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O67398

- DNLI_AQUAE

UniProt

O67398 - DNLI_AQUAE

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Protein

Probable DNA ligase

Gene

lig

Organism
Aquifex aeolicus (strain VF5)
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi

Functioni

DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.By similarity

Catalytic activityi

ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m).

Cofactori

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei248 – 2481ATPBy similarity
Active sitei250 – 2501N6-AMP-lysine intermediateBy similarity
Binding sitei255 – 2551ATPBy similarity
Binding sitei270 – 2701ATPBy similarity
Binding sitei299 – 2991ATPBy similarity
Binding sitei339 – 3391ATPBy similarity
Binding sitei416 – 4161ATPBy similarity
Binding sitei422 – 4221ATPBy similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. DNA binding Source: InterPro
  3. DNA ligase (ATP) activity Source: RefGenome
  4. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. cell cycle Source: UniProtKB-KW
  2. cell division Source: UniProtKB-KW
  3. DNA biosynthetic process Source: InterPro
  4. DNA ligation Source: RefGenome
  5. DNA ligation involved in DNA repair Source: InterPro
  6. DNA recombination Source: UniProtKB-HAMAP
  7. lagging strand elongation Source: RefGenome
  8. nucleotide-excision repair Source: RefGenome
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Cell cycle, Cell division, DNA damage, DNA recombination, DNA repair, DNA replication

Keywords - Ligandi

ATP-binding, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciAAEO224324:GJBH-1004-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable DNA ligase (EC:6.5.1.1)
Alternative name(s):
Polydeoxyribonucleotide synthase [ATP]
Gene namesi
Name:lig
Ordered Locus Names:aq_1394
OrganismiAquifex aeolicus (strain VF5)
Taxonomic identifieri224324 [NCBI]
Taxonomic lineageiBacteriaAquificaeAquificalesAquificaceaeAquifex
ProteomesiUP000000798: Chromosome

Subcellular locationi

GO - Cellular componenti

  1. chromosome Source: RefGenome
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 584584Probable DNA ligasePRO_0000059623Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi224324.aq_1394.

Structurei

3D structure databases

ProteinModelPortaliO67398.
SMRiO67398. Positions 1-579.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ATP-dependent DNA ligase family.Curated

Phylogenomic databases

eggNOGiCOG1793.
HOGENOMiHOG000036008.
InParanoidiO67398.
KOiK10747.
OMAiLDPSGYN.
OrthoDBiEOG6Q8HXT.

Family and domain databases

Gene3Di1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
HAMAPiMF_00407. DNA_ligase.
InterProiIPR022865. DNA_ligae_ATP-dep_bac/arc.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamiPF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view]
SUPFAMiSSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR00574. dnl1. 1 hit.
PROSITEiPS00697. DNA_LIGASE_A1. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O67398-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEYRILAEFY ERIEKTTSRI EMVSSLVELF KQTPKELIDK VVYLSIGKIA
60 70 80 90 100
PEYTGLDYNF GEKLAIRALS RVLKIPALEI EKRVRQEGDL GEAGRKLYEE
110 120 130 140 150
LGFKPEGTLT VEEVYNGLLN IAKAVGIGSQ ERKISIFASL LKKATPLEAK
160 170 180 190 200
YLLRTITERL RLGIGDNTIL EALSIAFTGS SVNREVVERA YNLTSDLGYV
210 220 230 240 250
AKILAEKGLE GVKQVKIQVG RPVRPMLAER MSSPILILRK LGGKCGAEYK
260 270 280 290 300
YDGERIQAHR KGDEFYLFSR RLENITHQYP DLIEFLKEAI PHDFIVELEA
310 320 330 340 350
VVIDPASGEI RPFQELMHRK VKYVTKYHIT KYPVAGFLFD IIYLDGEDLT
360 370 380 390 400
LKPYPERREI LEKVVKRTDR IGLVPRKIVD NVEDLENFFY QAIEEGCEGL
410 420 430 440 450
VCKSLAPNSI YQAGKRGFLW IKYKRDYKSV LADTLDLVVV GGFYGKGQRK
460 470 480 490 500
GTFGSLLMAC YDPESDMFKT VTKVGTGFTE DDFKKLEEIL MPRKLNHRHP
510 520 530 540 550
RVNSILEADM WFEPYLVLEI TGAELTLSPV HTCGWGKVSP NRGIGLRFPR
560 570 580
FTGRYRFDKR PEDATTEQEI IEMYRMQRKI RVRS
Length:584
Mass (Da):66,945
Last modified:June 20, 2001 - v2
Checksum:iCB96A7451E9BDC1D
GO

Sequence cautioni

The sequence AAC07362.1 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000657 Genomic DNA. Translation: AAC07362.1. Different initiation.
PIRiD70421.
RefSeqiNP_213963.1. NC_000918.1.

Genome annotation databases

EnsemblBacteriaiAAC07362; AAC07362; aq_1394.
GeneIDi1192929.
KEGGiaae:aq_1394.
PATRICi20959956. VBIAquAeo85532_1092.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000657 Genomic DNA. Translation: AAC07362.1 . Different initiation.
PIRi D70421.
RefSeqi NP_213963.1. NC_000918.1.

3D structure databases

ProteinModelPortali O67398.
SMRi O67398. Positions 1-579.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 224324.aq_1394.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAC07362 ; AAC07362 ; aq_1394 .
GeneIDi 1192929.
KEGGi aae:aq_1394.
PATRICi 20959956. VBIAquAeo85532_1092.

Phylogenomic databases

eggNOGi COG1793.
HOGENOMi HOG000036008.
InParanoidi O67398.
KOi K10747.
OMAi LDPSGYN.
OrthoDBi EOG6Q8HXT.

Enzyme and pathway databases

BioCyci AAEO224324:GJBH-1004-MONOMER.

Family and domain databases

Gene3Di 1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
HAMAPi MF_00407. DNA_ligase.
InterProi IPR022865. DNA_ligae_ATP-dep_bac/arc.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view ]
Pfami PF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view ]
SUPFAMi SSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsi TIGR00574. dnl1. 1 hit.
PROSITEi PS00697. DNA_LIGASE_A1. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: VF5.

Entry informationi

Entry nameiDNLI_AQUAE
AccessioniPrimary (citable) accession number: O67398
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: June 20, 2001
Last modified: November 26, 2014
This is version 97 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3