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Protein

dCTP deaminase, dUMP-forming

Gene

dcd

Organism
Aquifex aeolicus (strain VF5)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Bifunctional enzyme that catalyzes both the deamination of dCTP to dUTP and the hydrolysis of dUTP to dUMP without releasing the toxic dUTP intermediate.UniRule annotation

Catalytic activityi

dCTP + 2 H2O = dUMP + diphosphate + NH3.UniRule annotation

Pathwayi: dUMP biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes dUMP from dCTP.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. dCTP deaminase, dUMP-forming (dcd)
This subpathway is part of the pathway dUMP biosynthesis, which is itself part of Pyrimidine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes dUMP from dCTP, the pathway dUMP biosynthesis and in Pyrimidine metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei110 – 111Important for bifunctional activityUniRule annotation2
Binding sitei113dCTPUniRule annotation1
Active sitei123Proton donor/acceptorUniRule annotation1
Binding sitei142dCTPUniRule annotation1
Binding sitei156dCTPUniRule annotation1
Binding sitei163dCTPUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi96 – 101dCTP bindingUniRule annotation6
Nucleotide bindingi121 – 123dCTP bindingUniRule annotation3

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processNucleotide metabolism
LigandNucleotide-binding

Enzyme and pathway databases

BioCyciAAEO224324:G1G15-1139-MONOMER
UniPathwayiUPA00610; UER00667

Names & Taxonomyi

Protein namesi
Recommended name:
dCTP deaminase, dUMP-formingUniRule annotation (EC:3.5.4.30UniRule annotation)
Alternative name(s):
Bifunctional dCTP deaminase:dUTPaseUniRule annotation
DCD-DUTUniRule annotation
Gene namesi
Name:dcdUniRule annotation
Ordered Locus Names:aq_1607
OrganismiAquifex aeolicus (strain VF5)
Taxonomic identifieri224324 [NCBI]
Taxonomic lineageiBacteriaAquificaeAquificalesAquificaceaeAquifex
Proteomesi
  • UP000000798 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001559631 – 180dCTP deaminase, dUMP-formingAdd BLAST180

Interactioni

Subunit structurei

Homotrimer.UniRule annotation

Protein-protein interaction databases

STRINGi224324.aq_1607

Structurei

3D structure databases

ProteinModelPortaliO67539
SMRiO67539
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the dCTP deaminase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105DHP Bacteria
COG0717 LUCA
HOGENOMiHOG000228601
InParanoidiO67539
KOiK01494
OMAiGWIDAGF
OrthoDBiPOG091H02A6

Family and domain databases

CDDicd07557 trimeric_dUTPase, 1 hit
Gene3Di2.70.40.10, 1 hit
HAMAPiMF_00146 dCTP_deaminase, 1 hit
InterProiView protein in InterPro
IPR011962 dCTP_deaminase
IPR029054 dUTPase-like
IPR036157 dUTPase-like_sf
IPR033704 dUTPase_trimeric
PfamiView protein in Pfam
PF00692 dUTPase, 1 hit
SUPFAMiSSF51283 SSF51283, 1 hit
TIGRFAMsiTIGR02274 dCTP_deam, 1 hit

Sequencei

Sequence statusi: Complete.

O67539-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MILSDRSIRE LIEKGELKVE PYEPSHVQCS SLDLRLGNQI ALYEGEGVID
60 70 80 90 100
VKKGTKGVRI LEFEEYFDIM PKQFLLATTL EYISLPPYVT AFVEGRSSLG
110 120 130 140 150
RLGLFIENAG WVDAGFEGQI TLELFNANDR PIRLYRGMRI CQLVFARLDR
160 170 180
PPERVYSGKY KGQKGVVPSR IHMDEELKSE
Length:180
Mass (Da):20,545
Last modified:August 1, 1998 - v1
Checksum:iB2710421A2FA48D6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000657 Genomic DNA Translation: AAC07499.1
PIRiA70439
RefSeqiNP_214104.1, NC_000918.1
WP_010881042.1, NC_000918.1

Genome annotation databases

EnsemblBacteriaiAAC07499; AAC07499; aq_1607
GeneIDi1193162
KEGGiaae:aq_1607
PATRICifig|224324.8.peg.1241

Similar proteinsi

Entry informationi

Entry nameiDCDB_AQUAE
AccessioniPrimary (citable) accession number: O67539
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: August 1, 1998
Last modified: May 23, 2018
This is version 105 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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