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O67398

- DNLI_AQUAE

UniProt

O67398 - DNLI_AQUAE

Protein

Probable DNA ligase

Gene

lig

Organism
Aquifex aeolicus (strain VF5)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 95 (01 Oct 2014)
      Sequence version 2 (20 Jun 2001)
      Previous versions | rss
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    Functioni

    DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.By similarity

    Catalytic activityi

    ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m).

    Cofactori

    Divalent metal cations.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei248 – 2481ATPBy similarity
    Active sitei250 – 2501N6-AMP-lysine intermediateBy similarity
    Binding sitei255 – 2551ATPBy similarity
    Binding sitei270 – 2701ATPBy similarity
    Binding sitei299 – 2991ATPBy similarity
    Binding sitei339 – 3391ATPBy similarity
    Binding sitei416 – 4161ATPBy similarity
    Binding sitei422 – 4221ATPBy similarity

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. DNA binding Source: InterPro
    3. DNA ligase (ATP) activity Source: RefGenome
    4. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. cell cycle Source: UniProtKB-KW
    2. cell division Source: UniProtKB-KW
    3. DNA ligation Source: RefGenome
    4. DNA ligation involved in DNA repair Source: InterPro
    5. DNA recombination Source: UniProtKB-HAMAP
    6. lagging strand elongation Source: RefGenome
    7. nucleotide-excision repair Source: RefGenome

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    Cell cycle, Cell division, DNA damage, DNA recombination, DNA repair, DNA replication

    Keywords - Ligandi

    ATP-binding, Metal-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciAAEO224324:GJBH-1004-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable DNA ligase (EC:6.5.1.1)
    Alternative name(s):
    Polydeoxyribonucleotide synthase [ATP]
    Gene namesi
    Name:lig
    Ordered Locus Names:aq_1394
    OrganismiAquifex aeolicus (strain VF5)
    Taxonomic identifieri224324 [NCBI]
    Taxonomic lineageiBacteriaAquificaeAquificalesAquificaceaeAquifex
    ProteomesiUP000000798: Chromosome

    Subcellular locationi

    GO - Cellular componenti

    1. chromosome Source: RefGenome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 584584Probable DNA ligasePRO_0000059623Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi224324.aq_1394.

    Structurei

    3D structure databases

    ProteinModelPortaliO67398.
    SMRiO67398. Positions 1-579.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ATP-dependent DNA ligase family.Curated

    Phylogenomic databases

    eggNOGiCOG1793.
    HOGENOMiHOG000036008.
    KOiK10747.
    OMAiLDPSGYN.
    OrthoDBiEOG6Q8HXT.

    Family and domain databases

    Gene3Di1.10.3260.10. 1 hit.
    2.40.50.140. 1 hit.
    HAMAPiMF_00407. DNA_ligase.
    InterProiIPR022865. DNA_ligae_ATP-dep_bac/arc.
    IPR000977. DNA_ligase_ATP-dep.
    IPR012309. DNA_ligase_ATP-dep_C.
    IPR012310. DNA_ligase_ATP-dep_cent.
    IPR016059. DNA_ligase_ATP-dep_CS.
    IPR012308. DNA_ligase_ATP-dep_N.
    IPR012340. NA-bd_OB-fold.
    [Graphical view]
    PfamiPF04679. DNA_ligase_A_C. 1 hit.
    PF01068. DNA_ligase_A_M. 1 hit.
    PF04675. DNA_ligase_A_N. 1 hit.
    [Graphical view]
    SUPFAMiSSF117018. SSF117018. 1 hit.
    SSF50249. SSF50249. 1 hit.
    TIGRFAMsiTIGR00574. dnl1. 1 hit.
    PROSITEiPS00697. DNA_LIGASE_A1. 1 hit.
    PS50160. DNA_LIGASE_A3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O67398-1 [UniParc]FASTAAdd to Basket

