Reviewed,
UniProtKB/Swiss-Prot O67240 (SAHH_AQUAE)
Last modified
February 9, 2010.
Version 68.
History...
Clusters with 100%,
90%,
50% identity |
Documents (2) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Adenosylhomocysteinase EC=3.3.1.1 Alternative name(s): S-adenosyl-L-homocysteine hydrolase Short name=AdoHcyase | ||||||
| Gene names |
| ||||||
| Organism | Aquifex aeolicus [Complete proteome] [HAMAP] | ||||||
| Taxonomic identifier | 63363 [NCBI] | ||||||
| Taxonomic lineage | Bacteria › Aquificae › Aquificales › Aquificaceae › Aquifex |
Protein attributes
| Sequence length | 418 AA. |
| Sequence status | Complete. |
| Protein existence | Inferred from homology. |
General annotation (Comments)
| Catalytic activity | S-adenosyl-L-homocysteine + H2O = L-homocysteine + adenosine. HAMAP MF_00563 |
| Cofactor | Binds 1 NAD per subunit By similarity. HAMAP MF_00563 |
| Pathway | Amino-acid biosynthesis; L-homocysteine biosynthesis; L-homocysteine from S-adenosyl-L-homocysteine: step 1/1. HAMAP MF_00563 |
| Subcellular location | Cytoplasm By similarity HAMAP MF_00563. |
| Sequence similarities | Belongs to the adenosylhomocysteinase family. |
Ontologies
| Keywords | |
|---|---|
| Biological process | One-carbon metabolism |
| Cellular component | Cytoplasm |
| Ligand | NAD |
| Molecular function | Hydrolase |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | one-carbon metabolic process Inferred from electronic annotation. Source: HAMAP |
| Cellular component | cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular function | adenosylhomocysteinase activity Inferred from electronic annotation. Source: HAMAP bindingInferred from electronic annotation. Source: InterPro |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 418 | 418 | Adenosylhomocysteinase HAMAP MF_00563 | PRO_0000116941 | |||||
Regions | |||||||||
| Region | 177 – 344 | 168 | NAD binding By similarity | ||||||
Sites | |||||||||
| Binding site | 53 | 1 | Substrate By similarity | ||||||
| Binding site | 125 | 1 | Substrate By similarity | ||||||
| Binding site | 150 | 1 | Substrate By similarity | ||||||
| Binding site | 180 | 1 | Substrate By similarity | ||||||
| Binding site | 184 | 1 | Substrate By similarity | ||||||
Sequences
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References
| [1] | "The complete genome of the hyperthermophilic bacterium Aquifex aeolicus." Deckert G., Warren P.V., Gaasterland T., Young W.G., Lenox A.L., Graham D.E., Overbeek R., Snead M.A., Keller M., Aujay M., Huber R., Feldman R.A., Short J.M., Olsen G.J., Swanson R.V. Nature 392:353-358(1998) [PubMed: 9537320] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: VF5. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | AE000657 Genomic DNA. Translation: AAC07197.1. |
| PIR | E70401. |
| RefSeq | NP_213804.1. |
3D structure databases | |
| SMR | O67240. Positions 1-418. |
| ModBase | Search... |
Genome annotation databases | |
| GeneID | 1192586. |
| GenomeReviews | Gene locus aq_1180 in contig AE000657_GR. |
| KEGG | aae:aq_1180. |
| NMPDR | fig|224324.1.peg.819. |
Organism-specific databases | |
| CMR | Search... |
Phylogenomic databases | |
| HOGENOM | HBG352029. |
| OMA | FLFEQKY. |
| PhylomeDB | O67240. |
Enzyme and pathway databases | |
| BioCyc | AAEO224324:AQ_1180-MONOMER. |
| BRENDA | 3.3.1.1. 189781. |
Family and domain databases | |
| HAMAP | MF_00563_B. AdoHcyase_B. [Tree] |
| InterPro | IPR015878. Ado_hCys_hydrolase_NAD-bd. IPR016040. NAD(P)-bd_dom. IPR000043. S-Ado-L-homoCys_hydrolase. IPR020082. S-Ado-L-homoCys_hydrolase_CS. [Graphical view] |
| PANTHER | PTHR23420. Ad_hcy_hydrolase. 1 hit. |
| Pfam | PF05221. AdoHcyase. 1 hit. PF00670. AdoHcyase_NAD. 1 hit. [Graphical view] |
| PIRSF | PIRSF001109. Ad_hcy_hydrolase. 1 hit. |
| TIGRFAMs | TIGR00936. ahcY. 1 hit. |
| PROSITE | PS00738. ADOHCYASE_1. 1 hit. PS00739. ADOHCYASE_2. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | SAHH_AQUAE | ||||||||
| Accession | Primary (citable) accession number: O67240 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes) | ||||||||
Relevant documents
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

Clusters with


