Reviewed,
UniProtKB/Swiss-Prot O67398 (DNLI_AQUAE)
Last modified
May 5, 2009.
Version 59.
History...
Clusters with 100%,
90%,
50% identity |
Documents (1) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Probable DNA ligase EC=6.5.1.1 Alternative name(s): Polydeoxyribonucleotide synthase [ATP] | ||||
| Gene names |
| ||||
| Organism | Aquifex aeolicus [Complete proteome] [HAMAP] | ||||
| Taxonomic identifier | 63363 [NCBI] | ||||
| Taxonomic lineage | Bacteria › Aquificae › Aquificales › Aquificaceae › Aquifex |
Protein attributes
| Sequence length | 584 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Inferred from homology. |
General annotation (Comments)
| Function | DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair By similarity. |
| Catalytic activity | ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m). HAMAP MF_00407 |
| Cofactor | Divalent metal cations By similarity. |
| Sequence similarities | Belongs to the ATP-dependent DNA ligase family. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Cell cycle Cell division DNA damage DNA recombination DNA repair DNA replication |
| Ligand | ATP-binding Metal-binding Nucleotide-binding |
| Molecular function | Ligase |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | DNA recombination Inferred from electronic annotation. Source: HAMAP DNA repairInferred from electronic annotation. Source: HAMAP DNA replicationInferred from electronic annotation. Source: HAMAP cell cycleInferred from electronic annotation. Source: UniProtKB-KW cell divisionInferred from electronic annotation. Source: UniProtKB-KW |
| Molecular function | ATP binding Inferred from electronic annotation. Source: HAMAP DNA bindingInferred from electronic annotation. Source: InterPro DNA ligase (ATP) activityInferred from electronic annotation. Source: HAMAP metal ion bindingInferred from electronic annotation. Source: UniProtKB-KW |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 584 | 584 | Probable DNA ligase HAMAP MF_00407 | PRO_0000059623 | |||||
Sites | |||||||||
| Active site | 250 | 1 | N6-AMP-lysine intermediate By similarity | ||||||
| Binding site | 248 | 1 | ATP By similarity | ||||||
| Binding site | 255 | 1 | ATP By similarity | ||||||
| Binding site | 270 | 1 | ATP By similarity | ||||||
| Binding site | 299 | 1 | ATP By similarity | ||||||
| Binding site | 339 | 1 | ATP By similarity | ||||||
| Binding site | 416 | 1 | ATP By similarity | ||||||
| Binding site | 422 | 1 | ATP By similarity | ||||||
Sequences
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References
| [1] | "The complete genome of the hyperthermophilic bacterium Aquifex aeolicus." Deckert G., Warren P.V., Gaasterland T., Young W.G., Lenox A.L., Graham D.E., Overbeek R., Snead M.A., Keller M., Aujay M., Huber R., Feldman R.A., Short J.M., Olsen G.J., Swanson R.V. Nature 392:353-358(1998) [PubMed: 9537320] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: VF5. |
Cross-references
Sequence databases | |
|---|---|
| AE000657 Genomic DNA. Translation: AAC07362.1. Different initiation. | |
| PIR | D70421. |
| RefSeq | NP_213963.1. |
3D structure databases | |
| ModBase | Search... |
Genome annotation databases | |
| GeneID | 1192929. |
| GenomeReviews | Gene locus aq_1394 in contig AE000657_GR. |
| KEGG | aae:aq_1394. |
| NMPDR | fig|224324.1.peg.978. |
Organism-specific databases | |
| CMR | Search... |
Phylogenomic databases | |
| HOGENOM | O67398. |
| OMA | O67398. RNWLKLK. |
Enzyme and pathway databases | |
| BioCyc | AAEO224324:AQ_1394-MON. |
| BRENDA | 6.5.1.1. 189781. |
Family and domain databases | |
| HAMAP | MF_00407. [Tree] |
| InterPro | IPR000977. DNA_ligase. IPR012309. DNA_ligase_A_C. IPR012310. DNA_ligase_A_M. IPR012308. DNA_ligase_A_N. IPR016059. DNA_ligase_CS. IPR012340. NA-bd_OB-fold. [Graphical view] |
| Gene3D | G3DSA:2.40.50.140. OB_NA_bd_sub. 1 hit. |
| Pfam | PF04679. DNA_ligase_A_C. 1 hit. PF01068. DNA_ligase_A_M. 1 hit. PF04675. DNA_ligase_A_N. 1 hit. [Graphical view] |
| TIGRFAMs | TIGR00574. dnl1. 1 hit. |
| PROSITE | PS00697. DNA_LIGASE_A1. 1 hit. PS00333. DNA_LIGASE_A2. False negative. PS50160. DNA_LIGASE_A3. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | DNLI_AQUAE | ||||||||
| Accession | Primary (citable) accession number: O67398 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes) | ||||||||

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