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Protein

Inorganic pyrophosphatase

Gene

ppa

Organism
Aquifex aeolicus (strain VF5)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions.UniRule annotation

Catalytic activityi

Diphosphate + H2O = 2 phosphate.UniRule annotation

Cofactori

Mg2+UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei29SubstrateUniRule annotation1
Binding sitei43SubstrateUniRule annotation1
Binding sitei55SubstrateUniRule annotation1
Metal bindingi65Magnesium 1UniRule annotation1
Metal bindingi70Magnesium 1UniRule annotation1
Metal bindingi70Magnesium 2UniRule annotation1
Metal bindingi102Magnesium 1UniRule annotation1
Binding sitei141SubstrateUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

Magnesium, Metal-binding

Enzyme and pathway databases

BRENDAi3.6.1.1. 396.

Names & Taxonomyi

Protein namesi
Recommended name:
Inorganic pyrophosphataseUniRule annotation (EC:3.6.1.1UniRule annotation)
Alternative name(s):
Pyrophosphate phospho-hydrolaseUniRule annotation
Short name:
PPaseUniRule annotation
Gene namesi
Name:ppaUniRule annotation
Ordered Locus Names:aq_1547
OrganismiAquifex aeolicus (strain VF5)
Taxonomic identifieri224324 [NCBI]
Taxonomic lineageiBacteriaAquificaeAquificalesAquificaceaeAquifex
Proteomesi
  • UP000000798 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001374751 – 178Inorganic pyrophosphataseAdd BLAST178

Interactioni

Subunit structurei

Homohexamer.UniRule annotation

Protein-protein interaction databases

STRINGi224324.aq_1547.

Structurei

3D structure databases

ProteinModelPortaliO67501.
SMRiO67501.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PPase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105F0N. Bacteria.
COG0221. LUCA.
HOGENOMiHOG000236472.
InParanoidiO67501.
KOiK01507.
OMAiAVYYPAN.
OrthoDBiPOG091H05Q5.

Family and domain databases

CDDicd00412. pyrophosphatase. 1 hit.
Gene3Di3.90.80.10. 1 hit.
HAMAPiMF_00209. Inorganic_PPase. 1 hit.
InterProiIPR008162. Pyrophosphatase.
[Graphical view]
PANTHERiPTHR10286. PTHR10286. 1 hit.
PfamiPF00719. Pyrophosphatase. 1 hit.
[Graphical view]
SUPFAMiSSF50324. SSF50324. 1 hit.
PROSITEiPS00387. PPASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O67501-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGYDQLPPGK NPPEDIYVVI EIPQGSAVKY ELDKDTGVIF VDRFLFTAMY
60 70 80 90 100
YPFNYGFVPQ TLADDGDPVD VLVISREPVV PGAVMRCRPI GMLEMRDEAG
110 120 130 140 150
IDTKVIAVPH EKLDPSYSNI KTVDNLPEIV REKIKHFFEH YKELEPGKWV
160 170
KVENWKGLQD AIEEIKKGIE NYKKNKEG
Length:178
Mass (Da):20,343
Last modified:August 1, 1998 - v1
Checksum:i3F24C48904451327
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000657 Genomic DNA. Translation: AAC07463.1.
PIRiC70434.
RefSeqiNP_214066.1. NC_000918.1.
WP_010881004.1. NC_000918.1.

Genome annotation databases

EnsemblBacteriaiAAC07463; AAC07463; aq_1547.
GeneIDi1193124.
KEGGiaae:aq_1547.
PATRICi20960174. VBIAquAeo85532_1200.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000657 Genomic DNA. Translation: AAC07463.1.
PIRiC70434.
RefSeqiNP_214066.1. NC_000918.1.
WP_010881004.1. NC_000918.1.

3D structure databases

ProteinModelPortaliO67501.
SMRiO67501.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi224324.aq_1547.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC07463; AAC07463; aq_1547.
GeneIDi1193124.
KEGGiaae:aq_1547.
PATRICi20960174. VBIAquAeo85532_1200.

Phylogenomic databases

eggNOGiENOG4105F0N. Bacteria.
COG0221. LUCA.
HOGENOMiHOG000236472.
InParanoidiO67501.
KOiK01507.
OMAiAVYYPAN.
OrthoDBiPOG091H05Q5.

Enzyme and pathway databases

BRENDAi3.6.1.1. 396.

Family and domain databases

CDDicd00412. pyrophosphatase. 1 hit.
Gene3Di3.90.80.10. 1 hit.
HAMAPiMF_00209. Inorganic_PPase. 1 hit.
InterProiIPR008162. Pyrophosphatase.
[Graphical view]
PANTHERiPTHR10286. PTHR10286. 1 hit.
PfamiPF00719. Pyrophosphatase. 1 hit.
[Graphical view]
SUPFAMiSSF50324. SSF50324. 1 hit.
PROSITEiPS00387. PPASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiIPYR_AQUAE
AccessioniPrimary (citable) accession number: O67501
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: August 1, 1998
Last modified: November 2, 2016
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.