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O67604

- RISA_AQUAE

UniProt

O67604 - RISA_AQUAE

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Protein

Riboflavin synthase

Gene
ribE, ribC, aq_1707
Organism
Aquifex aeolicus (strain VF5)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the dismutation of two molecules of 6,7-dimethyl-8-ribityllumazine, resulting in the formation of riboflavin and 5-amino-6-(D-ribitylamino)uracil By similarity.

Catalytic activityi

2 6,7-dimethyl-8-(1-D-ribityl)lumazine = riboflavin + 4-(1-D-ribitylamino)-5-amino-2,6-dihydroxypyrimidine.

Pathwayi

GO - Molecular functioni

  1. oxidoreductase activity Source: InterPro
  2. riboflavin synthase activity Source: UniProtKB-EC

GO - Biological processi

  1. riboflavin biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Riboflavin biosynthesis

Enzyme and pathway databases

BioCyciAAEO224324:GJBH-1221-MONOMER.
RETL1328306-WGS:GSTH-1526-MONOMER.
UniPathwayiUPA00275; UER00405.

Names & Taxonomyi

Protein namesi
Recommended name:
Riboflavin synthase (EC:2.5.1.9)
Short name:
RS
Gene namesi
Name:ribE
Synonyms:ribC
Ordered Locus Names:aq_1707
OrganismiAquifex aeolicus (strain VF5)
Taxonomic identifieri224324 [NCBI]
Taxonomic lineageiBacteriaAquificaeAquificalesAquificaceaeAquifex
ProteomesiUP000000798: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 207207Riboflavin synthasePRO_0000068157Add
BLAST

Interactioni

Subunit structurei

Homotrimer By similarity.

Protein-protein interaction databases

STRINGi224324.aq_1707.

Structurei

3D structure databases

ProteinModelPortaliO67604.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati1 – 9494Lumazine-binding 1Add
BLAST
Repeati95 – 19197Lumazine-binding 2Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni4 – 63Substrate binding By similarity
Regioni45 – 473Substrate binding By similarity
Regioni59 – 646Substrate binding By similarity

Sequence similaritiesi

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiCOG0307.
HOGENOMiHOG000151757.
KOiK00793.
OMAiRIAFENS.
OrthoDBiEOG6VMTQH.

Family and domain databases

Gene3Di2.40.30.20. 2 hits.
InterProiIPR023366. ATPase_asu-like.
IPR001783. Lumazine-bd.
IPR026017. Lumazine-bd_dom.
IPR017938. Riboflavin_synthase-like_b-brl.
[Graphical view]
PANTHERiPTHR21098. PTHR21098. 1 hit.
PfamiPF00677. Lum_binding. 2 hits.
[Graphical view]
PIRSFiPIRSF000498. Riboflavin_syn_A. 1 hit.
SUPFAMiSSF63380. SSF63380. 2 hits.
TIGRFAMsiTIGR00187. ribE. 1 hit.
PROSITEiPS51177. LUMAZINE_BIND. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O67604-1 [UniParc]FASTAAdd to Basket

« Hide

MFTGLVEDLG KVKNLTLSSK GAKLSVETKL EDVKLGDSVS VNGACLTVVD    50
IKSSTLTFDV SPETLKRTNL GKLKTGDYVN LERALRVGER LGGHIVQGHV 100
DFTAPVKSFN FLGEHYELVI EIPEEWSIYV VEKGSIALDG ISLTVNYVKE 150
NKVFINIIPH TYKSTNLQFK KVGDLLNVET DILGKYVINY LNKLKKKEDI 200
FKEFLKW 207
Length:207
Mass (Da):23,196
Last modified:August 1, 1998 - v1
Checksum:i322A09FF7B15E432
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE000657 Genomic DNA. Translation: AAC07572.1.
PIRiB70447.
RefSeqiNP_214170.1. NC_000918.1.

Genome annotation databases

EnsemblBacteriaiAAC07572; AAC07572; aq_1707.
GeneIDi1193319.
KEGGiaae:aq_1707.
PATRICi20960412. VBIAquAeo85532_1311.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE000657 Genomic DNA. Translation: AAC07572.1 .
PIRi B70447.
RefSeqi NP_214170.1. NC_000918.1.

3D structure databases

ProteinModelPortali O67604.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 224324.aq_1707.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAC07572 ; AAC07572 ; aq_1707 .
GeneIDi 1193319.
KEGGi aae:aq_1707.
PATRICi 20960412. VBIAquAeo85532_1311.

Phylogenomic databases

eggNOGi COG0307.
HOGENOMi HOG000151757.
KOi K00793.
OMAi RIAFENS.
OrthoDBi EOG6VMTQH.

Enzyme and pathway databases

UniPathwayi UPA00275 ; UER00405 .
BioCyci AAEO224324:GJBH-1221-MONOMER.
RETL1328306-WGS:GSTH-1526-MONOMER.

Family and domain databases

Gene3Di 2.40.30.20. 2 hits.
InterProi IPR023366. ATPase_asu-like.
IPR001783. Lumazine-bd.
IPR026017. Lumazine-bd_dom.
IPR017938. Riboflavin_synthase-like_b-brl.
[Graphical view ]
PANTHERi PTHR21098. PTHR21098. 1 hit.
Pfami PF00677. Lum_binding. 2 hits.
[Graphical view ]
PIRSFi PIRSF000498. Riboflavin_syn_A. 1 hit.
SUPFAMi SSF63380. SSF63380. 2 hits.
TIGRFAMsi TIGR00187. ribE. 1 hit.
PROSITEi PS51177. LUMAZINE_BIND. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: VF5.

Entry informationi

Entry nameiRISA_AQUAE
AccessioniPrimary (citable) accession number: O67604
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: August 1, 1998
Last modified: July 9, 2014
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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