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Protein

NADH-quinone oxidoreductase subunit N 1

Gene

nuoN1

Organism
Aquifex aeolicus (strain VF5)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.UniRule annotation

Catalytic activityi

NADH + a quinone = NAD+ + a quinol.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processTransport
LigandNAD, Ubiquinone

Enzyme and pathway databases

BioCyciAAEO224324:G1G15-938-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
NADH-quinone oxidoreductase subunit N 1UniRule annotation (EC:1.6.5.11UniRule annotation)
Alternative name(s):
NADH dehydrogenase I subunit N 1UniRule annotation
NDH-1 subunit N 1UniRule annotation
Gene namesi
Name:nuoN1UniRule annotation
Ordered Locus Names:aq_1322
OrganismiAquifex aeolicus (strain VF5)
Taxonomic identifieri224324 [NCBI]
Taxonomic lineageiBacteriaAquificaeAquificalesAquificaceaeAquifex
Proteomesi
  • UP000000798 Componenti: Chromosome

Subcellular locationi

  • Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei6 – 26HelicalUniRule annotationAdd BLAST21
Transmembranei33 – 53HelicalUniRule annotationAdd BLAST21
Transmembranei65 – 85HelicalUniRule annotationAdd BLAST21
Transmembranei98 – 118HelicalUniRule annotationAdd BLAST21
Transmembranei122 – 142HelicalUniRule annotationAdd BLAST21
Transmembranei155 – 175HelicalUniRule annotationAdd BLAST21
Transmembranei192 – 212HelicalUniRule annotationAdd BLAST21
Transmembranei237 – 257HelicalUniRule annotationAdd BLAST21
Transmembranei259 – 279HelicalUniRule annotationAdd BLAST21
Transmembranei285 – 305HelicalUniRule annotationAdd BLAST21
Transmembranei312 – 332HelicalUniRule annotationAdd BLAST21
Transmembranei356 – 376HelicalUniRule annotationAdd BLAST21
Transmembranei401 – 421HelicalUniRule annotationAdd BLAST21
Transmembranei436 – 456HelicalUniRule annotationAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003910981 – 464NADH-quinone oxidoreductase subunit N 1Add BLAST464

Keywords - PTMi

Quinone

Interactioni

Subunit structurei

NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.UniRule annotation

Protein-protein interaction databases

STRINGi224324.aq_1322

Family & Domainsi

Sequence similaritiesi

Belongs to the complex I subunit 2 family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105CNR Bacteria
COG1007 LUCA
HOGENOMiHOG000100794
InParanoidiO67342
KOiK00343
OMAiHFWVPEV
OrthoDBiPOG091H0B2L

Family and domain databases

HAMAPiMF_00445 NDH1_NuoN_1, 1 hit
InterProiView protein in InterPro
IPR010096 NADH-Q_OxRdtase_suN/2
IPR001750 ND/Mrp_mem
PfamiView protein in Pfam
PF00361 Proton_antipo_M, 1 hit
TIGRFAMsiTIGR01770 NDH_I_N, 1 hit

Sequencei

Sequence statusi: Complete.

O67342-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNWNAILPEA ILAIGILTVF ILELFLERKH YKFLSVLAFI FVVLSGYSIF
60 70 80 90 100
FVNYPAKLFF DGFSVDALNL IGKLFILAVT GFVLLSSYDY FSKKNSQYGE
110 120 130 140 150
LPYLYLIATL GLMVMISSDN LAIIFTGLEL ASITMYILVG LFRREYLSKE
160 170 180 190 200
GAFKYLVIGT TGTSMYALGS ALVYASSGSM VLSPVKEENT LFALGVILII
210 220 230 240 250
SALALKVSAV PFHFWTPDAY EGAPTPTTAY LSTVPKIGMY FLFVKLTMYL
260 270 280 290 300
FSAFPDWKYV VMLLAVLSMF YGNIVAYAQK SVKRLLAYSS IAHAGYFLTA
310 320 330 340 350
LTAVDKHLFS ALLFYVFVYA LATVGAFTVL AILEKKEGWT HHFLDFKGLK
360 370 380 390 400
EENPVLASML ALFLFALIGI PPAAVFLGKL GIFFGLVKTD MFALGILFAI
410 420 430 440 450
ASLISAGYYL KVIVYMFLYS GEVRHGQTTV SAGEAFTVLG TAFLVIFFGL
460
FPHVVLDFIL RALS
Length:464
Mass (Da):51,286
Last modified:August 1, 1998 - v1
Checksum:i5C72D12A83E8FF26
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000657 Genomic DNA Translation: AAC07305.1
PIRiC70414
RefSeqiNP_213906.1, NC_000918.1
WP_010880844.1, NC_000918.1

Genome annotation databases

EnsemblBacteriaiAAC07305; AAC07305; aq_1322
GeneIDi1192780
KEGGiaae:aq_1322
PATRICifig|224324.8.peg.1030

Similar proteinsi

Entry informationi

Entry nameiNUON1_AQUAE
AccessioniPrimary (citable) accession number: O67342
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 9, 2010
Last sequence update: August 1, 1998
Last modified: March 28, 2018
This is version 110 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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