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Protein

Inorganic pyrophosphatase

Gene

ppa

Organism
Aquifex aeolicus (strain VF5)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

Diphosphate + H2O = 2 phosphate.

Cofactori

Mg2+By similarityNote: Binds 4 Mg2+ ions per subunit. Other metal ions can support activity, but at a lower rate. Two Mg2+ ions are required for the activation of the enzyme and are present before substrate binds, two additional Mg2+ ions form complexes with substrate and product.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi65 – 651Magnesium 1By similarity
Metal bindingi70 – 701Magnesium 1By similarity
Metal bindingi70 – 701Magnesium 2By similarity
Metal bindingi102 – 1021Magnesium 1By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

Magnesium, Metal-binding

Enzyme and pathway databases

BioCyciAAEO224324:GJBH-1108-MONOMER.
BRENDAi3.6.1.1. 396.

Names & Taxonomyi

Protein namesi
Recommended name:
Inorganic pyrophosphatase (EC:3.6.1.1)
Alternative name(s):
Pyrophosphate phospho-hydrolase
Short name:
PPase
Gene namesi
Name:ppa
Ordered Locus Names:aq_1547
OrganismiAquifex aeolicus (strain VF5)
Taxonomic identifieri224324 [NCBI]
Taxonomic lineageiBacteriaAquificaeAquificalesAquificaceaeAquifex
Proteomesi
  • UP000000798 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 178178Inorganic pyrophosphatasePRO_0000137475Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi224324.aq_1547.

Structurei

3D structure databases

ProteinModelPortaliO67501.
SMRiO67501. Positions 5-173.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PPase family.Curated

Phylogenomic databases

eggNOGiENOG4105F0N. Bacteria.
COG0221. LUCA.
HOGENOMiHOG000236472.
InParanoidiO67501.
KOiK01507.
OMAiEILGWQD.
OrthoDBiEOG6NKR4X.

Family and domain databases

Gene3Di3.90.80.10. 1 hit.
HAMAPiMF_00209. Inorganic_PPase.
InterProiIPR008162. Pyrophosphatase.
[Graphical view]
PANTHERiPTHR10286. PTHR10286. 1 hit.
PfamiPF00719. Pyrophosphatase. 1 hit.
[Graphical view]
SUPFAMiSSF50324. SSF50324. 1 hit.
PROSITEiPS00387. PPASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O67501-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGYDQLPPGK NPPEDIYVVI EIPQGSAVKY ELDKDTGVIF VDRFLFTAMY
60 70 80 90 100
YPFNYGFVPQ TLADDGDPVD VLVISREPVV PGAVMRCRPI GMLEMRDEAG
110 120 130 140 150
IDTKVIAVPH EKLDPSYSNI KTVDNLPEIV REKIKHFFEH YKELEPGKWV
160 170
KVENWKGLQD AIEEIKKGIE NYKKNKEG
Length:178
Mass (Da):20,343
Last modified:August 1, 1998 - v1
Checksum:i3F24C48904451327
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000657 Genomic DNA. Translation: AAC07463.1.
PIRiC70434.
RefSeqiNP_214066.1. NC_000918.1.
WP_010881004.1. NC_000918.1.

Genome annotation databases

EnsemblBacteriaiAAC07463; AAC07463; aq_1547.
GeneIDi1193124.
KEGGiaae:aq_1547.
PATRICi20960174. VBIAquAeo85532_1200.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000657 Genomic DNA. Translation: AAC07463.1.
PIRiC70434.
RefSeqiNP_214066.1. NC_000918.1.
WP_010881004.1. NC_000918.1.

3D structure databases

ProteinModelPortaliO67501.
SMRiO67501. Positions 5-173.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi224324.aq_1547.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC07463; AAC07463; aq_1547.
GeneIDi1193124.
KEGGiaae:aq_1547.
PATRICi20960174. VBIAquAeo85532_1200.

Phylogenomic databases

eggNOGiENOG4105F0N. Bacteria.
COG0221. LUCA.
HOGENOMiHOG000236472.
InParanoidiO67501.
KOiK01507.
OMAiEILGWQD.
OrthoDBiEOG6NKR4X.

Enzyme and pathway databases

BioCyciAAEO224324:GJBH-1108-MONOMER.
BRENDAi3.6.1.1. 396.

Family and domain databases

Gene3Di3.90.80.10. 1 hit.
HAMAPiMF_00209. Inorganic_PPase.
InterProiIPR008162. Pyrophosphatase.
[Graphical view]
PANTHERiPTHR10286. PTHR10286. 1 hit.
PfamiPF00719. Pyrophosphatase. 1 hit.
[Graphical view]
SUPFAMiSSF50324. SSF50324. 1 hit.
PROSITEiPS00387. PPASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: VF5.

Entry informationi

Entry nameiIPYR_AQUAE
AccessioniPrimary (citable) accession number: O67501
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: August 1, 1998
Last modified: November 11, 2015
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.