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Protein

Tryptophan synthase beta chain 2

Gene

trpB2

Organism
Aquifex aeolicus (strain VF5)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.By similarity

Catalytic activityi

L-serine + 1-C-(indol-3-yl)glycerol 3-phosphate = L-tryptophan + D-glyceraldehyde 3-phosphate + H2O.

Cofactori

Pathwayi: L-tryptophan biosynthesis

This protein is involved in step 5 of the subpathway that synthesizes L-tryptophan from chorismate.
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. Anthranilate synthase component 1 (trpE)
  2. Anthranilate phosphoribosyltransferase (trpD)
  3. N-(5'-phosphoribosyl)anthranilate isomerase (trpF)
  4. Indole-3-glycerol phosphate synthase (trpC)
  5. Tryptophan synthase alpha chain (trpA), Tryptophan synthase beta chain 1 (trpB1), Tryptophan synthase beta chain 2 (trpB2)
This subpathway is part of the pathway L-tryptophan biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-tryptophan from chorismate, the pathway L-tryptophan biosynthesis and in Amino-acid biosynthesis.

GO - Molecular functioni

Keywordsi

Molecular functionLyase
Biological processAmino-acid biosynthesis, Aromatic amino acid biosynthesis, Tryptophan biosynthesis
LigandPyridoxal phosphate

Enzyme and pathway databases

BioCyciAAEO224324:G1G15-1008-MONOMER
UniPathwayiUPA00035; UER00044

Names & Taxonomyi

Protein namesi
Recommended name:
Tryptophan synthase beta chain 2 (EC:4.2.1.20)
Gene namesi
Name:trpB2
Ordered Locus Names:aq_1410
OrganismiAquifex aeolicus (strain VF5)
Taxonomic identifieri224324 [NCBI]
Taxonomic lineageiBacteriaAquificaeAquificalesAquificaceaeAquifex
Proteomesi
  • UP000000798 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000989131 – 434Tryptophan synthase beta chain 2Add BLAST434

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei110N6-(pyridoxal phosphate)lysineBy similarity1

Interactioni

Subunit structurei

Tetramer of two alpha and two beta chains.By similarity

Protein-protein interaction databases

STRINGi224324.aq_1410

Structurei

3D structure databases

ProteinModelPortaliO67409
SMRiO67409
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TrpB family.Curated

Phylogenomic databases

eggNOGiENOG4108JEB Bacteria
COG1350 LUCA
HOGENOMiHOG000161709
InParanoidiO67409
KOiK06001
OMAiPPIHAGG
OrthoDBiPOG091H12UO

Family and domain databases

CDDicd06446 Trp-synth_B, 1 hit
HAMAPiMF_00133 Trp_synth_beta, 1 hit
InterProiView protein in InterPro
IPR001926 PLP-dep
IPR006316 Trp_synth_b-like
IPR006653 Trp_synth_b_CS
IPR006654 Trp_synth_beta
IPR023026 Trp_synth_beta/beta-like
IPR036052 Trypto_synt_PLP_dependent
PANTHERiPTHR43565 PTHR43565, 1 hit
PfamiView protein in Pfam
PF00291 PALP, 1 hit
PIRSFiPIRSF001413 Trp_syn_beta, 1 hit
PIRSF500824 TrpB_prok, 1 hit
SUPFAMiSSF53686 SSF53686, 1 hit
TIGRFAMsiTIGR01415 trpB_rel, 1 hit
PROSITEiView protein in PROSITE
PS00168 TRP_SYNTHASE_BETA, 1 hit

Sequencei

Sequence statusi: Complete.

O67409-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRKFLLSEGE IPKKWLNILP LLPEPLEPPL DPETMEPVKP EKLLAIFPEP
60 70 80 90 100
LVEQEVSDKE WIDIPEEVLD IYSLWRPTPL HRAKNLEEFL GTPAKIFYKN
110 120 130 140 150
ESVSPPGSHK PNTAVAQAYY NKISGVKRLT TETGAGQWGS ALSFATQFFD
160 170 180 190 200
LQCRVYMVRV SYNQKPYRRI LMETWKGEVI PSPSPYTNAG RKYYEENPEH
210 220 230 240 250
PGSLGIAISE AIEEAASRED TKYSLGSVLN HVLLHQTVIG LEAKKQMEEA
260 270 280 290 300
GYYPDVIIGA VGGGSNFAGL SFPFLADVLR GDKRKEDLKV LAVEPEACPT
310 320 330 340 350
LTKGEYKYDF GDSVGLTPLI KMYTLGHDFV PSPIHAGGLR YHGDAPLVCK
360 370 380 390 400
LYNLGYIDAV AYKQTEVFEA AVTFARTEGI VPAPESAHAI KAAIDEALKC
410 420 430
KETGEEKVIL FNLSGHGYFD LSAYDKYLHG ELTD
Length:434
Mass (Da):48,314
Last modified:August 1, 1998 - v1
Checksum:i7D1921128B07C39B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000657 Genomic DNA Translation: AAC07370.1
PIRiG70422
RefSeqiNP_213974.1, NC_000918.1
WP_010880912.1, NC_000918.1

Genome annotation databases

EnsemblBacteriaiAAC07370; AAC07370; aq_1410
GeneIDi1192940
KEGGiaae:aq_1410
PATRICifig|224324.8.peg.1105

Similar proteinsi

Entry informationi

Entry nameiTRPB2_AQUAE
AccessioniPrimary (citable) accession number: O67409
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: August 1, 1998
Last modified: March 28, 2018
This is version 113 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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