Reviewed,
UniProtKB/Swiss-Prot O67604 (RISA_AQUAE)
Last modified
November 3, 2009.
Version 57.
History...
Clusters with 100%,
90%,
50% identity |
Documents (2) |
Third-party data |
Customize display | text xml rdf/xml gff fasta |
Names and origin
| Protein names | Recommended name: Riboflavin synthase alpha chain EC=2.5.1.9 | ||||||
| Gene names |
| ||||||
| Organism | Aquifex aeolicus [Complete proteome] [HAMAP] | ||||||
| Taxonomic identifier | 63363 [NCBI] | ||||||
| Taxonomic lineage | Bacteria › Aquificae › Aquificales › Aquificaceae › Aquifex |
Protein attributes
| Sequence length | 207 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Inferred from homology. |
General annotation (Comments)
| Function | Riboflavin synthase is a bifunctional enzyme complex catalyzing the formation of riboflavin from 5-amino-6-(1'-D)-ribityl-amino-2,4(1H,3H)-pyrimidinedione and L-3,4-dihydrohy-2-butanone-4-phosphate via 6,7-dimethyl-8-lumazine. The alpha subunit catalyzes the dismutation of 6,7-dimethyl-8-lumazine to riboflavin and 5-amino-6-(1'-D)-ribityl-amino-2,4(1H,3H)-pyrimidinedione By similarity. |
| Catalytic activity | 2 6,7-dimethyl-8-(1-D-ribityl)lumazine = riboflavin + 4-(1-D-ribitylamino)-5-amino-2,6-dihydroxypyrimidine. |
| Pathway | |
| Subunit structure | Oligomer that consist of 3 alpha subunits and 60 beta subunits By similarity. |
| Sequence similarities | Contains 2 lumazine-binding repeats. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Riboflavin biosynthesis |
| Domain | Repeat |
| Molecular function | Transferase |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | riboflavin biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW |
| Molecular function | riboflavin synthase activity Inferred from electronic annotation. Source: EC |
| Complete GO annotation... | |
Sequence annotation (Features)
Sequences
| ||||||||||||||||||
References
| [1] | "The complete genome of the hyperthermophilic bacterium Aquifex aeolicus." Deckert G., Warren P.V., Gaasterland T., Young W.G., Lenox A.L., Graham D.E., Overbeek R., Snead M.A., Keller M., Aujay M., Huber R., Feldman R.A., Short J.M., Olsen G.J., Swanson R.V. Nature 392:353-358(1998) [PubMed: 9537320] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: VF5. |
Cross-references
Sequence databases | |
|---|---|
| AE000657 Genomic DNA. Translation: AAC07572.1. | |
| PIR | B70447. |
| RefSeq | NP_214170.1. |
3D structure databases | |
| HSSP | HSSP built from PDB template 1KZL based on UniProtKB Q9Y7P0. |
| ModBase | Search... |
Genome annotation databases | |
| GeneID | 1193319. |
| GenomeReviews | Gene locus aq_1707 in contig AE000657_GR. |
| KEGG | aae:aq_1707. |
| NMPDR | fig|224324.1.peg.1185. |
Organism-specific databases | |
| CMR | Search... |
Phylogenomic databases | |
| HOGENOM | O67604. |
| OMA | GDRLGGH. |
Enzyme and pathway databases | |
| BioCyc | AAEO224324:AQ_1707-MON. |
| BRENDA | 2.5.1.9. 189781. |
Family and domain databases | |
| InterPro | IPR001783. Lumazine_bd. [Graphical view] |
| PANTHER | PTHR21098. Lumazine_bd. 1 hit. |
| Pfam | PF00677. Lum_binding. 2 hits. [Graphical view] |
| PIRSF | PIRSF000498. Riboflavin_syn_A. 1 hit. |
| ProDom | PD004110. Lum_binding. 2 hits. [Graphical view] [Entries sharing at least one domain] |
| TIGRFAMs | TIGR00187. ribE. 1 hit. |
| PROSITE | PS51177. LUMAZINE_BIND. 2 hits. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | RISA_AQUAE | ||||||||
| Accession | Primary (citable) accession number: O67604 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes) | ||||||||
Relevant documents
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

Clusters with