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    MEYRILAEFY ERIEKTTSRI EMVSSLVELF KQTPKELIDK VVYLSIGKIA    50
    PEYTGLDYNF GEKLAIRALS RVLKIPALEI EKRVRQEGDL GEAGRKLYEE 100
    LGFKPEGTLT VEEVYNGLLN IAKAVGIGSQ ERKISIFASL LKKATPLEAK 150
    YLLRTITERL RLGIGDNTIL EALSIAFTGS SVNREVVERA YNLTSDLGYV 200
    AKILAEKGLE GVKQVKIQVG RPVRPMLAER MSSPILILRK LGGKCGAEYK 250
    YDGERIQAHR KGDEFYLFSR RLENITHQYP DLIEFLKEAI PHDFIVELEA 300
    VVIDPASGEI RPFQELMHRK VKYVTKYHIT KYPVAGFLFD IIYLDGEDLT 350
    LKPYPERREI LEKVVKRTDR IGLVPRKIVD NVEDLENFFY QAIEEGCEGL 400
    VCKSLAPNSI YQAGKRGFLW IKYKRDYKSV LADTLDLVVV GGFYGKGQRK 450
    GTFGSLLMAC YDPESDMFKT VTKVGTGFTE DDFKKLEEIL MPRKLNHRHP 500
    RVNSILEADM WFEPYLVLEI TGAELTLSPV HTCGWGKVSP NRGIGLRFPR 550
    FTGRYRFDKR PEDATTEQEI IEMYRMQRKI RVRS 584
    Length:584
    Mass (Da):66,945
    Last modified:June 20, 2001 - v2
    Checksum:iCB96A7451E9BDC1D
    GO

    Sequence cautioni

    The sequence AAC07362.1 differs from that shown. Reason: Erroneous initiation.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE000657 Genomic DNA. Translation: AAC07362.1. Different initiation.
    PIRiD70421.
    RefSeqiNP_213963.1. NC_000918.1.

    Genome annotation databases

    EnsemblBacteriaiAAC07362; AAC07362; aq_1394.
    GeneIDi1192929.
    KEGGiaae:aq_1394.
    PATRICi20959956. VBIAquAeo85532_1092.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE000657 Genomic DNA. Translation: AAC07362.1 . Different initiation.
    PIRi D70421.
    RefSeqi NP_213963.1. NC_000918.1.

    3D structure databases

    ProteinModelPortali O67398.
    SMRi O67398. Positions 1-579.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 224324.aq_1394.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAC07362 ; AAC07362 ; aq_1394 .
    GeneIDi 1192929.
    KEGGi aae:aq_1394.
    PATRICi 20959956. VBIAquAeo85532_1092.

    Phylogenomic databases

    eggNOGi COG1793.
    HOGENOMi HOG000036008.
    KOi K10747.
    OMAi LDPSGYN.
    OrthoDBi EOG6Q8HXT.

    Enzyme and pathway databases

    BioCyci AAEO224324:GJBH-1004-MONOMER.

    Family and domain databases

    Gene3Di 1.10.3260.10. 1 hit.
    2.40.50.140. 1 hit.
    HAMAPi MF_00407. DNA_ligase.
    InterProi IPR022865. DNA_ligae_ATP-dep_bac/arc.
    IPR000977. DNA_ligase_ATP-dep.
    IPR012309. DNA_ligase_ATP-dep_C.
    IPR012310. DNA_ligase_ATP-dep_cent.
    IPR016059. DNA_ligase_ATP-dep_CS.
    IPR012308. DNA_ligase_ATP-dep_N.
    IPR012340. NA-bd_OB-fold.
    [Graphical view ]
    Pfami PF04679. DNA_ligase_A_C. 1 hit.
    PF01068. DNA_ligase_A_M. 1 hit.
    PF04675. DNA_ligase_A_N. 1 hit.
    [Graphical view ]
    SUPFAMi SSF117018. SSF117018. 1 hit.
    SSF50249. SSF50249. 1 hit.
    TIGRFAMsi TIGR00574. dnl1. 1 hit.
    PROSITEi PS00697. DNA_LIGASE_A1. 1 hit.
    PS50160. DNA_LIGASE_A3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: VF5.

    Entry informationi

    Entry nameiDNLI_AQUAE
    AccessioniPrimary (citable) accession number: O67398
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 20, 2001
    Last sequence update: June 20, 2001
    Last modified: October 1, 2014
    This is version 95 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3