O67434 (O67434_AQUAE) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Putative uncharacterized protein EMBL AAC07406.1

Gene names

Ordered Locus Names:

aq_1447

Organism

Aquifex aeolicus (strain VF5)

Taxonomic identifier

224324 [NCBI]

Taxonomic lineage

Bacteria › Aquificae › Aquificales › Aquificaceae › Aquifex

Protein attributes

Sequence length	706 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

Ontologies

Keywords
Ligand	Calcium PDB 1YVU Metal-binding PDB 1YVU
Technical term	3D-structure PDB 1YVU PDB 2F8S PDB 2F8T PDB 2NUB Complete proteome Reference proteome
Gene Ontology (GO)
Molecular function	metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW nucleic acid binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Sites
	Metal binding	502	1	Calcium PDB 1YVU
	Metal binding	683	1	Calcium PDB 1YVU

Sequences

	Sequence		Length	Mass (Da)
	O67434 [UniParc]. Last modified August 1, 1998. Version 1. Checksum: 6211641D88BA850D	FASTA	706	83,122
	10 20 30 40 50 60 MGKEALLNLY RIEYRPKDTT FTVFKPTHEI QKEKLNKVRW RVFLQTGLPT FRREDEFWCA 70 80 90 100 110 120 GKVEKDTLYL TLSNGEIVEL KRVGEEEFRG FQNERECQEL FRDFLTKTKV KDKFISDFYK 130 140 150 160 170 180 KFRDKITVQG KNRKIALIPE VNEKVLKSEE GYFLLHLDLK FRIQPFETLQ TLLERNDFNP 190 200 210 220 230 240 KRIRVKPIGI DFVGRVQDVF KAKEKGEEFF RLCMERSTHK SSKKAWEELL KNRELREKAF 250 260 270 280 290 300 LVVLEKGYTY PATILKPVLT YENLEDEERN EVADIVRMEP GKRLNLIRYI LRRYVKALRD 310 320 330 340 350 360 YGWYISPEEE RAKGKLNFKD TVLDAKGKNT KVITNLRKFL ELCRPFVKKD VLSVEIISVS 370 380 390 400 410 420 VYKKLEWRKE EFLKELINFL KNKGIKLKIK GKSLILAQTR EEAKEKLIPV INKIKDVDLV 430 440 450 460 470 480 IVFLEEYPKV DPYKSFLLYD FVKRELLKKM IPSQVILNRT LKNENLKFVL LNVAEQVLAK 490 500 510 520 530 540 TGNIPYKLKE IEGKVDAFVG IDISRITRDG KTVNAVAFTK IFNSKGELVR YYLTSYPAFG 550 560 570 580 590 600 EKLTEKAIGD VFSLLEKLGF KKGSKIVVHR DGRLYRDEVA AFKKYGELYG YSLELLEIIK 610 620 630 640 650 660 RNNPRFFSNE KFIKGYFYKL SEDSVILATY NQVYEGTHQP IKVRKVYGEL PVEVLCSQIL 670 680 690 700 SLTLMNYSSF QPIKLPATVH YSDKITKLML RGIEPIKKEG DIMYWL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The complete genome of the hyperthermophilic bacterium Aquifex aeolicus." Deckert G., Warren P.V., Gaasterland T., Young W.G., Lenox A.L., Graham D.E., Overbeek R., Snead M.A., Keller M., Aujay M., Huber R., Feldman R.A., Short J.M., Olsen G.J., Swanson R.V. Nature 392:353-358(1998) [PubMed: 9537320] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: VF5.
[2]	"A potential protein-RNA recognition event along the RISC-loading pathway from the structure of A. aeolicus Argonaute with externally bound siRNA." Yuan Y.R., Pei Y., Chen H.Y., Tuschl T., Patel D.J. Structure 14:1557-1565(2006) [PubMed: 17027504] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (3.00 ANGSTROMS).
[3]	"Structure of Aquifex aeolicus argonaute highlights conformational flexibility of the PAZ domain as a potential regulator of RNA-induced silencing complex function." Rashid U.J., Paterok D., Koglin A., Gohlke H., Piehler J., Chen J.C. J. Biol. Chem. 282:13824-13832(2007) [PubMed: 17130125] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (3.20 ANGSTROMS).
[4]	"Crystal structure of A. aeolicus argonaute, a site-specific DNA-guided endoribonuclease, provides insights into RISC-mediated mRNA cleavage." Yuan Y.R., Pei Y., Ma J.B., Kuryavyi V., Zhadina M., Meister G., Chen H.Y., Dauter Z., Tuschl T., Patel D.J. Mol. Cell 19:405-419(2005) [PubMed: 16061186] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (2.90 ANGSTROMS) IN COMPLEX WITH CALCIUM.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AE000657 Genomic DNA. Translation: AAC07406.1.

PIR

H70425.

RefSeq

NP_213999.1. NC_000918.1.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1YVU	X-ray	2.90	A	1-706	[»]
2F8S	X-ray	3.00	A/B	1-706	[»]
2F8T	X-ray	3.10	A/B	1-706	[»]
2NUB	X-ray	3.20	A	1-706	[»]

ProteinModelPortal

O67434.

SMR

O67434. Positions 3-706.

ModBase

Search...

Protein-protein interaction databases

DIP

DIP-29161N.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

GeneID

1192965.

GenomeReviews

Gene locus aq_1447 in contig AE000657_GR.

KEGG

aae:aq_1447.

NMPDR

fig|224324.1.peg.1014.

PATRIC

20960030. VBIAquAeo85532_1129.

Phylogenomic databases

OMA

IDISRIT.

Family and domain databases

InterPro

IPR003100. PAZ.
IPR003165. Piwi.
IPR012337. RNaseH-like_dom.
[Graphical view]

KO

K07578.

Pfam

PF02171. Piwi. 1 hit.
[Graphical view]

SMART

SM00950. Piwi. 1 hit.
[Graphical view]

SUPFAM

SSF101690. PAZ. 1 hit.
SSF53098. RNaseH_fold. 1 hit.

PROSITE

PS50822. PIWI. 1 hit.
[Graphical view]

ProtoNet

Search...

Entry information

Entry name

O67434_AQUAE

Accession

Primary (citable) accession number: O67434

Entry history

Integrated into UniProtKB/TrEMBL:	August 1, 1998
Last sequence update:	August 1, 1998
Last modified:	January 25, 2012
This is version 61 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)