O67221 (AK_AQUAE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Aspartokinase
EC=2.7.2.4

Alternative name(s):
Aspartate kinase

Gene names

Name:	lysC
Ordered Locus Names:	aq_1152

Organism

Aquifex aeolicus (strain VF5)

Taxonomic identifier

224324 [NCBI]

Taxonomic lineage

Bacteria › Aquificae › Aquificales › Aquificaceae › Aquifex

Protein attributes

Sequence length	415 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + L-aspartate = ADP + 4-phospho-L-aspartate.
Pathway	Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; (S)-tetrahydrodipicolinate from L-aspartate: step 1/4. Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-homoserine from L-aspartate: step 1/3. Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 1/5.
Sequence similarities	Belongs to the aspartokinase family. Contains 2 ACT domains.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Diaminopimelate biosynthesis Lysine biosynthesis
Domain	Repeat
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	diaminopimelate biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW amino acid binding Inferred from electronic annotation. Source: InterPro aspartate kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 415	415	Aspartokinase		PRO_0000066671
Regions
	Domain	262 – 335	74	ACT 1
	Domain	342 – 405	64	ACT 2

Sequences

	Sequence		Length	Mass (Da)
	O67221 [UniParc]. Last modified August 1, 1998. Version 1. Checksum: E8111750A8C14162	FASTA	415	45,519
	10 20 30 40 50 60 MKILVQKFGG TSVGTLERIE LCAKRVIKAL EKGYKPVVVS SAMAGETDSL IELAKKVHPR 70 80 90 100 110 120 PPEREMDTLL AVGEQKAIAL FAMTLNKLGY PAVSLCGWQV PIITDNVHTK ARIRKIGISR 130 140 150 160 170 180 LLSLIEEGYI PVVAGFQGVT EDWEITTLGR GGSDTTAVAL AAALKADCEI NTDVPGVFTA 190 200 210 220 230 240 DPRIVPNAKK IKKISYEEML ELASLGAKVM QIRSVEFAAK YNVRIHVRST FSEEEGTWIV 250 260 270 280 290 300 PEDEVMEKVA VRGITVDTKE TRFTVVRVPD KPGIAAEIFK ALGDAHIVVD MIVQNVSHEG 310 320 330 340 350 360 YTDMSFTVNK TDADKAEEIV KKIAQKIGAK EVVRDDKVAK ISIVGIGMKS AYGVAGRMFD 370 380 390 400 410 ILARNGINIK AISTSEIKIS CLIDEKYAEL AVRALHEEFI EEMEEFETIN GKNKE

References

[1]

"The complete genome of the hyperthermophilic bacterium Aquifex aeolicus." Deckert G., Warren P.V., Gaasterland T., Young W.G., Lenox A.L., Graham D.E., Overbeek R., Snead M.A., Keller M., Aujay M., Huber R., Feldman R.A., Short J.M., Olsen G.J., Swanson R.V. Nature 392:353-358(1998) [PubMed: 9537320] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: VF5.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE000657 Genomic DNA. Translation: AAC07182.1.
PIR	B70399.
RefSeq	NP_213785.1. NC_000918.1.
3D structure databases
ProteinModelPortal	O67221.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1192567.
GenomeReviews	Gene locus aq_1152 in contig AE000657_GR.
KEGG	aae:aq_1152.
NMPDR	fig|224324.1.peg.800.
PATRIC	20959554. VBIAquAeo85532_0897.
Phylogenomic databases
HOGENOM	HBG724395.
OMA	VHVRSSF.
PhylomeDB	O67221.
ProtClustDB	CLSK2299606.
Enzyme and pathway databases
BioCyc	AAEO224324:AQ_1152-MONOMER.
Family and domain databases
InterPro	IPR002912. ACT-bd. IPR001048. Asp/Glu/Uridylate_kinase. IPR005260. Asp_kin_monofn. IPR001341. Asp_kinase_dom. IPR018042. Aspartate_kinase_CS. [Graphical view]
Gene3D	G3DSA:3.40.1160.10. Aa_kinase. 1 hit.
KO	K00928.
Pfam	PF00696. AA_kinase. 1 hit. PF01842. ACT. 2 hits. [Graphical view]
PIRSF	PIRSF000726. Asp_kin. 1 hit.
SUPFAM	SSF53633. Aa_kinase. 1 hit.
TIGRFAMs	TIGR00656. Asp_kin_monofn. 1 hit. TIGR00657. Asp_kinases. 1 hit.
PROSITE	PS00324. ASPARTOKINASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

AK_AQUAE

Accession

Primary (citable) accession number: O67221

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	August 1, 1998
Last modified:	January 25, 2012
This is version 71 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program