 'large scale' references
[1]"The complete genome of the hyperthermophilic bacterium Aquifex aeolicus."
Deckert G., Warren P.V., Gaasterland T., Young W.G., Lenox A.L., Graham D.E., Overbeek R., Snead M.A., Keller M., Aujay M., Huber R., Feldman R.A., Short J.M., Olsen G.J., Swanson R.V.
Nature 392:353-358(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: VF5.
[2]"Crystal structure of aq_1716 from Aquifex aeolicus VF5."
Southeast collaboratory for structural genomics (SECSG)
Submitted (APR-2007) to the PDB data bank
Cited for: X-RAY CRYSTALLOGRAPHY (1.84 ANGSTROMS), SUBUNIT.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AE000657 Genomic DNA. Translation: AAC07575.1.
PIRH70447.
RefSeqNP_214176.1. NC_000918.1.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
2P68X-ray1.84A/B1-248[»]
2PNFX-ray1.80A/B1-248[»]
ProteinModelPortalO67610.
SMRO67610. Positions 1-248.
ModBaseSearch...

Protein-protein interaction databases

STRING224324.aq_1716.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAC07575; AAC07575; aq_1716.
GeneID1193325.
KEGGaae:aq_1716.
PATRIC20960424. VBIAquAeo85532_1317.

Phylogenomic databases

eggNOGCOG1028.
KOK00059.
OMAYLASNEG.
ProtClustDBCLSK2299806.

Enzyme and pathway databases

BioCycAAEO224324:GJBH-1227-MONOMER.
UniPathwayUPA00094.

Family and domain databases

Gene3D3.40.50.720. 1 hit.
InterProIPR011284. 3oxo_ACP_reduc.
IPR002198. DH_sc/Rdtase_SDR.
IPR002347. Glc/ribitol_DH.
IPR016040. NAD(P)-bd_dom.
IPR020904. Sc_DH/Rdtase_CS.
[Graphical view]
PIRSFPIRSF000126. 11-beta-HSD1. 1 hit.
PRINTSPR00081. GDHRDH.
PR00080. SDRFAMILY.
TIGRFAMsTIGR01830. 3oxo_ACP_reduc. 1 hit.
PROSITEPS00061. ADH_SHORT. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceO67610.

Entry information

Entry nameFABG_AQUAE
AccessionPrimary (citable) accession number: O67610
Entry history
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: August 1, 1998
Last modified: May 1, 2013
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

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