Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

O67420

- LPXB_AQUAE

UniProt

O67420 - LPXB_AQUAE

Protein

Lipid-A-disaccharide synthase

Gene

lpxB

Organism
Aquifex aeolicus (strain VF5)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 74 (01 Oct 2014)
      Sequence version 1 (01 Aug 1998)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.By similarity

    Catalytic activityi

    UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine + 2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate = UDP + 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6-beta-D-2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate.

    Pathwayi

    GO - Molecular functioni

    1. lipid-A-disaccharide synthase activity Source: UniProtKB-EC

    GO - Biological processi

    1. lipid A biosynthetic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Glycosyltransferase, Transferase

    Keywords - Biological processi

    Lipid A biosynthesis, Lipid biosynthesis, Lipid metabolism

    Enzyme and pathway databases

    BioCyciAAEO224324:GJBH-1026-MONOMER.
    UniPathwayiUPA00359; UER00481.

    Protein family/group databases

    CAZyiGT19. Glycosyltransferase Family 19.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Lipid-A-disaccharide synthase (EC:2.4.1.182)
    Gene namesi
    Name:lpxB
    Ordered Locus Names:aq_1427
    OrganismiAquifex aeolicus (strain VF5)
    Taxonomic identifieri224324 [NCBI]
    Taxonomic lineageiBacteriaAquificaeAquificalesAquificaceaeAquifex
    ProteomesiUP000000798: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 356356Lipid-A-disaccharide synthasePRO_0000190151Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi224324.aq_1427.

    Structurei

    3D structure databases

    ProteinModelPortaliO67420.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the LpxB family.Curated

    Phylogenomic databases

    eggNOGiCOG0763.
    HOGENOMiHOG000018004.
    KOiK00748.
    OMAiTIYENAG.
    OrthoDBiEOG6FBWZR.

    Family and domain databases

    HAMAPiMF_00392. LpxB.
    InterProiIPR003835. Glyco_trans_19.
    [Graphical view]
    PfamiPF02684. LpxB. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00215. lpxB. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    O67420-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKKIFLSLAD RSASNYVYEI LKEGFEEYEI YGLTDEKLEK IGVKSVARYS    50
    EISTVGLIEA LPKVFKFLKI YRKILKNLKN TDTLIACDAP ALNLRLIKDA 100
    RKLGVKRIIY FISPQVWAWK PKRAEIIANY CDHVIVILPF EKKIYRKFPN 150
    LKVHYVGHPL VDLVKPQKTK EEFMKAFKKE PLPLLLGSRE GEIRRHVKLL 200
    KGIIEELKKS FDVISPTFRE FSKFIERELK VKTLTYEGAS YDCFFYSKAS 250
    LIASGTASLE AGIAGNPHVV YYKVNPITYF LGKRLVKVPY ISLVNILLKE 300
    EVVPEFIQKS SDEILKGFEK VYKNEEEIKE KLGTLKFILG ERFVIRKLRE 350
    LFLEIV 356
    Length:356
    Mass (Da):41,300
    Last modified:August 1, 1998 - v1
    Checksum:i1B4CFBA5F409CD68
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE000657 Genomic DNA. Translation: AAC07386.1.
    PIRiB70424.
    RefSeqiNP_213985.1. NC_000918.1.

    Genome annotation databases

    EnsemblBacteriaiAAC07386; AAC07386; aq_1427.
    GeneIDi1192951.
    KEGGiaae:aq_1427.
    PATRICi20960004. VBIAquAeo85532_1116.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE000657 Genomic DNA. Translation: AAC07386.1 .
    PIRi B70424.
    RefSeqi NP_213985.1. NC_000918.1.

    3D structure databases

    ProteinModelPortali O67420.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 224324.aq_1427.

    Protein family/group databases

    CAZyi GT19. Glycosyltransferase Family 19.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAC07386 ; AAC07386 ; aq_1427 .
    GeneIDi 1192951.
    KEGGi aae:aq_1427.
    PATRICi 20960004. VBIAquAeo85532_1116.

    Phylogenomic databases

    eggNOGi COG0763.
    HOGENOMi HOG000018004.
    KOi K00748.
    OMAi TIYENAG.
    OrthoDBi EOG6FBWZR.

    Enzyme and pathway databases

    UniPathwayi UPA00359 ; UER00481 .
    BioCyci AAEO224324:GJBH-1026-MONOMER.

    Family and domain databases

    HAMAPi MF_00392. LpxB.
    InterProi IPR003835. Glyco_trans_19.
    [Graphical view ]
    Pfami PF02684. LpxB. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00215. lpxB. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: VF5.

    Entry informationi

    Entry nameiLPXB_AQUAE
    AccessioniPrimary (citable) accession number: O67420
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 1, 2001
    Last sequence update: August 1, 1998
    Last modified: October 1, 2014
    This is version 74 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3