O67607 (OTC_AQUAE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Ornithine carbamoyltransferase
Short name=OTCase
EC=2.1.3.3

Gene names

Name:	argF
Ordered Locus Names:	aq_1711

Organism

Aquifex aeolicus (strain VF5)

Taxonomic identifier

224324 [NCBI]

Taxonomic lineage

Bacteria › Aquificae › Aquificales › Aquificaceae › Aquifex

Protein attributes

Sequence length	306 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Carbamoyl phosphate + L-ornithine = phosphate + L-citrulline. HAMAP MF_01109
Pathway	Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 1/3. HAMAP MF_01109
Subcellular location	Cytoplasm Probable HAMAP MF_01109.
Sequence similarities	Belongs to the ATCase/OTCase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Arginine biosynthesis
Cellular component	Cytoplasm
Molecular function	Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	arginine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	ornithine carbamoyltransferase complex Inferred from electronic annotation. Source: InterPro
Molecular function	amino acid binding Inferred from electronic annotation. Source: InterPro ornithine carbamoyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 306	306	Ornithine carbamoyltransferase HAMAP MF_01109		PRO_0000112874
Regions
	Region	50 – 54	5	Carbamoyl phosphate binding By similarity
	Region	260 – 263	4	Ornithine binding By similarity
Sites
	Binding site	101	1	Carbamoyl phosphate By similarity
	Binding site	128	1	Carbamoyl phosphate By similarity
	Site	27	1	Important for structural integrity By similarity
	Site	141	1	Important for structural integrity By similarity

Sequences

	Sequence		Length	Mass (Da)
	O67607 [UniParc]. Last modified August 1, 1998. Version 1. Checksum: 9D2E93B8C73C2FE7	FASTA	306	34,724
	10 20 30 40 50 60 MKRDFVDLWD LSPKEAWEIV KKTLKVKKGE EELGKPLSGK TIALLFTKPS TRTRVSFEVG 70 80 90 100 110 120 IYQLGGNSLF FQEKELQVSR GEDVRDTART LSKYVDGVIV RNHSHTWLKE FANFASVPVI 130 140 150 160 170 180 NALTNMSHPC QILSDVFTLY EHYGEELKNL KVAYVGDGNN VCNTLMVGAG MFGLKLFVAT 190 200 210 220 230 240 PEGYEPNSYY YKKALEFSKE NGGSVELTNN PVESVKDADV VYTDVWVSMG EENKNIEAFL 250 260 270 280 290 300 PYQVNEKLLS FAKSSVKVMH CLPAKKGQEI TEEVFEKNAD FIFTQAENRL HTQKTLMEFL FREPQA

References

[1]	"The complete genome of the hyperthermophilic bacterium Aquifex aeolicus." Deckert G., Warren P.V., Gaasterland T., Young W.G., Lenox A.L., Graham D.E., Overbeek R., Snead M.A., Keller M., Aujay M., Huber R., Feldman R.A., Short J.M., Olsen G.J., Swanson R.V. Nature 392:353-358(1998) [PubMed: 9537320] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: VF5.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE000657 Genomic DNA. Translation: AAC07566.1.
PIR	E70447.
RefSeq	NP_214173.1. NC_000918.1.
3D structure databases
ProteinModelPortal	O67607.
ModBase	Search...
Proteomic databases
PRIDE	O67607.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1193322.
GenomeReviews	Gene locus aq_1711 in contig AE000657_GR.
KEGG	aae:aq_1711.
NMPDR	fig|224324.1.peg.1188.
PATRIC	20960418. VBIAquAeo85532_1314.
Phylogenomic databases
HOGENOM	HBG579429.
OMA	KHLLSIK.
PhylomeDB	O67607.
ProtClustDB	PRK00779.
Enzyme and pathway databases
BioCyc	AAEO224324:AQ_1711-MONOMER.
Family and domain databases
HAMAP	MF_01109. OTCase. [Tree]
InterPro	IPR006132. Asp/Orn_carbamoyltranf_P-bd. IPR006130. Asp/Orn_carbamoylTrfase. IPR006131. Asp_carbamoyltransf_Asp/Orn-bd. IPR002292. Orn/put_carbamltrans. IPR024904. Orn_carbamltrans. [Graphical view]
KO	K00611.
Pfam	PF00185. OTCace. 1 hit. PF02729. OTCace_N. 1 hit. [Graphical view]
PRINTS	PR00100. AOTCASE. PR00102. OTCASE.
SUPFAM	SSF53671. Asp/Orn_carbamoyltranf. 1 hit.
TIGRFAMs	TIGR00658. Orni_carb_tr. 1 hit.
PROSITE	PS00097. CARBAMOYLTRANSFERASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

OTC_AQUAE

Accession

Primary (citable) accession number: O67607

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 11, 2003
Last sequence update:	August 1, 1998
Last modified:	January 25, 2012
This is version 76 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program