O67604 (RISA_AQUAE) Reviewed, UniProtKB/Swiss-Prot
Last modified
January 25, 2012.
Version 71.
History...
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Riboflavin synthase alpha chain EC=2.5.1.9 | ||||||
| Gene names |
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| Organism | Aquifex aeolicus (strain VF5) | ||||||
| Taxonomic identifier | 224324 [NCBI] | ||||||
| Taxonomic lineage | Bacteria › Aquificae › Aquificales › Aquificaceae › Aquifex |
Protein attributes
| Sequence length | 207 AA. |
| Sequence status | Complete. |
| Protein existence | Inferred from homology |
General annotation (Comments)
| Function | Riboflavin synthase is a bifunctional enzyme complex catalyzing the formation of riboflavin from 5-amino-6-(1'-D)-ribityl-amino-2,4(1H,3H)-pyrimidinedione and L-3,4-dihydrohy-2-butanone-4-phosphate via 6,7-dimethyl-8-lumazine. The alpha subunit catalyzes the dismutation of 6,7-dimethyl-8-lumazine to riboflavin and 5-amino-6-(1'-D)-ribityl-amino-2,4(1H,3H)-pyrimidinedione By similarity. |
| Catalytic activity | 2 6,7-dimethyl-8-(1-D-ribityl)lumazine = riboflavin + 4-(1-D-ribitylamino)-5-amino-2,6-dihydroxypyrimidine. |
| Pathway | |
| Subunit structure | Oligomer that consist of 3 alpha subunits and 60 beta subunits By similarity. |
| Sequence similarities | Contains 2 lumazine-binding repeats. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Riboflavin biosynthesis |
| Domain | Repeat |
| Molecular function | Transferase |
| Technical term | Complete proteome Reference proteome |
| Gene Ontology (GO) | |
| Biological process | riboflavin biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW |
| Molecular function | oxidoreductase activity Inferred from electronic annotation. Source: InterPro riboflavin synthase activityInferred from electronic annotation. Source: EC |
| Complete GO annotation... | |
Sequence annotation (Features)
Sequences
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References
| [1] | "The complete genome of the hyperthermophilic bacterium Aquifex aeolicus." Deckert G., Warren P.V., Gaasterland T., Young W.G., Lenox A.L., Graham D.E., Overbeek R., Snead M.A., Keller M., Aujay M., Huber R., Feldman R.A., Short J.M., Olsen G.J., Swanson R.V. Nature 392:353-358(1998) [PubMed: 9537320] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: VF5. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | AE000657 Genomic DNA. Translation: AAC07572.1. |
| PIR | B70447. |
| RefSeq | NP_214170.1. NC_000918.1. |
3D structure databases | |
| ProteinModelPortal | O67604. |
| ModBase | Search... |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| GeneID | 1193319. |
| GenomeReviews | Gene locus aq_1707 in contig AE000657_GR. |
| KEGG | aae:aq_1707. |
| NMPDR | fig|224324.1.peg.1185. |
| PATRIC | 20960412. VBIAquAeo85532_1311. |
Phylogenomic databases | |
| HOGENOM | HBG289809. |
| OMA | PVNLEVD. |
| PhylomeDB | O67604. |
| ProtClustDB | PRK09289. |
Enzyme and pathway databases | |
| BioCyc | AAEO224324:AQ_1707-MONOMER. |
Family and domain databases | |
| InterPro | IPR023366. ATPase_F1/A1-cplx_a_su_N. IPR001783. Lumazine-bd. IPR017938. Riboflavin_synthase-like_b-brl. [Graphical view] |
| Gene3D | G3DSA:2.40.30.20. G3DSA:2.40.30.20. 2 hits. |
| KO | K00793. |
| PANTHER | PTHR21098. Lumazine_bd. 1 hit. |
| Pfam | PF00677. Lum_binding. 2 hits. [Graphical view] |
| PIRSF | PIRSF000498. Riboflavin_syn_A. 1 hit. |
| SUPFAM | SSF63380. Riboflavin_synthase_like_b-brl. 2 hits. |
| TIGRFAMs | TIGR00187. RibE. 1 hit. |
| PROSITE | PS51177. LUMAZINE_BIND. 2 hits. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | RISA_AQUAE | ||||||||
| Accession | Primary (citable) accession number: O67604 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Prokaryotic Protein Annotation Program | ||||||||
Relevant documents
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

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