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O67480

- IDH_AQUAE

UniProt

O67480 - IDH_AQUAE

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Protein

Isocitrate dehydrogenase [NADP]

Gene
icd, aq_1512
Organism
Aquifex aeolicus (strain VF5)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.

Cofactori

Binds 1 magnesium or manganese ion per subunit By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei123 – 1231Substrate By similarity
Binding sitei125 – 1251Substrate By similarity
Binding sitei129 – 1291Substrate By similarity
Binding sitei139 – 1391Substrate By similarity
Binding sitei162 – 1621Substrate By similarity
Sitei169 – 1691Critical for catalysis By similarity
Sitei239 – 2391Critical for catalysis By similarity
Metal bindingi312 – 3121Magnesium or manganese By similarity

GO - Molecular functioni

  1. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
  2. magnesium ion binding Source: InterPro
  3. NAD binding Source: InterPro

GO - Biological processi

  1. glyoxylate cycle Source: UniProtKB-KW
  2. tricarboxylic acid cycle Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Glyoxylate bypass, Tricarboxylic acid cycle

Keywords - Ligandi

Magnesium, Manganese, Metal-binding, NADP

Enzyme and pathway databases

BioCyciAAEO224324:GJBH-1087-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Isocitrate dehydrogenase [NADP] (EC:1.1.1.42)
Short name:
IDH
Alternative name(s):
IDP
NADP(+)-specific ICDH
Oxalosuccinate decarboxylase
Gene namesi
Name:icd
Ordered Locus Names:aq_1512
OrganismiAquifex aeolicus (strain VF5)
Taxonomic identifieri224324 [NCBI]
Taxonomic lineageiBacteriaAquificaeAquificalesAquificaceaeAquifex
ProteomesiUP000000798: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 426426Isocitrate dehydrogenase [NADP]PRO_0000083548Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei123 – 1231Phosphoserine By similarity

Keywords - PTMi

Phosphoprotein

Interactioni

Protein-protein interaction databases

STRINGi224324.aq_1512.

Structurei

3D structure databases

ProteinModelPortaliO67480.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0538.
HOGENOMiHOG000021113.
KOiK00031.
OMAiCLRPIRY.
OrthoDBiEOG6SNDTP.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR001804. Isocitrate/isopropylmalate_DH.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11835. PTHR11835. 1 hit.
PfamiPF00180. Iso_dh. 1 hit.
[Graphical view]
PROSITEiPS00470. IDH_IMDH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O67480-1 [UniParc]FASTAAdd to Basket

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MNKTTFENVY YWEGKAQIPQ EGQFIKLKED KTLEVPDNPI IPFIEGDGIG    50
PEITQAMLLI INTAVEKTYN GSKKIYWVEL LAGDKAEEKT GERLPQETLD 100
VLKESIVGIK GPLGTPVGKG VRSINSALRR AFDYYSAVRP VYWMGQATPI 150
PNPERVDLVV FRENTDDVYA GVEFFAGTPE AKKVREFLIK EMGAKEEGFP 200
EDVGITVKPM SEFKTKRHVR KALRYALENN KKNVAVIGKG NIMKATEGAF 250
INWAFEVAEE PEFKGKVVTD PEAEPGEGQV KLTKVITDQM LMQLVLKPEA 300
WDVIIAQNLN GDYVSDLAAS LIGGPGFVPS GNIGDGYALF ESTHGTAWDI 350
AGKGIANPLS LTLSGAMMLE YIGWKEAAQK VYDAVRRTLA EHIGTPDIAS 400
GFQKQGIEAK AVGTMEFAEE ISKRIE 426
Length:426
Mass (Da):46,925
Last modified:August 1, 1998 - v1
Checksum:i06E47E36D844432A
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE000657 Genomic DNA. Translation: AAC07444.1.
PIRiF70431.
RefSeqiNP_214045.1. NC_000918.1.
WP_010880983.1. NC_000918.1.

Genome annotation databases

EnsemblBacteriaiAAC07444; AAC07444; aq_1512.
GeneIDi1193103.
KEGGiaae:aq_1512.
PATRICi20960134. VBIAquAeo85532_1180.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE000657 Genomic DNA. Translation: AAC07444.1 .
PIRi F70431.
RefSeqi NP_214045.1. NC_000918.1.
WP_010880983.1. NC_000918.1.

3D structure databases

ProteinModelPortali O67480.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 224324.aq_1512.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAC07444 ; AAC07444 ; aq_1512 .
GeneIDi 1193103.
KEGGi aae:aq_1512.
PATRICi 20960134. VBIAquAeo85532_1180.

Phylogenomic databases

eggNOGi COG0538.
HOGENOMi HOG000021113.
KOi K00031.
OMAi CLRPIRY.
OrthoDBi EOG6SNDTP.

Enzyme and pathway databases

BioCyci AAEO224324:GJBH-1087-MONOMER.

Family and domain databases

Gene3Di 3.40.718.10. 1 hit.
InterProi IPR019818. IsoCit/isopropylmalate_DH_CS.
IPR001804. Isocitrate/isopropylmalate_DH.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view ]
PANTHERi PTHR11835. PTHR11835. 1 hit.
Pfami PF00180. Iso_dh. 1 hit.
[Graphical view ]
PROSITEi PS00470. IDH_IMDH. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: VF5.

Entry informationi

Entry nameiIDH_AQUAE
AccessioniPrimary (citable) accession number: O67480
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: August 1, 1998
Last modified: September 3, 2014
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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