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O67420 (LPXB_AQUAE) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 72. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Lipid-A-disaccharide synthase

EC=2.4.1.182
Gene names
Name:lpxB
Ordered Locus Names:aq_1427
OrganismAquifex aeolicus (strain VF5) [Reference proteome] [HAMAP]
Taxonomic identifier224324 [NCBI]
Taxonomic lineageBacteriaAquificaeAquificalesAquificaceaeAquifex

Protein attributes

Sequence length356 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell By similarity. HAMAP-Rule MF_00392

Catalytic activity

UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine + 2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate = UDP + 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6-beta-D-2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate. HAMAP-Rule MF_00392

Pathway

Glycolipid biosynthesis; lipid IV(A) biosynthesis; lipid IV(A) from (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] and UDP-N-acetyl-alpha-D-glucosamine: step 5/6. HAMAP-Rule MF_00392

Sequence similarities

Belongs to the LpxB family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 356356Lipid-A-disaccharide synthase HAMAP-Rule MF_00392
PRO_0000190151

Sequences

Sequence LengthMass (Da)Tools
O67420 [UniParc].

Last modified August 1, 1998. Version 1.
Checksum: 1B4CFBA5F409CD68

FASTA35641,300
        10         20         30         40         50         60 
MKKIFLSLAD RSASNYVYEI LKEGFEEYEI YGLTDEKLEK IGVKSVARYS EISTVGLIEA 

        70         80         90        100        110        120 
LPKVFKFLKI YRKILKNLKN TDTLIACDAP ALNLRLIKDA RKLGVKRIIY FISPQVWAWK 

       130        140        150        160        170        180 
PKRAEIIANY CDHVIVILPF EKKIYRKFPN LKVHYVGHPL VDLVKPQKTK EEFMKAFKKE 

       190        200        210        220        230        240 
PLPLLLGSRE GEIRRHVKLL KGIIEELKKS FDVISPTFRE FSKFIERELK VKTLTYEGAS 

       250        260        270        280        290        300 
YDCFFYSKAS LIASGTASLE AGIAGNPHVV YYKVNPITYF LGKRLVKVPY ISLVNILLKE 

       310        320        330        340        350 
EVVPEFIQKS SDEILKGFEK VYKNEEEIKE KLGTLKFILG ERFVIRKLRE LFLEIV 

« Hide

References

[1]"The complete genome of the hyperthermophilic bacterium Aquifex aeolicus."
Deckert G., Warren P.V., Gaasterland T., Young W.G., Lenox A.L., Graham D.E., Overbeek R., Snead M.A., Keller M., Aujay M., Huber R., Feldman R.A., Short J.M., Olsen G.J., Swanson R.V.
Nature 392:353-358(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: VF5.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE000657 Genomic DNA. Translation: AAC07386.1.
PIRB70424.
RefSeqNP_213985.1. NC_000918.1.

3D structure databases

ProteinModelPortalO67420.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING224324.aq_1427.

Protein family/group databases

CAZyGT19. Glycosyltransferase Family 19.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAC07386; AAC07386; aq_1427.
GeneID1192951.
KEGGaae:aq_1427.
PATRIC20960004. VBIAquAeo85532_1116.

Phylogenomic databases

eggNOGCOG0763.
HOGENOMHOG000018004.
KOK00748.
OMAIARMLVN.
OrthoDBEOG6FBWZR.
ProtClustDBCLSK2299698.

Enzyme and pathway databases

BioCycAAEO224324:GJBH-1026-MONOMER.
UniPathwayUPA00359; UER00481.

Family and domain databases

HAMAPMF_00392. LpxB.
InterProIPR003835. Glyco_trans_19.
[Graphical view]
PfamPF02684. LpxB. 1 hit.
[Graphical view]
TIGRFAMsTIGR00215. lpxB. 1 hit.
ProtoNetSearch...

Entry information

Entry nameLPXB_AQUAE
AccessionPrimary (citable) accession number: O67420
Entry history
Integrated into UniProtKB/Swiss-Prot: June 1, 2001
Last sequence update: August 1, 1998
Last modified: February 19, 2014
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways