Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

O67604

- RISA_AQUAE

UniProt

O67604 - RISA_AQUAE

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Riboflavin synthase

Gene

ribE

Organism
Aquifex aeolicus (strain VF5)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the dismutation of two molecules of 6,7-dimethyl-8-ribityllumazine, resulting in the formation of riboflavin and 5-amino-6-(D-ribitylamino)uracil.By similarity

Catalytic activityi

2 6,7-dimethyl-8-(1-D-ribityl)lumazine = riboflavin + 4-(1-D-ribitylamino)-5-amino-2,6-dihydroxypyrimidine.

Pathwayi

GO - Molecular functioni

  1. oxidoreductase activity Source: InterPro
  2. riboflavin synthase activity Source: UniProtKB-EC

GO - Biological processi

  1. riboflavin biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Riboflavin biosynthesis

Enzyme and pathway databases

BioCyciAAEO224324:GJBH-1221-MONOMER.
RETL1328306-WGS:GSTH-1526-MONOMER.
UniPathwayiUPA00275; UER00405.

Names & Taxonomyi

Protein namesi
Recommended name:
Riboflavin synthase (EC:2.5.1.9)
Short name:
RS
Gene namesi
Name:ribE
Synonyms:ribC
Ordered Locus Names:aq_1707
OrganismiAquifex aeolicus (strain VF5)
Taxonomic identifieri224324 [NCBI]
Taxonomic lineageiBacteriaAquificaeAquificalesAquificaceaeAquifex
ProteomesiUP000000798: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 207207Riboflavin synthasePRO_0000068157Add
BLAST

Interactioni

Subunit structurei

Homotrimer.By similarity

Protein-protein interaction databases

STRINGi224324.aq_1707.

Structurei

3D structure databases

ProteinModelPortaliO67604.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati1 – 9494Lumazine-binding 1Add
BLAST
Repeati95 – 19197Lumazine-binding 2Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni4 – 63Substrate bindingBy similarity
Regioni45 – 473Substrate bindingBy similarity
Regioni59 – 646Substrate bindingBy similarity

Sequence similaritiesi

Contains 2 lumazine-binding repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiCOG0307.
HOGENOMiHOG000151757.
InParanoidiO67604.
KOiK00793.
OMAiRIAFENS.
OrthoDBiEOG6VMTQH.

Family and domain databases

Gene3Di2.40.30.20. 2 hits.
InterProiIPR023366. ATPase_asu-like.
IPR001783. Lumazine-bd.
IPR026017. Lumazine-bd_dom.
IPR017938. Riboflavin_synthase-like_b-brl.
[Graphical view]
PANTHERiPTHR21098. PTHR21098. 1 hit.
PfamiPF00677. Lum_binding. 2 hits.
[Graphical view]
PIRSFiPIRSF000498. Riboflavin_syn_A. 1 hit.
SUPFAMiSSF63380. SSF63380. 2 hits.
TIGRFAMsiTIGR00187. ribE. 1 hit.
PROSITEiPS51177. LUMAZINE_BIND. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O67604-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MFTGLVEDLG KVKNLTLSSK GAKLSVETKL EDVKLGDSVS VNGACLTVVD
60 70 80 90 100
IKSSTLTFDV SPETLKRTNL GKLKTGDYVN LERALRVGER LGGHIVQGHV
110 120 130 140 150
DFTAPVKSFN FLGEHYELVI EIPEEWSIYV VEKGSIALDG ISLTVNYVKE
160 170 180 190 200
NKVFINIIPH TYKSTNLQFK KVGDLLNVET DILGKYVINY LNKLKKKEDI

FKEFLKW
Length:207
Mass (Da):23,196
Last modified:August 1, 1998 - v1
Checksum:i322A09FF7B15E432
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000657 Genomic DNA. Translation: AAC07572.1.
PIRiB70447.
RefSeqiNP_214170.1. NC_000918.1.
WP_010881107.1. NC_000918.1.

Genome annotation databases

EnsemblBacteriaiAAC07572; AAC07572; aq_1707.
GeneIDi1193319.
KEGGiaae:aq_1707.
PATRICi20960412. VBIAquAeo85532_1311.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000657 Genomic DNA. Translation: AAC07572.1 .
PIRi B70447.
RefSeqi NP_214170.1. NC_000918.1.
WP_010881107.1. NC_000918.1.

3D structure databases

ProteinModelPortali O67604.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 224324.aq_1707.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAC07572 ; AAC07572 ; aq_1707 .
GeneIDi 1193319.
KEGGi aae:aq_1707.
PATRICi 20960412. VBIAquAeo85532_1311.

Phylogenomic databases

eggNOGi COG0307.
HOGENOMi HOG000151757.
InParanoidi O67604.
KOi K00793.
OMAi RIAFENS.
OrthoDBi EOG6VMTQH.

Enzyme and pathway databases

UniPathwayi UPA00275 ; UER00405 .
BioCyci AAEO224324:GJBH-1221-MONOMER.
RETL1328306-WGS:GSTH-1526-MONOMER.

Family and domain databases

Gene3Di 2.40.30.20. 2 hits.
InterProi IPR023366. ATPase_asu-like.
IPR001783. Lumazine-bd.
IPR026017. Lumazine-bd_dom.
IPR017938. Riboflavin_synthase-like_b-brl.
[Graphical view ]
PANTHERi PTHR21098. PTHR21098. 1 hit.
Pfami PF00677. Lum_binding. 2 hits.
[Graphical view ]
PIRSFi PIRSF000498. Riboflavin_syn_A. 1 hit.
SUPFAMi SSF63380. SSF63380. 2 hits.
TIGRFAMsi TIGR00187. ribE. 1 hit.
PROSITEi PS51177. LUMAZINE_BIND. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: VF5.

Entry informationi

Entry nameiRISA_AQUAE
AccessioniPrimary (citable) accession number: O67604
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: August 1, 1998
Last modified: October 29, 2014
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3