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Protein

Ornithine carbamoyltransferase

Gene

argF

Organism
Aquifex aeolicus (strain VF5)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline.By similarity

Catalytic activityi

Carbamoyl phosphate + L-ornithine = phosphate + L-citrulline.UniRule annotation

Pathwayi: L-arginine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes L-arginine from L-ornithine and carbamoyl phosphate.UniRule annotation
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. Ornithine carbamoyltransferase (argF)
  2. Argininosuccinate synthase (argG)
  3. Argininosuccinate lyase (argH)
This subpathway is part of the pathway L-arginine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-arginine from L-ornithine and carbamoyl phosphate, the pathway L-arginine biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei77Carbamoyl phosphateUniRule annotation1
Binding sitei101Carbamoyl phosphateUniRule annotation1
Binding sitei160OrnithineUniRule annotation1
Binding sitei224OrnithineUniRule annotation1
Binding sitei289Carbamoyl phosphateUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processAmino-acid biosynthesis, Arginine biosynthesis

Enzyme and pathway databases

BioCyciAAEO224324:G1G15-1218-MONOMER
UniPathwayiUPA00068; UER00112

Names & Taxonomyi

Protein namesi
Recommended name:
Ornithine carbamoyltransferaseUniRule annotation (EC:2.1.3.3UniRule annotation)
Short name:
OTCaseUniRule annotation
Gene namesi
Name:argFUniRule annotation
Ordered Locus Names:aq_1711
OrganismiAquifex aeolicus (strain VF5)
Taxonomic identifieri224324 [NCBI]
Taxonomic lineageiBacteriaAquificaeAquificalesAquificaceaeAquifex
Proteomesi
  • UP000000798 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001128741 – 306Ornithine carbamoyltransferaseAdd BLAST306

Proteomic databases

PRIDEiO67607

Interactioni

Protein-protein interaction databases

STRINGi224324.aq_1711

Structurei

3D structure databases

ProteinModelPortaliO67607
SMRiO67607
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni50 – 53Carbamoyl phosphate bindingUniRule annotation4
Regioni128 – 131Carbamoyl phosphate bindingUniRule annotation4
Regioni228 – 229Ornithine bindingUniRule annotation2
Regioni261 – 262Carbamoyl phosphate bindingUniRule annotation2

Sequence similaritiesi

Belongs to the ATCase/OTCase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105DBV Bacteria
COG0078 LUCA
HOGENOMiHOG000022686
InParanoidiO67607
KOiK00611
OMAiDGNNVCN
OrthoDBiPOG091H0543

Family and domain databases

Gene3Di3.40.50.1370, 2 hits
HAMAPiMF_01109 OTCase, 1 hit
InterProiView protein in InterPro
IPR006132 Asp/Orn_carbamoyltranf_P-bd
IPR006130 Asp/Orn_carbamoylTrfase
IPR036901 Asp/Orn_carbamoylTrfase_sf
IPR006131 Asp_carbamoyltransf_Asp/Orn-bd
IPR002292 Orn/put_carbamltrans
IPR024904 OTCase_ArgI
PfamiView protein in Pfam
PF00185 OTCace, 1 hit
PF02729 OTCace_N, 1 hit
PRINTSiPR00100 AOTCASE
PR00102 OTCASE
SUPFAMiSSF53671 SSF53671, 1 hit
TIGRFAMsiTIGR00658 orni_carb_tr, 1 hit
PROSITEiView protein in PROSITE
PS00097 CARBAMOYLTRANSFERASE, 1 hit

Sequencei

Sequence statusi: Complete.

O67607-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKRDFVDLWD LSPKEAWEIV KKTLKVKKGE EELGKPLSGK TIALLFTKPS
60 70 80 90 100
TRTRVSFEVG IYQLGGNSLF FQEKELQVSR GEDVRDTART LSKYVDGVIV
110 120 130 140 150
RNHSHTWLKE FANFASVPVI NALTNMSHPC QILSDVFTLY EHYGEELKNL
160 170 180 190 200
KVAYVGDGNN VCNTLMVGAG MFGLKLFVAT PEGYEPNSYY YKKALEFSKE
210 220 230 240 250
NGGSVELTNN PVESVKDADV VYTDVWVSMG EENKNIEAFL PYQVNEKLLS
260 270 280 290 300
FAKSSVKVMH CLPAKKGQEI TEEVFEKNAD FIFTQAENRL HTQKTLMEFL

FREPQA
Length:306
Mass (Da):34,724
Last modified:August 1, 1998 - v1
Checksum:i9D2E93B8C73C2FE7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000657 Genomic DNA Translation: AAC07566.1
PIRiE70447
RefSeqiNP_214173.1, NC_000918.1
WP_010881110.1, NC_000918.1

Genome annotation databases

EnsemblBacteriaiAAC07566; AAC07566; aq_1711
GeneIDi1193322
KEGGiaae:aq_1711
PATRICifig|224324.8.peg.1314

Similar proteinsi

Entry informationi

Entry nameiOTC_AQUAE
AccessioniPrimary (citable) accession number: O67607
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 11, 2003
Last sequence update: August 1, 1998
Last modified: March 28, 2018
This is version 111 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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