Skip Header

Contribute Send feedback
Read comments (?) or add your own

O67383 (ARLY_AQUAE) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 85. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Argininosuccinate lyase
Short name=ASAL
EC=4.3.2.1
Alternative name(s):
Arginosuccinase
Gene names
Name:argH
Ordered Locus Names:aq_1372
OrganismAquifex aeolicus (strain VF5)
Taxonomic identifier224324 [NCBI]
Taxonomic lineageBacteria › Aquificae › Aquificales › Aquificaceae › Aquifex

Protein attributes

Sequence length457 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

2-(N(omega)-L-arginino)succinate = fumarate + L-arginine. HAMAP MF_00006

Pathway

Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 3/3. HAMAP MF_00006

Subcellular location

Cytoplasm By similarity HAMAP MF_00006.

Sequence similarities

Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.

Ontologies

Keywords
   Biological processAmino-acid biosynthesis
Arginine biosynthesis
   Cellular componentCytoplasm
   Molecular functionLyase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological processarginine biosynthetic process via ornithine

Inferred from electronic annotation. Source: InterPro

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionargininosuccinate lyase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 457457Argininosuccinate lyase HAMAP MF_00006
PRO_0000137733

Sequences

Sequence LengthMass (Da)Tools
O67383 [UniParc].

Last modified August 1, 1998. Version 1.
Checksum: 2BEBD720AAB18155

FASTA45752,838
        10         20         30         40         50         60 
MEKPWSGRFK EETDKFVEDF TESVSFDKEL AFEDIEQDIA HVKTLQKAGI LTEEEARELI 

        70         80         90        100        110        120 
QELLKIKEEI KEGKFQWKKE LEDVHMNIEA ELINRLGDVG RKLHTARSRN DQVATDEKLY 

       130        140        150        160        170        180 
LKKEIKEVLQ LLKELRKTLV ELAETTVDFV MPSYTHLQRA QPIRVAHYFL AYREILLKDS 

       190        200        210        220        230        240 
ERLMDTYRRV DELPLGSGAV AGVDFPLDRF YTAELLGFNR VTRNSMYATA ERDFIIEFLS 

       250        260        270        280        290        300 
NCALIAQHLS RLAEDLIIWN TEEFNFVELP DKLCTGSSIM PQKKNPDVLE LIRGKTGRIY 

       310        320        330        340        350        360 
GNLIALLTTM KALPMAYNRD MQEDKEPLFD TLKNLKNMIK GMTLVLSDLR VKEQNMRKAS 

       370        380        390        400        410        420 
GNFLLITDIA NYLVEKGVPF RTAHHIAGSI VAYLLEKGKK LEEMTLEEFK QFSEKFEEDV 

       430        440        450 
FDILSPERAA DRKRVYGGTA KEEILRIIEV AKAEEGL

« Hide

References

[1]"The complete genome of the hyperthermophilic bacterium Aquifex aeolicus."
Deckert G., Warren P.V., Gaasterland T., Young W.G., Lenox A.L., Graham D.E., Overbeek R., Snead M.A., Keller M., Aujay M., Huber R., Feldman R.A., Short J.M., Olsen G.J., Swanson R.V.
Nature 392:353-358(1998) [PubMed: 9537320] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: VF5.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AE000657 Genomic DNA. Translation: AAC07341.1.
PIRD70419.
RefSeqNP_213947.1. NC_000918.1.

3D structure databases

ProteinModelPortalO67383.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID1192913.
GenomeReviewsGene locus aq_1372 in contig AE000657_GR.
KEGGaae:aq_1372.
NMPDRfig|224324.1.peg.962.
PATRIC20959920. VBIAquAeo85532_1074.

Phylogenomic databases

HOGENOMHBG539632.
OMAMAEDLIF.
PhylomeDBO67383.
ProtClustDBPRK00855.

Enzyme and pathway databases

BioCycAAEO224324:AQ_1372-MONOMER.

Family and domain databases

HAMAPMF_00006. Arg_succ_lyase.
[Tree]
InterProIPR009049. Argininosuccinate_lyase.
IPR003031. D_crystallin.
IPR000362. Fumarate_lyase.
IPR020557. Fumarate_lyase_CS.
IPR008948. L-Aspartase-like.
IPR022761. Lyase1_N.
[Graphical view]
KOK01755.
PANTHERPTHR11444:SF3. argH. 1 hit.
PfamPF00206. Lyase_1. 1 hit.
[Graphical view]
PRINTSPR00145. ARGSUCLYASE.
PR00149. FUMRATELYASE.
SUPFAMSSF48557. L-Aspartase-like. 1 hit.
TIGRFAMsTIGR00838. ArgH. 1 hit.
PROSITEPS00163. FUMARATE_LYASES. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameARLY_AQUAE
AccessionPrimary (citable) accession number: O67383
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: August 1, 1998
Last modified: January 25, 2012
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents