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Protein

Threonine--tRNA ligase

Gene

thrS

Organism
Aquifex aeolicus (strain VF5)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-threonine + tRNA(Thr) = AMP + diphosphate + L-threonyl-tRNA(Thr).

Cofactori

Zn2+By similarityNote: Binds 1 zinc ion per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi336Zinc; catalyticBy similarity1
Metal bindingi387Zinc; catalyticBy similarity1
Metal bindingi513Zinc; catalyticBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Metal-binding, Nucleotide-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Threonine--tRNA ligase (EC:6.1.1.3)
Alternative name(s):
Threonyl-tRNA synthetase
Short name:
ThrRS
Gene namesi
Name:thrS
Ordered Locus Names:aq_1667
OrganismiAquifex aeolicus (strain VF5)
Taxonomic identifieri224324 [NCBI]
Taxonomic lineageiBacteriaAquificaeAquificalesAquificaceaeAquifex
Proteomesi
  • UP000000798 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001009331 – 638Threonine--tRNA ligaseAdd BLAST638

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi224324.aq_1667.

Structurei

3D structure databases

ProteinModelPortaliO67583.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni243 – 536CatalyticAdd BLAST294

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4105C22. Bacteria.
COG0441. LUCA.
HOGENOMiHOG000003880.
InParanoidiO67583.
KOiK01868.
OMAiFYYDFAY.
OrthoDBiPOG091H01SS.

Family and domain databases

CDDicd00771. ThrRS_core. 1 hit.
Gene3Di3.40.50.800. 1 hit.
HAMAPiMF_00184. Thr_tRNA_synth. 1 hit.
InterProiIPR002314. aa-tRNA-synt_IIb.
IPR006195. aa-tRNA-synth_II.
IPR004154. Anticodon-bd.
IPR002320. Thr-tRNA-ligase_IIa.
IPR018163. Thr/Ala-tRNA-synth_IIc_edit.
IPR033728. ThrRS_core.
IPR012947. tRNA_SAD.
[Graphical view]
PfamiPF03129. HGTP_anticodon. 1 hit.
PF00587. tRNA-synt_2b. 1 hit.
PF07973. tRNA_SAD. 1 hit.
[Graphical view]
PRINTSiPR01047. TRNASYNTHTHR.
SMARTiSM00863. tRNA_SAD. 1 hit.
[Graphical view]
SUPFAMiSSF52954. SSF52954. 1 hit.
SSF55186. SSF55186. 1 hit.
TIGRFAMsiTIGR00418. thrS. 1 hit.
PROSITEiPS50862. AA_TRNA_LIGASE_II. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O67583-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEKIKVKIKG KEYEVEKGTP LGKIFELAGI KDALGGVING KIIDLQTPVR
60 70 80 90 100
ESGEIKPVYR GSKESLEIMR HSLAHIMAQA LKELYGAKKV HLGVGPTTEE
110 120 130 140 150
GFYYDVEVEG HKITEEDLPK IEQKMKEIIE RDYPILRREL SREEAIKLFD
160 170 180 190 200
KLKEKYKIDI IKEIPEEEVI SVYEQGDFID LCKGPHLPST GKAGAFKLTS
210 220 230 240 250
ISGAYWKGRS DQPQLTRIYG IAYWSDKEVK ERLKFYEEVK KRDHRRLGKE
260 270 280 290 300
LEFFTIDDNV GAGLILWLPR GAIYRKVLED YLREEHLKRG YQLVYTPHVG
310 320 330 340 350
KSKLWETSGH LECYKQNMFP SMKIDEEEYY VKPMNCPFHI AIYKSRTRSY
360 370 380 390 400
KELPLKLFEL GTVYRYELSG VLHGLLRVRG FTQDDAHIVC TPEQVNDVIR
410 420 430 440 450
ETLDFALSTL KDFGFNEFKI YLSTRPEYSI GSDEQWEVSQ NALKKAIEDL
460 470 480 490 500
GYEYEIDEGG GAFYGPKIDV KIRDAIGRMW QLSTIQFDFN LPERFDMTYV
510 520 530 540 550
GPDNKKHRPY MIHRALLGSI ERFTGILLEH YAGLLPIWLS PTQVMIIPIA
560 570 580 590 600
DRHHEYAKKV YEFLKENGIR AEMDLREERM NAKIRDAELK KIPVILVVGD
610 620 630
REAQNNTVSV RTKKEGNLGS MELNKFLDWI KEKIKNKE
Length:638
Mass (Da):74,097
Last modified:August 1, 1998 - v1
Checksum:i5ECBA8227C047955
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000657 Genomic DNA. Translation: AAC07549.1.
PIRiF70444.
RefSeqiNP_214149.1. NC_000918.1.
WP_010881086.1. NC_000918.1.

Genome annotation databases

EnsemblBacteriaiAAC07549; AAC07549; aq_1667.
GeneIDi1193299.
KEGGiaae:aq_1667.
PATRICi20960356. VBIAquAeo85532_1290.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000657 Genomic DNA. Translation: AAC07549.1.
PIRiF70444.
RefSeqiNP_214149.1. NC_000918.1.
WP_010881086.1. NC_000918.1.

3D structure databases

ProteinModelPortaliO67583.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi224324.aq_1667.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC07549; AAC07549; aq_1667.
GeneIDi1193299.
KEGGiaae:aq_1667.
PATRICi20960356. VBIAquAeo85532_1290.

Phylogenomic databases

eggNOGiENOG4105C22. Bacteria.
COG0441. LUCA.
HOGENOMiHOG000003880.
InParanoidiO67583.
KOiK01868.
OMAiFYYDFAY.
OrthoDBiPOG091H01SS.

Family and domain databases

CDDicd00771. ThrRS_core. 1 hit.
Gene3Di3.40.50.800. 1 hit.
HAMAPiMF_00184. Thr_tRNA_synth. 1 hit.
InterProiIPR002314. aa-tRNA-synt_IIb.
IPR006195. aa-tRNA-synth_II.
IPR004154. Anticodon-bd.
IPR002320. Thr-tRNA-ligase_IIa.
IPR018163. Thr/Ala-tRNA-synth_IIc_edit.
IPR033728. ThrRS_core.
IPR012947. tRNA_SAD.
[Graphical view]
PfamiPF03129. HGTP_anticodon. 1 hit.
PF00587. tRNA-synt_2b. 1 hit.
PF07973. tRNA_SAD. 1 hit.
[Graphical view]
PRINTSiPR01047. TRNASYNTHTHR.
SMARTiSM00863. tRNA_SAD. 1 hit.
[Graphical view]
SUPFAMiSSF52954. SSF52954. 1 hit.
SSF55186. SSF55186. 1 hit.
TIGRFAMsiTIGR00418. thrS. 1 hit.
PROSITEiPS50862. AA_TRNA_LIGASE_II. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSYT_AQUAE
AccessioniPrimary (citable) accession number: O67583
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: August 1, 1998
Last modified: November 2, 2016
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.