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O67494 (AROA_AQUAE) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 79. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
3-phosphoshikimate 1-carboxyvinyltransferase
EC=2.5.1.19
Alternative name(s):
5-enolpyruvylshikimate-3-phosphate synthase
Short name=EPSP synthase
Short name=EPSPS
Gene names
Name:aroA
Ordered Locus Names:aq_1536
OrganismAquifex aeolicus (strain VF5)
Taxonomic identifier224324 [NCBI]
Taxonomic lineageBacteria › Aquificae › Aquificales › Aquificaceae › Aquifex

Protein attributes

Sequence length431 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Phosphoenolpyruvate + 3-phosphoshikimate = phosphate + 5-O-(1-carboxyvinyl)-3-phosphoshikimate. HAMAP MF_00210

Pathway

Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 6/7. HAMAP MF_00210

Subunit structure

Monomer By similarity. HAMAP MF_00210

Subcellular location

Cytoplasm By similarity HAMAP MF_00210.

Sequence similarities

Belongs to the EPSP synthase family.

Ontologies

Keywords
   Biological processAmino-acid biosynthesis
Aromatic amino acid biosynthesis
   Cellular componentCytoplasm
   Molecular functionTransferase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological processaromatic amino acid family biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular function3-phosphoshikimate 1-carboxyvinyltransferase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 4314313-phosphoshikimate 1-carboxyvinyltransferase HAMAP MF_00210
PRO_0000088217

Sequences

Sequence LengthMass (Da)Tools
O67494 [UniParc].

Last modified August 1, 1998. Version 1.
Checksum: EF842512EBE41D2A

FASTA43147,793
        10         20         30         40         50         60 
MKKIEKIKRV KGELRVPSDK SITHRAFILG ALASGETLVR KPLISGDTLA TLEILKAIRT 

        70         80         90        100        110        120 
KVREGKEEVL IEGRNYTFLE PHDVLDAKNS GTTARIMSGV LSTQPFFSVL TGDESLKNRP 

       130        140        150        160        170        180 
MLRVVEPLRE MGAKIDGREE GNKLPIAIRG GNLKGISYFN KKSSAQVKSA LLLAGLRAEG 

       190        200        210        220        230        240 
MTEVVEPYLS RDHTERMLKL FGAEVITIPE ERGHIVKIKG GQELQGTEVY CPADPSSAAY 

       250        260        270        280        290        300 
FAALATLAPE GEIRLKEVLL NPTRDGFYRK LIEMGGDISF ENYRELSNEP MADLVVRPVD 

       310        320        330        340        350        360 
NLKPVKVSPE EVPTLIDEIP ILAVLMAFAD GVSEVKGAKE LRYKESDRIK AIVTNLRKLG 

       370        380        390        400        410        420 
VQVEEFEDGF AIHGTKEIKG GVIETFKDHR IAMAFAVLGL VVEEEVIIDH PECVTVSYPE 

       430 
FWEDILKVVE F

« Hide

References

[1]"The complete genome of the hyperthermophilic bacterium Aquifex aeolicus."
Deckert G., Warren P.V., Gaasterland T., Young W.G., Lenox A.L., Graham D.E., Overbeek R., Snead M.A., Keller M., Aujay M., Huber R., Feldman R.A., Short J.M., Olsen G.J., Swanson R.V.
Nature 392:353-358(1998) [PubMed: 9537320] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: VF5.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AE000657 Genomic DNA. Translation: AAC07443.1.
PIRD70433.
RefSeqNP_214059.1. NC_000918.1.

3D structure databases

ProteinModelPortalO67494.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID1193117.
GenomeReviewsGene locus aq_1536 in contig AE000657_GR.
KEGGaae:aq_1536.
NMPDRfig|224324.1.peg.1074.
PATRIC20960160. VBIAquAeo85532_1193.

Phylogenomic databases

HOGENOMHBG646626.
OMALECANIS.
PhylomeDBO67494.
ProtClustDBPRK02427.

Enzyme and pathway databases

BioCycAAEO224324:AQ_1536-MONOMER.

Family and domain databases

HAMAPMF_00210. EPSP_synth.
[Tree]
InterProIPR001986. Enolpyruvate_Tfrase_dom.
IPR006264. EPSP_synthase.
IPR023193. EPSP_synthase_CS.
IPR013792. RNA3'P_cycl/enolpyr_Trfase_a/b.
[Graphical view]
Gene3DG3DSA:3.65.10.10. EPSP_synthase. 2 hits.
KOK00800.
PfamPF00275. EPSP_synthase. 1 hit.
[Graphical view]
PIRSFPIRSF000505. EPSPS. 1 hit.
SUPFAMSSF55205. RNA3'_cycl/enolpyr_transf_A/B. 1 hit.
TIGRFAMsTIGR01356. AroA. 1 hit.
PROSITEPS00104. EPSP_SYNTHASE_1. 1 hit.
PS00885. EPSP_SYNTHASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameAROA_AQUAE
AccessionPrimary (citable) accession number: O67494
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: August 1, 1998
Last modified: January 25, 2012
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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