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Protein

NADH-quinone oxidoreductase subunit N 1

Gene

nuoN1

Organism
Aquifex aeolicus (strain VF5)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.UniRule annotation

Catalytic activityi

NADH + a quinone = NAD+ + a quinol.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Transport

Keywords - Ligandi

NAD, Ubiquinone

Enzyme and pathway databases

BioCyciAAEO224324:GJBH-944-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
NADH-quinone oxidoreductase subunit N 1UniRule annotation (EC:1.6.5.11UniRule annotation)
Alternative name(s):
NADH dehydrogenase I subunit N 1UniRule annotation
NDH-1 subunit N 1UniRule annotation
Gene namesi
Name:nuoN1UniRule annotation
Ordered Locus Names:aq_1322
OrganismiAquifex aeolicus (strain VF5)
Taxonomic identifieri224324 [NCBI]
Taxonomic lineageiBacteriaAquificaeAquificalesAquificaceaeAquifex
Proteomesi
  • UP000000798 Componenti: Chromosome

Subcellular locationi

  • Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei6 – 2621HelicalUniRule annotationAdd
BLAST
Transmembranei33 – 5321HelicalUniRule annotationAdd
BLAST
Transmembranei65 – 8521HelicalUniRule annotationAdd
BLAST
Transmembranei98 – 11821HelicalUniRule annotationAdd
BLAST
Transmembranei122 – 14221HelicalUniRule annotationAdd
BLAST
Transmembranei155 – 17521HelicalUniRule annotationAdd
BLAST
Transmembranei192 – 21221HelicalUniRule annotationAdd
BLAST
Transmembranei237 – 25721HelicalUniRule annotationAdd
BLAST
Transmembranei259 – 27921HelicalUniRule annotationAdd
BLAST
Transmembranei285 – 30521HelicalUniRule annotationAdd
BLAST
Transmembranei312 – 33221HelicalUniRule annotationAdd
BLAST
Transmembranei356 – 37621HelicalUniRule annotationAdd
BLAST
Transmembranei401 – 42121HelicalUniRule annotationAdd
BLAST
Transmembranei436 – 45621HelicalUniRule annotationAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 464464NADH-quinone oxidoreductase subunit N 1PRO_0000391098Add
BLAST

Keywords - PTMi

Quinone

Interactioni

Subunit structurei

NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.UniRule annotation

Protein-protein interaction databases

STRINGi224324.aq_1322.

Family & Domainsi

Sequence similaritiesi

Belongs to the complex I subunit 2 family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105CNR. Bacteria.
COG1007. LUCA.
HOGENOMiHOG000100794.
InParanoidiO67342.
KOiK00343.
OMAiQAGLFNF.
OrthoDBiEOG64JFNZ.

Family and domain databases

HAMAPiMF_00445. NDH1_NuoN_1.
InterProiIPR010096. NADH-Q_OxRdtase_suN/2.
IPR001750. ND/Mrp_mem.
[Graphical view]
PfamiPF00361. Proton_antipo_M. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01770. NDH_I_N. 1 hit.

Sequencei

Sequence statusi: Complete.

O67342-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNWNAILPEA ILAIGILTVF ILELFLERKH YKFLSVLAFI FVVLSGYSIF
60 70 80 90 100
FVNYPAKLFF DGFSVDALNL IGKLFILAVT GFVLLSSYDY FSKKNSQYGE
110 120 130 140 150
LPYLYLIATL GLMVMISSDN LAIIFTGLEL ASITMYILVG LFRREYLSKE
160 170 180 190 200
GAFKYLVIGT TGTSMYALGS ALVYASSGSM VLSPVKEENT LFALGVILII
210 220 230 240 250
SALALKVSAV PFHFWTPDAY EGAPTPTTAY LSTVPKIGMY FLFVKLTMYL
260 270 280 290 300
FSAFPDWKYV VMLLAVLSMF YGNIVAYAQK SVKRLLAYSS IAHAGYFLTA
310 320 330 340 350
LTAVDKHLFS ALLFYVFVYA LATVGAFTVL AILEKKEGWT HHFLDFKGLK
360 370 380 390 400
EENPVLASML ALFLFALIGI PPAAVFLGKL GIFFGLVKTD MFALGILFAI
410 420 430 440 450
ASLISAGYYL KVIVYMFLYS GEVRHGQTTV SAGEAFTVLG TAFLVIFFGL
460
FPHVVLDFIL RALS
Length:464
Mass (Da):51,286
Last modified:August 1, 1998 - v1
Checksum:i5C72D12A83E8FF26
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000657 Genomic DNA. Translation: AAC07305.1.
PIRiC70414.
RefSeqiNP_213906.1. NC_000918.1.
WP_010880844.1. NC_000918.1.

Genome annotation databases

EnsemblBacteriaiAAC07305; AAC07305; aq_1322.
GeneIDi1192780.
KEGGiaae:aq_1322.
PATRICi20959826. VBIAquAeo85532_1030.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000657 Genomic DNA. Translation: AAC07305.1.
PIRiC70414.
RefSeqiNP_213906.1. NC_000918.1.
WP_010880844.1. NC_000918.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi224324.aq_1322.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC07305; AAC07305; aq_1322.
GeneIDi1192780.
KEGGiaae:aq_1322.
PATRICi20959826. VBIAquAeo85532_1030.

Phylogenomic databases

eggNOGiENOG4105CNR. Bacteria.
COG1007. LUCA.
HOGENOMiHOG000100794.
InParanoidiO67342.
KOiK00343.
OMAiQAGLFNF.
OrthoDBiEOG64JFNZ.

Enzyme and pathway databases

BioCyciAAEO224324:GJBH-944-MONOMER.

Family and domain databases

HAMAPiMF_00445. NDH1_NuoN_1.
InterProiIPR010096. NADH-Q_OxRdtase_suN/2.
IPR001750. ND/Mrp_mem.
[Graphical view]
PfamiPF00361. Proton_antipo_M. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01770. NDH_I_N. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: VF5.

Entry informationi

Entry nameiNUON1_AQUAE
AccessioniPrimary (citable) accession number: O67342
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 9, 2010
Last sequence update: August 1, 1998
Last modified: November 11, 2015
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.