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O67581

- MDH2_AQUAE

UniProt

O67581 - MDH2_AQUAE

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Protein

Malate dehydrogenase 2

Gene
mdh2, aq_1665
Organism
Aquifex aeolicus (strain VF5)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the reversible oxidation of malate to oxaloacetate By similarity.UniRule annotation

Catalytic activityi

(S)-malate + NAD+ = oxaloacetate + NADH.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei100 – 1001Substrate By similarity
Binding sitei106 – 1061Substrate By similarity
Binding sitei113 – 1131NAD By similarity
Binding sitei138 – 1381Substrate By similarity
Binding sitei169 – 1691Substrate By similarity
Active sitei193 – 1931Proton acceptor By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi20 – 256NAD By similarity
Nucleotide bindingi136 – 1383NAD By similarity

GO - Molecular functioni

  1. L-malate dehydrogenase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. cellular carbohydrate metabolic process Source: InterPro
  2. malate metabolic process Source: InterPro
  3. tricarboxylic acid cycle Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Tricarboxylic acid cycle

Keywords - Ligandi

NAD

Enzyme and pathway databases

BioCyciAAEO224324:GJBH-1191-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Malate dehydrogenase 2 (EC:1.1.1.37)
Gene namesi
Name:mdh2
Ordered Locus Names:aq_1665
OrganismiAquifex aeolicus (strain VF5)
Taxonomic identifieri224324 [NCBI]
Taxonomic lineageiBacteriaAquificaeAquificalesAquificaceaeAquifex
ProteomesiUP000000798: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 334334Malate dehydrogenase 2UniRule annotationPRO_0000113423Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi224324.aq_1665.

Structurei

3D structure databases

ProteinModelPortaliO67581.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0039.
HOGENOMiHOG000213794.
KOiK00024.
OMAiYGVAMML.
OrthoDBiEOG6091FG.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
3.90.110.10. 1 hit.
HAMAPiMF_00487. Malate_dehydrog_3.
InterProiIPR001557. L-lactate/malate_DH.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR011275. Malate_DH_type3.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR11540. PTHR11540. 1 hit.
PfamiPF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000102. Lac_mal_DH. 1 hit.
PRINTSiPR00086. LLDHDRGNASE.
SUPFAMiSSF56327. SSF56327. 1 hit.

Sequencei

Sequence statusi: Complete.

O67581-1 [UniParc]FASTAAdd to Basket

« Hide

MKGKLINSFL MKKPKISVIG AGKVGENVAY LLTILGLGDV YLFARYKKGL    50
EPAKAKALDL KQMAVLMDID INVKGISYDK EGFEELKGSD IVVITAGIPR 100
REGMSREDLL YENLKILKKF TDAIKEYAKD SIIIVVSNPV DTLTYATIKL 150
TGFEPRRVIG MAGVLDSARF KNFVKEKIGI SNADIRTLVL GTHGDLMVPV 200
TSHSFIGDKP IEEVFSASEI DELIEKTRKG GAQIVSLMGT SAYYAPAASV 250
VIMVESIIND RKRVMPCSVY VEGEAAKHYE IEGVCIGLPV VLGKKGVEDF 300
ELVNLSGYEK RELLRSAKTL KEMVSLADKL LNEL 334
Length:334
Mass (Da):36,698
Last modified:August 1, 1998 - v1
Checksum:i18E64807D16B7C96
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE000657 Genomic DNA. Translation: AAC07547.1.
PIRiD70444.
RefSeqiNP_214147.1. NC_000918.1.

Genome annotation databases

EnsemblBacteriaiAAC07547; AAC07547; aq_1665.
GeneIDi1193297.
KEGGiaae:aq_1665.
PATRICi20960352. VBIAquAeo85532_1288.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE000657 Genomic DNA. Translation: AAC07547.1 .
PIRi D70444.
RefSeqi NP_214147.1. NC_000918.1.

3D structure databases

ProteinModelPortali O67581.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 224324.aq_1665.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAC07547 ; AAC07547 ; aq_1665 .
GeneIDi 1193297.
KEGGi aae:aq_1665.
PATRICi 20960352. VBIAquAeo85532_1288.

Phylogenomic databases

eggNOGi COG0039.
HOGENOMi HOG000213794.
KOi K00024.
OMAi YGVAMML.
OrthoDBi EOG6091FG.

Enzyme and pathway databases

BioCyci AAEO224324:GJBH-1191-MONOMER.

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
3.90.110.10. 1 hit.
HAMAPi MF_00487. Malate_dehydrog_3.
InterProi IPR001557. L-lactate/malate_DH.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR011275. Malate_DH_type3.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
PANTHERi PTHR11540. PTHR11540. 1 hit.
Pfami PF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF000102. Lac_mal_DH. 1 hit.
PRINTSi PR00086. LLDHDRGNASE.
SUPFAMi SSF56327. SSF56327. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: VF5.

Entry informationi

Entry nameiMDH2_AQUAE
AccessioniPrimary (citable) accession number: O67581
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: August 1, 1998
Last modified: May 14, 2014
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3