ID   AK_AQUAE                Reviewed;         415 AA.
AC   O67221;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1998, sequence version 1.
DT   16-JUN-2009, entry version 55.
DE   RecName: Full=Aspartokinase;
DE            EC=2.7.2.4;
DE   AltName: Full=Aspartate kinase;
GN   Name=lysC; OrderedLocusNames=aq_1152;
OS   Aquifex aeolicus.
OC   Bacteria; Aquificae; Aquificales; Aquificaceae; Aquifex.
OX   NCBI_TaxID=63363;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=VF5;
RX   MEDLINE=98196666; PubMed=9537320; DOI=10.1038/32831;
RA   Deckert G., Warren P.V., Gaasterland T., Young W.G., Lenox A.L.,
RA   Graham D.E., Overbeek R., Snead M.A., Keller M., Aujay M., Huber R.,
RA   Feldman R.A., Short J.M., Olsen G.J., Swanson R.V.;
RT   "The complete genome of the hyperthermophilic bacterium Aquifex
RT   aeolicus.";
RL   Nature 392:353-358(1998).
CC   -!- CATALYTIC ACTIVITY: ATP + L-aspartate = ADP + 4-phospho-L-
CC       aspartate.
CC   -!- PATHWAY: Amino-acid biosynthesis; L-lysine biosynthesis via DAP
CC       pathway; tetrahydrodipicolinate from L-aspartate: step 1/4.
CC   -!- PATHWAY: Amino-acid biosynthesis; L-methionine biosynthesis via de
CC       novo pathway; L-homoserine from L-aspartate: step 1/3.
CC   -!- PATHWAY: Amino-acid biosynthesis; L-threonine biosynthesis; L-
CC       threonine from L-aspartate: step 1/5.
CC   -!- SIMILARITY: Belongs to the aspartokinase family.
CC   -!- SIMILARITY: Contains 2 ACT domains.
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DR   EMBL; AE000657; AAC07182.1; -; Genomic_DNA.
DR   PIR; B70399; B70399.
DR   RefSeq; NP_213785.1; -.
DR   GeneID; 1192567; -.
DR   GenomeReviews; AE000657_GR; aq_1152.
DR   KEGG; aae:aq_1152; -.
DR   NMPDR; fig|224324.1.peg.800; -.
DR   HOGENOM; O67221; -.
DR   OMA; O67221; YEEMLEM.
DR   BioCyc; AAEO224324:AQ_1152-MON; -.
DR   BRENDA; 2.7.2.4; 189781.
DR   GO; GO:0016597; F:amino acid binding; IEA:InterPro.
DR   GO; GO:0004072; F:aspartate kinase activity; IEA:EC.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0019877; P:diaminopimelate biosynthetic process; IEA:UniProtKB-KW.
DR   InterPro; IPR002912; ACT_bd.
DR   InterPro; IPR001048; Asp/Glu/Uridylate_kinase.
DR   InterPro; IPR005260; Asp_kin_monofn.
DR   InterPro; IPR001341; Asp_kin_reg.
DR   InterPro; IPR018042; Aspartate_kinase_CS.
DR   Gene3D; G3DSA:3.40.1160.10; Aa_kinase; 1.
DR   Pfam; PF00696; AA_kinase; 1.
DR   Pfam; PF01842; ACT; 2.
DR   TIGRFAMs; TIGR00656; asp_kin_monofn; 1.
DR   TIGRFAMs; TIGR00657; asp_kinases; 1.
DR   PROSITE; PS00324; ASPARTOKINASE; 1.
PE   3: Inferred from homology;
KW   Amino-acid biosynthesis; ATP-binding; Complete proteome;
KW   Diaminopimelate biosynthesis; Kinase; Lysine biosynthesis;
KW   Nucleotide-binding; Repeat; Transferase.
FT   CHAIN         1    415       Aspartokinase.
FT                                /FTId=PRO_0000066671.
FT   DOMAIN      262    335       ACT 1.
FT   DOMAIN      342    405       ACT 2.
SQ   SEQUENCE   415 AA;  45519 MW;  E8111750A8C14162 CRC64;
     MKILVQKFGG TSVGTLERIE LCAKRVIKAL EKGYKPVVVS SAMAGETDSL IELAKKVHPR
     PPEREMDTLL AVGEQKAIAL FAMTLNKLGY PAVSLCGWQV PIITDNVHTK ARIRKIGISR
     LLSLIEEGYI PVVAGFQGVT EDWEITTLGR GGSDTTAVAL AAALKADCEI NTDVPGVFTA
     DPRIVPNAKK IKKISYEEML ELASLGAKVM QIRSVEFAAK YNVRIHVRST FSEEEGTWIV
     PEDEVMEKVA VRGITVDTKE TRFTVVRVPD KPGIAAEIFK ALGDAHIVVD MIVQNVSHEG
     YTDMSFTVNK TDADKAEEIV KKIAQKIGAK EVVRDDKVAK ISIVGIGMKS AYGVAGRMFD
     ILARNGINIK AISTSEIKIS CLIDEKYAEL AVRALHEEFI EEMEEFETIN GKNKE
//