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Protein

Malate dehydrogenase 2

Gene

mdh2

Organism
Aquifex aeolicus (strain VF5)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the reversible oxidation of malate to oxaloacetate.By similarity

Catalytic activityi

(S)-malate + NAD+ = oxaloacetate + NADH.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei100SubstrateBy similarity1
Binding sitei106SubstrateBy similarity1
Binding sitei113NADBy similarity1
Binding sitei138SubstrateBy similarity1
Binding sitei169SubstrateBy similarity1
Active sitei193Proton acceptorBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi19 – 25NADBy similarity7
Nucleotide bindingi136 – 138NADBy similarity3

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processTricarboxylic acid cycle
LigandNAD

Names & Taxonomyi

Protein namesi
Recommended name:
Malate dehydrogenase 2By similarity (EC:1.1.1.37By similarity)
Gene namesi
Name:mdh2By similarity
Ordered Locus Names:aq_1665
OrganismiAquifex aeolicus (strain VF5)
Taxonomic identifieri224324 [NCBI]
Taxonomic lineageiBacteriaAquificaeAquificalesAquificaceaeAquifex
Proteomesi
  • UP000000798 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001134231 – 334Malate dehydrogenase 2Add BLAST334

Proteomic databases

PRIDEiO67581.

Interactioni

Protein-protein interaction databases

STRINGi224324.aq_1665.

Structurei

3D structure databases

ProteinModelPortaliO67581.
SMRiO67581.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the LDH/MDH superfamily.Curated

Phylogenomic databases

eggNOGiENOG4105C80. Bacteria.
COG0039. LUCA.
HOGENOMiHOG000213794.
InParanoidiO67581.
KOiK00024.
OrthoDBiPOG091H02EQ.

Family and domain databases

CDDicd01339. LDH-like_MDH. 1 hit.
Gene3Di3.90.110.10. 1 hit.
InterProiView protein in InterPro
IPR001557. L-lactate/malate_DH.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR011275. Malate_DH_type3.
IPR036291. NAD(P)-bd_dom_sf.
PfamiView protein in Pfam
PF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
PIRSFiPIRSF000102. Lac_mal_DH. 1 hit.
PRINTSiPR00086. LLDHDRGNASE.
SUPFAMiSSF51735. SSF51735. 1 hit.
SSF56327. SSF56327. 1 hit.

Sequencei

Sequence statusi: Complete.

O67581-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKGKLINSFL MKKPKISVIG AGKVGENVAY LLTILGLGDV YLFARYKKGL
60 70 80 90 100
EPAKAKALDL KQMAVLMDID INVKGISYDK EGFEELKGSD IVVITAGIPR
110 120 130 140 150
REGMSREDLL YENLKILKKF TDAIKEYAKD SIIIVVSNPV DTLTYATIKL
160 170 180 190 200
TGFEPRRVIG MAGVLDSARF KNFVKEKIGI SNADIRTLVL GTHGDLMVPV
210 220 230 240 250
TSHSFIGDKP IEEVFSASEI DELIEKTRKG GAQIVSLMGT SAYYAPAASV
260 270 280 290 300
VIMVESIIND RKRVMPCSVY VEGEAAKHYE IEGVCIGLPV VLGKKGVEDF
310 320 330
ELVNLSGYEK RELLRSAKTL KEMVSLADKL LNEL
Length:334
Mass (Da):36,698
Last modified:August 1, 1998 - v1
Checksum:i18E64807D16B7C96
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000657 Genomic DNA. Translation: AAC07547.1.
PIRiD70444.
RefSeqiNP_214147.1. NC_000918.1.
WP_010881084.1. NC_000918.1.

Genome annotation databases

EnsemblBacteriaiAAC07547; AAC07547; aq_1665.
GeneIDi1193297.
KEGGiaae:aq_1665.
PATRICifig|224324.8.peg.1288.

Entry informationi

Entry nameiMDH2_AQUAE
AccessioniPrimary (citable) accession number: O67581
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: August 1, 1998
Last modified: October 25, 2017
This is version 108 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families