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O67581

- MDH2_AQUAE

UniProt

O67581 - MDH2_AQUAE

Protein

Malate dehydrogenase 2

Gene

mdh2

Organism
Aquifex aeolicus (strain VF5)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 89 (01 Oct 2014)
      Sequence version 1 (01 Aug 1998)
      Previous versions | rss
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    Functioni

    Catalyzes the reversible oxidation of malate to oxaloacetate.UniRule annotation

    Catalytic activityi

    (S)-malate + NAD+ = oxaloacetate + NADH.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei100 – 1001SubstrateUniRule annotation
    Binding sitei106 – 1061SubstrateUniRule annotation
    Binding sitei113 – 1131NADUniRule annotation
    Binding sitei138 – 1381SubstrateUniRule annotation
    Binding sitei169 – 1691SubstrateUniRule annotation
    Active sitei193 – 1931Proton acceptorUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi20 – 256NADUniRule annotation
    Nucleotide bindingi136 – 1383NADUniRule annotation

    GO - Molecular functioni

    1. L-malate dehydrogenase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. cellular carbohydrate metabolic process Source: InterPro
    2. malate metabolic process Source: InterPro
    3. tricarboxylic acid cycle Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Tricarboxylic acid cycle

    Keywords - Ligandi

    NAD

    Enzyme and pathway databases

    BioCyciAAEO224324:GJBH-1191-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Malate dehydrogenase 2UniRule annotation (EC:1.1.1.37UniRule annotation)
    Gene namesi
    Name:mdh2UniRule annotation
    Ordered Locus Names:aq_1665
    OrganismiAquifex aeolicus (strain VF5)
    Taxonomic identifieri224324 [NCBI]
    Taxonomic lineageiBacteriaAquificaeAquificalesAquificaceaeAquifex
    ProteomesiUP000000798: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 334334Malate dehydrogenase 2PRO_0000113423Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi224324.aq_1665.

    Structurei

    3D structure databases

    ProteinModelPortaliO67581.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the LDH/MDH superfamily. MDH type 3 family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0039.
    HOGENOMiHOG000213794.
    KOiK00024.
    OMAiYGVAMML.
    OrthoDBiEOG6091FG.

    Family and domain databases

    Gene3Di3.40.50.720. 1 hit.
    3.90.110.10. 1 hit.
    HAMAPiMF_00487. Malate_dehydrog_3.
    InterProiIPR001557. L-lactate/malate_DH.
    IPR022383. Lactate/malate_DH_C.
    IPR001236. Lactate/malate_DH_N.
    IPR015955. Lactate_DH/Glyco_Ohase_4_C.
    IPR011275. Malate_DH_type3.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view]
    PANTHERiPTHR11540. PTHR11540. 1 hit.
    PfamiPF02866. Ldh_1_C. 1 hit.
    PF00056. Ldh_1_N. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000102. Lac_mal_DH. 1 hit.
    PRINTSiPR00086. LLDHDRGNASE.
    SUPFAMiSSF56327. SSF56327. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    O67581-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKGKLINSFL MKKPKISVIG AGKVGENVAY LLTILGLGDV YLFARYKKGL    50
    EPAKAKALDL KQMAVLMDID INVKGISYDK EGFEELKGSD IVVITAGIPR 100
    REGMSREDLL YENLKILKKF TDAIKEYAKD SIIIVVSNPV DTLTYATIKL 150
    TGFEPRRVIG MAGVLDSARF KNFVKEKIGI SNADIRTLVL GTHGDLMVPV 200
    TSHSFIGDKP IEEVFSASEI DELIEKTRKG GAQIVSLMGT SAYYAPAASV 250
    VIMVESIIND RKRVMPCSVY VEGEAAKHYE IEGVCIGLPV VLGKKGVEDF 300
    ELVNLSGYEK RELLRSAKTL KEMVSLADKL LNEL 334
    Length:334
    Mass (Da):36,698
    Last modified:August 1, 1998 - v1
    Checksum:i18E64807D16B7C96
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE000657 Genomic DNA. Translation: AAC07547.1.
    PIRiD70444.
    RefSeqiNP_214147.1. NC_000918.1.

    Genome annotation databases

    EnsemblBacteriaiAAC07547; AAC07547; aq_1665.
    GeneIDi1193297.
    KEGGiaae:aq_1665.
    PATRICi20960352. VBIAquAeo85532_1288.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE000657 Genomic DNA. Translation: AAC07547.1 .
    PIRi D70444.
    RefSeqi NP_214147.1. NC_000918.1.

    3D structure databases

    ProteinModelPortali O67581.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 224324.aq_1665.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAC07547 ; AAC07547 ; aq_1665 .
    GeneIDi 1193297.
    KEGGi aae:aq_1665.
    PATRICi 20960352. VBIAquAeo85532_1288.

    Phylogenomic databases

    eggNOGi COG0039.
    HOGENOMi HOG000213794.
    KOi K00024.
    OMAi YGVAMML.
    OrthoDBi EOG6091FG.

    Enzyme and pathway databases

    BioCyci AAEO224324:GJBH-1191-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.720. 1 hit.
    3.90.110.10. 1 hit.
    HAMAPi MF_00487. Malate_dehydrog_3.
    InterProi IPR001557. L-lactate/malate_DH.
    IPR022383. Lactate/malate_DH_C.
    IPR001236. Lactate/malate_DH_N.
    IPR015955. Lactate_DH/Glyco_Ohase_4_C.
    IPR011275. Malate_DH_type3.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view ]
    PANTHERi PTHR11540. PTHR11540. 1 hit.
    Pfami PF02866. Ldh_1_C. 1 hit.
    PF00056. Ldh_1_N. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000102. Lac_mal_DH. 1 hit.
    PRINTSi PR00086. LLDHDRGNASE.
    SUPFAMi SSF56327. SSF56327. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: VF5.

    Entry informationi

    Entry nameiMDH2_AQUAE
    AccessioniPrimary (citable) accession number: O67581
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 16, 2004
    Last sequence update: August 1, 1998
    Last modified: October 1, 2014
    This is version 89 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3