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O67292 (CDSA_AQUAE) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 78. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Phosphatidate cytidylyltransferase
EC=2.7.7.41
Alternative name(s):
CDP-DAG synthase
CDP-DG synthase
CDP-diacylglycerol synthase
Short name=CDS
CDP-diglyceride pyrophosphorylase
CDP-diglyceride synthase
CTP:phosphatidate cytidylyltransferase
Gene names
Name:cdsA
Synonyms:cds
Ordered Locus Names:aq_1249
OrganismAquifex aeolicus (strain VF5)
Taxonomic identifier224324 [NCBI]
Taxonomic lineageBacteria › Aquificae › Aquificales › Aquificaceae › Aquifex

Protein attributes

Sequence length259 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

CTP + phosphatidate = diphosphate + CDP-diacylglycerol.

Pathway

Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol 3-phosphate: step 3/3.

Subcellular location

Cell membrane; Multi-pass membrane protein By similarity.

Sequence similarities

Belongs to the CDS family.

Ontologies

Keywords
   Biological processPhospholipid biosynthesis
   Cellular componentCell membrane
Membrane
   DomainTransmembrane
Transmembrane helix
   Molecular functionNucleotidyltransferase
Transferase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological processphospholipid biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentintegral to membrane

Inferred from electronic annotation. Source: UniProtKB-KW

plasma membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionphosphatidate cytidylyltransferase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 259259Phosphatidate cytidylyltransferase
PRO_0000090725

Regions

Transmembrane31 – 5121Helical; Potential
Transmembrane69 – 8921Helical; Potential
Transmembrane103 – 12321Helical; Potential
Transmembrane129 – 14921Helical; Potential
Transmembrane170 – 19021Helical; Potential
Transmembrane193 – 21321Helical; Potential
Transmembrane236 – 25621Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
O67292 [UniParc].

Last modified August 1, 1998. Version 1.
Checksum: D5FB386647BD0D0E

FASTA25929,486
        10         20         30         40         50         60 
MRITQGERES SGEFLMSREF YGVLIGVTTL LVIFLPKSLF LLVILFLCFA ISREVSVALG 

        70         80         90        100        110        120 
ENEVFYFSPL VLLTYYFADP LVFPLIGLLS LYFAYKRWEL NSFFKSTFLL FYPALFLVYL 

       130        140        150        160        170        180 
IKIKEISTYY LLIFIFGIWI NDVFAYYIGK NFGKTPLFPK ISPKKTVEGF LGGVLFGSLF 

       190        200        210        220        230        240 
FALTLPYGIL NSFLLGTFVL TVGVAGDYFK SFIKRQVGIK DFSNVFGEHG GFTDRFDALV 

       250 
FSAPVFYLIM CAGELNCKL

« Hide

References

[1]"The complete genome of the hyperthermophilic bacterium Aquifex aeolicus."
Deckert G., Warren P.V., Gaasterland T., Young W.G., Lenox A.L., Graham D.E., Overbeek R., Snead M.A., Keller M., Aujay M., Huber R., Feldman R.A., Short J.M., Olsen G.J., Swanson R.V.
Nature 392:353-358(1998) [PubMed: 9537320] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: VF5.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AE000657 Genomic DNA. Translation: AAC07246.1.
PIRA70408.
RefSeqNP_213856.1. NC_000918.1.

3D structure databases

ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID1192730.
GenomeReviewsGene locus aq_1249 in contig AE000657_GR.
KEGGaae:aq_1249.
NMPDRfig|224324.1.peg.871.
PATRIC20959710. VBIAquAeo85532_0973.

Phylogenomic databases

HOGENOMHBG732679.
OMAMEDTNRW.
PhylomeDBO67292.
ProtClustDBCLSK2299630.

Enzyme and pathway databases

BioCycAAEO224324:AQ_1249-MONOMER.

Family and domain databases

InterProIPR000374. PC_trans.
[Graphical view]
KOK00981.
PfamPF01148. CTP_transf_1. 1 hit.
[Graphical view]
PROSITEPS01315. CDS. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCDSA_AQUAE
AccessionPrimary (citable) accession number: O67292
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: August 1, 1998
Last modified: January 25, 2012
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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