Reviewed, UniProtKB/Swiss-Prot O67539 (DCD_AQUAE)

Names and origin

Protein names

Recommended name:
    Deoxycytidine triphosphate deaminase
      Short name=dCTP deaminase
    EC=3.5.4.13

Gene names

Name:	dcd
Ordered Locus Names:	aq_1607

Organism

Aquifex aeolicus [Complete proteome] [HAMAP]

Taxonomic identifier

63363 [NCBI]

Taxonomic lineage

Bacteria › Aquificae › Aquificales › Aquificaceae › Aquifex

Protein attributes

Sequence length	180 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	dCTP + H2O = dUTP + NH3. HAMAP MF_00146
Pathway	Pyrimidine metabolism; dUMP biosynthesis; dUMP from dCTP (dUTP route): step 1/2. HAMAP MF_00146
Sequence similarities	Belongs to the dCTP deaminase family.

Ontologies

Keywords
Biological process	Nucleotide metabolism
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	dUTP biosynthetic process Inferred from electronic annotation. Source: InterPro pyrimidine ribonucleotide biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular function	dCTP deaminase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 180	180	Deoxycytidine triphosphate deaminase HAMAP MF_00146		PRO_0000155963

Sequences

	Sequence		Length	Mass (Da)
	O67539-1 [UniParc]. Last modified August 1, 1998. Version 1. Checksum: B2710421A2FA48D6	FASTA	180	20,545
	10 20 30 40 50 60 MILSDRSIRE LIEKGELKVE PYEPSHVQCS SLDLRLGNQI ALYEGEGVID VKKGTKGVRI 70 80 90 100 110 120 LEFEEYFDIM PKQFLLATTL EYISLPPYVT AFVEGRSSLG RLGLFIENAG WVDAGFEGQI 130 140 150 160 170 180 TLELFNANDR PIRLYRGMRI CQLVFARLDR PPERVYSGKY KGQKGVVPSR IHMDEELKSE

References

[1]

"The complete genome of the hyperthermophilic bacterium Aquifex aeolicus." Deckert G., Warren P.V., Gaasterland T., Young W.G., Lenox A.L., Graham D.E., Overbeek R., Snead M.A., Keller M., Aujay M., Huber R., Feldman R.A., Short J.M., Olsen G.J., Swanson R.V. Nature 392:353-358(1998) [PubMed: 9537320] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: VF5.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE000657 Genomic DNA. Translation: AAC07499.1.
PIR	A70439.
RefSeq	NP_214104.1.
3D structure databases
HSSP	HSSP built from PDB template 1OGH based on UniProtKB Q57872.
ModBase	Search...
Genome annotation databases
GeneID	1193162.
GenomeReviews	Gene locus aq_1607 in contig AE000657_GR.
KEGG	aae:aq_1607.
NMPDR	fig|224324.1.peg.1119.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	O67539.
OMA	ITLEIVA.
Enzyme and pathway databases
BioCyc	AAEO224324:AQ_1607-MON.
BRENDA	3.5.4.13. 189781.
Family and domain databases
HAMAP	MF_00146. [Tree]
InterPro	IPR011962. dCTP_deam. IPR008180. DeoxyUTP_pyroPase_dom. [Graphical view]
Pfam	PF00692. dUTPase. 1 hit. [Graphical view]
ProDom	PD004900. dCTP_deaminase. 1 hit. [Graphical view] [Entries sharing at least one domain]
TIGRFAMs	TIGR02274. dCTP_deam. 1 hit.
ProtoNet	Search...

Entry information

Entry name

DCD_AQUAE

Accession

Primary (citable) accession number: O67539

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 1, 2000
Last sequence update:	August 1, 1998
Last modified:	November 3, 2009
This is version 54 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)