ID   O67325_AQUAE            Unreviewed;       810 AA.
AC   O67325;
DT   01-AUG-1998, integrated into UniProtKB/TrEMBL.
DT   01-AUG-1998, sequence version 1.
DT   27-MAR-2024, entry version 135.
DE   SubName: Full=ATP-dependent Clp protease {ECO:0000313|EMBL:AAC07290.1};
GN   Name=clpC {ECO:0000313|EMBL:AAC07290.1};
GN   OrderedLocusNames=aq_1296 {ECO:0000313|EMBL:AAC07290.1};
OS   Aquifex aeolicus (strain VF5).
OC   Bacteria; Aquificota; Aquificae; Aquificales; Aquificaceae; Aquifex.
OX   NCBI_TaxID=224324 {ECO:0000313|EMBL:AAC07290.1, ECO:0000313|Proteomes:UP000000798};
RN   [1] {ECO:0000313|EMBL:AAC07290.1, ECO:0000313|Proteomes:UP000000798}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=VF5 {ECO:0000313|EMBL:AAC07290.1,
RC   ECO:0000313|Proteomes:UP000000798};
RX   PubMed=9537320; DOI=10.1038/32831;
RA   Deckert G., Warren P.V., Gaasterland T., Young W.G., Lenox A.L.,
RA   Graham D.E., Overbeek R., Snead M.A., Keller M., Aujay M., Huber R.,
RA   Feldman R.A., Short J.M., Olson G.J., Swanson R.V.;
RT   "The complete genome of the hyperthermophilic bacterium Aquifex aeolicus.";
RL   Nature 392:353-358(1998).
CC   -!- SIMILARITY: Belongs to the ClpA/ClpB family.
CC       {ECO:0000256|RuleBase:RU004432}.
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DR   EMBL; AE000657; AAC07290.1; -; Genomic_DNA.
DR   PIR; B70412; B70412.
DR   RefSeq; NP_213889.1; NC_000918.1.
DR   RefSeq; WP_010880827.1; NC_000918.1.
DR   AlphaFoldDB; O67325; -.
DR   STRING; 224324.aq_1296; -.
DR   EnsemblBacteria; AAC07290; AAC07290; aq_1296.
DR   KEGG; aae:aq_1296; -.
DR   PATRIC; fig|224324.8.peg.1013; -.
DR   eggNOG; COG0542; Bacteria.
DR   HOGENOM; CLU_005070_4_1_0; -.
DR   InParanoid; O67325; -.
DR   OrthoDB; 9803641at2; -.
DR   Proteomes; UP000000798; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IBA:GO_Central.
DR   GO; GO:0008233; F:peptidase activity; IEA:UniProtKB-KW.
DR   GO; GO:0034605; P:cellular response to heat; IBA:GO_Central.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   CDD; cd00009; AAA; 1.
DR   CDD; cd19499; RecA-like_ClpB_Hsp104-like; 1.
DR   Gene3D; 1.10.8.60; -; 2.
DR   Gene3D; 1.10.1780.10; Clp, N-terminal domain; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR   Gene3D; 4.10.860.10; UVR domain; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR003959; ATPase_AAA_core.
DR   InterPro; IPR019489; Clp_ATPase_C.
DR   InterPro; IPR036628; Clp_N_dom_sf.
DR   InterPro; IPR004176; Clp_R_dom.
DR   InterPro; IPR001270; ClpA/B.
DR   InterPro; IPR018368; ClpA/B_CS1.
DR   InterPro; IPR028299; ClpA/B_CS2.
DR   InterPro; IPR041546; ClpA/ClpB_AAA_lid.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR001943; UVR_dom.
DR   PANTHER; PTHR11638; ATP-DEPENDENT CLP PROTEASE; 1.
DR   PANTHER; PTHR11638:SF193; CHAPERONE PROTEIN CLPB; 1.
DR   Pfam; PF00004; AAA; 1.
DR   Pfam; PF07724; AAA_2; 1.
DR   Pfam; PF17871; AAA_lid_9; 1.
DR   Pfam; PF02861; Clp_N; 2.
DR   Pfam; PF10431; ClpB_D2-small; 1.
DR   PRINTS; PR00300; CLPPROTEASEA.
DR   SMART; SM00382; AAA; 2.
DR   SMART; SM01086; ClpB_D2-small; 1.
DR   SUPFAM; SSF81923; Double Clp-N motif; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR   PROSITE; PS51903; CLP_R; 1.
DR   PROSITE; PS00870; CLPAB_1; 1.
DR   PROSITE; PS00871; CLPAB_2; 1.
DR   PROSITE; PS50151; UVR; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|RuleBase:RU004432};
KW   Chaperone {ECO:0000256|ARBA:ARBA00023186, ECO:0000256|RuleBase:RU004432};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Hydrolase {ECO:0000313|EMBL:AAC07290.1};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW   ECO:0000256|RuleBase:RU004432}; Protease {ECO:0000313|EMBL:AAC07290.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000798};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737, ECO:0000256|PROSITE-
KW   ProRule:PRU01251}.
FT   DOMAIN          2..141
FT                   /note="Clp R"
FT                   /evidence="ECO:0000259|PROSITE:PS51903"
FT   DOMAIN          410..445
FT                   /note="UVR"
FT                   /evidence="ECO:0000259|PROSITE:PS50151"
FT   COILED          406..433
FT                   /evidence="ECO:0000256|SAM:Coils"
SQ   SEQUENCE   810 AA;  92356 MW;  5DC9A95904AA38E7 CRC64;
     MFEKFTERAR QVILRAREEA LELGHSYLGS EHILLALIKD EDIPVLVLSK LGVSPEKIRK
     AIMGQITKGS HSGEVLFAPD AKRVIEFAVE EARILHHQFV GPEHLLIGVV REKTGLGGRI
     LRSFGLDEYS VRREVLQLLG ELPPQESQRY VSTPNLDRFS RDLTQMAREG KLDPVIGREK
     EIERVIQILV RRRKNNPVLL GDPGVGKTAI VEGLAQRIAN KEVPEPLLNK RVVALDLAAL
     VAGTKYRGQF EERLKNILKE LEKANNVILF IDELHTLVGA GSAEGSIDAS NMLKPALARG
     EIQVIGATTV DEYRKYIEKD GALERRFQPV YVEQPSPEDT IQILYGLKPK FEEFHKVEYT
     PEAIEKAVEL SVKYITDRNL PDKAIDVMDE AGALVKLKAT QLPPELKEIE EKIKELEKEK
     EKAVKEQDYE KAAKIRDEEL RLRAKFETMK AKWKEEMEKN RPKVTDEDVA EVVARWTGVP
     VKRVHESDAE KLLHIEEELK KRVVGQDEAI KAVAKAIRRS RVGLKGKHRP IGVFMFLGPT
     GVGKTETAKA LAEYLFGTED ALIRFDMSEY MEKHTVSRLI GAPPGYVGYE EGGQLTEAVR
     RRPYSVLLFD EIEKAHPDVF NIFLQIFDDG RLTDGLGRTV DFSNTIIIMT SNLGARLITG
     GTMGFEKKQG LLNFEEMRKN VLDQVKRTFS PEFLNRLDEI IVFRPLEKKD IEQILELQLK
     EINEKLKDWN VRVKLHKSFV NWIIEKEYKP EFGARSLKRA LQRHVEDLLA EELIKGTLKG
     VEEVEIRVRN DKPYLKPVKK KEKVEALLEK
//