Reviewed,
UniProtKB/Swiss-Prot O67334 (NUOB_AQUAE)
Last modified
November 25, 2008.
Version 52.
History...
Clusters with 100%,
90%,
50% identity |
Documents (1) |
Third-party data |
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Names and origin
| Protein names | Recommended name: NADH-quinone oxidoreductase chain B EC=1.6.99.5 Alternative name(s): NADH dehydrogenase I, chain B NDH-1, chain B | ||||
| Gene names |
| ||||
| Organism | Aquifex aeolicus [Complete proteome] [HAMAP] | ||||
| Taxonomic identifier | 63363 [NCBI] | ||||
| Taxonomic lineage | Bacteria › Aquificae › Aquificales › Aquificaceae › Aquifex |
Protein attributes
| Sequence length | 179 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Inferred from homology. |
General annotation (Comments)
| Function | NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient By similarity. |
| Catalytic activity | NADH + quinone = NAD(+) + quinol. |
| Cofactor | Binds 1 4Fe-4S cluster Potential. |
| Sequence similarities | Belongs to the complex I 20 kDa subunit family. |
Ontologies
Keywords | |
|---|---|
| Ligand | 4Fe-4S Iron Iron-sulfur Metal-binding NAD |
| Molecular function | Oxidoreductase |
| PTM | Quinone |
| Technical term | Complete proteome |
Gene Ontology (GO) | |
| Biological process | mitochondrial electron transport, NADH to ubiquinone Inferred from electronic annotation. Source: InterPro |
| Molecular function | 4 iron, 4 sulfur cluster binding Inferred from electronic annotation. Source: InterPro NADH dehydrogenase (ubiquinone) activityInferred from electronic annotation. Source: InterPro iron ion bindingInferred from electronic annotation. Source: UniProtKB-KW quinone bindingInferred from electronic annotation. Source: UniProtKB-KW |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 179 | 179 | NADH-quinone oxidoreductase chain B | PRO_0000118764 | |||||
Sites | |||||||||
| Metal binding | 35 | 1 | Iron-sulfur (4Fe-4S) Potential | ||||||
| Metal binding | 36 | 1 | Iron-sulfur (4Fe-4S) Potential | ||||||
| Metal binding | 100 | 1 | Iron-sulfur (4Fe-4S) Potential | ||||||
| Metal binding | 129 | 1 | Iron-sulfur (4Fe-4S) Potential | ||||||
Sequences
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References
| [1] | "The complete genome of the hyperthermophilic bacterium Aquifex aeolicus." Deckert G., Warren P.V., Gaasterland T., Young W.G., Lenox A.L., Graham D.E., Overbeek R., Snead M.A., Keller M., Aujay M., Huber R., Feldman R.A., Short J.M., Olsen G.J., Swanson R.V. Nature 392:353-358(1998) [PubMed: 9537320] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: VF5. |
Cross-references
Sequence databases | |
|---|---|
| AE000657 Genomic DNA. Translation: AAC07297.1. | |
| PIR | C70413. |
| RefSeq | NP_213898.1. |
3D structure databases | |
| ModBase | Search... |
Genome annotation databases | |
| GeneID | 1192772. |
| GenomeReviews | Gene locus aq_1312 in contig AE000657_GR. |
| KEGG | aae:aq_1312. |
| NMPDR | fig|224324.1.peg.913. |
Organism-specific databases | |
| CMR | Search... |
Phylogenomic databases | |
| HOGENOM | O67334. |
Enzyme and pathway databases | |
| BioCyc | AAEO224324:AQ_1312-MON. |
Family and domain databases | |
| InterPro | IPR006138. NADH_DHase_20kDa_su. IPR014406. NiFe_hyd_3_ssu/Q_oxred_NuoB. IPR006137. OxRdtase_q6. [Graphical view] |
| PANTHER | PTHR11995:SF2. NADH_DH_20kDa. 1 hit. PTHR11995. NiFe_hyd_3_ssu/Q_oxred_NuoB. 1 hit. |
| Pfam | PF01058. Oxidored_q6. 1 hit. [Graphical view] |
| TIGRFAMs | TIGR01957. nuoB_fam. 1 hit. |
| PROSITE | PS01150. COMPLEX1_20K. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| LinkHub | O67334. |
Entry information
| Entry name | NUOB_AQUAE | ||||||||
| Accession | Primary (citable) accession number: O67334 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes) | ||||||||

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