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O67480

- IDH_AQUAE

UniProt

O67480 - IDH_AQUAE

Protein

Isocitrate dehydrogenase [NADP]

Gene

icd

Organism
Aquifex aeolicus (strain VF5)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 89 (01 Oct 2014)
      Sequence version 1 (01 Aug 1998)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.

    Cofactori

    Binds 1 magnesium or manganese ion per subunit.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei123 – 1231SubstrateBy similarity
    Binding sitei125 – 1251SubstrateBy similarity
    Binding sitei129 – 1291SubstrateBy similarity
    Binding sitei139 – 1391SubstrateBy similarity
    Binding sitei162 – 1621SubstrateBy similarity
    Sitei169 – 1691Critical for catalysisBy similarity
    Sitei239 – 2391Critical for catalysisBy similarity
    Metal bindingi312 – 3121Magnesium or manganeseBy similarity

    GO - Molecular functioni

    1. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
    2. magnesium ion binding Source: InterPro
    3. NAD binding Source: InterPro

    GO - Biological processi

    1. glyoxylate cycle Source: UniProtKB-KW
    2. tricarboxylic acid cycle Source: UniProtKB-KW

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Glyoxylate bypass, Tricarboxylic acid cycle

    Keywords - Ligandi

    Magnesium, Manganese, Metal-binding, NADP

    Enzyme and pathway databases

    BioCyciAAEO224324:GJBH-1087-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Isocitrate dehydrogenase [NADP] (EC:1.1.1.42)
    Short name:
    IDH
    Alternative name(s):
    IDP
    NADP(+)-specific ICDH
    Oxalosuccinate decarboxylase
    Gene namesi
    Name:icd
    Ordered Locus Names:aq_1512
    OrganismiAquifex aeolicus (strain VF5)
    Taxonomic identifieri224324 [NCBI]
    Taxonomic lineageiBacteriaAquificaeAquificalesAquificaceaeAquifex
    ProteomesiUP000000798: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 426426Isocitrate dehydrogenase [NADP]PRO_0000083548Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei123 – 1231PhosphoserineBy similarity

    Keywords - PTMi

    Phosphoprotein

    Interactioni

    Protein-protein interaction databases

    STRINGi224324.aq_1512.

    Structurei

    3D structure databases

    ProteinModelPortaliO67480.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0538.
    HOGENOMiHOG000021113.
    KOiK00031.
    OMAiCLRPIRY.
    OrthoDBiEOG6SNDTP.

    Family and domain databases

    Gene3Di3.40.718.10. 1 hit.
    InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
    IPR001804. Isocitrate/isopropylmalate_DH.
    IPR024084. IsoPropMal-DH-like_dom.
    [Graphical view]
    PANTHERiPTHR11835. PTHR11835. 1 hit.
    PfamiPF00180. Iso_dh. 1 hit.
    [Graphical view]
    PROSITEiPS00470. IDH_IMDH. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O67480-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNKTTFENVY YWEGKAQIPQ EGQFIKLKED KTLEVPDNPI IPFIEGDGIG    50
    PEITQAMLLI INTAVEKTYN GSKKIYWVEL LAGDKAEEKT GERLPQETLD 100
    VLKESIVGIK GPLGTPVGKG VRSINSALRR AFDYYSAVRP VYWMGQATPI 150
    PNPERVDLVV FRENTDDVYA GVEFFAGTPE AKKVREFLIK EMGAKEEGFP 200
    EDVGITVKPM SEFKTKRHVR KALRYALENN KKNVAVIGKG NIMKATEGAF 250
    INWAFEVAEE PEFKGKVVTD PEAEPGEGQV KLTKVITDQM LMQLVLKPEA 300
    WDVIIAQNLN GDYVSDLAAS LIGGPGFVPS GNIGDGYALF ESTHGTAWDI 350
    AGKGIANPLS LTLSGAMMLE YIGWKEAAQK VYDAVRRTLA EHIGTPDIAS 400
    GFQKQGIEAK AVGTMEFAEE ISKRIE 426
    Length:426
    Mass (Da):46,925
    Last modified:August 1, 1998 - v1
    Checksum:i06E47E36D844432A
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE000657 Genomic DNA. Translation: AAC07444.1.
    PIRiF70431.
    RefSeqiNP_214045.1. NC_000918.1.
    WP_010880983.1. NC_000918.1.

    Genome annotation databases

    EnsemblBacteriaiAAC07444; AAC07444; aq_1512.
    GeneIDi1193103.
    KEGGiaae:aq_1512.
    PATRICi20960134. VBIAquAeo85532_1180.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE000657 Genomic DNA. Translation: AAC07444.1 .
    PIRi F70431.
    RefSeqi NP_214045.1. NC_000918.1.
    WP_010880983.1. NC_000918.1.

    3D structure databases

    ProteinModelPortali O67480.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 224324.aq_1512.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAC07444 ; AAC07444 ; aq_1512 .
    GeneIDi 1193103.
    KEGGi aae:aq_1512.
    PATRICi 20960134. VBIAquAeo85532_1180.

    Phylogenomic databases

    eggNOGi COG0538.
    HOGENOMi HOG000021113.
    KOi K00031.
    OMAi CLRPIRY.
    OrthoDBi EOG6SNDTP.

    Enzyme and pathway databases

    BioCyci AAEO224324:GJBH-1087-MONOMER.

    Family and domain databases

    Gene3Di 3.40.718.10. 1 hit.
    InterProi IPR019818. IsoCit/isopropylmalate_DH_CS.
    IPR001804. Isocitrate/isopropylmalate_DH.
    IPR024084. IsoPropMal-DH-like_dom.
    [Graphical view ]
    PANTHERi PTHR11835. PTHR11835. 1 hit.
    Pfami PF00180. Iso_dh. 1 hit.
    [Graphical view ]
    PROSITEi PS00470. IDH_IMDH. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: VF5.

    Entry informationi

    Entry nameiIDH_AQUAE
    AccessioniPrimary (citable) accession number: O67480
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: August 1, 1998
    Last modified: October 1, 2014
    This is version 89 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3