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Protein

Isocitrate dehydrogenase [NADP]

Gene

icd

Organism
Aquifex aeolicus (strain VF5)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.

Cofactori

Mg2+By similarity, Mn2+By similarityNote: Binds 1 Mg2+ or Mn2+ ion per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei123SubstrateBy similarity1
Binding sitei125SubstrateBy similarity1
Binding sitei129SubstrateBy similarity1
Binding sitei139SubstrateBy similarity1
Binding sitei162SubstrateBy similarity1
Sitei169Critical for catalysisBy similarity1
Sitei239Critical for catalysisBy similarity1
Metal bindingi312Magnesium or manganeseBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processGlyoxylate bypass, Tricarboxylic acid cycle
LigandMagnesium, Manganese, Metal-binding, NADP

Enzyme and pathway databases

BioCyciAAEO224324:G1G15-1081-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Isocitrate dehydrogenase [NADP] (EC:1.1.1.42)
Short name:
IDH
Alternative name(s):
IDP
NADP(+)-specific ICDH
Oxalosuccinate decarboxylase
Gene namesi
Name:icd
Ordered Locus Names:aq_1512
OrganismiAquifex aeolicus (strain VF5)
Taxonomic identifieri224324 [NCBI]
Taxonomic lineageiBacteriaAquificaeAquificalesAquificaceaeAquifex
Proteomesi

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000835481 – 426Isocitrate dehydrogenase [NADP]Add BLAST426

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei123PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiO67480

Interactioni

Protein-protein interaction databases

STRINGi224324.aq_1512

Structurei

3D structure databases

ProteinModelPortaliO67480
SMRiO67480
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4108HMX Bacteria
COG0538 LUCA
HOGENOMiHOG000021113
InParanoidiO67480
KOiK00031
OMAiFQQIQTR
OrthoDBiPOG091H01VB

Family and domain databases

InterProiView protein in InterPro
IPR019818 IsoCit/isopropylmalate_DH_CS
IPR004439 Isocitrate_DH_NADP_dimer_prok
IPR024084 IsoPropMal-DH-like_dom
PANTHERiPTHR43504 PTHR43504, 1 hit
PfamiView protein in Pfam
PF00180 Iso_dh, 1 hit
SMARTiView protein in SMART
SM01329 Iso_dh, 1 hit
PROSITEiView protein in PROSITE
PS00470 IDH_IMDH, 1 hit

Sequencei

Sequence statusi: Complete.

O67480-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNKTTFENVY YWEGKAQIPQ EGQFIKLKED KTLEVPDNPI IPFIEGDGIG
60 70 80 90 100
PEITQAMLLI INTAVEKTYN GSKKIYWVEL LAGDKAEEKT GERLPQETLD
110 120 130 140 150
VLKESIVGIK GPLGTPVGKG VRSINSALRR AFDYYSAVRP VYWMGQATPI
160 170 180 190 200
PNPERVDLVV FRENTDDVYA GVEFFAGTPE AKKVREFLIK EMGAKEEGFP
210 220 230 240 250
EDVGITVKPM SEFKTKRHVR KALRYALENN KKNVAVIGKG NIMKATEGAF
260 270 280 290 300
INWAFEVAEE PEFKGKVVTD PEAEPGEGQV KLTKVITDQM LMQLVLKPEA
310 320 330 340 350
WDVIIAQNLN GDYVSDLAAS LIGGPGFVPS GNIGDGYALF ESTHGTAWDI
360 370 380 390 400
AGKGIANPLS LTLSGAMMLE YIGWKEAAQK VYDAVRRTLA EHIGTPDIAS
410 420
GFQKQGIEAK AVGTMEFAEE ISKRIE
Length:426
Mass (Da):46,925
Last modified:August 1, 1998 - v1
Checksum:i06E47E36D844432A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000657 Genomic DNA Translation: AAC07444.1
PIRiF70431
RefSeqiNP_214045.1, NC_000918.1
WP_010880983.1, NC_000918.1

Genome annotation databases

EnsemblBacteriaiAAC07444; AAC07444; aq_1512
GeneIDi1193103
KEGGiaae:aq_1512
PATRICifig|224324.8.peg.1180

Similar proteinsi

Entry informationi

Entry nameiIDH_AQUAE
AccessioniPrimary (citable) accession number: O67480
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: August 1, 1998
Last modified: May 23, 2018
This is version 108 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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