O67420 (LPXB_AQUAE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Lipid-A-disaccharide synthase
EC=2.4.1.182

Gene names

Name:	lpxB
Ordered Locus Names:	aq_1427

Organism

Aquifex aeolicus (strain VF5)

Taxonomic identifier

224324 [NCBI]

Taxonomic lineage

Bacteria › Aquificae › Aquificales › Aquificaceae › Aquifex

Protein attributes

Sequence length	356 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell By similarity. HAMAP MF_00392
Catalytic activity	UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine + 2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate = UDP + 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6-beta-D-2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate. HAMAP MF_00392
Pathway	Glycolipid biosynthesis; lipid IV(A) biosynthesis; lipid IV(A) from (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] and UDP-N-acetyl-alpha-D-glucosamine: step 5/6. HAMAP MF_00392
Sequence similarities	Belongs to the LpxB family.

Ontologies

Keywords
Biological process	Lipid A biosynthesis Lipid synthesis
Molecular function	Glycosyltransferase Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	lipid A biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	lipid-A-disaccharide synthase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 356	356	Lipid-A-disaccharide synthase HAMAP MF_00392		PRO_0000190151

Sequences

	Sequence		Length	Mass (Da)
	O67420 [UniParc]. Last modified August 1, 1998. Version 1. Checksum: 1B4CFBA5F409CD68	FASTA	356	41,300
	10 20 30 40 50 60 MKKIFLSLAD RSASNYVYEI LKEGFEEYEI YGLTDEKLEK IGVKSVARYS EISTVGLIEA 70 80 90 100 110 120 LPKVFKFLKI YRKILKNLKN TDTLIACDAP ALNLRLIKDA RKLGVKRIIY FISPQVWAWK 130 140 150 160 170 180 PKRAEIIANY CDHVIVILPF EKKIYRKFPN LKVHYVGHPL VDLVKPQKTK EEFMKAFKKE 190 200 210 220 230 240 PLPLLLGSRE GEIRRHVKLL KGIIEELKKS FDVISPTFRE FSKFIERELK VKTLTYEGAS 250 260 270 280 290 300 YDCFFYSKAS LIASGTASLE AGIAGNPHVV YYKVNPITYF LGKRLVKVPY ISLVNILLKE 310 320 330 340 350 EVVPEFIQKS SDEILKGFEK VYKNEEEIKE KLGTLKFILG ERFVIRKLRE LFLEIV

References

[1]

"The complete genome of the hyperthermophilic bacterium Aquifex aeolicus." Deckert G., Warren P.V., Gaasterland T., Young W.G., Lenox A.L., Graham D.E., Overbeek R., Snead M.A., Keller M., Aujay M., Huber R., Feldman R.A., Short J.M., Olsen G.J., Swanson R.V. Nature 392:353-358(1998) [PubMed: 9537320] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: VF5.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE000657 Genomic DNA. Translation: AAC07386.1.
PIR	B70424.
RefSeq	NP_213985.1. NC_000918.1.
3D structure databases
ProteinModelPortal	O67420.
ModBase	Search...
Protein family/group databases
CAZy	GT19. Glycosyltransferase Family 19.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1192951.
GenomeReviews	Gene locus aq_1427 in contig AE000657_GR.
KEGG	aae:aq_1427.
NMPDR	fig|224324.1.peg.1000.
PATRIC	20960004. VBIAquAeo85532_1116.
Phylogenomic databases
HOGENOM	HBG584837.
OMA	IGLANIM.
PhylomeDB	O67420.
ProtClustDB	CLSK2299698.
Enzyme and pathway databases
BioCyc	AAEO224324:AQ_1427-MONOMER.
Family and domain databases
HAMAP	MF_00392. LpxB. [Tree]
InterPro	IPR003835. Glyco_trans_19. [Graphical view]
KO	K00748.
Pfam	PF02684. LpxB. 1 hit. [Graphical view]
TIGRFAMs	TIGR00215. LpxB. 1 hit.
ProtoNet	Search...

Entry information

Entry name

LPXB_AQUAE

Accession

Primary (citable) accession number: O67420

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 1, 2001
Last sequence update:	August 1, 1998
Last modified:	January 25, 2012
This is version 60 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program