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Protein

3-oxoacyl-[acyl-carrier-protein] reductase FabG

Gene

fabG

Organism
Aquifex aeolicus (strain VF5)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalyzes the NADPH-dependent reduction of beta-ketoacyl-ACP substrates to beta-hydroxyacyl-ACP products, the first reductive step in the elongation cycle of fatty acid biosynthesis.By similarity

Catalytic activityi

(3R)-3-hydroxyacyl-[acyl-carrier-protein] + NADP+ = 3-oxoacyl-[acyl-carrier-protein] + NADPH.

Pathwayi: fatty acid biosynthesis

This protein is involved in the pathway fatty acid biosynthesis, which is part of Lipid metabolism.
View all proteins of this organism that are known to be involved in the pathway fatty acid biosynthesis and in Lipid metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei39NADPBy similarity1
Binding sitei92NADP; via carbonyl oxygenBy similarity1
Binding sitei144SubstrateBy similarity1
Active sitei157Proton acceptorPROSITE-ProRule annotation1
Binding sitei190NADP; via amide nitrogen and carbonyl oxygenBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi14 – 17NADPBy similarity4
Nucleotide bindingi65 – 66NADPBy similarity2
Nucleotide bindingi157 – 161NADPBy similarity5

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processFatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism
LigandNADP

Enzyme and pathway databases

BioCyciAAEO224324:G1G15-1221-MONOMER
UniPathwayiUPA00094

Names & Taxonomyi

Protein namesi
Recommended name:
3-oxoacyl-[acyl-carrier-protein] reductase FabG (EC:1.1.1.100)
Alternative name(s):
3-ketoacyl-acyl carrier protein reductase
Beta-Ketoacyl-acyl carrier protein reductase
Beta-ketoacyl-ACP reductase
Gene namesi
Name:fabG
Ordered Locus Names:aq_1716
OrganismiAquifex aeolicus (strain VF5)
Taxonomic identifieri224324 [NCBI]
Taxonomic lineageiBacteriaAquificaeAquificalesAquificaceaeAquifex
Proteomesi
  • UP000000798 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000546641 – 2483-oxoacyl-[acyl-carrier-protein] reductase FabGAdd BLAST248

Interactioni

Subunit structurei

Homotetramer.1 Publication

Protein-protein interaction databases

STRINGi224324.aq_1716

Structurei

Secondary structure

1248
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi9 – 12Combined sources4
Helixi18 – 29Combined sources12
Beta strandi33 – 40Combined sources8
Helixi41 – 55Combined sources15
Beta strandi59 – 63Combined sources5
Helixi69 – 82Combined sources14
Beta strandi87 – 91Combined sources5
Helixi101 – 103Combined sources3
Helixi106 – 116Combined sources11
Helixi118 – 127Combined sources10
Helixi129 – 134Combined sources6
Beta strandi137 – 142Combined sources6
Helixi145 – 149Combined sources5
Helixi155 – 175Combined sources21
Helixi176 – 178Combined sources3
Beta strandi180 – 187Combined sources8
Helixi193 – 197Combined sources5
Helixi200 – 208Combined sources9
Helixi218 – 229Combined sources12
Helixi231 – 233Combined sources3
Beta strandi240 – 244Combined sources5

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2P68X-ray1.84A/B1-248[»]
2PNFX-ray1.80A/B1-248[»]
ProteinModelPortaliO67610
SMRiO67610
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO67610

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4105CHR Bacteria
ENOG410XNW1 LUCA
InParanoidiO67610
KOiK00059
OMAiICDKDES
OrthoDBiPOG091H012M

Family and domain databases

InterProiView protein in InterPro
IPR011284 3oxo_ACP_reduc
IPR036291 NAD(P)-bd_dom_sf
IPR020904 Sc_DH/Rdtase_CS
IPR002347 SDR_fam
PRINTSiPR00081 GDHRDH
PR00080 SDRFAMILY
SUPFAMiSSF51735 SSF51735, 1 hit
TIGRFAMsiTIGR01830 3oxo_ACP_reduc, 1 hit
PROSITEiView protein in PROSITE
PS00061 ADH_SHORT, 1 hit

Sequencei

Sequence statusi: Complete.

O67610-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEIKLQGKVS LVTGSTRGIG RAIAEKLASA GSTVIITGTS GERAKAVAEE
60 70 80 90 100
IANKYGVKAH GVEMNLLSEE SINKAFEEIY NLVDGIDILV NNAGITRDKL
110 120 130 140 150
FLRMSLLDWE EVLKVNLTGT FLVTQNSLRK MIKQRWGRIV NISSVVGFTG
160 170 180 190 200
NVGQVNYSTT KAGLIGFTKS LAKELAPRNV LVNAVAPGFI ETDMTAVLSE
210 220 230 240
EIKQKYKEQI PLGRFGSPEE VANVVLFLCS ELASYITGEV IHVNGGMF
Length:248
Mass (Da):26,867
Last modified:August 1, 1998 - v1
Checksum:i5CFD9EB9AD83F2C5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000657 Genomic DNA Translation: AAC07575.1
PIRiH70447
RefSeqiNP_214176.1, NC_000918.1
WP_010881113.1, NC_000918.1

Genome annotation databases

EnsemblBacteriaiAAC07575; AAC07575; aq_1716
GeneIDi1193325
KEGGiaae:aq_1716
PATRICifig|224324.8.peg.1317

Similar proteinsi

Entry informationi

Entry nameiFABG_AQUAE
AccessioniPrimary (citable) accession number: O67610
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: August 1, 1998
Last modified: March 28, 2018
This is version 118 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome
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Main funding by: National Institutes of Health