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Reviewed, UniProtKB/Swiss-Prot O67240 (SAHH_AQUAE)

Last modified November 3, 2009. Version 64. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Adenosylhomocysteinase
    EC=3.3.1.1
Alternative name(s):
    S-adenosyl-L-homocysteine hydrolase
      Short name=AdoHcyase
Gene names
Name: ahcY
Synonyms: sahH
Ordered Locus Names: aq_1180
OrganismAquifex aeolicus [Complete proteome] [HAMAP]
Taxonomic identifier63363 [NCBI]
Taxonomic lineageBacteria › Aquificae › Aquificales › Aquificaceae › Aquifex

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Protein attributes

Sequence length418 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceInferred from homology.

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General annotation (Comments)

Catalytic activity

S-adenosyl-L-homocysteine + H2O = L-homocysteine + adenosine. HAMAP MF_00563

Cofactor

Binds 1 NAD per subunit By similarity.

Pathway

Amino-acid biosynthesis; L-homocysteine biosynthesis; L-homocysteine from S-adenosyl-L-homocysteine: step 1/1. HAMAP MF_00563

Subcellular location

Cytoplasm By similarity.

Sequence similarities

Belongs to the adenosylhomocysteinase family.

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Ontologies

Keywords
   Biological processOne-carbon metabolism
   Cellular componentCytoplasm
   LigandNAD
   Molecular functionHydrolase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processone-carbon metabolic process

Inferred from electronic annotation. Source: HAMAP

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionadenosylhomocysteinase activity

Inferred from electronic annotation. Source: HAMAP

binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 418418Adenosylhomocysteinase HAMAP MF_00563
PRO_0000116941

Regions

Region177 – 344168NAD binding By similarity

Sites

Binding site531Substrate By similarity
Binding site1251Substrate By similarity
Binding site1501Substrate By similarity
Binding site1801Substrate By similarity
Binding site1841Substrate By similarity

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Sequences

Sequence LengthMass (Da)Tools
O67240-1 [UniParc].

Last modified August 1, 1998. Version 1.
Checksum: 0E778869976E7DA9

FASTA41846,840
        10         20         30         40         50         60 
MEFDVKDLSL AEEGLKRIEW AEMDMPVLRQ IRERFSKEKP LKGKKISACL HVTTETANLM 

        70         80         90        100        110        120 
RTLKEGGAEV YLTASNPLST QDDVAAALVK YFEIPVFAIR GEDRETYYKH LRAVIEKEPD 

       130        140        150        160        170        180 
VVIDDGADLI STLHKEYPGL AEKVLGGMEE TTTGVIRLRA MAEQGVLKFP IIAVNDAYTK 

       190        200        210        220        230        240 
HMFDNRYGTG QSTIDGILRA TNRLLAGSYF VVAGYGWCGK GVAQRARGMG AIVIVTEVDP 

       250        260        270        280        290        300 
IKALEARMDG FLVMPMEEAA KLGDFFVTVT GNIHVIRREH FEVMKDGAIV ANSGHFNVEI 

       310        320        330        340        350        360 
DIPALEEMAV EKREIRKEVT EYKLKDGRRI YLLAEGRLVN LAAAEGHPAS VMDMSFSNQA 

       370        380        390        400        410 
LSAEYIVKHH KELEKKVYRV PREIDEAVAR LKLNALGIKI DELTEEQKKY LSSWEMGT

« Hide

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References

[1]"The complete genome of the hyperthermophilic bacterium Aquifex aeolicus."
Deckert G., Warren P.V., Gaasterland T., Young W.G., Lenox A.L., Graham D.E., Overbeek R., Snead M.A., Keller M., Aujay M., Huber R., Feldman R.A., Short J.M., Olsen G.J., Swanson R.V.
Nature 392:353-358(1998) [PubMed: 9537320] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: VF5.

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Cross-references

Sequence databases

AE000657 Genomic DNA. Translation: AAC07197.1.
PIRE70401.
RefSeqNP_213804.1.

3D structure databases

HSSPHSSP built from PDB template 1LI4 based on UniProtKB P23526.
ModBaseSearch...

Genome annotation databases

GeneID1192586.
GenomeReviewsGene locus aq_1180 in contig AE000657_GR.
KEGGaae:aq_1180.
NMPDRfig|224324.1.peg.819.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMO67240.
OMAEAYMDGF.

Enzyme and pathway databases

BioCycAAEO224324:AQ_1180-MON.
BRENDA3.3.1.1. 189781.

Family and domain databases

HAMAPMF_00563.
[Tree]
InterProIPR015878. Ado_hCys_hydrolase_NAD-bd.
IPR000043. S-Ado-L-homoCys_hydrolase.
IPR020082. S-Ado-L-homoCys_hydrolase_CS.
[Graphical view]
PANTHERPTHR23420. Ad_hcy_hydrolase. 1 hit.
PfamPF05221. AdoHcyase. 1 hit.
PF00670. AdoHcyase_NAD. 1 hit.
[Graphical view]
PIRSFPIRSF001109. Ad_hcy_hydrolase. 1 hit.
TIGRFAMsTIGR00936. ahcY. 1 hit.
PROSITEPS00738. ADOHCYASE_1. 1 hit.
PS00739. ADOHCYASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

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Entry information

Entry nameSAHH_AQUAE
AccessionPrimary (citable) accession number: O67240
Entry history
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: August 1, 1998
Last modified: November 3, 2009
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

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Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents