O67441 (GCST_AQUAE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Aminomethyltransferase
EC=2.1.2.10

Alternative name(s):
Glycine cleavage system T protein

Gene names

Name:	gcvT
Ordered Locus Names:	aq_1458

Organism

Aquifex aeolicus (strain VF5)

Taxonomic identifier

224324 [NCBI]

Taxonomic lineage

Bacteria › Aquificae › Aquificales › Aquificaceae › Aquifex

Protein attributes

Sequence length	350 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	The glycine cleavage system catalyzes the degradation of glycine By similarity. HAMAP MF_00259
Catalytic activity	[Protein]-S(8)-aminomethyldihydrolipoyllysine + tetrahydrofolate = [protein]-dihydrolipoyllysine + 5,10-methylenetetrahydrofolate + NH3. HAMAP MF_00259
Subunit structure	The glycine cleavage system is composed of four proteins: P, T, L and H By similarity.
Sequence similarities	Belongs to the GcvT family.
Sequence caution	The sequence AAC07401.1 differs from that shown. Reason: Frameshift at position 46.

Ontologies

Keywords
Molecular function	Aminotransferase Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	glycine catabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: InterPro
Molecular function	aminomethyltransferase activity Inferred from electronic annotation. Source: EC transaminase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 350	350	Aminomethyltransferase HAMAP MF_00259		PRO_0000122534

Sequences

	Sequence		Length	Mass (Da)
	O67441 [UniParc]. Last modified December 1, 2000. Version 2. Checksum: 688BFC891407A0FB	FASTA	350	40,336
	10 20 30 40 50 60 MILFYFMQTP LYYVHKHLKA KFTNFAGWTM PLQYTSIIEE VRAVRXRAGV FDISHMGRLL 70 80 90 100 110 120 IEDPEKKLQY FTTNNLDKLS VGKVQYNLLP NEKGGIKDDV TVYMLSEIEF FLCVNAANRQ 130 140 150 160 170 180 KVINWLSPHL KLRDLSGELV QIALQGPKSE EIISKFYPVS DLKYYRFKVF DKTIISRTGY 190 200 210 220 230 240 TGEDGFEIYV SPEEGKELFL ELVKLAKPCG LGARDVLRIE AGLPLYGNEL SEEITPIEVN 250 260 270 280 290 300 LEKFVDFSKE FIGKEAMLKK KVKKKLFGLE LTEKGIPRKG YRVFKGDREI GWISSGTYSP 310 320 330 340 350 TLNKGIALCF VDIEERKEGN EVEIEVRGRR VRGVLRKYPF VRTPAGRYQK

References

[1]

"The complete genome of the hyperthermophilic bacterium Aquifex aeolicus." Deckert G., Warren P.V., Gaasterland T., Young W.G., Lenox A.L., Graham D.E., Overbeek R., Snead M.A., Keller M., Aujay M., Huber R., Feldman R.A., Short J.M., Olsen G.J., Swanson R.V. Nature 392:353-358(1998) [PubMed: 9537320] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: VF5.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE000657 Genomic DNA. Translation: AAC07401.1. Frameshift.
PIR	G70426.
RefSeq	NP_214006.1. NC_000918.1.
3D structure databases
ProteinModelPortal	O67441.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1192972.
GenomeReviews	Gene locus aq_1458 in contig AE000657_GR.
KEGG	aae:aq_1458.
NMPDR	fig|224324.1.peg.1021.
PATRIC	20960048. VBIAquAeo85532_1138.
Phylogenomic databases
HOGENOM	HBG299834.
OMA	KALYGGM.
PhylomeDB	O67441.
ProtClustDB	CLSK2748457.
Enzyme and pathway databases
BioCyc	AAEO224324:AQ_1458-MONOMER.
Family and domain databases
HAMAP	MF_00259. GcvT. [Tree]
InterPro	IPR013977. GCV_T_C. IPR006222. GCV_T_N. IPR006223. GcvT. IPR022903. NH2_Me_Trfase. [Graphical view]
KO	K00605.
PANTHER	PTHR13847:SF5. PTHR13847:SF5. 1 hit.
Pfam	PF01571. GCV_T. 1 hit. PF08669. GCV_T_C. 1 hit. [Graphical view]
PIRSF	PIRSF006487. GcvT. 1 hit.
TIGRFAMs	TIGR00528. GcvT. 1 hit.
ProtoNet	Search...

Entry information

Entry name

GCST_AQUAE

Accession

Primary (citable) accession number: O67441

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 1, 2000
Last sequence update:	December 1, 2000
Last modified:	January 25, 2012
This is version 71 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program