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Protein

Lysine--tRNA ligase

Gene

lysS

Organism
Aquifex aeolicus (strain VF5)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-lysine + tRNA(Lys) = AMP + diphosphate + L-lysyl-tRNA(Lys).

Cofactori

Mg2+By similarityNote: Binds 3 Mg2+ ions per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi501Magnesium 1By similarity1
Metal bindingi508Magnesium 1By similarity1
Metal bindingi508Magnesium 2By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciAAEO224324:G1G15-852-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Lysine--tRNA ligase (EC:6.1.1.6)
Alternative name(s):
Lysyl-tRNA synthetase
Short name:
LysRS
Gene namesi
Name:lysS
Ordered Locus Names:aq_1202
OrganismiAquifex aeolicus (strain VF5)
Taxonomic identifieri224324 [NCBI]
Taxonomic lineageiBacteriaAquificaeAquificalesAquificaceaeAquifex
Proteomesi

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001525951 – 597Lysine--tRNA ligaseAdd BLAST597

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi224324.aq_1202

Structurei

3D structure databases

ProteinModelPortaliO67258
SMRiO67258
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4105CRK Bacteria
COG1190 LUCA
HOGENOMiHOG000236578
InParanoidiO67258
KOiK04567
OMAiMMNIIPG
OrthoDBiPOG091H0098

Family and domain databases

CDDicd00775 LysRS_core, 1 hit
HAMAPiMF_00252 Lys_tRNA_synth_class2, 1 hit
InterProiView protein in InterPro
IPR004364 aa-tRNA-synt_II
IPR006195 aa-tRNA-synth_II
IPR002313 Lys-tRNA-ligase_II
IPR034762 Lys-tRNA-ligase_II_bac/euk
IPR018149 Lys-tRNA-synth_II_C
IPR012340 NA-bd_OB-fold
IPR004365 NA-bd_OB_tRNA
PfamiView protein in Pfam
PF00152 tRNA-synt_2, 1 hit
PF01336 tRNA_anti-codon, 1 hit
PIRSFiPIRSF039101 LysRS2, 1 hit
PRINTSiPR00982 TRNASYNTHLYS
SUPFAMiSSF50249 SSF50249, 2 hits
TIGRFAMsiTIGR00499 lysS_bact, 1 hit
PROSITEiView protein in PROSITE
PS50862 AA_TRNA_LIGASE_II, 1 hit

Sequencei

Sequence statusi: Complete.

O67258-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLSLLSSEIF FSAIQYNLSL MEEVRLKKLQ ELREKGINPY PYRFEVTDFI
60 70 80 90 100
GNIRKQYEEE PPENYKVRVK GVAKRVSRTE NGYMVRLADE KGIEILVFTK
110 120 130 140 150
EEGLKPKESY TFEGILKRVE GKLSLVEAVL TEEEGEEVYK IKEQFDYDPN
160 170 180 190 200
FRPVSLAGRL VSMRSMGKAI FGHIQDLTGK IQIYLKKDVI GEEKLKFFND
210 220 230 240 250
YIDVGDIVGV RGKLFRTNTG ELTVEVEEYQ LLAKSLHPLP EKWHGLKDVE
260 270 280 290 300
VRYRQRYLDL IANPEARRIF MLRTKLITEM RKFFEMHGFI EVETPILQPI
310 320 330 340 350
ASGANARPFV TYHNFLETEL YLRIAPELYL KRLIVGGFPR VYEIGKNFRN
360 370 380 390 400
ESVDRTHNPE FTMVEFYAAY WDYHDLIKFT EDMFVYLLEK TLGTLKVKYG
410 420 430 440 450
EWELDFSPPF KKVRYFDLLK EKTGKDKDFF LKDLEGLRKL AKELEIPDVE
460 470 480 490 500
RMTHAKLLDK VFEKVAEEDL IQPTFVIDFP KILSPLAKTH REDPDLVERF
510 520 530 540 550
ELIIARYEVA NAYTELNDPF DQKERFLEQL KEKQMGDEEA MDMDEDFIRA
560 570 580 590
LEYGMPPTAG EGIGIDRLVM ILANTDSIRE VILFPQLKPE KKKKEAP
Length:597
Mass (Da):70,024
Last modified:August 1, 1998 - v1
Checksum:i66D6DAB0D588819B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000657 Genomic DNA Translation: AAC07218.1
PIRiG70403
RefSeqiNP_213822.1, NC_000918.1
WP_010880760.1, NC_000918.1

Genome annotation databases

EnsemblBacteriaiAAC07218; AAC07218; aq_1202
GeneIDi1192604
KEGGiaae:aq_1202
PATRICifig|224324.8.peg.936

Similar proteinsi

Entry informationi

Entry nameiSYK_AQUAE
AccessioniPrimary (citable) accession number: O67258
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: August 1, 1998
Last modified: March 28, 2018
This is version 124 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

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