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Protein

Sec-independent protein translocase protein TatC

Gene

tatC

Organism
Aquifex aeolicus (strain VF5)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Protein transport, Translocation, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Sec-independent protein translocase protein TatCUniRule annotation
Gene namesi
Name:tatCUniRule annotation
Ordered Locus Names:aq_1267
OrganismiAquifex aeolicus (strain VF5)
Taxonomic identifieri224324 [NCBI]
Taxonomic lineageiBacteriaAquificaeAquificalesAquificaceaeAquifex
Proteomesi
  • UP000000798 Componenti: Chromosome

Subcellular locationi

  • Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei15 – 35HelicalUniRule annotationAdd BLAST21
Transmembranei61 – 81HelicalUniRule annotationAdd BLAST21
Transmembranei103 – 123HelicalUniRule annotationAdd BLAST21
Transmembranei152 – 172HelicalUniRule annotationAdd BLAST21
Transmembranei191 – 211HelicalUniRule annotationAdd BLAST21
Transmembranei212 – 232HelicalUniRule annotationAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000980931 – 240Sec-independent protein translocase protein TatCAdd BLAST240

Interactioni

Subunit structurei

Forms a complex with TatA.UniRule annotation

Protein-protein interaction databases

STRINGi224324.aq_1267.

Structurei

Secondary structure

1240
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi6 – 30Combined sources25
Helixi32 – 46Combined sources15
Beta strandi56 – 58Combined sources3
Helixi60 – 88Combined sources29
Turni89 – 92Combined sources4
Turni97 – 100Combined sources4
Helixi101 – 120Combined sources20
Helixi122 – 128Combined sources7
Turni129 – 131Combined sources3
Beta strandi133 – 135Combined sources3
Beta strandi138 – 141Combined sources4
Helixi146 – 163Combined sources18
Helixi166 – 175Combined sources10
Helixi181 – 202Combined sources22
Helixi206 – 225Combined sources20

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4B4AX-ray3.50A1-240[»]
4HTSX-ray4.00A1-232[»]
4HTTX-ray6.80A/B1-235[»]
SMRiO67305.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TatC family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105DCX. Bacteria.
COG0805. LUCA.
HOGENOMiHOG000245380.
InParanoidiO67305.
KOiK03118.
OMAiATQIYKF.
OrthoDBiPOG091H02DA.

Family and domain databases

HAMAPiMF_00902. TatC. 1 hit.
InterProiIPR019820. Sec-indep_translocase_CS.
IPR002033. TatC.
[Graphical view]
PANTHERiPTHR30371:SF0. PTHR30371:SF0. 1 hit.
PfamiPF00902. TatC. 1 hit.
[Graphical view]
PRINTSiPR01840. TATCFAMILY.
TIGRFAMsiTIGR00945. tatC. 1 hit.
PROSITEiPS01218. TATC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O67305-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPLTEHLREL RYRLIISIIA FLIGSGIAFY FAKYVFEILK EPILKSYPEV
60 70 80 90 100
ELITLSPTEP LFILIKISLA VGFIIASPVI LYQFWRFIEP ALYSHEKRAF
110 120 130 140 150
IPLLLGSILL FMLGALFAYF IVLPLALKFL LGLGFTQLLA TPYLSVDMYI
160 170 180 190 200
SFVLKLVVAF GIAFEMPIVL YVLQKAGVIT PEQLASFRKY FIVIAFVIGA
210 220 230 240
IIAPDVSTQV LMAIPLLLLY EISIFLGKLA TRKKKEIQKA
Length:240
Mass (Da):27,129
Last modified:August 1, 1998 - v1
Checksum:iFC3125C54D5B9047
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000657 Genomic DNA. Translation: AAC07267.1.
PIRiF70409.
RefSeqiNP_213869.1. NC_000918.1.
WP_010880807.1. NC_000918.1.

Genome annotation databases

EnsemblBacteriaiAAC07267; AAC07267; aq_1267.
GeneIDi1192743.
KEGGiaae:aq_1267.
PATRICi20959740. VBIAquAeo85532_0988.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000657 Genomic DNA. Translation: AAC07267.1.
PIRiF70409.
RefSeqiNP_213869.1. NC_000918.1.
WP_010880807.1. NC_000918.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4B4AX-ray3.50A1-240[»]
4HTSX-ray4.00A1-232[»]
4HTTX-ray6.80A/B1-235[»]
SMRiO67305.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi224324.aq_1267.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC07267; AAC07267; aq_1267.
GeneIDi1192743.
KEGGiaae:aq_1267.
PATRICi20959740. VBIAquAeo85532_0988.

Phylogenomic databases

eggNOGiENOG4105DCX. Bacteria.
COG0805. LUCA.
HOGENOMiHOG000245380.
InParanoidiO67305.
KOiK03118.
OMAiATQIYKF.
OrthoDBiPOG091H02DA.

Family and domain databases

HAMAPiMF_00902. TatC. 1 hit.
InterProiIPR019820. Sec-indep_translocase_CS.
IPR002033. TatC.
[Graphical view]
PANTHERiPTHR30371:SF0. PTHR30371:SF0. 1 hit.
PfamiPF00902. TatC. 1 hit.
[Graphical view]
PRINTSiPR01840. TATCFAMILY.
TIGRFAMsiTIGR00945. tatC. 1 hit.
PROSITEiPS01218. TATC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTATC_AQUAE
AccessioniPrimary (citable) accession number: O67305
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: August 1, 1998
Last modified: November 2, 2016
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.